Q-Flux: A method to assess hepatic mitochondrial succinate dehydrogenase, methylmalonyl-CoA mutase, and glutaminase fluxes in vivo

Acute effects of the food preservative propionic acid on glucose metabolism in humans

(2021) Gail K Adler et al.   BMJ Open Diabetes Research & Care

Fumarate is a terminal electron acceptor in the mammalian electron transport chain

(2021) Jessica B. Spinelli et al.   SCIENCE

In vivo genome editing at the albumin locus to treat methylmalonic acidemia

(2021) Jessica L. Schneller et al.   Molecular Therapy-Methods & Clinical Development

Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis

(2020) Rachel J. Perry et al.   NATURE

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

(2020) Stephanie J. Alexopoulos et al.   Nature Communications

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

(2020) Kun Lyu et al.   Cell Metabolism

Promoterless, nuclease‐free genome editing confers a growth advantage for corrected hepatocytes in mice with methylmalonic acidemia

(2020) Randy J. Chandler et al.   HEPATOLOGY

Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis

(2020) Marie Winther-Sørensen et al.   Molecular Metabolism

The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans

(2019) Amir Tirosh et al.   Science Translational Medicine

Gene Therapy for Methylmalonic Acidemia: Past, Present, and Future

(2019) Randy Joseph Chandler et al.   HUMAN GENE THERAPY

Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair

(2019) Markus Ruetz et al.   SCIENCE

Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates

(2019) Leigh Goedeke et al.   Science Translational Medicine

Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis

(2018) Katrine D. Galsgaard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation

(2018) Rachel J. Perry et al.   CELL

Targeting hepatic glutaminase activity to ameliorate hyperglycemia

(2018) Russell A Miller et al.   NATURE MEDICINE

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)

(2017) Rachel J. Perry et al.   Nature Communications

Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by 13 C Magnetic Resonance Spectroscopy

(2016) Kitt Falk Petersen et al.   Cell Metabolism

Glucagon: acute actions on hepatic metabolism

(2016) Russell A. Miller et al.   DIABETOLOGIA

Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism

(2016) Rachel J. Perry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mass spectrometry-based microassay of 2H and 13C plasma glucose labeling to quantify liver metabolic fluxes in vivo

(2015) Clinton M. Hasenour et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle

(2015) Tiago C. Alves et al.   Cell Metabolism

A roadmap for interpreting 13 C metabolite labeling patterns from cells

(2015) Joerg M Buescher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

INCA: a computational platform for isotopically non-stationary metabolic flux analysis

(2014) J. D. Young   BIOINFORMATICS

Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

(2014) Rachel J Perry et al.   NATURE MEDICINE

In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation

(2013) Paulo A. Gameiro et al.   Cell Metabolism

Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy

(2013) Douglas E Befroy et al.   NATURE MEDICINE

Measuring Deuterium Enrichment of Glucose Hydrogen Atoms by Gas Chromatography/Mass Spectrometry

(2011) Maciek R. Antoniewicz et al.   ANALYTICAL CHEMISTRY

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance

(2011) Tiago C. Alves et al.   HEPATOLOGY

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

Structure, mechanism and regulation of pyruvate carboxylase

(2008) Sarawut Jitrapakdee et al.   BIOCHEMICAL JOURNAL