Regulation of hepatic glucose metabolism in health and disease

Mechanism for leptin’s acute insulin-independent effect to reverse diabetic ketoacidosis

(2017) Rachel J. Perry et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

(2017) Kasper W. ter Horst et al.   Cell Reports

The current role of thiazolidinediones in diabetes management

(2016) Christos V. Rizos et al.   ARCHIVES OF TOXICOLOGY

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

(2016) Brian Finan et al.   CELL

Asprosin, a Fasting-Induced Glucogenic Protein Hormone

(2016) Chase Romere et al.   CELL

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

(2016) Paul M. Titchenell et al.   Cell Metabolism

Integrin-Linked Kinase Is Necessary for the Development of Diet-Induced Hepatic Insulin Resistance

(2016) Ashley S. Williams et al.   DIABETES

Clinical Trials, Triumphs, and Tribulations of Glucagon Receptor Antagonists

(2016) Mackenzie J. Pearson et al.   DIABETES CARE

Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis

(2016) Rachel J. Perry et al.   DIABETOLOGIA

Glucagon is the key factor in the development of diabetes

(2016) Young H. Lee et al.   DIABETOLOGIA

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

(2016) Max C. Petersen et al.   JOURNAL OF CLINICAL INVESTIGATION

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

(2016) Matthew James Armstrong et al.   LANCET

Circadian time signatures of fitness and disease

(2016) Joseph Bass et al.   SCIENCE

Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes

(2016) Adam R. Konopka et al.   Cell Reports

Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival

(2016) Ursula H. Neumann et al.   Molecular Metabolism

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Glucokinase regulatory protein

(2015) Anne Raimondo et al.   CURRENT OPINION IN LIPIDOLOGY

Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies

(2015) Christof M. Kazda et al.   DIABETES CARE

6. Obesity Management for the Treatment of Type 2 Diabetes

(2015)   DIABETES CARE

7. Approaches to Glycemic Treatment

(2015)   DIABETES CARE

Short-term administration of the glucagon receptor antagonist LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes

(2015) R. P. Kelly et al.   DIABETES OBESITY & METABOLISM

Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2

(2015) Meghan F. Hogan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dosing profile profoundly influences nicotinic acid’s ability to improve metabolic control in rats

(2015) Tobias Kroon et al.   JOURNAL OF LIPID RESEARCH

Glucagon receptor antagonism induces increased cholesterol absorption

(2015) Hong-Ping Guan et al.   JOURNAL OF LIPID RESEARCH

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo

(2015) Paul M. Titchenell et al.   Nature Communications

FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

(2015) InSug O-Sullivan et al.   Nature Communications

The Amelioration of Hepatic Steatosis by Thyroid Hormone Receptor Agonists Is Insufficient to Restore Insulin Sensitivity in Ob/Ob Mice

(2015) Alexandro J. Martagón et al.   PLoS One

The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents

(2014) Greg M. Kowalski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein

(2014) Kirsty S. Cullen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Control of Gluconeogenesis by Metformin: Does Redox Trump Energy Charge?

(2014) Joseph A. Baur et al.   Cell Metabolism

Thiazolidinediones and the Promise of Insulin Sensitization in Type 2 Diabetes

(2014) Raymond E. Soccio et al.   Cell Metabolism

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)

(2014) Jia Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

(2014) Rachel J Perry et al.   NATURE MEDICINE

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

(2014) Brian Finan et al.   NATURE MEDICINE

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells

(2014) Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways

(2013) Daniel F. Vatner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler

(2013) Rachel J. Perry et al.   Cell Metabolism

A Noncanonical, GSK3-Independent Pathway Controls Postprandial Hepatic Glycogen Deposition

(2013) Min Wan et al.   Cell Metabolism

Glucose-6-Phosphate-Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis

(2013) A. von Wilamowitz-Moellendorff et al.   DIABETES

Insulin-mediated suppression of lipolysis in adipose tissue and skeletal muscle of obese type 2 diabetic men and men with normal glucose tolerance

(2013) Johan W. E. Jocken et al.   DIABETOLOGIA

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Cooperation between brain and islet in glucose homeostasis and diabetes

(2013) Michael W. Schwartz et al.   NATURE

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Effects of Niacin on Glucose Levels, Coronary Stenosis Progression, and Clinical Events in Subjects With Normal Baseline Glucose Levels (

(2012) Binh An P. Phan et al.   AMERICAN JOURNAL OF CARDIOLOGY

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

(2012) Laurent Bultot et al.   BIOCHEMICAL JOURNAL

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects

(2012) Faidon Magkos et al.   GASTROENTEROLOGY

Central nervous system control of metabolism

(2012) Martin G. Myers et al.   NATURE

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes

(2012) Yiguo Wang et al.   NATURE

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

(2012) Zheng Sun et al.   NATURE MEDICINE

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

(2012) Mingjian Lu et al.   NATURE MEDICINE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic manifestations of insulin deficiency do not occur without glucagon action

(2012) Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hepatic Glucose Uptake and Storage In Vivo

(2012) Mary Courtney Moore et al.   Advances in Nutrition

Glucagon secretion and signaling in the development of diabetes

(2012) Herbert Y. Gaisano et al.   Frontiers in Physiology

Hormonal Regulation of Hepatic Glucose Production in Health and Disease

(2011) Hua V. Lin et al.   Cell Metabolism

Loss of Inverse Relationship Between Pulsatile Insulin and Glucagon Secretion in Patients With Type 2 Diabetes

(2011) B. A. Menge et al.   DIABETES

Glucagon antagonism as a potential therapeutic target in type 2 diabetes

(2011) J. I. Bagger et al.   DIABETES OBESITY & METABOLISM

Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs

(2011) Christopher J. Ramnanan et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Pathogenesis of Fasting and Postprandial Hyperglycemia in Type 2 Diabetes: Implications for Therapy

(2010) R. A. Rizza   DIABETES

Molecular Characterization of Insulin-Mediated Suppression of Hepatic Glucose Production In Vivo

(2010) C. J. Ramnanan et al.   DIABETES

Hepatic Overexpression of a Constitutively Active Form of Liver Glycogen Synthase Improves Glucose Homeostasis

(2010) Susana Ros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxOs Function Synergistically to Promote Glucose Production

(2010) Rebecca A. Haeusler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

(2010) Eric E Zhang et al.   NATURE MEDICINE

The metabolic actions of glucagon revisited

(2010) Kirk M. Habegger et al.   Nature Reviews Endocrinology

Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity

(2010) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse

(2009) Owen P. McGuinness et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

(2009) Ling He et al.   CELL

Effects of Insulin on the Metabolic Control of Hepatic Gluconeogenesis In Vivo

(2009) Dale S. Edgerton et al.   DIABETES

Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis

(2009) Amalia Gastaldelli et al.   HEPATOLOGY

Control of Liver Glycogen Synthase Activity and Intracellular Distribution by Phosphorylation

(2009) Susana Ros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes

(2009) V. T. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucokinase and molecular aspects of liver glycogen metabolism

(2008) Loranne Agius   BIOCHEMICAL JOURNAL

The Glucagon Receptor Is Required for the Adaptive Metabolic Response to Fasting

(2008) Christine Longuet et al.   Cell Metabolism

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

(2008) Yi Liu et al.   NATURE

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of protein translocation in the regulation of glycogen metabolism

(2007) Michael J. Jurczak et al.   JOURNAL OF CELLULAR BIOCHEMISTRY