Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism

The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

(2021) Deyang Yu et al.   Cell Metabolism

PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity

(2021) Maynara L. Andrade et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

(2020) Sharanya Sivanand et al.   CANCER CELL

Amino acids in cancer

(2020) Elizabeth L. Lieu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Differential regulation of mTORC1 activation by leucine and β-hydroxy-β-methylbutyrate in skeletal muscle of neonatal pigs

(2020) Agus Suryawan et al.   JOURNAL OF APPLIED PHYSIOLOGY

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

(2020) Jin-Tao Li et al.   NATURE CELL BIOLOGY

Regulation of Skeletal Muscle Function by Amino Acids

(2020) Yasutomi Kamei et al.   Nutrients

Statins activate the NLRP3 inflammasome and impair insulin signalling via p38 and mTOR

(2020) Brandyn D. Henriksbo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effect of valine on myotube insulin sensitivity and metabolism with and without insulin resistance

(2020) Madison E. Rivera et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer

(2020) Qin Tian et al.   ONCOGENE

APN-mediated phosphorylation of BCKDK promotes hepatocellular carcinoma metastasis and proliferation via the ERK signaling pathway

(2020) Mengying Zhai et al.   Cell Death & Disease

Are Fatty Acids Gluconeogenic Precursors?

(2020) Michael H Green   JOURNAL OF NUTRITION

What Constitutes a Gluconeogenic Precursor?

(2020) Mark A Tetrick et al.   JOURNAL OF NUTRITION

MiR-125a-3p-KLF15-BCAA Regulates the Skeletal Muscle Branched-Chain Amino Acid Metabolism in Nile Tilapia (Oreochromis niloticus) During Starvation

(2020) Honghui Li et al.   Frontiers in Genetics

Exploring mechanistic links between extracellular BCAA & muscle insulin resistance: an in vitro approach

(2020) Hannah Crossland et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression

(2019) Russell E. Ericksen et al.   Cell Metabolism

Impaired Skeletal Muscle Branched-Chain Amino Acids Catabolism Contributes to Their Increased Circulating Levels in a Non-Obese Insulin-Resistant Fructose-Fed Rat Model

(2019) Jérémie David et al.   Nutrients

Branched-chain amino acids in disease

(2019) Phillip J. White et al.   SCIENCE

The ubiquitin ligase UBE3B, disrupted in intellectual disability and absent speech, regulates metabolic pathways by targeting BCKDK

(2019) Solmi Cheon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of branched-chain amino acid–catabolizing enzymes in intertissue signaling, metabolic remodeling, and energy homeostasis

(2019) Dipsikha Biswas et al.   FASEB JOURNAL

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

(2019) Meiyi Zhou et al.   DIABETES

Mitigation of Muscle Loss in Stressed Physiology: Military Relevance

(2019) David D. Church et al.   Nutrients

Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster?

(2019) Jie Jiang et al.   Cancers

Effect of metformin on myotube BCAA catabolism

(2019) Madison E. Rivera et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Fasting and rapamycin: diabetes versus benevolent glucose intolerance

(2019) Mikhail V. Blagosklonny   Cell Death & Disease

BCAA Catabolic Defect Alters Glucose Metabolism in Lean Mice

(2019) Ji Wang et al.   Frontiers in Physiology

Branched-chain amino acids sustain pancreatic cancer growth by regulating lipid metabolism

(2019) Ji Hyeon Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The Effects of BCAAs on Insulin Resistance in Athletes

(2019) Jian SHOU et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Dysregulation of glutaminase and glutamine synthetase in cancer

(2019) José M. Matés et al.   CANCER LETTERS

PP2Cm overexpression alleviates MI/R injury mediated by a BCAA catabolism defect and oxidative stress in diabetic mice

(2019) Kun Lian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model

(2019) Allison M Owen et al.   eLife

Skeletal muscle amino acid transporter and BCAT2 expression prior to and following interval running or resistance exercise in mode-specific trained males

(2018) Paul A. Roberson et al.   AMINO ACIDS

MiR-330-5p negatively regulates ovine preadipocyte differentiation by targeting branched-chain aminotransferase 2

(2018) Tao Shi et al.   ANIMAL SCIENCE JOURNAL

Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways

(2018) Michelle van Geldermalsen et al.   BMC CANCER

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase

(2018) Phillip J. White et al.   Cell Metabolism

Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements

(2018) Milan Holeček   Nutrition & Metabolism

Krüppel-like factor 15: Regulator of BCAA metabolism and circadian protein rhythmicity

(2018) Liyan Fan et al.   PHARMACOLOGICAL RESEARCH

Dietary supplementation with ketoacids protects against CKD-induced oxidative damage and mitochondrial dysfunction in skeletal muscle of 5/6 nephrectomised rats

(2018) Dongtao Wang et al.   Skeletal Muscle

Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice

(2018) Lisa M. Walter et al.   EBioMedicine

Anti-ageing pipeline starts to mature

(2018) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Crystal structure and catalytic activity of the PPM1K N94K mutant

(2018) Meisam Rostaminasab Dolatabad et al.   JOURNAL OF NEUROCHEMISTRY

Plasma Branched-Chain Amino Acids and Risk of Incident Type 2 Diabetes: Results from the PREVEND Prospective Cohort Study

(2018) Jose Flores-Guerrero et al.   Journal of Clinical Medicine

Neuroprotective Strategy in Retinal Degeneration: Suppressing ER Stress-Induced Cell Death via Inhibition of the mTOR Signal

(2017) Bin Fan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endurance Exercise Attenuates Postprandial Whole-Body Leucine Balance in Trained Men

(2017) MICHAEL MAZZULLA et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

MicroRNA-182 Regulates Neurite Outgrowth Involving the PTEN/AKT Pathway

(2017) Wu M. Wang et al.   Frontiers in Cellular Neuroscience

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling

(2017) Mee-Sup Yoon   Nutrients

Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition

(2017) Takuya Ishikawa et al.   Scientific Reports

Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP

(2017) Anna B. Ziegler et al.   Cell Reports

BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer

(2017) Peipei Xue et al.   EBioMedicine

Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism

(2017) María Isabel Hernández-Alvarez et al.   Scientific Reports

Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner

(2016) Mahshid Moghei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Activation of mTORC1 by leucine is potentiated by branched-chain amino acids and even more so by essential amino acids following resistance exercise

(2016) Marcus Moberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Leucine alleviates dexamethasone-induced suppression of muscle protein synthesis via synergy involvement of mTOR and AMPK pathways

(2016) X. J. Wang et al.   BIOSCIENCE REPORTS

Low-protein diet supplemented with ketoacids ameliorates proteinuria in 3/4 nephrectomised rats by directly inhibiting the intrarenal renin–angiotensin system

(2016) Jia-ying Zhang et al.   BRITISH JOURNAL OF NUTRITION

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

(2016) Dora C. Tărlungeanu et al.   CELL

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart FailureCLINICAL PERSPECTIVE

(2016) Haipeng Sun et al.   CIRCULATION

BCAT1, a key prognostic predictor of hepatocellular carcinoma, promotes cell proliferation and induces chemoresistance to cisplatin

(2016) Yi-Hu Zheng et al.   LIVER INTERNATIONAL

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Induction of Connective Tissue Growth Factor Expression by Hypoxia in Human Lung Fibroblasts via the MEKK1/MEK1/ERK1/GLI-1/GLI-2 and AP-1 Pathways

(2016) Yi Cheng et al.   PLoS One

The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism

(2016) Mee-Sup Yoon   Nutrients

mTORC1 is involved in the regulation of branched-chain amino acid catabolism in mouse heart

(2016) Hongmin Zhen et al.   FEBS Open Bio

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

(2016) Phillip J. White et al.   Molecular Metabolism

Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism

(2016) Carles Lerin et al.   Molecular Metabolism

Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD

(2016) Davis S. Sonnet et al.   Scientific Reports

Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells

(2015) Bang-fen Pan et al.   ACTA PHARMACOLOGICA SINICA

Alternative Fuels for Cancer Cells

(2015) Melissa M. Keenan et al.   CANCER JOURNAL

Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes

(2015) Pieter Giesbertz et al.   DIABETOLOGIA

Global deletion of BCATm increases expression of skeletal muscle genes associated with protein turnover

(2015) Christopher J. Lynch et al.   PHYSIOLOGICAL GENOMICS

Maternal Diabetes Leads to Adaptation in Embryonic Amino Acid Metabolism during Early Pregnancy

(2015) Jacqueline Gürke et al.   PLoS One

A Trial for the ages

(2015) S. S. Hall   SCIENCE

Branched-chain amino acids and the association with type 2 diabetes

(2015) Xiaoping Chen et al.   Journal of Diabetes Investigation

BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism

(2015) Zhi-Qiang Wang et al.   Oncotarget

Glutamine deficiency in extracellular fluid exerts adverse effects on protein and amino acid metabolism in skeletal muscle of healthy, laparotomized, and septic rats

(2014) Milan Holecek et al.   AMINO ACIDS

Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes

(2014) Mako Yasuda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Impaired Adiponectin Signaling Contributes to Disturbed Catabolism of Branched-Chain Amino Acids in Diabetic Mice

(2014) Kun Lian et al.   DIABETES

β-Hydroxy-β-methylbutyrate facilitates PI3K/Akt-dependent mammalian target of rapamycin and FoxO1/3a phosphorylations and alleviates tumor necrosis factor α/interferon γ–induced MuRF-1 expression in C2C12 cells

(2014) Kaoru Kimura et al.   NUTRITION RESEARCH

Metabolomic profiles and childhood obesity

(2014) Wei Perng et al.   Obesity

Effects of Leucine Supplementation and Serum Withdrawal on Branched-Chain Amino Acid Pathway Gene and Protein Expression in Mouse Adipocytes

(2014) Abderrazak Kitsy et al.   PLoS One

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium

(2014) O V Leontieva et al.   Cell Death & Disease

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

(2014) Lynne Chantranupong et al.   Cell Reports

Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity

(2013) Denise E. Lackey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sex Hormones and Macronutrient Metabolism

(2013) Raffaella Comitato et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Potential Role of Branched-Chain Amino Acid Catabolism in Regulating Fat Oxidation

(2013) Heikki Kainulainen et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Time course of gene expression during mouse skeletal muscle hypertrophy

(2013) Thomas Chaillou et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism

(2013) D. J. Wilkinson et al.   JOURNAL OF PHYSIOLOGY-LONDON

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

(2013) Martje Tönjes et al.   NATURE MEDICINE

Branched-chain amino acids and ammonia metabolism in liver disease: Therapeutic implications

(2013) Milan Holecek   NUTRITION

Leucine and Protein Metabolism in Obese Zucker Rats

(2013) Pengxiang She et al.   PLoS One

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain  -ketoacid dehydrogenase kinase

(2013) S.-C. Tso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the PI3-Kinase/Akt/mTOR Signaling Pathway

(2013) Burhan Hassan et al.   Surgical Oncology Clinics of North America

Branched-chain amino acids in liver diseases

(2013) Kazuto Tajiri   WORLD JOURNAL OF GASTROENTEROLOGY

Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway

(2012) Jing-tao Lu et al.   ACTA PHARMACOLOGICA SINICA

mTORC1 and the regulation of skeletal muscle anabolism and mass

(2012) Olasunkanmi A.J. Adegoke et al.   Applied Physiology Nutrition and Metabolism

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Klf15 Orchestrates Circadian Nitrogen Homeostasis

(2012) Darwin Jeyaraj et al.   Cell Metabolism

Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise

(2012) Jared M. Dickinson et al.   CLINICAL NUTRITION

Adiponectin Corrects High-Fat Diet-Induced Disturbances in Muscle Metabolomic Profile and Whole-Body Glucose Homeostasis

(2012) Y. Liu et al.   DIABETES

Adiponectin: mechanistic insights and clinical implications

(2012) A. T. Turer et al.   DIABETOLOGIA

Structural and Biochemical Characterization of Human Mitochondrial Branched-chain α-Ketoacid Dehydrogenase Phosphatase

(2012) R. Max Wynn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-specific and Nutrient Regulation of the Branched-chain α-Keto Acid Dehydrogenase Phosphatase, Protein Phosphatase 2Cm (PP2Cm)

(2012) Meiyi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy

(2012) G. Novarino et al.   SCIENCE

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression

(2011) Yun-Seung Jeong et al.   PLoS One

Acute hyperammonemia activates branched-chain amino acid catabolism and decreases their extracellular concentrations: different sensitivity of red and white muscle

(2010) Milan Holecek et al.   AMINO ACIDS

Effect of an oral branched chain amino acid-enriched snack in cirrhotic patients with sleep disturbance

(2010) Tatsuki Ichikawa et al.   HEPATOLOGY RESEARCH

Disruption of BCAA metabolism in mice impairs exercise metabolism and endurance

(2010) Pengxiang She et al.   JOURNAL OF APPLIED PHYSIOLOGY

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

(2010) Hakan Cam et al.   MOLECULAR CELL

Inhibition of Branched-Chain α-Ketoacid Dehydrogenase Kinase by Thiamine Pyrophosphate at Different Potassium Ionic Levels

(2009) Keiichi AKITA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

A low-protein diet supplemented with ketoacids plays a more protective role against oxidative stress of rat kidney tissue with 5/6 nephrectomy than a low-protein diet alone

(2009) Xiang Gao et al.   BRITISH JOURNAL OF NUTRITION

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

EFFECT OF EXERCISE ON GLUTAMINE SYNTHESIS AND TRANSPORT IN SKELETAL MUSCLE FROM RATS

(2009) Ronaldo VT dos Santos et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Muscle atrophy in immobilization and senescence in humans

(2009) Andrew J Murton et al.   CURRENT OPINION IN NEUROLOGY

Branched-chain Amino Acid Metabolon

(2009) Mohammad Mainul Islam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells

(2009) Gang Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma Acylcarnitine Profiles Suggest Incomplete Long-Chain Fatty Acid β-Oxidation and Altered Tricarboxylic Acid Cycle Activity in Type 2 Diabetic African-American Women

(2009) Sean H. Adams et al.   JOURNAL OF NUTRITION

Branched-Chain Amino-Acid Metabolism in Renal Failure

(2009) Noël J.M. Cano   JOURNAL OF RENAL NUTRITION

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Adverse metabolic and cardiovascular consequences of circadian misalignment

(2009) F. A. J. L. Scheer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of a late evening snack combined with α-glucosidase inhibitor on liver cirrhosis

(2008) Keiko Korenaga et al.   HEPATOLOGY RESEARCH