Scorpion venom peptides: Molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers

Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K+ Channel KV1.2 and Small- and Intermediate-Conductance Ca2+-Activated K+ Channels KCa2.2 and KCa3.1

(2023) Muhammad Umair Naseem et al.   Toxins

Autophagy in Inflammatory Response against SARS-CoV-2

(2023) Roxana Resnik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BotCl, the First Chlorotoxin-Like Peptide Inhibiting Newcastle Disease Virus: The Emergence of a New Scorpion Venom AMPs Family

(2023) Abir Jlassi et al.   MOLECULES

Comment on epidemiology of scorpionism in France: nationwide scorpion exposure. Description of Buthus pyrenaeus envenoming

(2022) Jules-Antoine Vaucel et al.   CLINICAL TOXICOLOGY

Scorpion Species with Smaller Body Sizes and Narrower Chelae Have the Highest Venom Potency

(2022) Alannah Forde et al.   Toxins

Scorpion Neurotoxin Syb-prII-1 Exerts Analgesic Effect through Nav1.8 Channel and MAPKs Pathway

(2022) Fei Bai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Innovative treatments for epilepsy: Venom peptides, cannabinoids, and neurostimulation

(2022) Larissa Silva de Lima et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges

(2022) Chaochao Yu et al.   Journal of Zhejiang University-SCIENCE B

Mechanisms underlying the inhibition of KV1.3 channel by scorpion toxin ImKTX58

(2022) Xu Zhang et al.   MOLECULAR PHARMACOLOGY

The Strong Anti-Tumor Effect of Smp24 in Lung Adenocarcinoma A549 Cells Depends on Its Induction of Mitochondrial Dysfunctions and ROS Accumulation

(2022) Ruiyin Guo et al.   Toxins

Smp24, a Scorpion-Venom Peptide, Exhibits Potent Antitumor Effects against Hepatoma HepG2 Cells via Multi-Mechanisms In Vivo and In Vitro

(2022) Tienthanh Nguyen et al.   Toxins

Antimicrobial Activity Developed by Scorpion Venoms and Its Peptide Component

(2022) Clara Andrea Rincón-Cortés et al.   Toxins

Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis

(2022) Yan Hu et al.   Journal of Neuroinflammation

Characterization of a Family of Scorpion Toxins Modulating Ca2+-Activated Cl− Current in Vascular Myocytes

(2022) Jean-Luc Morel et al.   Toxins

Epidemiology of scorpionism in France: nationwide scorpion exposure

(2021) Jules-Antoine Vaucel et al.   CLINICAL TOXICOLOGY

CTX-CNF1 Recombinant Protein Selectively Targets Glioma Cells In Vivo

(2021) Eleonora Vannini et al.   Toxins

Discovery of a New Analgesic Peptide, Leptucin, from the Iranian Scorpion, Hemiscorpius lepturus

(2021) Sedigheh Bagheri-Ziari et al.   MOLECULES

Mapping the interaction surface of scorpion β-toxins with an insect sodium channel

(2021) Boris S. Zhorov et al.   BIOCHEMICAL JOURNAL

The ever‐increasing importance of cancer as a leading cause of premature death worldwide

(2021) Freddie Bray et al.   CANCER

Antimicrobial/anticancer peptides: bioactive molecules and therapeutic agents

(2021) Kimia Kardani et al.   Immunotherapy

Advances in TRP channel drug discovery: from target validation to clinical studies

(2021) Ari-Pekka Koivisto et al.   NATURE REVIEWS DRUG DISCOVERY

Structural and functional characterization of NDBP-4 family antimicrobial peptides from the scorpion Mesomexovis variegatus

(2021) Juana María Jiménez-Vargas et al.   PEPTIDES

Study of Anti-Inflammatory and Analgesic Activity of Scorpion Toxins DKK-SP1/2 from Scorpion Buthus martensii Karsch (BmK)

(2021) Yunxia Liu et al.   Toxins

BmK86-P1, a New Degradation Peptide with Desirable Thermostability and Kv1.2 Channel-Specific Activity from Traditional Chinese Scorpion Medicinal Material

(2021) Chenhu Qin et al.   Toxins

Scorpion-Derived Antiviral Peptides with a Special Focus on Medically Important Viruses: An Update

(2021) Moulay Abdelmonaim El Hidan et al.   Biomed Research International

Blockade of Microglial Kv1.3 Potassium Channels by the Peptide HsTX1[R14A] Attenuates Lipopolysaccharide-mediated Neuroinflammation

(2021) Joseph A. Nicolazzo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Scorpion Venom peptide, AGAP inhibits TRPV1 and potentiates the analgesic effect of lidocaine

(2021) Sylvanus Kampo et al.   Heliyon

Scorpion envenomation: state of the art

(2020) Fekri Abroug et al.   INTENSIVE CARE MEDICINE

Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma

(2020) Dongrui Wang et al.   Science Translational Medicine

Pleiotropic Anticancer Properties of Scorpion Venom Peptides: Rhopalurus princeps Venom as an Anticancer Agent

(2020) Arthur G Mikaelian et al.   Drug Design Development and Therapy

Scorpion Toxins and Ion Channels: Potential Applications in Cancer Therapy

(2020) Rosa Amalia Dueñas-Cuellar et al.   Toxins

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

(2020) Mehdi Bouhaddou et al.   CELL

Voltage-Gated K+/Na+ Channels and Scorpion Venom Toxins in Cancer

(2020) Alexis Díaz-García et al.   Frontiers in Pharmacology

From Animal Poisons and Venoms to Medicines: Achievements, Challenges and Perspectives in Drug Discovery

(2020) Karla de Castro Figueiredo Bordon et al.   Frontiers in Pharmacology

Scorpion Venom: Detriments and Benefits

(2020) Shirin Ahmadi et al.   Biomedicines

Toxin-like neuropeptides in the sea anemone Nematostella unravel recruitment from the nervous system to venom

(2020) Maria Y. Sachkova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biology, venom composition, and scorpionism induced by brazilian scorpion Tityus stigmurus (Thorell, 1876) (Scorpiones: Buthidae): A mini-review

(2020) Allanny Alves Furtado et al.   TOXICON

Epilepsy-Related Voltage-Gated Sodium Channelopathies: A Review

(2020) Luis Felipe Santos Menezes et al.   Frontiers in Pharmacology

Methionine 58 is a key residue in the modulation of BmK scorpion toxin AGP-SYPU2 activity through in silico and in vivo studies

(2020) Yong Cui et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Scorpion Venom Analgesic Peptide, BmK AGAP Inhibits Stemness, and Epithelial-Mesenchymal Transition by Down-Regulating PTX3 in Breast Cancer

(2019) Sylvanus Kampo et al.   Frontiers in Oncology

Chlorotoxin targets ERα/VASP signaling pathway to combat breast cancer

(2019) Ying Wang et al.   Cancer Medicine

Structural basis of α-scorpion toxin action on Nav channels

(2019) Thomas Clairfeuille et al.   SCIENCE

Epilepsy in adults

(2019) Roland D Thijs et al.   LANCET

BmK AEP, an Anti-Epileptic Peptide Distinctly Affects the Gating of Brain Subtypes of Voltage-Gated Sodium Channels

(2019) Fan Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression

(2019) Isadora S Oliveira et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Diverse Structural Features of Potassium Channels Characterized by Scorpion Toxins as Molecular Probes

(2019) Yonghui Zhao et al.   MOLECULES

Peptides with therapeutic potential in the venom of the scorpion Buthus martensii Karsch

(2019) Zhongjie Li et al.   PEPTIDES

Kalium 2.0, a comprehensive database of polypeptide ligands of potassium channels

(2019) Valentin M. Tabakmakher et al.   Scientific Data

Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review

(2019) Henning Hermanns et al.   BRITISH JOURNAL OF ANAESTHESIA

Anti-tumoral effect of scorpion peptides: Emerging new cellular targets and signaling pathways

(2019) Najet Srairi-Abid et al.   CELL CALCIUM

TsNTxP, a non-toxic protein from Tityus serrulatus scorpion venom, induces antinociceptive effects by suppressing glutamate release in mice

(2019) Flávia Karine Rigo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Smp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus

(2019) Alaa M. H. El-Bitar et al.   International Journal of Peptide Research and Therapeutics

A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain

(2019) John V. Lin King et al.   CELL

Scorpion venomics: a 2019 overview

(2019) Jimena I. Cid-Uribe et al.   Expert Review of Proteomics

Selective Blockade of Neuronal BK (α + β4) Channels Preventing Epileptic Seizure

(2019) Xinlian Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Immunosuppressive effects of a novel potassium channel toxin Ktx-Sp2 from Scorpiops Pocoki

(2019) Yubiao Zhang et al.   Cell and Bioscience

RK1, the first very short peptide from Buthus occitanus tunetanus inhibits tumor cell migration, proliferation and angiogenesis

(2018) Oussema Khamessi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clinical use of toxic proteins and peptides from Tian Hua Fen and scorpion venom

(2018) Chen Ling et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The new definition and classification of seizures and epilepsy

(2018) Jessica J. Falco-Walter et al.   EPILEPSY RESEARCH

Functional role of Kv1.1 and Kv1.3 channels in the neoplastic progression steps of three cancer cell lines, elucidated by scorpion peptides

(2018) Dorra Aissaoui et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Triggering of cancer cell cycle arrest by a novel scorpion venom-derived peptide-Gonearrestide

(2018) Bin Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The evolution and distribution of noxious species of scorpions (Arachnida: Scorpiones)

(2018) Wilson R. Lourenço   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Expression of recombinant α-toxin BmKM9 from scorpion Buthus martensii Karsch and its functional characterization on sodium channels

(2018) Fan Yang et al.   PEPTIDES

Scorpion Venom Peptides As A Potential Source For Human Drug Candidates

(2018) Bushra Uzair et al.   PROTEIN AND PEPTIDE LETTERS

BotAF, a new Buthus occitanus tunetanus scorpion toxin, produces potent analgesia in rodents

(2018) Riadh Maatoug et al.   TOXICON

Scorpion toxins to unravel the conundrum of ion channel structure and functioning

(2018) Ernesto Ortiz et al.   TOXICON

Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1

(2018) Zhengyang Zeng et al.   Theranostics

Sea Anemones: Quiet Achievers in the Field of Peptide Toxins

(2018) Peter J. Prentis et al.   Toxins

Biophysical characterization and antitumor activity of synthetic Pantinin peptides from scorpion's venom

(2018) Edson Crusca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation

(2018) José Ignacio Veytia-Bucheli et al.   Cell Communication and Signaling

A scorpion venom peptide Ev37 restricts viral late entry by alkalizing acidic organelles

(2018) Fangfang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chlorotoxin—A Multimodal Imaging Platform for Targeting Glioma Tumors

(2018) Gadi Cohen et al.   Toxins

On the form and bio-mechanics of venom-injection elements

(2018) Benny Bar-On   Acta Biomaterialia

The roles of conserved aromatic residues (Tyr5 and Tyr42) in interaction of scorpion toxin BmK AGP-SYPU1 with human Na v 1.7

(2017) Xiangxue Meng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Antiviral activity of animal venom peptides and related compounds

(2017) Élida Cleyse Gomes da Mata et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Pharmacological screening technologies for venom peptide discovery

(2017) Jutty Rajan Prashanth et al.   NEUROPHARMACOLOGY

Recombinant Expression, Functional Characterization of Two Scorpion Venom Toxins with Three Disulfide Bridges from the Chinese Scorpion Buthus martensii Karsch

(2017) Shengguo Lin et al.   PROTEIN AND PEPTIDE LETTERS

The global cancer burden and human development: A review

(2017) Miranda M. Fidler et al.   SCANDINAVIAN JOURNAL OF PUBLIC HEALTH

St20, a new venomous animal derived natural peptide with immunosuppressive and anti-inflammatory activities

(2017) Min Xiao et al.   TOXICON

Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis

(2017) Jie Huang et al.   Cell and Bioscience

Animal Toxins Providing Insights into TRPV1 Activation Mechanism

(2017) Matan Geron et al.   Toxins

Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology

(2017) Sina Jami et al.   Toxins

Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis

(2017) Judith Land et al.   Frontiers in Immunology

A bimodal activation mechanism underlies scorpion toxin–induced pain

(2017) Shilong Yang et al.   Science Advances

The scorpion venom peptide BmKn2 induces apoptosis in cancerous but not in normal human oral cells

(2016) Saranya Satitmanwiwat et al.   BIOMEDICINE & PHARMACOTHERAPY

Immunosuppressive evidence ofTityus serrulatustoxins Ts6 and Ts15: insights of a novel K+channel pattern in T cells

(2016) Manuela B. Pucca et al.   IMMUNOLOGY

Structure–function relationships of peptides forming the calcin family of ryanodine receptor ligands

(2016) Liang Xiao et al.   JOURNAL OF GENERAL PHYSIOLOGY

Kalium: a database of potassium channel toxins from scorpion venom

(2016) Alexey I. Kuzmenkov et al.   Database-The Journal of Biological Databases and Curation

A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro

(2016) Zhengyang Zeng et al.   Toxins

The Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune Diseases

(2016) Fang Ye et al.   Toxins

Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins

(2016) Caroline Cremonez et al.   Toxins

Biotechnological Trends in Spider and Scorpion Antivenom Development

(2016) Andreas Laustsen et al.   Toxins

Ion Channels in Innate and Adaptive Immunity

(2015) Stefan Feske et al.   Annual Review of Immunology

Venom-spraying behavior of the scorpion Parabuthus transvaalicus (Arachnida: Buthidae)

(2015) Zia Nisani et al.   BEHAVIOURAL PROCESSES

Mesomartoxin, a new Kv1.2-selective scorpion toxin interacting with the channel selectivity filter

(2015) Xueli Wang et al.   BIOCHEMICAL PHARMACOLOGY

Diversity of Potassium Channel Ligands: Focus on Scorpion Toxins

(2015) A. I. Kuzmenkov et al.   BIOCHEMISTRY-MOSCOW

Chlorotoxin-Conjugated Nanoparticles for Targeted Imaging and Therapy of Glioma

(2015) Lingzhou Zhao et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

(2015) Edgar Pérez-Herrero et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Mechanisms of human autoimmunity

(2015) Michael D. Rosenblum et al.   JOURNAL OF CLINICAL INVESTIGATION

Allosteric interactions between receptor site 3 and 4 of voltage-gated sodium channels: a novel perspective for the underlying mechanism of scorpion sting-induced pain

(2015) Yi-Jun Feng et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Scorpion venom components as potential candidates for drug development

(2015) Ernesto Ortiz et al.   TOXICON

Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel

(2015) Md Hakim et al.   Toxins

AaeAP1 and AaeAP2: Novel Antimicrobial Peptides from the Venom of the Scorpion, Androctonus aeneas: Structural Characterisation, Molecular Cloning of Biosynthetic Precursor-Encoding cDNAs and Engineering of Analogues with Enhanced Antimicrobial and Anticancer Activities

(2015) Qiang Du et al.   Toxins

Chlorotoxin: A Helpful Natural Scorpion Peptide to Diagnose Glioma and Fight Tumor Invasion

(2015) Lucie Dardevet et al.   Toxins

Scorpions from Mexico: From Species Diversity to Venom Complexity

(2015) Carlos Santibáñez-López et al.   Toxins

Scorpion venoms as a potential source of novel cancer therapeutic compounds

(2014) Jian Ding et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The role of disulfide bonds in structure and activity of chlorotoxin

(2014) Paola G Ojeda et al.   Future Medicinal Chemistry

Near-infrared imaging of brain tumors using the Tumor Paint BLZ-100 to achieve near-complete resection of brain tumors

(2014) Pramod V. Butte et al.   Neurosurgical Focus

Clinical comparison of scorpion envenomation by Androctonus mauritanicus and Buthus occitanus in children

(2014) Bouchra Aboumaâd et al.   TOXICON

Overview of Scorpion Species from China and Their Toxins

(2014) Zhijian Cao et al.   Toxins

Characterization of IRDye 800CW chlorotoxin as a targeting agent for brain tumors

(2013) Joy L. Kovar et al.   ANALYTICAL BIOCHEMISTRY

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1

(2013) Wei Hong et al.   ANTIVIRAL RESEARCH

Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: Evaluation of their antimicrobial and anticancer activities

(2013) Xiaoxiao Guo et al.   BIOCHIMIE

Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus

(2013) Wei Hong et al.   BIOMATERIALS

Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold

(2013) Bin Gao et al.   BIOSCIENCE REPORTS

Scorpion beta-toxins and voltage-gated sodium channels: interactions and effects 

(2013) Martha Escalona   Frontiers in Bioscience-Landmark

Molecular diversity of Chaerilidae venom peptides reveals the dynamic evolution of scorpion venom components from Buthidae to non-Buthidae

(2013) Yawen He et al.   Journal of Proteomics

The scorpion toxin Amm VIII induces pain hypersensitivity through gain-of-function of TTX-sensitive Na+ channels

(2013) Najwa Abbas et al.   PAIN

Scorpion venom peptides with no disulfide bridges: A review

(2013) Ammar Almaaytah et al.   PEPTIDES

Purification, characterization, and bioactivity of a new analgesic-antitumor peptide from Chinese scorpion Buthus martensii Karsch

(2013) Jian-Hua Shao et al.   PEPTIDES

Antinociceptive Effects of Analgesic-Antitumor Peptide (AGAP), a Neurotoxin from the Scorpion Buthus martensii Karsch, on Formalin-Induced Inflammatory Pain through a Mitogen-Activated Protein Kinases–Dependent Mechanism in Mice

(2013) Qinghong Mao et al.   PLoS One

Multiple actions of  -LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins

(2013) J. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scorpion venom components that affect ion-channels function

(2013) V. Quintero-Hernández et al.   TOXICON

Vietnamese Heterometrus laoticus scorpion venom: Evidence for analgesic and anti-inflammatory activity and isolation of new polypeptide toxin acting on Kv1.3 potassium channel

(2013) Anh N. Hoang et al.   TOXICON

Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K+ channel toxins

(2012) Xueli Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): The first member of a new κ-KTX subfamily

(2012) Thomas Vandendriessche et al.   BIOCHEMICAL PHARMACOLOGY

Mucroporin-M1 Inhibits Hepatitis B Virus Replication by Activating the Mitogen-activated Protein Kinase (MAPK) Pathway and Down-regulating HNF4αin Vitroandin Vivo

(2012) Zhenhuan Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Inhibition of CCR7−Effector Memory T Cell Activation by a Novel Peptide Targeting Kv1.3 Channel in a Rat Experimental Autoimmune Encephalomyelitis Model

(2012) Zhi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping the Interaction Site for a β-Scorpion Toxin in the Pore Module of Domain III of Voltage-gated Na+Channels

(2012) Joel Z. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

StCT2, a new antibacterial peptide characterized from the venom of the scorpion Scorpiops tibetanus

(2012) Luyang Cao et al.   PEPTIDES

Anti-HIV-1 Activity of a New Scorpion Venom Peptide Derivative Kn2-7

(2012) Yaoqing Chen et al.   PLoS One

Antibacterial Activity and Mechanism of a Scorpion Venom Peptide Derivative In Vitro and In Vivo

(2012) Luyang Cao et al.   PLoS One

Emerging options for the management of scorpion stings

(2012) Jean-Philippe Chippaux   Drug Design Development and Therapy

Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator

(2011) Rong Zhao et al.   EPILEPSY & BEHAVIOR

Extreme diversity of scorpion venom peptides and proteins revealed by transcriptomic analysis: Implication for proteome evolution of scorpion venom arsenal

(2011) Yibao Ma et al.   Journal of Proteomics

The Roles of Sodium Channels in Nociception: Implications for Mechanisms of Neuropathic Pain

(2011) Min Liu et al.   PAIN MEDICINE

Virucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses

(2011) Qiaoli Li et al.   PEPTIDES

The new kappa-KTx 2.5 from the scorpion Opisthacanthus cayaporum

(2011) Thalita Soares Camargos et al.   PEPTIDES

Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: Gaining insight into a new mechanism for the functional diversification of scorpion venom peptides

(2011) Xian-Chun Zeng et al.   PEPTIDES

Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif

(2011) J. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo

(2010) Soo Hwa Jang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Scorpion Venom and the Inflammatory Response

(2010) Vera L. Petricevich   MEDIATORS OF INFLAMMATION

Involvement of endogenous opioid system in scorpion toxin-induced antinociception in mice

(2010) Marie-France Martin-Eauclaire et al.   NEUROSCIENCE LETTERS

A new natural α-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV

(2010) Ran Yan et al.   PEPTIDES

ImKTx88, a novel selective Kv1.3 channel blocker derived from the scorpion Isometrus maculates

(2010) Song Han et al.   TOXICON

Alpha-helical cationic antimicrobial peptides: relationships of structure and function

(2010) Yibing Huang et al.   Protein & Cell

Imcroporin, a New Cationic Antimicrobial Peptide from the Venom of the Scorpion Isometrus maculates

(2009) Z. Zhao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Definition of human autoimmunity — autoantibodies versus autoimmune disease

(2009) Ana Lleo et al.   AUTOIMMUNITY REVIEWS

BmKCT toxin inhibits glioma proliferation and tumor metastasis

(2009) Shaozhong Fan et al.   CANCER LETTERS

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

Annexin A2 Is a Molecular Target for TM601, a Peptide with Tumor-targeting and Anti-angiogenic Effects

(2009) Kamala Kesavan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidemiology of scorpionism: A global appraisal

(2008) J.-P. Chippaux et al.   ACTA TROPICA

Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy

(2008) R Zhao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease

(2008) Song Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels

(2008) Shi-Jin Yin et al.   JOURNAL OF PROTEOME RESEARCH