Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K+ Channel KV1.2 and Small- and Intermediate-Conductance Ca2+-Activated K+ Channels KCa2.2 and KCa3.1

sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity

(2022) Agota Csoti et al.   BIOCHEMICAL PHARMACOLOGY

Cm28, a scorpion toxin having a unique primary structure, inhibits KV1.2 and KV1.3 with high affinity

(2022) Muhammad Umair Naseem et al.   JOURNAL OF GENERAL PHYSIOLOGY

Allosteric inhibitors targeting the calmodulin-PIP2 interface of SK4 K + channels for atrial fibrillation treatment

(2022) Shira Burg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators

(2022) Purushotham Selvakumar et al.   Nature Communications

Discovery of K V 1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

(2021) Špela Gubič et al.   MEDICINAL RESEARCH REVIEWS

4-Aminopyridine is a promising treatment option for patients with gain-of-function KCNA2 -encephalopathy

(2021) Ulrike B. S. Hedrich et al.   Science Translational Medicine

Colombian Scorpion Centruroides margaritatus: Purification and Characterization of a Gamma Potassium Toxin with Full-Block Activity on the hERG1 Channel

(2021) José Beltrán-Vidal et al.   Toxins

IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era

(2020) Bui Quang Minh et al.   MOLECULAR BIOLOGY AND EVOLUTION

Kv1.3 Channel as a Key Therapeutic Target for Neuroinflammatory Diseases: State of the Art and Beyond

(2020) Xiaoli Wang et al.   Frontiers in Neuroscience

Kalium 2.0, a comprehensive database of polypeptide ligands of potassium channels

(2019) Valentin M. Tabakmakher et al.   Scientific Data

Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels

(2019) Brandon M. Brown et al.   Annual Review of Pharmacology and Toxicology

A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model

(2018) George Thom et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The C-terminal HRET sequence of Kv1.3 regulates gating rather than targeting of Kv1.3 to the plasma membrane

(2018) Orsolya Voros et al.   Scientific Reports

APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel KV10.1

(2017) Lien Moreels et al.   Marine Drugs

UFBoot2: Improving the Ultrafast Bootstrap Approximation

(2017) Diep Thi Hoang et al.   MOLECULAR BIOLOGY AND EVOLUTION

ModelFinder: fast model selection for accurate phylogenetic estimates

(2017) Subha Kalyaanamoorthy et al.   NATURE METHODS

Blood–brain barrier shuttle peptides: an emerging paradigm for brain delivery

(2016) Benjamí Oller-Salvia et al.   CHEMICAL SOCIETY REVIEWS

Ion Channels in Innate and Adaptive Immunity

(2015) Stefan Feske et al.   Annual Review of Immunology

Targeting ion channels for cancer therapy by repurposing the approved drugs

(2015) Vijay Pralhad Kale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pharmacological gating modulation of small- and intermediate-conductance Ca2+-activated K+channels (KCa2.x and KCa3.1)

(2015) Palle Christophersen et al.   Channels

Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses

(2015) Maria Mathilde Haugaard et al.   HEART RHYTHM

An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility

(2015) Adam Bartok et al.   Scientific Reports

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K+ channel

(2013) Anirban Banerjee et al.   eLife

New Tricks of an Old Pattern

(2012) Alma Leticia Saucedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Diversity of Acidic Scorpion Potassium Channel Toxins

(2012) Zong-Yun Chen et al.   PLoS One

The axon initial segment in nervous system disease and injury

(2011) Shelly A. Buffington et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Therapeutic potential of KCa3.1 blockers: recent advances and promising trends

(2010) Heike Wulff et al.   Expert Review of Clinical Pharmacology

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus

(2009) Ferenc Papp et al.   TOXICON

Animal Toxins Acting on Voltage-Gated Potassium Channels

(2008) Stephanie Mouhat et al.   CURRENT PHARMACEUTICAL DESIGN