Animal Toxins Providing Insights into TRPV1 Activation Mechanism

Activation of transient receptor potential vanilloid 1 by lipoxygenase metabolites depends on PKC phosphorylation

(2017) Rakesh Kumar et al.   FASEB JOURNAL

Lysophosphatidic acid-induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1

(2017) Hiroki Kittaka et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPV1 activation power can switch an action mode for its polypeptide ligands

(2017) Maxim V. Nikolaev et al.   PLoS One

Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release

(2017) Chuchu Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A bimodal activation mechanism underlies scorpion toxin–induced pain

(2017) Shilong Yang et al.   Science Advances

Centipede venoms as a source of drug leads

(2016) Eivind A.B. Undheim et al.   Expert Opinion on Drug Discovery

Tyrosine Residue in the TRPV1 Vanilloid Binding Pocket Regulates Deactivation Kinetics

(2016) Rakesh Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kunitz-Type Peptide HCRG21 from the Sea Anemone Heteractis crispa Is a Full Antagonist of the TRPV1 Receptor

(2016) Margarita Monastyrnaya et al.   Marine Drugs

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin

(2016) Chanhyung Bae et al.   eLife

Understanding Thermosensitive Transient Receptor Potential Channels as Versatile Polymodal Cellular Sensors

(2015) Jacob K. Hilton et al.   BIOCHEMISTRY

From Foe to Friend: Using Animal Toxins to Investigate Ion Channel Function

(2015) Jeet Kalia et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

(2015) Fan Yang et al.   Nature Chemical Biology

Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin

(2015) Khaled Elokely et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

(2015) Shilong Yang et al.   Nature Communications

The pain receptor TRPV1 displays agonist-dependent activation stoichiometry

(2015) Adina Hazan et al.   Scientific Reports

Topical Mannitol Reduces Capsaicin-Induced Pain: Results of a Pilot-Level, Double-Blind, Randomized Controlled Trial

(2015) Helene Bertrand et al.   PM&R

Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel

(2015) Md Hakim et al.   Toxins

Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels

(2015) Kanchan Gupta et al.   eLife

Single particle electron cryo-microscopy of a mammalian ion channel

(2014) Maofu Liao et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Isolation and characterization of SsmTx-I, a Specific Kv2.1 blocker from the venom of the centipedeScolopendra Subspinipes MutilansL. Koch

(2014) Minzhi Chen et al.   JOURNAL OF PEPTIDE SCIENCE

A structural view of ligand-dependent activation in thermoTRP channels

(2014) Ximena Steinberg et al.   Frontiers in Physiology

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

Transient receptor potential (TRP) channels: a clinical perspective

(2013) Yosuke Kaneko et al.   BRITISH JOURNAL OF PHARMACOLOGY

Divalent cations activate TRPV1 through promoting conformational change of the extracellular region

(2013) Fan Yang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Polypeptide Modulators of TRPV1 Produce Analgesia without Hyperthermia

(2013) Yaroslav Andreev et al.   Marine Drugs

Functionally Important Amino Acid Residues in the Transient Receptor Potential Vanilloid 1 (TRPV1) Ion Channel - An Overview of the Current Mutational Data

(2013) Zoltán Winter et al.   Molecular Pain

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids

(2013) Erhu Cao et al.   NEURON

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models

(2013) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different types of toxins targeting TRPV1 in pain

(2013) Jia-Wei Min et al.   TOXICON

Exploring structure-function relationships between TRP and Kv channels

(2013) Jeet Kalia et al.   Scientific Reports

Structure and function of invertebrate Kunitz serine protease inhibitors

(2012) Shiwanthi Ranasinghe et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations

(2012) Yuanyuan Cui et al.   JOURNAL OF GENERAL PHYSIOLOGY

Black mamba venom peptides target acid-sensing ion channels to abolish pain

(2012) Sylvie Diochot et al.   NATURE

High Yield Production and Refolding of the Double-Knot Toxin, an Activator of TRPV1 Channels

(2012) Chanhyung Bae et al.   PLoS One

Receptor-targeting mechanisms of pain-causing toxins: How ow?

(2012) Christopher J. Bohlen et al.   TOXICON

Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch

(2011) P. Anand et al.   BRITISH JOURNAL OF ANAESTHESIA

Ion-Channel Modulators: More Diversity Than Previously Thought

(2011) Sébastien Dilly et al.   CHEMBIOCHEM

Bioactive cystine knot proteins

(2011) Norelle L Daly et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain

(2011) Christopher J. Bohlen et al.   NATURE

Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif

(2011) J. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels

(2011) D. E. Clapham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels

(2011) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain

(2010) Christopher J. Bohlen et al.   CELL

Nociceptors: the sensors of the pain pathway

(2010) Adrienne E. Dubin et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Diversity and Functional Evolution of Scorpion Potassium Channel Toxins

(2010) Shunyi Zhu et al.   MOLECULAR & CELLULAR PROTEOMICS

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain

(2010) Jörg Grandl et al.   NATURE NEUROSCIENCE

Thermosensitive TRP channel pore turret is part of the temperature activation pathway

(2010) F. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Proton inhibition of unitary currents of vanilloid receptors

(2009) Beiying Liu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks

(2008) Gilbert Y. Wong et al.   BRAIN RESEARCH REVIEWS

Analgesic Compound from Sea AnemoneHeteractis crispaIs the First Polypeptide Inhibitor of Vanilloid Receptor 1 (TRPV1)

(2008) Yaroslav A. Andreev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Modeling of the Full-length Human TRPV1 Channel in Closed and Desensitized States

(2008) G. Fernández-Ballester et al.   JOURNAL OF MEMBRANE BIOLOGY

Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

(2008) Diana M Bautista et al.   NATURE NEUROSCIENCE

Transient receptor potential channels: targeting pain at the source

(2008) Ardem Patapoutian et al.   NATURE REVIEWS DRUG DISCOVERY

A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating

(2008) Benjamin R. Myers et al.   NEURON

TRPV1 antagonists: the challenges for therapeutic targeting

(2008) Neelima Khairatkar-Joshi et al.   TRENDS IN MOLECULAR MEDICINE

Painful toxins acting at TRPV1

(2007) Brett A. Cromer et al.   TOXICON

The emerging role of TRPV1 in diabetes and obesity

(2007) Anish Suri et al.   TRENDS IN PHARMACOLOGICAL SCIENCES