Mapping the interaction surface of scorpion β-toxins with an insect sodium channel

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

(2021) Daohua Jiang et al.   Nature Communications

How a Scorpion Toxin Selectively Captures a Prey Sodium Channel: the Molecular and Evolutionary Basis Uncovered

(2020) Shunyi Zhu et al.   MOLECULAR BIOLOGY AND EVOLUTION

Structural Basis for High-Affinity Trapping of the NaV1.7 Channel in Its Resting State by Tarantula Toxin

(2020) Goragot Wisedchaisri et al.   MOLECULAR CELL

Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA

(2019) Xiaojing Pan et al.   SCIENCE

Structural basis of α-scorpion toxin action on Nav channels

(2019) Thomas Clairfeuille et al.   SCIENCE

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

(2019) Hui Xu et al.   CELL

Intersegment contacts determine geometry of the open and closed states in P-loop channels

(2019) Denis B. Tikhonov et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel

(2019) Goragot Wisedchaisri et al.   CELL

Structure of the Cardiac Sodium Channel

(2019) Daohua Jiang et al.   CELL

Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape

(2018) Daniel T. Infield et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

(2018) Xiaojing Pan et al.   SCIENCE

Structural basis for the modulation of voltage-gated sodium channels by animal toxins

(2018) Huaizong Shen et al.   SCIENCE

Genetically engineering better fungal biopesticides

(2017) Brian Lovett et al.   PEST MANAGEMENT SCIENCE

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

(2017) Huaizong Shen et al.   SCIENCE

Consequences of insecticide resistance on malaria transmission

(2017) Haoues Alout et al.   PLoS Pathogens

Insecticide Resistance in African Anopheles Mosquitoes: A Worsening Situation that Needs Urgent Action to Maintain Malaria Control

(2016) Hilary Ranson et al.   TRENDS IN PARASITOLOGY

Insecticide Resistance in Mosquitoes: Impact, Mechanisms, and Research Directions

(2015) Nannan Liu   Annual Review of Entomology

Combined Covalent-Electrostatic Model of Hydrogen Bonding Improves Structure Prediction with Rosetta

(2015) Matthew J. O’Meara et al.   Journal of Chemical Theory and Computation

Molecular biology of insect sodium channels and pyrethroid resistance

(2014) Ke Dong et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Crystal structures of the human Dysferlin inner DysF domain

(2014) Altin Sula et al.   BMC STRUCTURAL BIOLOGY

Mapping the Interaction Site for a β-Scorpion Toxin in the Pore Module of Domain III of Voltage-gated Na+Channels

(2012) Joel Z. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping of scorpion toxin receptor sites at voltage-gated sodium channels

(2012) Michael Gurevitz   TOXICON

Substitutions in the Domain III Voltage-sensing Module Enhance the Sensitivity of an Insect Sodium Channel to a Scorpion β-Toxin

(2011) Weizhong Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Map of the Receptor Site for β-Scorpion Toxins in Domain II of Voltage-gated Sodium Channels

(2011) Joel Z. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coupling between Residues on S4 and S1 Defines the Voltage-Sensor Resting Conformation in NaChBac

(2010) Tzur Paldi et al.   BIOPHYSICAL JOURNAL

Docking flexible ligands in proteins with a solvent exposure- and distance-dependent dielectric function

(2010) Daniel P. Garden et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

A negative charge in transmembrane segment 1 of domain II of the cockroach sodium channel is critical for channel gating and action of pyrethroid insecticides

(2010) Yuzhe Du et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Insecticidal activity of scorpion toxin (ButaIT) and snowdrop lectin (GNA) containing fusion proteins towards pest species of different orders

(2009) Elaine C Fitches et al.   PEST MANAGEMENT SCIENCE

Two Separate Interfaces between the Voltage Sensor and Pore Are Required for the Function of Voltage-Dependent K+ Channels

(2009) Seok-Yong Lee et al.   PLOS BIOLOGY

Structure, Function, and Modification of the Voltage Sensor in Voltage-Gated Ion Channels

(2008) Sara I. Börjesson et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Access and Binding of Local Anesthetics in the Closed Sodium Channel

(2008) I. Bruhova et al.   MOLECULAR PHARMACOLOGY