Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology

Peptide from Sea AnemoneMetridium senileAffects Transient Receptor Potential Ankyrin-repeat 1 (TRPA1) Function and Produces Analgesic Effect

(2017) Yulia A. Logashina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural determinants of the hyperalgesic activity of myotoxic Lys49-phospholipase A2

(2017) Vanessa Olzon Zambelli et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

The pharmacology of voltage-gated sodium channel activators

(2017) Jennifer R. Deuis et al.   NEUROPHARMACOLOGY

Acid-sensing ion channel (ASIC) structure and function: Insights from spider, snake and sea anemone venoms

(2017) Ben Cristofori-Armstrong et al.   NEUROPHARMACOLOGY

Na V 1.7 as a pain target – From gene to pharmacology

(2017) Irina Vetter et al.   PHARMACOLOGY & THERAPEUTICS

How the Cobra Got Its Flesh-Eating Venom: Cytotoxicity as a Defensive Innovation and Its Co-Evolution with Hooding, Aposematic Marking, and Spitting

(2017) Nadya Panagides et al.   Toxins

A bimodal activation mechanism underlies scorpion toxin–induced pain

(2017) Shilong Yang et al.   Science Advances

Arizona bark scorpion venom resistance in the pallid bat, Antrozous pallidus

(2017) Bradley H. Hopp et al.   PLoS One

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1

(2017) Marco C. Inserra et al.   Scientific Reports

Dietary breadth is positively correlated with venom complexity in cone snails

(2016) Mark A. Phuong et al.   BMC GENOMICS

The peptide Phα1β, from spider venom, acts as a TRPA1 channel antagonist with antinociceptive effects in mice

(2016) Raquel Tonello et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

(2016) Jeremiah D. Osteen et al.   NATURE

The TRPM2 ion channel is required for sensitivity to warmth

(2016) Chun-Hsiang Tan et al.   NATURE

Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia

(2016) Elisangela Bressan et al.   PAIN

Potassium channels in neuropathic pain

(2016) Jérôme Busserolles et al.   PAIN

Ts8 scorpion toxin inhibits the Kv4.2 channel and produces nociception in vivo

(2016) Manuela Berto Pucca et al.   TOXICON

Melittin, the Major Pain-Producing Substance of Bee Venom

(2016) Jun Chen et al.   Neuroscience Bulletin

The Snake with the Scorpion’s Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus)

(2016) Daryl Yang et al.   Toxins

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain

(2016) Jennifer Deuis et al.   Toxins

Role of leak potassium channels in pain signaling

(2015) Xiang-Yao Li et al.   BRAIN RESEARCH BULLETIN

Functional diversity and evolutionary dynamics of thermoTRP channels

(2015) Shigeru Saito et al.   CELL CALCIUM

Pore-forming toxins: ancient, but never really out of fashion

(2015) Matteo Dal Peraro et al.   NATURE REVIEWS MICROBIOLOGY

δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails

(2015) Ai-Hua Jin et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

(2015) Shilong Yang et al.   Nature Communications

Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel

(2015) Md Hakim et al.   Toxins

Ancient Venom Systems: A Review on Cnidaria Toxins

(2015) Mahdokht Jouiaei et al.   Toxins

Emerging potassium channel targets for the treatment of pain

(2015) Christoforos Tsantoulas   Current Opinion in Supportive and Palliative Care

A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain

(2014) Junhong Gui et al.   CURRENT BIOLOGY

Single particle electron cryo-microscopy of a mammalian ion channel

(2014) Maofu Liao et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission

(2014) Xiaona Du et al.   PAIN

Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails

(2014) Sébastien Dutertre et al.   Nature Communications

Chemical Engineering and Structural and Pharmacological Characterization of the α-Scorpion Toxin OD1

(2013) Thomas Durek et al.   ACS Chemical Biology

Gain-of-Function Mutations in SCN11A Cause Familial Episodic Pain

(2013) Xiang Yang Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Potassium Channels in Peripheral Pain Pathways: Expression, Function and Therapeutic Potential

(2013) Xiaona Du et al.   Current Neuropharmacology

Unravelling the complex venom landscapes of lethal Australian funnel-web spiders (Hexathelidae: Atracinae) using LC-MALDI-TOF mass spectrometry

(2013) Alexandre Palagi et al.   Journal of Proteomics

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Bacteria activate sensory neurons that modulate pain and inflammation

(2013) Isaac M. Chiu et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

A de novo gain-of-function mutation in SCN11A causes loss of pain perception

(2013) Enrico Leipold et al.   NATURE GENETICS

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways

(2013) Jennifer R. Deuis et al.   PAIN

Voltage-Gated Sodium Channel in Grasshopper Mice Defends Against Bark Scorpion Toxin

(2013) A. H. Rowe et al.   SCIENCE

Secreted Phospholipases A2 of Snake Venoms: Effects on the Peripheral Neuromuscular System with Comments on the Role of Phospholipases A2 in Disorders of the CNS and Their Uses in Industry

(2013) John Harris et al.   Toxins

Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides)

(2012) Irina Vetter et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling

(2012) Irina Vetter et al.   EMBO JOURNAL

Sea-Anemone Toxin ATX-II Elicits A-Fiber-Dependent Pain and Enhances Resurgent and Persistent Sodium Currents in Large Sensory Neurons

(2012) Alexandra B Klinger et al.   Molecular Pain

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

(2012) Julie K. Klint et al.   TOXICON

The venom optimization hypothesis revisited

(2012) David Morgenstern et al.   TOXICON

Effects of a non-selective TRPC channel blocker, SKF-96365, on melittininduced spontaneous persistent nociception and inflammatory pain hypersensitivity

(2012) Jing Ding et al.   Neuroscience Bulletin

Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels

(2011) David J Adams et al.   BRITISH JOURNAL OF PHARMACOLOGY

A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain

(2011) Christopher J. Bohlen et al.   NATURE

New insights into visceral hypersensitivity—clinical implications in IBS

(2011) QiQi Zhou et al.   Nature Reviews Gastroenterology & Hepatology

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

(2011) Joris Vriens et al.   NEURON

Isolation and Characterization of CvIV4: A Pain Inducing α- Scorpion Toxin

(2011) Ashlee H. Rowe et al.   PLoS One

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

(2011) K. Zimmermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

Venomics: a new paradigm for natural products-based drug discovery

(2010) Irina Vetter et al.   AMINO ACIDS

Sodium Channels in Normal and Pathological Pain

(2010) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain

(2010) Christopher J. Bohlen et al.   CELL

Acid Sensing Ion Channels and Acid Nociception

(2009) G. Dube et al.   CURRENT PHARMACEUTICAL DESIGN

Variable Threshold of Trigeminal Cold-Thermosensitive Neurons Is Determined by a Balance between TRPM8 and Kv1 Potassium Channels

(2009) R. Madrid et al.   JOURNAL OF NEUROSCIENCE

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Crotalphine, a novel potent analgesic peptide from the venom of the South American rattlesnake Crotalus durissus terrificus

(2008) Katsuhiro Konno et al.   PEPTIDES