From Animal Poisons and Venoms to Medicines: Achievements, Challenges and Perspectives in Drug Discovery

Apitherapy for Osteoarthritis: Perspectives from Basic Research

(2020) Andrés Jagua-Gualdrón et al.   Complementary Medicine Research

Beyond hemostasis: a snake venom serine protease with potassium channel blocking and potential antitumor activities

(2020) Johara Boldrini-França et al.   Scientific Reports

Friends or Foes? Emerging Impacts of Biological Toxins

(2019) Graeme C. Clark et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Role of Toxins in the Pursuit for Novel Analgesics

(2019) Yossi Maatuf et al.   Toxins

Platelet Glycoprotein IIb/IIIa Receptor Inhibitor Tirofiban in Acute Ischemic Stroke

(2019) Ming Yang et al.   DRUGS

Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression

(2019) Isadora S Oliveira et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Phase 1 Safety, Pharmacokinetics, and Fluorescence Imaging Study of Tozuleristide (BLZ-100) in Adults With Newly Diagnosed or Recurrent Gliomas

(2019) Chirag G Patil et al.   NEUROSURGERY

Editorial: Animal Toxins as Comprehensive Pharmacological Tools to Identify Diverse Ion Channels

(2019) Yuri Utkin et al.   Frontiers in Pharmacology

A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain

(2019) John V. Lin King et al.   CELL

Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain

(2019) Chu-Ting Chang et al.   Frontiers in Neuroscience

Peptide therapeutics from venom: Current status and potential

(2018) Michael W. Pennington et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and characterization of crotamine-functionalized gold nanoparticles

(2018) Richard L. Karpel et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Natriuretic peptide based therapeutics for heart failure: Cenderitide: A novel first-in-class designer natriuretic peptide

(2018) Tomoko Ichiki et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Scorpion Venom–Toxins that Aid in Drug Development: A Review

(2018) Arijit Ghosh et al.   International Journal of Peptide Research and Therapeutics

Co-Localization of Crotamine with Internal Membranes and Accentuated Accumulation in Tumor Cells

(2018) Nicole Mambelli-Lisboa et al.   MOLECULES

Arthropod toxins and their antinociceptive properties: From venoms to painkillers

(2018) Victoria Monge-Fuentes et al.   PHARMACOLOGY & THERAPEUTICS

Phoneutria nigriventer venom: A pharmacological treasure

(2018) Steve Peigneur et al.   TOXICON

The use of natural ingredients in innovative Korean cosmeceuticals

(2018) Margit LW Juhász et al.   Journal of Cosmetic Dermatology

Dual actions of Psalmotoxin at ASIC1a and ASIC2a heteromeric channels (ASIC1a/2a)

(2018) Yi Liu et al.   Scientific Reports

In vitro assessment of cytotoxic activities of Lachesis muta muta snake venom

(2018) Stephanie Stransky et al.   PLoS Neglected Tropical Diseases

Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation

(2018) José Ignacio Veytia-Bucheli et al.   Cell Communication and Signaling

The Role of European Healthcare Databases for Post-Marketing Drug Effectiveness, Safety and Value Evaluation: Where Does Italy Stand?

(2018) Gianluca Trifirò et al.   DRUG SAFETY

Neurobiology and therapeutic applications of neurotoxins targeting transmitter release

(2018) Saak V. Ovsepian et al.   PHARMACOLOGY & THERAPEUTICS

CPP-Ts: a new intracellular calcium channel modulator and a promising tool for drug delivery in cancer cells

(2018) Bárbara Bruna Ribeiro de Oliveira-Mendes et al.   Scientific Reports

New generation CPPs show distinct selectivity for cancer and noncancer cells

(2018) Felista L. Tansi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Deep sequencing analysis of toad Rhinella schneideri skin glands and partial biochemical characterization of its cutaneous secretion

(2018) Priscila Yumi Tanaka Shibao et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Exenatide: pharmacokinetics, clinical use, and future directions

(2017) Filip K. Knop et al.   EXPERT OPINION ON PHARMACOTHERAPY

First-in-human phase I study of SOR-C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumors

(2017) S. Fu et al.   INVESTIGATIONAL NEW DRUGS

Heterologous fibrin sealant derived from snake venom: from bench to bedside – an overview

(2017) Rui Seabra Ferreira et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Guanidinium Toxins and Their Interactions with Voltage-Gated Sodium Ion Channels

(2017) Lorena Durán-Riveroll et al.   Marine Drugs

Biotechnological and Pharmacological Applications of Biotoxins and Other Bioactive Molecules from Dinoflagellates

(2017) Joana Assunção et al.   Marine Drugs

Efficacy and safety of desmoteplase in acute ischemic stroke patients

(2017) Xiaoqiang Li et al.   MEDICINE

Prostate Cancer Theranostics Targeting Gastrin-Releasing Peptide Receptors

(2017) Lucia Baratto et al.   MOLECULAR IMAGING AND BIOLOGY

Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries

(2017) Ana Gomes et al.   MOLECULES

New Insights in the Design of Bioactive Peptides and Chelating Agents for Imaging and Therapy in Oncology

(2017) et al.   MOLECULES

Na V 1.7 as a pain target – From gene to pharmacology

(2017) Irina Vetter et al.   PHARMACOLOGY & THERAPEUTICS

Lixisenatide, a Once-Daily Prandial Glucagon-Like Peptide-1 Receptor Agonist for the Treatment of Adults with Type 2 Diabetes

(2017) Jennifer M. Trujillo et al.   PHARMACOTHERAPY

Safety and efficacy of venom immunotherapy: a real life study

(2017) Agnieszka Kołaczek et al.   Postepy Dermatologii i Alergologii

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

(2017) Irène R. Chassagnon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain

(2017) Haylie K. Romero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy

(2017) Melissa E. Schechter et al.   Science Translational Medicine

The spider toxin Phα1β recombinant possesses strong analgesic activity

(2017) Flavia Karine Rigo et al.   TOXICON

Anti-obesogenic and hypolipidemic effects of a glucagon-like peptide-1 receptor agonist derived from the saliva of the Gila monster

(2017) Patricia Lucio Alves et al.   TOXICON

Pre-clinical evaluation of voltage-gated calcium channel blockers derived from the spider P. nigriventer in glioma progression

(2017) Natália Fontana Nicoletti et al.   TOXICON

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities

(2017) Kamayani Singh et al.   Scientific Reports

Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis

(2017) Jie Huang et al.   Cell and Bioscience

Computational Studies of Snake Venom Toxins

(2017) Paola Ojeda et al.   Toxins

Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery

(2017) Bingmiao Gao et al.   Toxins

Bioactivity of Natural and Engineered Antimicrobial Peptides from Venom of the Scorpions Urodacus yaschenkoi and U. manicatus

(2017) Karen Luna-Ramirez et al.   Toxins

Hi1a as a Novel Neuroprotective Agent for Ischemic Stroke by Inhibition of Acid-Sensing Ion Channel 1a

(2017) Yandong Ren et al.   Translational Stroke Research

A single-label fluorescent derivatization method for quantitative determination of neurotoxin in vivo by capillary electrophoresis coupled with laser-induced fluorescence detection

(2016) Cuiwei Chen et al.   ANALYST

Snake venom toxins: toxicity and medicinal applications

(2016) Yau Sang Chan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

ArgTX-636, a polyamine isolated from spider venom: A novel class of melanogenesis inhibitors

(2016) Marion Verdoni et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chlorotoxin: Structure, activity, and potential uses in cancer therapy

(2016) Paola G. Ojeda et al.   BIOPOLYMERS

Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties

(2016) Pieter Okkerse et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Antimicrobial peptides from frog skin biodiversity and therapeutic promises

(2016) Ali Ladram   Frontiers in Bioscience-Landmark

Immunosuppressive evidence ofTityus serrulatustoxins Ts6 and Ts15: insights of a novel K+channel pattern in T cells

(2016) Manuela B. Pucca et al.   IMMUNOLOGY

Hemocoagulase agkistrodon-induced anaphylactic shock: A case report and literature review

(2016) Yan-Yan Xu et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Glioblastoma multiforme targeted therapy: The Chlorotoxin story

(2016) Or Cohen-Inbar et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Delivery of ziconotide to cerebrospinal fluid via intranasal pathway for the treatment of chronic pain

(2016) Prashanth Manda et al.   JOURNAL OF CONTROLLED RELEASE

Exploring the in vivo wound healing effects of a recombinant hemolin from the caterpillar Lonomia obliqua

(2016) Ana Claudia Sato et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia

(2016) Elisangela Bressan et al.   PAIN

Bee Venom for the Treatment of Parkinson Disease – A Randomized Controlled Clinical Trial

(2016) Andreas Hartmann et al.   PLoS One

Desmoteplase for Acute Ischemic Stroke within 3 to 9 Hours after Symptom Onset: Evidence from Randomized Controlled Trials

(2016) Ligen Shi et al.   Scientific Reports

Pre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumors

(2016) Antonella Accardo et al.   EJNMMI Research

Recent results of exenatide use as adjunctive therapy in the treatment of patients with type 2 diabetes

(2016) Peggy Odegard et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Expression of a new serine protease from Crotalus durissus collilineatus venom in Pichia pastoris and functional comparison with the native enzyme

(2015) Johara Boldrini-França et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

PnPP-19, a Synthetic and Nontoxic Peptide Designed from a Phoneutria nigriventer Toxin, Potentiates Erectile Function via NO/cGMP

(2015) Carolina Nunes Silva et al.   JOURNAL OF UROLOGY

Tetrodotoxin, an Extremely Potent Marine Neurotoxin: Distribution, Toxicity, Origin and Therapeutical Uses

(2015) Jorge Lago et al.   Marine Drugs

WITHDRAWN—a resource for withdrawn and discontinued drugs

(2015) Vishal B. Siramshetty et al.   NUCLEIC ACIDS RESEARCH

Mastoparan induces apoptosis in B16F10-Nex2 melanoma cells via the intrinsic mitochondrial pathway and displays antitumor activity in vivo

(2015) Ricardo A. de Azevedo et al.   PEPTIDES

Cell-penetrating peptides transport therapeutics into cells

(2015) Joshua D. Ramsey et al.   PHARMACOLOGY & THERAPEUTICS

PEGylation: a successful approach to improve the biopharmaceutical potential of snake venom thrombin-like serine protease

(2015) Débora da-Silva-Freitas et al.   PROTEIN AND PEPTIDE LETTERS

Scorpion venom components as potential candidates for drug development

(2015) Ernesto Ortiz et al.   TOXICON

Toxins Targeting the KV1.3 Channel: Potential Immunomodulators for Autoimmune Diseases

(2015) Yipeng Zhao et al.   Toxins

Three Valuable Peptides from Bee and Wasp Venoms for Therapeutic and Biotechnological Use: Melittin, Apamin and Mastoparan

(2015) Miguel Moreno et al.   Toxins

The beneficial effects of honeybee-venom serum on facial wrinkles in humans

(2015) Sang Mi Han et al.   Clinical Interventions in Aging

Effects of cinobufacini injection on cell proliferation and the expression of topoisomerases in human HepG-2 hepatocellular carcinoma cells

(2015) YING LIU et al.   Molecular Medicine Reports

The effective control of a bleeding injury using a medical adhesive containing batroxobin

(2014) Kyung Eun You et al.   Biomedical Materials

Increased Susceptibility to Apoptosis and Growth Arrest of Human Breast Cancer Cells Treated by a Snake Venom-Loaded Silica Nanoparticles

(2014) Gamal Badr et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Discovery of a new antiviral protein isolated Lonomia obliqua analysed by bioinformatics and real-time approaches

(2014) Ana Carolina Viegas Carmo et al.   CYTOTECHNOLOGY

Signal Detection of Potentially Drug-Induced Acute Liver Injury in Children Using a Multi-Country Healthcare Database Network

(2014) Carmen Ferrajolo et al.   DRUG SAFETY

Recommendations for the Use of Leeches in Reconstructive Plastic Surgery

(2014) Kosta Y. Mumcuoglu   Evidence-based Complementary and Alternative Medicine

Scorpion venoms as a potential source of novel cancer therapeutic compounds

(2014) Jian Ding et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Venom-based biotoxins as potential analgesics

(2014) Parisa Gazerani et al.   Expert Review of Neurotherapeutics

Administration strategies for proteins and peptides

(2014) D. Ibraheem et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous subcutaneous delivery of exenatide via ITCA 650 leads to sustained glycemic control and weight loss for 48 weeks in metformin-treated subjects with type 2 diabetes

(2014) Robert R. Henry et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Near-infrared imaging of brain tumors using the Tumor Paint BLZ-100 to achieve near-complete resection of brain tumors

(2014) Pramod V. Butte et al.   Neurosurgical Focus

Antiphospholipid antibody testing for the antiphospholipid syndrome: a comprehensive practical review including a synopsis of challenges and recent guidelines

(2014) Emmanuel J. Favaloro et al.   PATHOLOGY

Peripheral Sensitization Increases Opioid Receptor Expression and Activation by Crotalphine in Rats

(2014) Vanessa Olzon Zambelli et al.   PLoS One

Toxins and drug discovery

(2014) Alan L. Harvey   TOXICON

Positron Emission Tomography (PET) Imaging of Prostate Cancer with a Gastrin Releasing Peptide Receptor Antagonist - from Mice to Men

(2014) Gesche Wieser et al.   Theranostics

Bee venom acupuncture for rheumatoid arthritis: a systematic review of randomised clinical trials

(2014) Ju Ah Lee et al.   BMJ Open

Comparative Evaluation of Recombinant Protein Production in Different Biofactories: The Green Perspective

(2014) Matilde Merlin et al.   Biomed Research International

Characterization of IRDye 800CW chlorotoxin as a targeting agent for brain tumors

(2013) Joy L. Kovar et al.   ANALYTICAL BIOCHEMISTRY

Neuronal nicotinic receptors as analgesic targets: It's a winding road

(2013) Iboro C. Umana et al.   BIOCHEMICAL PHARMACOLOGY

Recent progress and future options in the development of GLP-1 receptor agonists for the treatment of diabesity

(2013) Martin Lorenz et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lixisenatide: First Global Approval

(2013) Shelley Elkinson et al.   DRUGS

Melittin: A lytic peptide with anticancer properties

(2013) Goran Gajski et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells

(2013) Chun Li et al.   Evidence-based Complementary and Alternative Medicine

Ziconotide: a clinical update and pharmacologic review

(2013) Jason E Pope et al.   EXPERT OPINION ON PHARMACOTHERAPY

Anticancer Effects of Bufalin on Human Hepatocellular Carcinoma HepG2 Cells: Roles of Apoptosis and Autophagy

(2013) Qing Miao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Batroxobin Binds Fibrin with Higher Affinity and Promotes Clot Expansion to a Greater Extent than Thrombin

(2013) Trang T. Vu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Practice Guidelines for the Management of Hypertension in the Community

(2013) Michael A. Weber et al.   Journal of Clinical Hypertension

Efficacy and safety of Huachansu combined with chemotherapy in advanced gastric cancer: A meta-analysis

(2013) Xuefeng Xie et al.   MEDICAL HYPOTHESES

A mastoparan-derived peptide has broad-spectrum antiviral activity against enveloped viruses

(2013) Christopher J. Sample et al.   PEPTIDES

Peripheral kappa and delta opioid receptors are involved in the antinociceptive effect of crotalphine in a rat model of cancer pain

(2013) Patricia Brigatte et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

In Vivo Detection of Human TRPV6-Rich Tumors with Anti-Cancer Peptides Derived from Soricidin

(2013) Chris V. Bowen et al.   PLoS One

Targeting voltage-gated calcium channels: developments in peptide and small-molecule inhibitors for the treatment of neuropathic pain

(2012) S Vink et al.   BRITISH JOURNAL OF PHARMACOLOGY

Treatment with tirofiban for acute coronary syndrome (ACS): a systematic review and network analysis

(2012) S. H. Lang et al.   CURRENT MEDICAL RESEARCH AND OPINION

Update of Peptides with Antibacterial Activity

(2012) X. Vila-Farres et al.   CURRENT MEDICINAL CHEMISTRY

Through the looking glass - a new world of proteins enabled by chemical synthesis

(2012) Stephen Kent et al.   JOURNAL OF PEPTIDE SCIENCE

Black mamba venom peptides target acid-sensing ion channels to abolish pain

(2012) Sylvie Diochot et al.   NATURE

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Critical Role of Heat Shock Protein 27 in Bufalin-Induced Apoptosis in Human Osteosarcomas: A Proteomic-Based Research

(2012) Xian-biao Xie et al.   PLoS One

The long road of research on snake venom serine proteinases

(2012) Solange M.T. Serrano   TOXICON

Enantiomer-Specific Bioactivities of Peptidomimetic Analogues of Mastoparan and Mitoparan: Characterization of Inverso Mastoparan as a Highly Efficient Cell Penetrating Peptide

(2011) Sarah Jones et al.   BIOCONJUGATE CHEMISTRY

A potential strategy for high-grade gliomas: combination treatment with lithium chloride and BmK CT

(2011) Yuejun Fu et al.   BIOTECHNOLOGY LETTERS

Direct thrombin inhibitors

(2011) Catherine J. Lee et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Desmoteplase: discovery, insights and opportunities for ischaemic stroke

(2011) Robert L Medcalf   BRITISH JOURNAL OF PHARMACOLOGY

Encapsulation of Exenatide in Poly-(d,l-Lactide-Co-Glycolide) Microspheres Produced an Investigational Long-Acting Once-Weekly Formulation for Type 2 Diabetes

(2011) Mary Beth DeYoung et al.   Diabetes Technology & Therapeutics

Venoms as a platform for human drugs: translating toxins into therapeutics

(2011) Glenn F King   EXPERT OPINION ON BIOLOGICAL THERAPY

Ancrod and Fibrin Formation

(2011) Shuo Liu et al.   STROKE

Bradykinin-potentiating peptides: Beyond captopril

(2011) Antonio C.M. Camargo et al.   TOXICON

From snake venom toxins to therapeutics – Cardiovascular examples

(2011) Cho Yeow Koh et al.   TOXICON

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

(2010) Richard J. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo

(2010) Soo Hwa Jang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor

(2010) Fanghua Qi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Losac, the First Hemolin that Exhibits Procogulant Activity through Selective Factor X Proteolytic Activation

(2010) Miryam Paola Alvarez-Flores et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The development of Byetta (exenatide) from the venom of the Gila monster as an anti-diabetic agent

(2010) Brian L. Furman   TOXICON

Fibrolase: Trials and Tribulations

(2010) Francis S. Markland et al.   Toxins

Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain

(2010) Howard Howard Smith   Therapeutics and Clinical Risk Management

Medicinal leech therapy (Hirudotherapy) : A brief overview

(2010) Amrit Pal Singh   Complementary Therapies in Clinical Practice

Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain

(2009) Oleg O. Krishtal   ANNALS OF NEUROLOGY

Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer

(2009) Zhiqiang Meng et al.   CANCER

Cosmeceuticals and peptides

(2009) Lijuan Zhang et al.   CLINICS IN DERMATOLOGY

Annexin A2 Is a Molecular Target for TM601, a Peptide with Tumor-targeting and Anti-angiogenic Effects

(2009) Kamala Kesavan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacodynamics Pharmacodynamics of a Novel Designer Natriuretic Peptide, CD-NP, in a First-in-Human Clinical Trial in Healthy Subjects

(2009) Candace Y. W. Lee et al.   JOURNAL OF CLINICAL PHARMACOLOGY

χ-Conopeptide Pharmacophore Development: Toward a Novel Class of Norepinephrine Transporter Inhibitor (Xen2174) for Pain⊥

(2009) Andreas Brust et al.   JOURNAL OF MEDICINAL CHEMISTRY

A New Fibrin Sealant FromCrotalus durissus terrificusVenom: Applications in Medicine

(2009) L. C. Barros et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Engineering a Stable and Selective Peptide Blocker of the Kv1.3 Channel in T Lymphocytes

(2009) M. W. Pennington et al.   MOLECULAR PHARMACOLOGY

Drug Development: From Concept to Marketing!

(2009) Nihad A.M. Tamimi et al.   NEPHRON CLINICAL PRACTICE

CNSB004 (Leconotide) Causes Antihyperalgesia Without Side Effects When Given Intravenously: A Comparison with Ziconotide in a Rat Model of Diabetic Neuropathic Pain

(2009) Anton Kolosov et al.   PAIN MEDICINE

Penile erection inducedin vivoby a purified toxin from the Brazilian spiderPhoneutria nigriventer

(2008) Enrico Andrade et al.   BJU INTERNATIONAL

Conus Venoms - A Rich Source of Peptide-Based Therapeutics

(2008) Tiffany Han et al.   CURRENT PHARMACEUTICAL DESIGN

Crotalphine induces potent antinociception in neuropathic pain by acting at peripheral opioid receptors

(2008) Vanessa Pacciari Gutierrez et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bombesin Receptor Antagonists May Be Preferable to Agonists for Tumor Targeting

(2008) R. Cescato et al.   JOURNAL OF NUCLEAR MEDICINE

Design, Synthesis, and Actions of a Novel Chimeric Natriuretic Peptide: CD-NP

(2008) Ondrej Lisy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adaptive design methods in clinical trials – a review

(2008) Shein-Chung Chow et al.   Orphanet Journal of Rare Diseases

Analgesic effect in rodents of native and recombinant Phα1β toxin, a high-voltage-activated calcium channel blocker isolated from armed spider venom

(2008) Alessandra H. Souza et al.   PAIN

Crotalphine, a novel potent analgesic peptide from the venom of the South American rattlesnake Crotalus durissus terrificus

(2008) Katsuhiro Konno et al.   PEPTIDES

Tx2-6 toxin of the Phoneutria nigriventer spider potentiates rat erectile function

(2008) K.P. Nunes et al.   TOXICON

Platelet-rich plasma and platelet gel preparation using Plateltex®

(2008) L. Mazzucco et al.   VOX SANGUINIS

Efficacy and safety of gemcitabine-oxaliplatin combined with huachansu in patients with advanced gallbladder carcinoma

(2008) Tian-Jie Qin et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Anticoagulants from hematophagous animals

(2008) Cho Yeow Koh et al.   Expert Review of Hematology