Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology
出版年份 2023 全文链接
标题
Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology
作者
关键词
-
出版物
EUROPEAN JOURNAL OF CELL BIOLOGY
Volume 102, Issue 3, Pages 151338
出版商
Elsevier BV
发表日期
2023-07-06
DOI
10.1016/j.ejcb.2023.151338
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- STING trafficking as a new dimension of immune signaling
- (2023) Devon Jeltema et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
- (2023) Lan Fang et al. CANCER CELL
- Emerging evidence for adapting radiotherapy to immunotherapy
- (2023) Lorenzo Galluzzi et al. Nature Reviews Clinical Oncology
- Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation
- (2023) Mutian Jia et al. Nature Communications
- Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells
- (2023) Mahesh Pandit et al. Nature Communications
- ATAD3A mediates activation of RAS-independent mitochondrial ERK1/2 signaling, favoring head and neck cancer development
- (2022) Liwei Lang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Tumor ENPP1(CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer
- (2022) Borja Ruiz-Fernandez de Cordoba et al. Cancer Discovery
- Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS–cGAMP–STING Pathway
- (2022) Christopher Ritchie et al. Annual Review of Biochemistry
- Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition
- (2022) Justin T. Low et al. CANCER CELL
- The role of TBK1 in cancer pathogenesis and anticancer immunity
- (2022) Austin P. Runde et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Increased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway
- (2022) Yujia Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis
- (2022) Dan Zhang et al. NATURE CELL BIOLOGY
- LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint
- (2022) Wilson McKerrow et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling
- (2022) Jacqueline A. Carozza et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation
- (2022) Haiyan Gu et al. Nature Communications
- Increased activation of cGAS‐STING pathway enhances radiosensitivity of non‐small cell lung cancer cells
- (2022) Aiying Xue et al. Thoracic Cancer
- Genome Replication Is Associated With Release of Immunogenic DNA Waste
- (2022) Nadja Schubert et al. Frontiers in Immunology
- IFN-γ activates the tumor cell-intrinsic STING pathway through the induction of DNA damage and cytosolic dsDNA formation
- (2022) Hui Xiong et al. OncoImmunology
- Comprehensive Pan-Cancer Analysis Reveals the Role of UHRF1-Mediated DNA Methylation and Immune Infiltration in Renal Cell Carcinoma
- (2022) Xiao Pan et al. Journal of Oncology
- Circulating plasma phospholipid fatty acid levels and breast cancer risk in the Cancer Prevention Study‐II Nutrition Cohort
- (2022) Michèle Matta et al. INTERNATIONAL JOURNAL OF CANCER
- The RNA-binding protein PCBP1 represses lung adenocarcinoma progression by stabilizing DKK1 mRNA and subsequently downregulating β-catenin
- (2022) Yujia Zheng et al. Journal of Translational Medicine
- TRIM56 Reduces Radiosensitization of Human Glioblastoma by Regulating FOXM1-Mediated DNA Repair
- (2022) Yun Dong et al. MOLECULAR NEUROBIOLOGY
- cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers
- (2022) Christy Hong et al. NATURE
- STING activation promotes robust immune response and NK cell–mediated tumor regression in glioblastoma models
- (2022) Gilles Berger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- cGAS-STING signaling encourages immune cell overcoming of fibroblast barricades in pancreatic cancer
- (2022) Ayano Kabashima et al. Scientific Reports
- Clinical significance of STING expression and methylation in lung adenocarcinoma based on bioinformatics analysis
- (2022) Ze lin et al. Scientific Reports
- DNA damage induces STING mediated IL-6-STAT3 survival pathway in triple-negative breast cancer cells and decreased survival of breast cancer patients
- (2022) Hitesh Vasiyani et al. APOPTOSIS
- Depletion of COPI in cancer cells: the role of ROS in the induction of lipid accumulation, non-canonical lipophagy and apoptosis
- (2022) A. Gasparian et al. MOLECULAR BIOLOGY OF THE CELL
- Endocytosis triggers V-ATPase-SYK–mediated priming of cGAS activation and innate immune response
- (2022) Yu-Lin Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- cGAS/cGAMP/STING signal propagation in the tumor microenvironment: Key role for myeloid cells in antitumor immunity
- (2022) Vera E. Mekers et al. RADIOTHERAPY AND ONCOLOGY
- The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS
- (2022) Tian-Chen Xiong et al. Nature Communications
- Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis
- (2022) Hongyang Liu et al. Cell Reports
- Compressive stress drives adhesion-dependent unjamming transitions in breast cancer cell migration
- (2022) Grace Cai et al. Frontiers in Cell and Developmental Biology
- STING promotes proliferation and induces drug resistance in colorectal cancer by regulating the AMPK-mTOR pathway
- (2022) Huihui Yao et al. Journal of Gastrointestinal Oncology
- Epigenetically suppressed tumor cell intrinsic STING promotes tumor immune escape
- (2022) Hui Zheng et al. BIOMEDICINE & PHARMACOTHERAPY
- Elevation of spermine remodels immunosuppressive microenvironment through driving the modification of PD-L1 in hepatocellular carcinoma
- (2022) Hong-Xiang Shi et al. Cell Communication and Signaling
- Regulation of cGAS activity by RNA‐modulated phase separation
- (2022) Silian Chen et al. EMBO REPORTS
- TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein
- (2022) Xu Yang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Interruption of post-Golgi STING trafficking activates tonic interferon signaling
- (2022) Xintao Tu et al. Nature Communications
- DNA mechanical flexibility controls DNA potential to activate cGAS-mediated immune surveillance
- (2022) Lina Wang et al. Nature Communications
- Increased tumor glycolysis is associated with decreased immune infiltration across human solid tumors
- (2022) Ivan J. Cohen et al. Frontiers in Immunology
- RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells
- (2022) Sho Sugawara et al. Communications Biology
- Anlotinib enhances the antitumor immunity of radiotherapy by activating cGAS/STING in non-small cell lung cancer
- (2022) Dong Han et al. Cell Death Discovery
- The cGAS–STING pathway and cancer
- (2022) Natasha Samson et al. Nature Cancer
- Model for predicting age-dependent safety and immunomodulatory effects of STING ligands in non-human primates
- (2022) Shokichi Takahama et al. Molecular Therapy-Methods & Clinical Development
- A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA
- (2021) Hong Sun et al. Cell Reports
- cGAS-STING pathway expression as a prognostic tool in NSCLC
- (2021) Kristine Raaby Gammelgaard et al. Translational Lung Cancer Research
- ATAD3A stabilizes GRP78 to suppress ER stress for acquired chemoresistance in colorectal cancer
- (2021) Kevin Chih‐Yang Huang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Identification of TRIM56 as a Potential Biomarker for Lung Adenocarcinoma
- (2021) Kun Lu et al. Cancer Management and Research
- SHP2-mediated inhibition of DNA repair contributes to cGAS-STING activation and chemotherapeutic sensitivity in colon cancer
- (2021) Bin Wei et al. CANCER RESEARCH
- Hepatitis B virus X protein promotes vimentin expression via LIM and SH3 domain protein 1 to facilitate epithelial-mesenchymal transition and hepatocarcinogenesis
- (2021) Hongjuan You et al. Cell Communication and Signaling
- TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections
- (2021) Seoyun Yum et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer
- (2021) Jin Young Baik et al. Nature Communications
- The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt
- (2021) Aaron Seth Tooley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A
- (2021) Alice Lepelley et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cellular functions of the protein kinase ATM and their relevance to human disease
- (2021) Ji-Hoon Lee et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- cGAS restricts colon cancer development by protecting intestinal barrier integrity
- (2021) Shuiqing Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer
- (2021) Si-Yu Wu et al. Journal for ImmunoTherapy of Cancer
- The clinical and molecular significance associated with STING signaling in breast cancer
- (2021) Eileen E. Parkes et al. npj Breast Cancer
- Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer
- (2021) Eileen E. Parkes et al. BRITISH JOURNAL OF CANCER
- p53 signaling in cancer progression and therapy
- (2021) Hany E. Marei et al. Cancer Cell International
- Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS–STING Signaling in Triple-Negative Breast Cancer
- (2021) Yang Hu et al. MOLECULAR CANCER THERAPEUTICS
- STING protects breast cancer cells from intrinsic and genotoxic-induced DNA instability via a non-canonical, cell-autonomous pathway
- (2021) Laura Cheradame et al. ONCOGENE
- ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation
- (2021) Yuanqin Yang et al. Science Advances
- Chromothripsis and telomere crisis: engines of genome instability
- (2020) Sally M Dewhurst CURRENT OPINION IN GENETICS & DEVELOPMENT
- Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses
- (2020) Geneviève Pépin et al. mBio
- Irradiation Induces Epithelial Cell Unjamming
- (2020) Michael J. O'Sullivan et al. Frontiers in Cell and Developmental Biology
- Fibrosis and cancer: A strained relationship
- (2020) Bram Piersma et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- PCBP1 modulates the innate immune response by facilitating the binding of cGAS to DNA
- (2020) Chen-Yang Liao et al. Cellular & Molecular Immunology
- TGF-β1 promotes epithelial-to-mesenchymal transition and stemness of prostate cancer cells by inducing PCBP1 degradation and alternative splicing of CD44
- (2020) Qi Chen et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels
- (2020) Abdul Basit et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation
- (2020) Huipeng Jiao et al. NATURE
- Pancreatic cancer stroma: an update on therapeutic targeting strategies
- (2020) Abdel N. Hosein et al. Nature Reviews Gastroenterology & Hepatology
- Molecular mechanisms and cellular functions of cGAS–STING signalling
- (2020) Karl-Peter Hopfner et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Irradiation induces cancer lung metastasis through activation of the cGAS–STING–CCL5 pathway in mesenchymal stromal cells
- (2020) Zhiyuan Zheng et al. Cell Death & Disease
- TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
- (2020) Katherine R. Balka et al. Cell Reports
- Old dogs, new trick: classic cancer therapies activate cGAS
- (2020) Seoyun Yum et al. CELL RESEARCH
- Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion
- (2020) Jianjun Wu et al. IMMUNITY
- Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway
- (2020) Xuewu Zhang et al. IMMUNITY
- Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy
- (2020) Takahiro Yamazaki et al. NATURE IMMUNOLOGY
- Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
- (2020) Yubin Guo et al. Nature Communications
- Identification of prognostic biomarkers and correlations with immune infiltrates among cGAS-STING in hepatocellular carcinoma
- (2020) Zhenhua Qi et al. BIOSCIENCE REPORTS
- Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer
- (2020) Liwei Lang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Tubulin Tyrosine Ligase Like 4 (TTLL4) overexpression in breast cancer cells is associated with brain metastasis and alters exosome biogenesis
- (2020) Julia Arnold et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- NLRP12 in innate immunity and inflammation
- (2020) Shraddha Tuladhar et al. MOLECULAR ASPECTS OF MEDICINE
- Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy
- (2020) Juyan Zheng et al. Molecular Cancer
- Cancer SLC43A2 alters T cell methionine metabolism and histone methylation
- (2020) Yingjie Bian et al. NATURE
- In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition
- (2020) Jennifer A. Mitchel et al. Nature Communications
- ELF1-activated FOXD3-AS1 promotes the migration, invasion and EMT of osteosarcoma cells via sponging miR-296-5p to upregulate ZCCHC3
- (2020) Lei Wang Journal of Bone Oncology
- Metastasis and immune evasion from extracellular cGAMP hydrolysis
- (2020) Jun Li et al. Cancer Discovery
- ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation
- (2020) Mengjie Hu et al. JOURNAL OF CLINICAL INVESTIGATION
- The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus
- (2019) Matteo Gentili et al. Cell Reports
- The double edge sword of fibrosis in cancer
- (2019) Chelsea Chandler et al. Translational Research
- Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression
- (2019) Dengke Bao et al. ONCOGENE
- TGFβ promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis
- (2019) Alec N. Woosley et al. ONCOGENE
- Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
- (2019) Xiang Gui et al. NATURE
- STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death
- (2019) Jianjun Wu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
- (2019) Tian Tian et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties
- (2019) Xiangqian Kong et al. CANCER CELL
- A STING to inflammation and autoimmunity
- (2019) Vijay Kumar JOURNAL OF LEUKOCYTE BIOLOGY
- A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1
- (2019) Baoyu Zhao et al. NATURE
- Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation
- (2019) Wei Xie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
- (2019) Carina C. de Oliveira Mann et al. Cell Reports
- Unjamming and collective migration in MCF10A breast cancer cell lines
- (2019) Jae Hun Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- PCBP2 promotes the development of glioma by regulating FHL3 /TGF‐β/Smad signaling pathway
- (2019) Jianhui Mao et al. JOURNAL OF CELLULAR PHYSIOLOGY
- TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877
- (2019) Ricardo J. Antonia et al. Scientific Reports
- Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity
- (2019) Linda Schadt et al. Cell Reports
- The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer
- (2019) John Kwon et al. Cancer Discovery
- AKT isoform-specific expression and activation across cancer lineages
- (2018) Jue Wang et al. BMC CANCER
- Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance
- (2018) Wen Zhou et al. CELL
- RNase H2, mutated in Aicardi‐Goutières syndrome, promotes LINE‐1 retrotransposition
- (2018) Maria Benitez‐Guijarro et al. EMBO JOURNAL
- Toll-like receptors in immunity and inflammatory diseases: Past, present, and future
- (2018) Kumar Vijay INTERNATIONAL IMMUNOPHARMACOLOGY
- Chromosomal instability drives metastasis through a cytosolic DNA response
- (2018) Samuel F. Bakhoum et al. NATURE
- Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production
- (2018) Hiroyasu Konno et al. ONCOGENE
- DNA-induced liquid phase condensation of cGAS activates innate immune signaling
- (2018) Mingjian Du et al. SCIENCE
- Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence
- (2018) Laura Vera-Ramirez et al. Nature Communications
- TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
- (2018) Gil Ju Seo et al. Nature Communications
- Poly(rC) binding protein 2 (PCBP2) promotes the viability of human gastric cancer cells by regulating CDK2
- (2018) Changyu Chen et al. FEBS Open Bio
- Ribonucleotide excision repair is essential to prevent squamous cell carcinoma of the skin.
- (2018) Björn Hiller et al. CANCER RESEARCH
- The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment
- (2018) Samuel F. Bakhoum et al. CELL
- PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translation
- (2018) Hongshun Shi et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development
- (2018) Guoshuang Shen et al. Journal of Hematology & Oncology
- Phase separation focuses DNA sensing
- (2018) Andrea Ablasser SCIENCE
- ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
- (2018) Huan Lian et al. Nature Communications
- KDM5 histone demethylases repress immune response via suppression of STING
- (2018) Lizhen Wu et al. PLOS BIOLOGY
- STING directly activates autophagy to tune the innate immune response
- (2018) Dong Liu et al. CELL DEATH AND DIFFERENTIATION
- Role of the cGAS–STING pathway in cancer development and oncotherapeutic approaches
- (2018) Li Teng Khoo et al. EMBO REPORTS
- Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice
- (2018) Konrad Aden et al. GASTROENTEROLOGY
- Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
- (2018) Haipeng Liu et al. NATURE
- The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum
- (2018) Sonal Srikanth et al. NATURE IMMUNOLOGY
- The allosteric activation of cGAS underpins its dynamic signaling landscape
- (2018) Richard M Hooy et al. eLife
- An Analysis of the Expression and Association with Immune Cell Infiltration of the cGAS/STING Pathway in Pan-Cancer
- (2018) Xiang An et al. Molecular Therapy-Nucleic Acids
- cGAS Micro-Manages Genotoxic Stress
- (2017) Mona Motwani et al. IMMUNITY
- PD-L1 induced by IFN-γ from tumor-associated macrophages via the JAK/STAT3 and PI3K/AKT signaling pathways promoted progression of lung cancer
- (2017) Xiaohui Zhang et al. International Journal of Clinical Oncology
- Macrophage Polarization: Anti-Cancer Strategies to Target Tumor-Associated Macrophage in Breast Cancer
- (2017) Muhammad Tariq et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- The ubiquitin ligase TRIM56 inhibits ovarian cancer progression by targeting vimentin
- (2017) Lei Zhao et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes
- (2017) Silvia Cerboni et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death
- (2017) Bridget Larkin et al. JOURNAL OF IMMUNOLOGY
- cGAS surveillance of micronuclei links genome instability to innate immunity
- (2017) Karen J. Mackenzie et al. NATURE
- Mitotic progression following DNA damage enables pattern recognition within micronuclei
- (2017) Shane M. Harding et al. NATURE
- Cytoplasmic chromatin triggers inflammation in senescence and cancer
- (2017) Zhixun Dou et al. NATURE
- cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders
- (2017) Liudmila Andreeva et al. NATURE
- Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
- (2017) Selene Glück et al. NATURE CELL BIOLOGY
- Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism
- (2017) Maroof Hasan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- cGAS is essential for cellular senescence
- (2017) Hui Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lung cancer in patients with idiopathic pulmonary fibrosis
- (2017) Theodoros Karampitsakos et al. PULMONARY PHARMACOLOGY & THERAPEUTICS
- UHRF1: The key regulator of epigenetics and molecular target for cancer therapeutics
- (2017) Harsimran Sidhu et al. TUMOR BIOLOGY
- The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer
- (2017) Waseem Ashraf et al. Oncotarget
- Decreased expression of STING predicts poor prognosis in patients with gastric cancer
- (2017) Shushu Song et al. Scientific Reports
- Expression analysis of inflammasome sensors and implication of NLRP12 inflammasome in prostate cancer
- (2017) Dev Karan et al. Scientific Reports
- AKT in cancer: new molecular insights and advances in drug development
- (2016) Prabhjot S. Mundi et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis
- (2016) Tianli Xia et al. CANCER RESEARCH
- Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection
- (2016) Martin K. Thomsen et al. HEPATOLOGY
- Vimentin, colon cancer progression and resistance to butyrate and other HDACis
- (2016) Darina L. Lazarova et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
- (2016) Qing Chen et al. NATURE
- Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
- (2016) Qi Chen et al. NATURE IMMUNOLOGY
- Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
- (2016) Pengyan Xia et al. NATURE IMMUNOLOGY
- FOXM1 and STAT3 interaction confers radioresistance in glioblastoma cells
- (2016) Uday B. Maachani et al. Oncotarget
- Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis
- (2016) Tianli Xia et al. Cell Reports
- STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease
- (2015) Nicole Dobbs et al. Cell Host & Microbe
- LINE-1 in cancer: multifaceted functions and potential clinical implications
- (2015) Lu Xiao-Jie et al. GENETICS IN MEDICINE
- The role for autophagy in cancer
- (2015) Eileen White JOURNAL OF CLINICAL INVESTIGATION
- Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein
- (2015) Y Teng et al. ONCOGENE
- Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway
- (2015) Gil Ju Seo et al. Cell Reports
- Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs
- (2014) Lingyin Li et al. Nature Chemical Biology
- Inflammation-driven carcinogenesis is mediated through STING
- (2014) Jeonghyun Ahn et al. Nature Communications
- A kinase-independent function of AKT promotes cancer cell survival
- (2014) Igor Vivanco et al. eLife
- STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment
- (2014) T. Ohkuri et al. Cancer Immunology Research
- The Role of Vimentin Intermediate Filaments in the Progression of Lung Cancer
- (2013) Martha E Kidd et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
- (2013) Pu Gao et al. CELL
- Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing
- (2013) Nadine Gehrke et al. IMMUNITY
- RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3
- (2013) Wei Han et al. JOURNAL OF CLINICAL INVESTIGATION
- Structural mechanism of cytosolic DNA sensing by cGAS
- (2013) Filiz Civril et al. NATURE
- Enpp1: A Potential Facilitator of Breast Cancer Bone Metastasis
- (2013) Wen Min Lau et al. PLoS One
- Sensing the Dark Side of DNA
- (2013) L. A. J. O'Neill SCIENCE
- STING-dependent cytosolic DNA sensing pathways
- (2013) Glen N. Barber TRENDS IN IMMUNOLOGY
- Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
- (2013) Philip J. Kranzusch et al. Cell Reports
- Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity
- (2012) Bjoern Hiller et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
- (2012) J. Wu et al. SCIENCE
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- IRF8 and IRF3 cooperatively regulate rapid interferon- induction in human blood monocytes
- (2011) P. Li et al. BLOOD
- Vimentin in cancer and its potential as a molecular target for cancer therapy
- (2011) Arun Satelli et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- A diverse range of gene products are effectors of the type I interferon antiviral response
- (2011) John W. Schoggins et al. NATURE
- Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome
- (2009) Claudio Hetz et al. MOLECULAR CELL
- Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human
- (2009) Krzysztof Kuchta et al. NUCLEIC ACIDS RESEARCH
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
- (2008) Hiroki Ishikawa et al. NATURE
- Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
- (2008) Martin F. Lavin NATURE REVIEWS MOLECULAR CELL BIOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started