Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS

(2022) Fei Wang et al.   MOLECULAR CELL

Phosphorylation and chromatin tethering prevent cGAS activation during mitosis

(2021) Tuo Li et al.   SCIENCE

Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification

(2021) Inah Hwang et al.   Nature Communications

uhrf1 and dnmt1 Loss Induces an Immune Response in Zebrafish Livers Due to Viral Mimicry by Transposable Elements

(2021) Elena Magnani et al.   Frontiers in Immunology

Structure, Activity and Function of the Suv39h1 and Suv39h2 Protein Lysine Methyltransferases

(2021) Sara Weirich et al.   Life-Basel

KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements

(2021) Shang-Min Zhang et al.   NATURE

Dietary Approaches to Cancer Therapy

(2020) Mylène Tajan et al.   CANCER CELL

Amino Assets: How Amino Acids Support Immunity

(2020) Beth Kelly et al.   Cell Metabolism

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

(2020) Kou Motani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for nucleosome-mediated inhibition of cGAS activity

(2020) Duanfang Cao et al.   CELL RESEARCH

Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy

(2020) Weimin Wang et al.   MOLECULAR CELL

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

(2020) Yingjie Bian et al.   NATURE

The Molecular Basis of Tight Nuclear Tethering and Inactivation of cGAS

(2020) Baoyu Zhao et al.   NATURE

Structural basis for sequestration and autoinhibition of cGAS by chromatin

(2020) Sebastian Michalski et al.   NATURE

Structural mechanism of cGAS inhibition by the nucleosome

(2020) Ganesh R. Pathare et al.   NATURE

Author Correction: Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

(2020) Chuanhui Han et al.   NATURE IMMUNOLOGY

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

(2020) Baptiste Guey et al.   SCIENCE

Structural basis for the inhibition of cGAS by nucleosomes

(2020) Tomoya Kujirai et al.   SCIENCE

Structural basis of nucleosome-dependent cGAS inhibition

(2020) Joshua A. Boyer et al.   SCIENCE

FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

(2020) Jia Z. Shen et al.   CELL

METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis

(2019) Shuo Liu et al.   CELL

Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation

(2019) Satomi Kori et al.   STRUCTURE

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer

(2019) Triparna Sen et al.   Cancer Discovery

Inhibition of ATM increases interferon signaling and sensitizes pancreatic cancer to immune checkpoint blockade therapy

(2019) Qiang Zhang et al.   CANCER RESEARCH

Methionine is a metabolic dependency of tumor-initiating cells

(2019) Zhenxun Wang et al.   NATURE MEDICINE

Dietary methionine influences therapy in mouse cancer models and alters human metabolism

(2019) Xia Gao et al.   NATURE

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

(2019) Hannah E Volkman et al.   eLife

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

ATR kinase inhibitor AZD6738 potentiates CD8+ T cell–dependent antitumor activity following radiation

(2018) Frank P. Vendetti et al.   JOURNAL OF CLINICAL INVESTIGATION

Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1

(2018) Robert M. Vaughan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

(2018) Haipeng Liu et al.   NATURE

PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer

(2018) Roman M. Chabanon et al.   JOURNAL OF CLINICAL INVESTIGATION

cGAS is essential for the antitumor effect of immune checkpoint blockade

(2017) Hua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

(2016) Eileen E. Parkes et al.   JNCI-Journal of the National Cancer Institute

Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals

(2016) Qian Zhao et al.   Nature Communications

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

(2016) Eileen E. Parkes et al.   JNCI-Journal of the National Cancer Institute

Methionine and cystine double deprivation stress suppresses glioma proliferation via inducing ROS/autophagy

(2015) Huailei Liu et al.   TOXICOLOGY LETTERS

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Methionine Inhibits Autophagy and Promotes Growth by Inducing the SAM-Responsive Methylation of PP2A

(2013) Benjamin M. Sutter et al.   CELL

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

cGAS Dimerization Entangles DNA Recognition

(2013) Philip J. Kranzusch et al.   IMMUNITY

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

(2013) Xin Li et al.   IMMUNITY

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

(2008) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE