UHRF1: The key regulator of epigenetics and molecular target for cancer therapeutics

Methylation of tumor suppressor gene CDH13 and SHP1 promoters and their epigenetic regulation by the UHRF1/PRMT5 complex in endometrial carcinoma

(2016) Yan Sheng et al.   GYNECOLOGIC ONCOLOGY

A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice

(2016) Haoxing Zhang et al.   Nature Communications

Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition

(2016) Jian Fang et al.   Nature Communications

UHRF1 gene silencing inhibits cell proliferation and promotes cell apoptosis in human cervical squamous cell carcinoma CaSki cells

(2016) Ting-Ting Ge et al.   Journal of Ovarian Research

Regulation of UHRF1 by dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p): inhibition of bladder cancer cell aggressiveness

(2016) Ryosuke Matsushita et al.   Oncotarget

Integrated microRNA and mRNA Signature Associated with the Transition from the Locally Confined to the Metastasized Clear Cell Renal Cell Carcinoma Exemplified by miR-146-5p

(2016) Zofia Wotschofsky et al.   PLoS One

Ubiquitin E3 ligase UHRF1 regulates p53 ubiquitination and p53-dependent cell apoptosis in clear cell Renal Cell Carcinoma

(2015) Jian Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Analysis of the UHRF1 expression in serum and tissue for gastric cancer detection

(2015) Mengyuan Ge et al.   BIOMARKERS

Changes in correlation between promoter methylation and gene expression in cancer

(2015) Matahi Moarii et al.   BMC GENOMICS

UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation

(2015) Lin Zhou et al.   CANCER BIOLOGY & THERAPY

Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis

(2015) Mingchen Zhu et al.   CANCER SCIENCE

DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

(2015) Weihua Qin et al.   CELL RESEARCH

Quantitative Proteomic Analysis of the Metastasis-Inhibitory Mechanism of miR-193a-3p in Non-Small Cell Lung Cancer

(2015) Wei Deng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Promoter methylation-independent reactivation of PAX1 by curcumin and resveratrol is mediated by UHRF1

(2015) Gaurav Parashar et al.   CLINICAL AND EXPERIMENTAL MEDICINE

miR-124 exerts tumor suppressive functions on the cell proliferation, motility and angiogenesis of bladder cancer by fine-tuning UHRF1

(2015) Xinsheng Wang et al.   FEBS Journal

MBD4 Interacts With and Recruits USP7 to Heterochromatic Foci

(2015) Huan Meng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis

(2015) Wafa Abu-Alainin et al.   JOURNAL OF PATHOLOGY

Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma

(2015) Elizabeth F Wiseman et al.   Molecular Cancer

The aberrant expression of MEG3 regulated by UHRF1 predicts the prognosis of hepatocellular carcinoma

(2015) Han Zhuo et al.   MOLECULAR CARCINOGENESIS

UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of E-cadherin in an Rb1-dependent manner

(2015) WEI LIU et al.   Molecular Medicine Reports

H3K9 methyltransferase G9a negatively regulates UHRF1 transcription during leukemia cell differentiation

(2015) Kee-Beom Kim et al.   NUCLEIC ACIDS RESEARCH

Analysis of UHRF1 expression in human ovarian cancer tissues and its regulation in cancer cell growth

(2015) Feng Yan et al.   TUMOR BIOLOGY

Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway

(2015) Mahmoud Alhosin et al.   Scientific Reports

An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1

(2015) Zhi-Min Zhang et al.   Cell Reports

UHRF1 Is a Sensor for DNA Interstrand Crosslinks and Recruits FANCD2 to Initiate the Fanconi Anemia Pathway

(2015) Chih-Chao Liang et al.   Cell Reports

UHRF1 Contributes to DNA Damage Repair as a Lesion Recognition Factor and Nuclease Scaffold

(2015) Yanyan Tian et al.   Cell Reports

From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?

(2015) Katarzyna Szarc vel Szic et al.   Clinical Epigenetics

Methylation Profiling of Multiple Tumor Suppressor Genes in Hepatocellular Carcinoma and the Epigenetic Mechanism of 3OST2 Regulation

(2015) Haiyan Chen et al.   Journal of Cancer

Conserved linker regions and their regulation determine multiple chromatin-binding modes of UHRF1

(2015) Maria Tauber et al.   Nucleus

Conserved linker regions and their regulation determine multiple chromatin-binding modes of UHRF1

(2015) Maria Tauber et al.   Nucleus

Abstract LB-180: Prognostic analysis of invasive circulating tumor cells (iCTCs) to monitor epithelial ovarian cancer

(2015) Wen-Tien Chen et al.   CANCER RESEARCH

Interpreting the language of histone and DNA modifications

(2014) Scott B. Rothbart et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Epigenetic repression of regulator of G-protein signaling 2 by ubiquitin-like with PHD and ring-finger domain 1 promotes bladder cancer progression

(2014) Liang Ying et al.   FEBS Journal

Negative modulation of the epigenetic regulator, UHRF1, by thyroid hormone receptors suppresses liver cancer cell growth

(2014) Sheng-Ming Wu et al.   INTERNATIONAL JOURNAL OF CANCER

Poly(ADP-ribose) Polymerase 1 (PARP1) Associates with E3 Ubiquitin-Protein Ligase UHRF1 and Modulates UHRF1 Biological Functions

(2014) Mike De Vos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accessibility of Different Histone H3-Binding Domains of UHRF1 Is Allosterically Regulated by Phosphatidylinositol 5-Phosphate

(2014) Kathy A. Gelato et al.   MOLECULAR CELL

Luteolin Induces Apoptosis in BE Colorectal Cancer Cells by Downregulating Calpain, UHRF1, and DNMT1 Expressions

(2014) Mounira Krifa et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

UHRF1 depletion suppresses growth of gallbladder cancer cells through induction of apoptosis and cell cycle arrest

(2014) YIYU QIN et al.   ONCOLOGY REPORTS

Upregulated UHRF1 Promotes Bladder Cancer Cell Invasion by Epigenetic Silencing of KiSS1

(2014) Yu Zhang et al.   PLoS One

Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins

(2013) Chao Liang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DNA Methyltransferase-1 Inhibitors as Epigenetic Therapy for Cancer

(2013) Varinder Singh et al.   CURRENT CANCER DRUG TARGETS

Regulation of UHRF1 by miR-146a/b modulates gastric cancer invasion and metastasis

(2013) Lin Zhou et al.   FASEB JOURNAL

Lysyl 5-Hydroxylation, a Novel Histone Modification, by Jumonji Domain Containing 6 (JMJD6)

(2013) Motoko Unoki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The UHRF1 Protein Stimulates the Activity and Specificity of the Maintenance DNA Methyltransferase DNMT1 by an Allosteric Mechanism

(2013) Pavel Bashtrykov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16INK4A re-expression related to UHRF1 and DNMT1 down-regulation

(2013) Mounira Krifa et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

DNA Damage Regulates UHRF1 Stability via the SCFβ-TrCPE3 Ligase

(2013) Hao Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibiting UHRF1 expression enhances radiosensitivity in human esophageal squamous cell carcinoma

(2013) Congrong Yang et al.   MOLECULAR BIOLOGY REPORTS

Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication

(2013) Atsuya Nishiyama et al.   NATURE

Tudor: a versatile family of histone methylation ‘readers’

(2013) Rui Lu et al.   TRENDS IN BIOCHEMICAL SCIENCES

The polyphenolic-rich Aronia melanocarpa juice kills teratocarcinomal cancer stem-like cells, but not their differentiated counterparts

(2013) Tanveer Sharif et al.   Journal of Functional Foods

UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9

(2013) Xiaoli Liu et al.   Nature Communications

UHRF1 Promotes Cell Growth and Metastasis Through Repression of p16ink4a in Colorectal Cancer

(2012) Feng Wang et al.   ANNALS OF SURGICAL ONCOLOGY

Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1

(2012) Mayada Achour et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diagnostic and prognostic value of plasma and tissue ubiquitin-like, containing PHD and RING finger domains 1 in breast cancer patients

(2012) Yao Geng et al.   CANCER SCIENCE

Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation

(2012) Scott B Rothbart et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression

(2012) L Sabatino et al.   ONCOGENE

The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression

(2012) F Babbio et al.   ONCOGENE

UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer

(2012) YASUHIDE KOFUNATO et al.   ONCOLOGY REPORTS

Aronia melanocarpa Juice Induces a Redox-Sensitive p73-Related Caspase 3-Dependent Apoptosis in Human Leukemia Cells

(2012) Tanveer Sharif et al.   PLoS One

Inhibition Effect of siRNA-Downregulated UHRF1 on Breast Cancer Growth

(2011) Feng Yan et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

UHRF1 is associated with tumor recurrence in non-muscle-invasive bladder cancer

(2011) Guo-Liang Yang et al.   MEDICAL ONCOLOGY

UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis

(2011) Jaime Chu et al.   MOLECULAR BIOLOGY OF THE CELL

PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression

(2011) Eerappa Rajakumara et al.   MOLECULAR CELL

Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1

(2011) Abdurazzag Abusnina et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain

(2011) Carina Frauer et al.   PLoS One

UHRF1 is a novel diagnostic marker of lung cancer

(2010) M Unoki et al.   BRITISH JOURNAL OF CANCER

UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer

(2010) Alexandros Daskalos et al.   CANCER

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis

(2010) Abdurazzag Abusnina et al.   CELLULAR SIGNALLING

UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications

(2010) Hideharu Hashimoto et al.   Epigenetics

Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1

(2010) Tanveer Sharif et al.   EUROPEAN JOURNAL OF CANCER

Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis

(2010) Allison Walter et al.   FASEB JOURNAL

Cancer Prevention With Natural Compounds

(2010) Norleena P. Gullett et al.   SEMINARS IN ONCOLOGY

UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity

(2009) Mayada Achour et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Drug discovery targeting epigenetic codes: The great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis

(2009) Motoko Unoki et al.   BIOCHEMICAL PHARMACOLOGY

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1

(2009) Mahmoud Alhosin et al.   BIOCHEMICAL PHARMACOLOGY

UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer

(2009) Wei Jin et al.   BREAST CANCER RESEARCH AND TREATMENT

UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer

(2009) M Unoki et al.   BRITISH JOURNAL OF CANCER

ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells

(2009) Zhiyuan Fang et al.   CELLULAR IMMUNOLOGY

Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells

(2009) Daniela Meilinger et al.   EMBO REPORTS

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Interplay between Np95 and Eme1 in the DNA damage response

(2008) Helena Mistry et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

(2008) Hideharu Hashimoto et al.   NATURE

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

(2008) George V. Avvakumov et al.   NATURE

UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells

(2008) Jong Kyong Kim et al.   NUCLEIC ACIDS RESEARCH