The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS

The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression

(2022) Breege V. Howley et al.   ONCOGENE

SUMOylation in Viral Replication and Antiviral Defense

(2022) Yao Fan et al.   Advanced Science

RNF115 Inhibits the Post‐ER Trafficking of TLRs and TLRs‐Mediated Immune Responses by Catalyzing K11‐Linked Ubiquitination of RAB1A and RAB13

(2022) Zhi‐Dong Zhang et al.   Advanced Science

Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly

(2021) Daniel Horn-Ghetko et al.   NATURE

ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation

(2021) Youqian Wu et al.   Nature Communications

RNF111-facilitated neddylation potentiates cGAS-mediated antiviral innate immune response

(2021) Chenhui Li et al.   PLoS Pathogens

ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity

(2021) GuanQun Liu et al.   Nature Microbiology

USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity

(2020) Qiang Zhang et al.   CELL RESEARCH

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

(2020) Song-Fang Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation and Consequences of cGAS Activation by Self-DNA

(2020) Christian Zierhut et al.   TRENDS IN CELL BIOLOGY

Neddylation of PTEN regulates its nuclear import and promotes tumor development

(2020) Ping Xie et al.   CELL RESEARCH

The Functional Deubiquitinating Enzymes in Control of Innate Antiviral Immunity

(2020) Zhi Zong et al.   Advanced Science

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance

(2018) Wen Zhou et al.   CELL

ISG15 in antiviral immunity and beyond

(2018) Yi-Chieh Perng et al.   NATURE REVIEWS MICROBIOLOGY

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

(2018) Gil Ju Seo et al.   Nature Communications

RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses

(2018) Zhao-Shan Liu et al.   Cell and Bioscience

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS

(2018) Tianzi Liuyu et al.   CELL RESEARCH

Regulation of germ cell development by ARI1 family ubiquitin ligases in C. elegans

(2018) Julian A. Poush et al.   Scientific Reports

Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation

(2017) Jianli Tao et al.   JOURNAL OF IMMUNOLOGY

Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129

(2017) Wen-Bo Zeng et al.   Molecular Neurodegeneration

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

(2017) Liudmila Andreeva et al.   NATURE

USP13 negatively regulates antiviral responses by deubiquitinating STING

(2017) He Sun et al.   Nature Communications

The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response

(2017) Qiang Wang et al.   PLoS Pathogens

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

(2016) Daniel C. Scott et al.   CELL

USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA

(2016) Man Zhang et al.   CELL RESEARCH

Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus

(2016) Ming-Ming Hu et al.   IMMUNITY

Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity

(2016) Katrin Peschke et al.   JOURNAL OF IMMUNOLOGY

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

(2016) Pengyan Xia et al.   NATURE IMMUNOLOGY

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

(2015) Ruth Wassermann et al.   Cell Host & Microbe

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

(2015) Angela C. Collins et al.   Cell Host & Microbe

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance

(2015) Lars Ketscher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

(2015) Jessica L. Grieves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

(2014) Xianqin Zhang et al.   NATURE

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

(2014) Xu Zhang et al.   Cell Reports

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

(2013) Ian R Kelsall et al.   EMBO JOURNAL

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

(2013) Xin Li et al.   IMMUNITY

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Activation of Double-stranded RNA-activated Protein Kinase (PKR) by Interferon-stimulated Gene 15 (ISG15) Modification Down-regulates Protein Translation

(2012) Fumihiko Okumura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification

(2010) H. X. Shi et al.   MOLECULAR AND CELLULAR BIOLOGY

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

Mice Lacking the ISG15 E1 Enzyme UbE1L Demonstrate Increased Susceptibility to both Mouse-Adapted and Non-Mouse-Adapted Influenza B Virus Infection

(2008) C. Lai et al.   JOURNAL OF VIROLOGY

ISG15 Arg151 and the ISG15-Conjugating Enzyme UbE1L Are Important for Innate Immune Control of Sindbis Virus

(2008) N. V. Giannakopoulos et al.   JOURNAL OF VIROLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE