cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

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(2016) Jungsan Sohn et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

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PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1

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The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

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Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

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Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

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Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

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Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

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Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

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Listeria monocytogenes induces IFN  expression through an IFI16-, cGAS- and STING-dependent pathway

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OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines

(2014) Jonathan L. Schmid-Burgk et al.   GENOME RESEARCH

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

(2014) Xu Zhang et al.   Cell Reports

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

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Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

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Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

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Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

(2013) Andrea Ablasser et al.   NATURE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

C/EBPα Induces Highly Efficient Macrophage Transdifferentiation of B Lymphoma and Leukemia Cell Lines and Impairs Their Tumorigenicity

(2013) Francesca Rapino et al.   Cell Reports

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(2012) Christian K Holm et al.   NATURE IMMUNOLOGY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

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Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter

(2011) Anna Rubio-Cosials et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA

(2011) Huu B Ngo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE