Emerging applications of phage therapy and fecal virome transplantation for treatment of Clostridioides difficile infection: challenges and perspectives

A Novel Bacteriophage with Broad Host Range against Clostridioides difficile Ribotype 078 Supports SlpA as the Likely Phage Receptor

(2022) M. J. Whittle et al.   Microbiology Spectrum

Alterations and Prediction of Functional Profiles of Gut Microbiota After Fecal Microbiota Transplantation for Iranian Recurrent Clostridioides difficile Infection with Underlying Inflammatory Bowel Disease: A Pilot Study

(2022) Masoumeh Azimirad et al.   Journal of Inflammation Research

Potential Role of the Host-Derived Cell-Wall Binding Domain of Endolysin CD16/50L as a Molecular Anchor in Preservation of Uninfected Clostridioides difficile for New Rounds of Phage Infection

(2022) Wichuda Phothichaisri et al.   Microbiology Spectrum

The Spread of Antibiotic Resistance Genes In Vivo Model

(2022) Shuan Tao et al.   Canadian Journal of Infectious Diseases & Medical Microbiology

The Life Cycle Transitions of Temperate Phages: Regulating Factors and Potential Ecological Implications

(2022) Menghui Zhang et al.   Viruses-Basel

Application of recombinant antibodies for treatment of Clostridioides difficile infection: Current status and future perspective

(2022) Hamideh Raeisi et al.   Frontiers in Immunology

Rapid-format recombinant antibody-based methods for the diagnosis of Clostridioides difficile infection: Recent advances and perspectives

(2022) Hamideh Raeisi et al.   Frontiers in Microbiology

Enteric Viruses and Inflammatory Bowel Disease

(2021) Georges Tarris et al.   Viruses-Basel

Clostridioides difficile Phage Biology and Application

(2021) Joshua Heuler et al.   FEMS MICROBIOLOGY REVIEWS

Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation

(2021) Kosuke Fujimoto et al.   GASTROENTEROLOGY

Causes and Consequences of Bacteriophage Diversification via Genetic Exchanges across Lifestyles and Bacterial Taxa

(2021) Jorge A Moura de Sousa et al.   MOLECULAR BIOLOGY AND EVOLUTION

A New Pipeline for Designing Phage Cocktails Based on Phage-Bacteria Infection Networks

(2021) Felipe Molina et al.   Frontiers in Microbiology

ACG Clinical Guidelines

(2021) Colleen R. Kelly et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Engineered Bacteriophage Therapeutics: Rationale, Challenges and Future

(2021) Małgorzata Łobocka et al.   BIODRUGS

Bacteriophages of Shiga Toxin-Producing Escherichia coli and Their Contribution to Pathogenicity

(2021) Lorena Rodríguez-Rubio et al.   Pathogens

Complete genome sequence of the newly discovered temperate Clostridioides difficile bacteriophage phiCDKH01 of the family Siphoviridae

(2021) Krzysztof Hinc et al.   ARCHIVES OF VIROLOGY

Gut microbiome ADP-ribosyltransferases are widespread phage-encoded fitness factors

(2021) Eric M. Brown et al.   Cell Host & Microbe

Characterization of an Endolysin Targeting Clostridioides difficile That Affects Spore Outgrowth

(2021) Shakhinur Islam Mondal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fecal filtrate transplantation protects against necrotizing enterocolitis

(2021) Anders Brunse et al.   ISME Journal

Impact of Phage CDHS-1 on the Transcription, Physiology and Pathogenicity of a Clostridioides difficile Ribotype 027 Strain, R20291

(2021) Janet Y. Nale et al.   Viruses-Basel

How Does COVID-19 Pandemic Impact on Incidence of Clostridioides difficile Infection and Exacerbation of Its Gastrointestinal Symptoms?

(2021) Masoumeh Azimirad et al.   Frontiers in Medicine

Phage Cocktail Development for Bacteriophage Therapy: Toward Improving Spectrum of Activity Breadth and Depth

(2021) Stephen T. Abedon et al.   Pharmaceuticals

Clostridioides difficile – phage relationship the RNA way

(2021) Victor Kreis et al.   CURRENT OPINION IN MICROBIOLOGY

New insights into intestinal phages

(2020) R. Sausset et al.   Mucosal Immunology

The arms race between bacteria and their phage foes

(2020) Hannah G. Hampton et al.   NATURE

Development of a Bacteriophage Cocktail to Constrain the Emergence of Phage-Resistant Pseudomonas aeruginosa

(2020) Yuhui Yang et al.   Frontiers in Microbiology

Taxonomy of prokaryotic viruses: 2018-2019 update from the ICTV Bacterial and Archaeal Viruses Subcommittee

(2020) Evelien M. Adriaenssens et al.   ARCHIVES OF VIROLOGY

Faecal virome transplantation decreases symptoms of type 2 diabetes and obesity in a murine model

(2020) Torben Sølbeck Rasmussen et al.   GUT

In Vivo Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials

(2020) Kurt Selle et al.   mBio

Biotechnological and Immunological Platforms Based on PGL-I Carbohydrate-Like Peptide of Mycobacterium leprae for Antibodies Detection Among Leprosy Clinical Forms

(2020) Mayara Ingrid Sousa Lima et al.   Frontiers in Microbiology

Isolation and Characterization of the Novel Phage JD032 and Global Transcriptomic Response during JD032 Infection of Clostridioides difficile Ribotype 078

(2020) Tinghua Li et al.   mSystems

Horizontal Gene Transfer as a Source of Conflict and Cooperation in Prokaryotes

(2020) Rebecca J. Hall et al.   Frontiers in Microbiology

Phages and their potential to modulate the microbiome and immunity

(2020) Sara Federici et al.   Cellular & Molecular Immunology

Phage Therapy in the Resistance Era: Where Do We Stand and Where Are We Going?

(2020) Tiffany Luong et al.   CLINICAL THERAPEUTICS

Bacteriophage endolysins as a potential weapon to combat Clostridioides difficile infection

(2020) Shakhinur Islam Mondal et al.   Gut Microbes

Phage Therapy in Gastrointestinal Diseases

(2020) Beatriz Gutiérrez et al.   Microorganisms

Phage Therapy, Lysin Therapy, and Antibiotics: A Trio Due to Come

(2020) Tomás G. Villa et al.   Antibiotics-Basel

Autochthonous faecal viral transfer (FVT) impacts the murine microbiome after antibiotic perturbation

(2020) Lorraine A. Draper et al.   BMC BIOLOGY

A Novel Bacteriophage Lysin-Human Defensin Fusion Protein Is Effective in Treatment of Clostridioides difficile Infection in Mice

(2019) Zhong Peng et al.   Frontiers in Microbiology

Phage therapy against Pseudomonas aeruginosa infections in a cystic fibrosis zebrafish model

(2019) Marco Cafora et al.   Scientific Reports

PHAGE Study: Effects of Supplemental Bacteriophage Intake on Inflammation and Gut Microbiota in Healthy Adults

(2019) Hallie Febvre et al.   Nutrients

Gut mucosal virome alterations in ulcerative colitis

(2019) Tao Zuo et al.   GUT

Sugar and Fatty Acids Ack-celerate Prophage Induction

(2019) Anushila Chatterjee et al.   Cell Host & Microbe

The Battle Within: Interactions of Bacteriophages and Bacteria in the Gastrointestinal Tract

(2019) Luisa De Sordi et al.   Cell Host & Microbe

NGS-based phylogeny of diphtheria-related pathogenicity factors in different Corynebacterium spp. implies species-specific virulence transmission

(2019) Alexandra Dangel et al.   BMC MICROBIOLOGY

Engineering of receptor-binding proteins in bacteriophages and phage tail-like bacteriocins

(2019) Dorien Dams et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Filamentous phages: masters of a microbial sharing economy

(2019) Iain D Hay et al.   EMBO REPORTS

Adjunctive fecal microbiota transplantation in supportive oncology: Emerging indications and considerations in immunocompromised patients

(2019) H.R. Wardill et al.   EBioMedicine

Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model

(2019) Bryan B. Hsu et al.   Cell Host & Microbe

Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients

(2019) Jessica R. Allegretti et al.   Clinical Gastroenterology and Hepatology

Rational development of transformation in Clostridium thermocellum ATCC 27405 via complete methylome analysis and evasion of native restriction–modification systems

(2019) Lauren A. Riley et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Bacteriophages benefit from generalized transduction

(2019) Alfred Fillol-Salom et al.   PLoS Pathogens

A Phage Protein Aids Bacterial Symbionts in Eukaryote Immune Evasion

(2019) Martin T. Jahn et al.   Cell Host & Microbe

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

(2019) Yi Duan et al.   NATURE

Risk factors and treatment outcomes of severe Clostridioides difficile infection in Singapore

(2019) H. L. Tay et al.   Scientific Reports

Whole-Virome Analysis Sheds Light on Viral Dark Matter in Inflammatory Bowel Disease

(2019) Adam G. Clooney et al.   Cell Host & Microbe

Efficiency of induction of Shiga-toxin lambdoid prophages in Escherichia coli due to oxidative and antibiotic stress depends on the combination of prophage and the bacterial strain

(2019) Michalina Filipiak et al.   JOURNAL OF APPLIED GENETICS

Applications of bacteriophages versus phage enzymes to combat and cure bacterial infections: an ambitious and also a realistic application?

(2018) Barbara Maciejewska et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

ICTV Virus Taxonomy Profile: Plasmaviridae

(2018) Mart Krupovic et al.   JOURNAL OF GENERAL VIROLOGY

Biotechnological applications of bacteriophages: State of the art

(2018) Liliam K. Harada et al.   MICROBIOLOGICAL RESEARCH

Characterizing Phage Genomes for Therapeutic Applications

(2018) Casandra Philipson et al.   Viruses-Basel

Development of Phage Lysins as Novel Therapeutics: A Historical Perspective

(2018) Vincent Fischetti   Viruses-Basel

Bacteriophages are more virulent to bacteria with human cells than they are in bacterial culture; insights from HT-29 cells

(2018) Jinyu Shan et al.   Scientific Reports

The Novel Phages phiCD5763 and phiCD2955 Represent Two Groups of Big Plasmidial Siphoviridae Phages of Clostridium difficile

(2018) Gabriel Ramírez-Vargas et al.   Frontiers in Microbiology

The use of faecal microbiota transplant as treatment for recurrent or refractoryClostridium difficileinfection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines

(2018) Benjamin H Mullish et al.   GUT

OUP accepted manuscript

(2018)   JOURNAL OF THE HISTORY OF MEDICINE AND ALLIED SCIENCES

Multiple factors contribute to bimodal toxin gene expression in Clostridioides (Clostridium) difficile

(2018) Eric M. Ransom et al.   MOLECULAR MICROBIOLOGY

Characterization of Bacteriophages Infecting Clinical Isolates of Clostridium difficile

(2018) Wichuda Phothichaisri et al.   Frontiers in Microbiology

Bacteriophages Contribute to Shaping Clostridioides (Clostridium) difficile Species

(2018) Louis-Charles Fortier   Frontiers in Microbiology

Cost-Effectiveness Analysis of Bezlotoxumab Added to Standard of Care Versus Standard of Care Alone for the Prevention of Recurrent Clostridium difficile Infection in High-Risk Patients in Spain

(2018) Miguel Salavert et al.   ADVANCES IN THERAPY

Recurrent Clostridium difficile Infection: Risk Factors, Treatment, and Prevention

(2018) Jung Hoon Song et al.   Gut and Liver

Fecal Microbiota Transplant for Recurrent Clostridium Difficile Infection in Pediatric Inflammatory Bowel Disease

(2018) Stanley Cho et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

(2018) Patrick Jault et al.   LANCET INFECTIOUS DISEASES

A Wake-Up Call: We Need Phage Therapy Now

(2018) Karin Moelling et al.   Viruses-Basel

The disparate effects of bacteriophages on antibiotic-resistant bacteria

(2018) Clara Torres-Barceló   Emerging Microbes & Infections

Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation

(2018) L. A. Draper et al.   Microbiome

Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection

(2017) Stephan J. Ott et al.   GASTROENTEROLOGY

Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome

(2017) Tao Zuo et al.   GUT

Lysogeny in nature: mechanisms, impact and ecology of temperate phages

(2017) Cristina Howard-Varona et al.   ISME Journal

A Clostridioides difficile bacteriophage genome encodes functional binary toxin-associated genes

(2017) Thomas Riedel et al.   JOURNAL OF BIOTECHNOLOGY

New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability

(2017) Joseph A. Kirk et al.   Science Translational Medicine

Transfer of Antibiotic Resistance in Staphylococcus aureus

(2017) Jakob Haaber et al.   TRENDS IN MICROBIOLOGY

Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics

(2017) Ewa Jończyk-Matysiak et al.   Viruses-Basel

Bacteriophage evolution differs by host, lifestyle and genome

(2017) Travis N. Mavrich et al.   Nature Microbiology

Newly identified bacteriolytic enzymes that target a wide range of clinical isolates ofClostridium difficile

(2016) Krunal K. Mehta et al.   BIOTECHNOLOGY AND BIOENGINEERING

Oral, frozen fecal microbiota transplant (FMT) capsules for recurrent Clostridium difficile infection

(2016) Ilan Youngster et al.   BMC Medicine

Phage Therapy in Bacterial Infections Treatment: One Hundred Years After the Discovery of Bacteriophages

(2016) Agata Anna Cisek et al.   CURRENT MICROBIOLOGY

Phages rarely encode antibiotic resistance genes: a cautionary tale for virome analyses

(2016) François Enault et al.   ISME Journal

Two Novel Myoviruses from the North of Iraq Reveal Insights into Clostridium difficile Phage Diversity and Biology

(2016) Srwa Rashid et al.   Viruses-Basel

Quorum Regulated Resistance of Vibrio cholerae against Environmental Bacteriophages

(2016) M. Mozammel Hoque et al.   Scientific Reports

The Regulatory Networks That Control Clostridium difficile Toxin Synthesis

(2016) Isabelle Martin-Verstraete et al.   Toxins

‘Get in Early’; Biofilm and Wax Moth (Galleria mellonella) Models Reveal New Insights into the Therapeutic Potential of Clostridium difficile Bacteriophages

(2016) Janet Y. Nale et al.   Frontiers in Microbiology

Clostridium difficile infection

(2016) Wiep Klaas Smits et al.   Nature Reviews Disease Primers

Three New Escherichia coli Phages from the Human Gut Show Promising Potential for Phage Therapy

(2016) Marion Dalmasso et al.   PLoS One

Using a Novel Lysin To Help Control Clostridium difficile Infections

(2015) Qiong Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacteriophage Combinations Significantly Reduce Clostridium difficile GrowthIn Vitroand ProliferationIn Vivo

(2015) Janet Y. Nale et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Escherichia coli O157:H7 strains harbor at least three distinct sequence types of Shiga toxin 2a-converting phages

(2015) Shuang Yin et al.   BMC GENOMICS

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

(2015) Jason M. Norman et al.   CELL

Diversity and Evolution in the Genome of Clostridium difficile

(2015) Daniel R. Knight et al.   CLINICAL MICROBIOLOGY REVIEWS

The gut microbiota and host health: a new clinical frontier

(2015) Julian R Marchesi et al.   GUT

A century of the phage: past, present and future

(2015) George P. C. Salmond et al.   NATURE REVIEWS MICROBIOLOGY

Phage tail-like particles kill Clostridium difficile and represent an alternative to conventional antibiotics

(2015) William Sangster et al.   SURGERY

Function of the CRISPR-Cas System of the Human Pathogen Clostridium difficile

(2015) Pierre Boudry et al.   mBio

Bacteriophage Therapy: Advances in Formulation Strategies and Human Clinical Trials

(2015) Dieter Vandenheuvel et al.   Annual Review of Virology

Antibiotic therapy and Clostridium difficile infection – primum non nocere – first do no harm

(2015) Mark Wilcox et al.   Infection and Drug Resistance

Global Transcriptional Response of Clostridium difficile Carrying the ϕCD38-2 Prophage

(2014) Ognjen Sekulovic et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of Temperate Phages Infecting Clostridium difficile Isolates of Human and Animal Origins

(2014) Ognjen Sekulovic et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cyclic Di-GMP Riboswitch-Regulated Type IV Pili Contribute to Aggregation of Clostridium difficile

(2014) Eric Bordeleau et al.   JOURNAL OF BACTERIOLOGY

What Does the Talking?: Quorum Sensing Signalling Genes Discovered in a Bacteriophage Genome

(2014) Katherine R. Hargreaves et al.   PLoS One

Risk Factors for Recurrence, Complications and Mortality in Clostridium difficile Infection: A Systematic Review

(2014) Claire Nour Abou Chakra et al.   PLoS One

Evaluation of bacteriophage therapy to control Clostridium difficile and toxin production in an in vitro human colon model system

(2013) Emma Meader et al.   ANAEROBE

Phage cocktails and the future of phage therapy

(2013) Benjamin K Chan et al.   Future Microbiology

Importance of prophages to evolution and virulence of bacterial pathogens

(2013) Louis-Charles Fortier et al.   Virulence

Evidence ofIn VivoProphage Induction during Clostridium difficile Infection

(2012) Mathieu Meessen-Pinard et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Prophage Carriage and Diversity within Clinically Relevant Strains of Clostridium difficile

(2012) Jinyu Shan et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Consequences of Clostridium difficile infection: understanding the healthcare burden

(2012) E. Bouza   CLINICAL MICROBIOLOGY AND INFECTION

Going viral: next-generation sequencing applied to phage populations in the human gut

(2012) Alejandro Reyes et al.   NATURE REVIEWS MICROBIOLOGY

Secretion of Clostridium difficile Toxins A and B Requires the Holin-like Protein TcdE

(2012) Revathi Govind et al.   PLoS Pathogens

Prophage-Stimulated Toxin Production in Clostridium difficile NAP1/027 Lysogens

(2011) O. Sekulovic et al.   JOURNAL OF BACTERIOLOGY

Structure-Based Modification of a Clostridium difficile-Targeting Endolysin Affects Activity and Host Range

(2011) M. J. Mayer et al.   JOURNAL OF BACTERIOLOGY

Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an in vitro model system

(2010) Emma Meader et al.   ANAEROBE

Genome analysis of the Clostridium difficile phage ΦCD6356, a temperate phage of the Siphoviridae family

(2010) Marianne Horgan et al.   GENE

Bacteriophage-Mediated Toxin Gene Regulation in Clostridium difficile

(2009) R. Govind et al.   JOURNAL OF VIROLOGY

Molecular Characterization of a Clostridium difficile Bacteriophage and Its Cloned Biologically Active Endolysin

(2008) M. J. Mayer et al.   JOURNAL OF BACTERIOLOGY