Potential Role of the Host-Derived Cell-Wall Binding Domain of Endolysin CD16/50L as a Molecular Anchor in Preservation of Uninfected Clostridioides difficile for New Rounds of Phage Infection

Structure and assembly of the S-layer in C. difficile

(2022) Paola Lanzoni-Mangutchi et al.   Nature Communications

The multi-domain architecture of a bacteriophage endolysin enables intramolecular synergism and regulation of bacterial lysis

(2021) Frank Oechslin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequence-function Relationships in Phage-encoded Bacterial Cell Wall Lytic Enzymes and their Implications for Phage-derived Products Design

(2021) Roberto Vázquez et al.   JOURNAL OF VIROLOGY

Burden of Clostridioides difficile infection (CDI) - a systematic review of the epidemiology of primary and recurrent CDI

(2021) Elaine Finn et al.   BMC INFECTIOUS DISEASES

Characterization of an Endolysin Targeting Clostridioides difficile That Affects Spore Outgrowth

(2021) Shakhinur Islam Mondal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Insights into the Role of Human Gut Microbiota in Clostridioides difficile Infection

(2020) Melina Kachrimanidou et al.   Microorganisms

Update on Treatment of Clostridioides difficile Infection

(2020) Janice M. Cho et al.   MAYO CLINIC PROCEEDINGS

In Vivo Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials

(2020) Kurt Selle et al.   mBio

Peptidoglycan analysis reveals that synergistic deacetylase activity in vegetative Clostridium difficile impacts the host response

(2020) Héloise Coullon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Antimicrobial resistance in Clostridioides (Clostridium) difficile derived from humans: a systematic review and meta-analysis

(2020) Mohammad Sholeh et al.   Antimicrobial Resistance and Infection Control

Bacteriophage endolysins as a potential weapon to combat Clostridioides difficile infection

(2020) Shakhinur Islam Mondal et al.   Gut Microbes

RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences

(2020) Stephen K Burley et al.   NUCLEIC ACIDS RESEARCH

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

The Bacterial Chromatin Protein HupA Can Remodel DNA and Associates with the Nucleoid in Clostridium difficile

(2019) Ana M. Oliveira Paiva et al.   JOURNAL OF MOLECULAR BIOLOGY

The requirement for co-germinants during Clostridium difficile spore germination is influenced by mutations in yabG and cspA

(2019) Ritu Shrestha et al.   PLoS Pathogens

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Structural Basis for Cell-Wall Recognition by Bacteriophage PBC5 Endolysin

(2019) Ko On Lee et al.   STRUCTURE

How the phage T4 injection machinery works including energetics, forces, and dynamic pathway

(2019) Ameneh Maghsoodi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-induced upregulation of the ubiquitin-relative Hub1 modulates pre-mRNA splicing and facilitates cadmium tolerance in Saccharomyces cerevisiae

(2019) Sittinan Chanarat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

False positives in using the zymogram assay for identification of peptidoglycan hydrolases

(2018) Cristian A. Escobar et al.   ANALYTICAL BIOCHEMISTRY

Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)

(2018) L Clifford McDonald et al.   CLINICAL INFECTIOUS DISEASES

A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core

(2018) Lukas Zimmermann et al.   JOURNAL OF MOLECULAR BIOLOGY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

The Auxiliary Role of the Amidase Domain in Cell Wall Binding and Exolytic Activity of Staphylococcal Phage Endolysins

(2018) Bokyung Son et al.   Viruses-Basel

Cwp19 Is a Novel Lytic Transglycosylase Involved in Stationary-Phase Autolysis Resulting in Toxin Release in Clostridium difficile

(2018) Sandra Wydau-Dematteis et al.   mBio

Phage spanins: diversity, topological dynamics and gene convergence

(2018) Rohit Kongari et al.   BMC BIOINFORMATICS

Catalytic diversity and cell wall binding repeats in the phage encoded endolysins

(2018) Sebastian S. Broendum et al.   MOLECULAR MICROBIOLOGY

Characterization of Bacteriophages Infecting Clinical Isolates of Clostridium difficile

(2018) Wichuda Phothichaisri et al.   Frontiers in Microbiology

Insights into drug resistance mechanisms in Clostridium difficile

(2017) Phurt Harnvoravongchai et al.   Essays in Biochemistry

Update on Antimicrobial Resistance in Clostridium difficile: Resistance Mechanisms and Antimicrobial Susceptibility Testing

(2017) Zhong Peng et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Error-Prone Splicing Controlled by the Ubiquitin Relative Hub1

(2017) Ramazan Karaduman et al.   MOLECULAR CELL

New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability

(2017) Joseph A. Kirk et al.   Science Translational Medicine

The CWB2 Cell Wall-Anchoring Module Is Revealed by the Crystal Structures of the Clostridium difficile Cell Wall Proteins Cwp8 and Cwp6

(2017) Aleksandra Usenik et al.   STRUCTURE

Deciphering how Cpl-7 cell wall-binding repeats recognize the bacterial peptidoglycan

(2017) Noemí Bustamante et al.   Scientific Reports

A Novel Antimicrobial Endolysin, LysPA26, against Pseudomonas aeruginosa

(2017) Mingquan Guo et al.   Frontiers in Microbiology

Heat shock increases conjugation efficiency in Clostridium difficile

(2016) Joseph A. Kirk et al.   ANAEROBE

Towards an automated analysis of bacterial peptidoglycan structure

(2016) Marshall Bern et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The Signal Sequence of the Abundant Extracellular Metalloprotease PPEP-1 Can Be Used to Secrete Synthetic Reporter Proteins in Clostridium difficile

(2016) Ana M. Oliveira Paiva et al.   ACS Synthetic Biology

A Clostridium difficile Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence

(2016) Michele Chu et al.   PLoS Pathogens

Biocontrol and Rapid Detection of Food-Borne Pathogens Using Bacteriophages and Endolysins

(2016) Jaewoo Bai et al.   Frontiers in Microbiology

IVA cloning: A single-tube universal cloning system exploiting bacterial In Vivo Assembly

(2016) Javier García-Nafría et al.   Scientific Reports

Wall Teichoic Acids Are Involved in the Medium-Induced Loss of Function of the Autolysin CD11 against Clostridium difficile

(2016) Xia Wu et al.   Scientific Reports

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

(2015) Andrew S. Dixon et al.   ACS Chemical Biology

Using a Novel Lysin To Help Control Clostridium difficile Infections

(2015) Qiong Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A novel and highly specific phage endolysin cell wall binding domain for detection of Bacillus cereus

(2015) Minsuk Kong et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Crystal Structure of the CTP1L Endolysin Reveals How Its Activity Is Regulated by a Secondary Translation Product

(2015) Matthew Dunne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Landscape of Realized Homologous Recombination in Pathogenic Bacteria

(2015) Koji Yahara et al.   MOLECULAR BIOLOGY AND EVOLUTION

Clostridium difficilesurface proteins are anchored to the cell wall using CWB2 motifs that recognise the anionic polymer PSII

(2015) Stephanie E. Willing et al.   MOLECULAR MICROBIOLOGY

Phage lysis: Three steps, three choices, one outcome

(2014) Ryland Young   JOURNAL OF MICROBIOLOGY

X-ray structure of a novel endolysin encoded by episomal phage phiSM101 ofClostridium perfringens

(2014) Eiji Tamai et al.   MOLECULAR MICROBIOLOGY

Clostridium difficile spore biology: sporulation, germination, and spore structural proteins

(2014) Daniel Paredes-Sabja et al.   TRENDS IN MICROBIOLOGY

The CD27L and CTP1L Endolysins Targeting Clostridia Contain a Built-in Trigger and Release Factor

(2014) Matthew Dunne et al.   PLoS Pathogens

Evaluation of bacteriophage therapy to control Clostridium difficile and toxin production in an in vitro human colon model system

(2013) Emma Meader et al.   ANAEROBE

Molecular Aspects and Comparative Genomics of Bacteriophage Endolysins

(2013) H. Oliveira et al.   JOURNAL OF VIROLOGY

Bile Acid Recognition by the Clostridium difficile Germinant Receptor, CspC, Is Important for Establishing Infection

(2013) Michael B. Francis et al.   PLoS Pathogens

Evaluation of Multiplex PCR with Enhanced Spore Germination for Detection ofClostridium difficilefrom Stool Samples of the Hospitalized Patients

(2013) Surang Chankhamhaengdecha et al.   Biomed Research International

Genomic Sequence of Bacteriophage ATCC 8074-B1 and Activity of Its Endolysin and Engineered Variants against Clostridium sporogenes

(2012) Melinda J. Mayer et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Association of Relapse of Clostridium difficile Disease with BI/NAP1/027

(2012) J. W. Marsh et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Recombinational Switching of the Clostridium difficile S-Layer and a Novel Glycosylation Gene Cluster Revealed by Large-Scale Whole-Genome Sequencing

(2012) Kate E. Dingle et al.   JOURNAL OF INFECTIOUS DISEASES

X-ray crystal structure of the streptococcal specific phage lysin PlyC

(2012) S. McGowan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral Proteins Acquired from a Host Converge to Simplified Domain Architectures

(2012) Nadav Rappoport et al.   PLoS Computational Biology

In vivo lysogenization of a Clostridium difficile bacteriophage ФCD119

(2011) Govind Revathi et al.   ANAEROBE

Prophage-Stimulated Toxin Production in Clostridium difficile NAP1/027 Lysogens

(2011) O. Sekulovic et al.   JOURNAL OF BACTERIOLOGY

Structure-Based Modification of a Clostridium difficile-Targeting Endolysin Affects Activity and Host Range

(2011) M. J. Mayer et al.   JOURNAL OF BACTERIOLOGY

Role of Net Charge on Catalytic Domain and Influence of Cell Wall Binding Domain on Bactericidal Activity, Specificity, and Host Range of Phage Lysins

(2011) Lieh Yoon Low et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clostridium difficileHas an Original Peptidoglycan Structure with a High Level ofN-Acetylglucosamine Deacetylation and Mainly 3-3 Cross-links

(2011) Johann Peltier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an in vitro model system

(2010) Emma Meader et al.   ANAEROBE

Holin triggering in real time

(2010) R. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Structural insights into the molecular organization of the S-layer fromClostridium difficile

(2009) Robert P. Fagan et al.   MOLECULAR MICROBIOLOGY

Clostridium difficile cell-surface polysaccharides composed of pentaglycosyl and hexaglycosyl phosphate repeating units

(2008) Jeyabarathy Ganeshapillai et al.   CARBOHYDRATE RESEARCH