Protein interaction networks in neurodegenerative diseases: from physiological function to aggregation

TDP-43 is a ubiquitylation substrate of the SCFcyclin F complex

(2022) Stephanie L. Rayner et al.   NEUROBIOLOGY OF DISEASE

Reverse engineering Lewy bodies: how far have we come and how far can we go?

(2021) Mohamed Bilal Fares et al.   NATURE REVIEWS NEUROSCIENCE

Interplay between tau and α‐synuclein LLPS

(2021) Anna Siegert et al.   PROTEIN SCIENCE

Triad of TDP43 control in neurodegeneration: autoregulation, localization and aggregation

(2021) Paraskevi Tziortzouda et al.   NATURE REVIEWS NEUROSCIENCE

TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau

(2021) Peter E. A. Ash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Dual Roles of Clusterin in Extracellular and Intracellular Proteostasis

(2021) Sandeep Satapathy et al.   TRENDS IN BIOCHEMICAL SCIENCES

CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice

(2021) Laura Caló et al.   BRAIN

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome

(2021) Edward L. Huttlin et al.   CELL

ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ

(2021) Stephanie L Rayner et al.   HUMAN MOLECULAR GENETICS

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains

(2021) Benjamin L. Piette et al.   MOLECULAR CELL

Double setback for ASO trials in Huntington disease

(2021) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

Modulating α-Synuclein Liquid–Liquid Phase Separation

(2021) Ajay Singh Sawner et al.   BIOCHEMISTRY

Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation

(2021) Jinge Gu et al.   CELL RESEARCH

DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation

(2021) Zhiqiang Hou et al.   Nature Communications

Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons

(2021) Benedict Tanudjojo et al.   Nature Communications

Hsp40s play complementary roles in the prevention of tau amyloid formation

(2021) Rose Irwin et al.   eLife

Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein

(2021) André D. G. Leitão et al.   Communications Biology

DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease

(2021) Sertan Arkan et al.   NEUROBIOLOGY OF DISEASE

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

(2021) Nathan Riguet et al.   Nature Communications

An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging

(2021) Maria Lucia Pigazzini et al.   Frontiers in Molecular Neuroscience

Proximity dependent biotinylation: key enzymes and adaptation to proteomics approaches

(2020) Payman Samavarchi-Tehrani et al.   MOLECULAR & CELLULAR PROTEOMICS

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

(2020) David R. Boyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation

(2020) Yunpeng Sun et al.   CELL RESEARCH

Amyloid-β oligomers are captured by the DNAJB6 chaperone: Direct detection of interactions that can prevent primary nucleation

(2020) Nicklas Österlund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species

(2020) Eliana Nachman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis

(2020) Arun Thiruvalluvan et al.   MOLECULAR CELL

Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network

(2020) Willianne I.M. Vonk et al.   MOLECULAR CELL

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

(2020) Nicolas R. Barthélemy et al.   NATURE MEDICINE

GSK3β and Tau Protein in Alzheimer’s Disease and Epilepsy

(2020) Danira Toral-Rios et al.   Frontiers in Cellular Neuroscience

Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure

(2020) Kun Zhao et al.   Nature Communications

BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain

(2020) Reza Pourhaghighi et al.   Cell Systems

Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: Effects on internalization by cells and identification of interacting interfaces

(2020) Maya Bendifallah et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

(2020) Ramanath Narayana Hegde et al.   EMBO JOURNAL

Shedding a new light on Huntington’s disease: how blood can both propagate and ameliorate disease pathology

(2020) Marie Rieux et al.   MOLECULAR PSYCHIATRY

Synergy between amyloid-β and tau in Alzheimer’s disease

(2020) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Praja1 RING ‐finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP ‐43 aggregate formation

(2020) Kazuhiko Watabe et al.   NEUROPATHOLOGY

SOD1-interacting proteins: Roles of aggregation cores and protein degradation systems

(2020) Mio Une et al.   NEUROSCIENCE RESEARCH

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells

(2020) Seung W. Ryu et al.   PLOS BIOLOGY

Genetic predispositions of Parkinson’s disease revealed in patient-derived brain cells

(2020) Jenne Tran et al.   npj Parkinsons Disease

The multi‐faceted role of mitochondria in the pathology of Parkinson’s disease

(2020) Dennison Trinh et al.   JOURNAL OF NEUROCHEMISTRY

The ubiquitin ligase UBE4B regulates amyloid precursor protein ubiquitination, endosomal trafficking, and amyloid β42 generation and secretion

(2020) Monica Gireud-Goss et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities

(2020) Sarah J. Tabrizi et al.   Nature Reviews Neurology

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic and chemical interactions

(2020) Rose Oughtred et al.   PROTEIN SCIENCE

Beyond aggregation: Pathological phase transitions in neurodegenerative disease

(2020) Cécile Mathieu et al.   SCIENCE

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains

(2020) Christian Haenig et al.   Cell Reports

Fyn Kinase Controls Tau Aggregation In Vivo

(2020) Adam Briner et al.   Cell Reports

Late-onset vs nonmendelian early-onset Alzheimer disease

(2020) Christiane Reitz et al.   Neurology-Genetics

Regulatory mechanisms of tau protein fibrillation under the conditions of liquid–liquid phase separation

(2020) Solomiia Boyko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of the amyloid precursor protein by human γ-secretase

(2019) Rui Zhou et al.   SCIENCE

Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS

(2019) Fernanda A. Sala et al.   PLOS BIOLOGY

Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity

(2019) Di Hu et al.   ACTA NEUROPATHOLOGICA

Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms

(2019) Maria Masnata et al.   ACTA NEUROPATHOLOGICA

Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)

(2019) Philip Wing-Lok Ho et al.   Autophagy

How is alpha‐synuclein cleared from the cell?

(2019) Leonidas Stefanis et al.   JOURNAL OF NEUROCHEMISTRY

Spontaneous driving forces give rise to protein−RNA condensates with coexisting phases and complex material properties

(2019) Steven Boeynaems et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

(2019) Tom Scheidt et al.   Science Advances

Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23

(2019) Svitlana Yablonska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body–like pathology

(2019) Juan A. Gerez et al.   Science Translational Medicine

Tau binding protein CAPON induces tau aggregation and neurodegeneration

(2019) Shoko Hashimoto et al.   Nature Communications

SOD1-positive aggregate accumulation in the CNS predicts slower disease progression and increased longevity in a mutant SOD1 mouse model of ALS

(2019) Cindy Gill et al.   Scientific Reports

The Molecular Chaperone DNAJB6, but Not DNAJB1, Suppresses the Seeded Aggregation of Alpha-Synuclein in Cells

(2019) Natasja Deshayes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of their Oligomers by the Proteasome Holoenzyme

(2019) Yu Ye et al.   JOURNAL OF MOLECULAR BIOLOGY

The pathobiology of perturbed mutant huntingtin protein–protein interactions in Huntington's disease

(2019) Erich E. Wanker et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of α-synuclein by chaperones in mammalian cells

(2019) Björn M. Burmann et al.   NATURE

The genetics of Parkinson disease

(2018) Hao Deng et al.   AGEING RESEARCH REVIEWS

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment

(2018) Qiang Guo et al.   CELL

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules

(2018) Sebastian Markmiller et al.   CELL

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation

(2018) Hannah E. R. Baughman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers

(2018) Ammon E. Posey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein

(2018) Isabelle R. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions

(2018) Thuy P. Dao et al.   MOLECULAR CELL

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation

(2018) Thomas R. Peskett et al.   MOLECULAR CELL

Herp Promotes Degradation of Mutant Huntingtin: Involvement of the Proteasome and Molecular Chaperones

(2018) Huanhuan Luo et al.   MOLECULAR NEUROBIOLOGY

LuTHy: a double‐readout bioluminescence‐based two‐hybrid technology for quantitative mapping of protein–protein interactions in mammalian cells

(2018) Philipp Trepte et al.   Molecular Systems Biology

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

(2018) Chao Peng et al.   NATURE

TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD

(2018) Ching-Chieh Chou et al.   NATURE NEUROSCIENCE

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

(2018) Sue-Ann Mok et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Large SOD1 aggregates, unlike trimeric SOD1, do not impact cell viability in a model of amyotrophic lateral sclerosis

(2018) Cheng Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients

(2018) Seda Koyuncu et al.   Nature Communications

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

(2018) Sue-Ann Mok et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

(2018) Gian-Luca McLelland et al.   eLife

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

(2018) Yaowang Li et al.   CELL RESEARCH

The ATPase VCP/p97 functions as a disaggregase against toxic Huntingtin-exon1 aggregates

(2018) Debasish Kumar Ghosh et al.   FEBS LETTERS

Influence of LRP-1 and Apolipoprotein E on Amyloid-β Uptake and Toxicity to Cerebrovascular Smooth Muscle Cells

(2018) Wan Adriyani W. Ruzali et al.   JOURNAL OF ALZHEIMERS DISEASE

The cryo-electron microscopy structure of huntingtin

(2018) Qiang Guo et al.   NATURE

The amyloid hypothesis on trial

(2018) Simon Makin   NATURE

Efficient proximity labeling in living cells and organisms with TurboID

(2018) Tess C Branon et al.   NATURE BIOTECHNOLOGY

A new era for understanding amyloid structures and disease

(2018) Matthew G. Iadanza et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

(2018) Binsen Li et al.   Nature Communications

Aggregated SOD1 causes selective death of cultured human motor neurons

(2018) Chen Benkler et al.   Scientific Reports

Mitochondrial cristae remodelling is associated with disrupted OPA1 oligomerisation in the Huntington's disease R6/2 fragment model

(2017) Tanja Hering et al.   EXPERIMENTAL NEUROLOGY

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

(2017) Jinsoo Seo et al.   JOURNAL OF NEUROSCIENCE

Architecture of the human interactome defines protein communities and disease networks

(2017) Edward L. Huttlin et al.   NATURE

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

(2017) Ian R. Mackenzie et al.   NEURON

Transfer of pathogenic and nonpathogenic cytosolic proteins between spinal cord motor neurons in vivo in chimeric mice

(2017) Eleanor V. Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis

(2017) Keiko Imamura et al.   Science Translational Medicine

Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program

(2017) Ping Wang et al.   Nature Communications

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

Parkin regulates translesion DNA synthesis in response to UV radiation

(2017) Xuefei Zhu et al.   Oncotarget

The MPTP Story

(2017) J. William Langston   Journal of Parkinsons Disease

Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms

(2017) Kristina Endres et al.   Frontiers in Molecular Neuroscience

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling

(2017) Ramy H. Malty et al.   Cell Systems

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

(2017) Francesco A. Aprile et al.   Scientific Reports

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19

(2017) Wen-Tian He et al.   Scientific Reports

Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer’s disease

(2017) Caoyi Chen et al.   Scientific Reports

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations

(2016) Igor Dikiy et al.   ACS Chemical Biology

cIAPs promote the proteasomal degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis

(2016) Jin Sun Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hsp90 directly interacts, in vitro , with amyloid structures and modulates their assembly and disassembly

(2016) Claire Schirmer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis

(2016) Han-Jou Chen et al.   BRAIN

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

(2016) Roland Hjerpe et al.   CELL

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins

(2016) Sarah N Fontaine et al.   EMBO JOURNAL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity

(2016) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration

(2016) Saurav Brahmachari et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of heat shock factor 1 maintains TAR DNA binding protein 43 solubility via induction of inducible heat shock protein 70 in cultured cells

(2016) Pei-Yi Lin et al.   JOURNAL OF NEUROSCIENCE RESEARCH

An improved smaller biotin ligase for BioID proximity labeling

(2016) Dae In Kim et al.   MOLECULAR BIOLOGY OF THE CELL

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model

(2016) Vaishali Kakkar et al.   MOLECULAR CELL

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

(2016) Wenzhang Wang et al.   NATURE MEDICINE

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration

(2016) Dominic M. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease

(2016) Zoi Alexopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core

(2016) Cody L. Hoop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain

(2016) Alexander E. Conicella et al.   STRUCTURE

Characterizing Protein–Protein Interactions Using Mass Spectrometry: Challenges and Opportunities

(2016) Arne H. Smits et al.   TRENDS IN BIOTECHNOLOGY

VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease

(2016) Xing Guo et al.   Nature Communications

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

(2016) Kelly L. Williams et al.   Nature Communications

Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?

(2016) Abid Oueslati   Journal of Parkinsons Disease

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

(2016) Florent Letronne et al.   EBioMedicine

Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients

(2016) Isil Keskin et al.   PLoS One

Aberrant association of misfolded SOD1 with Na+/K+ATPase-α3 impairs its activity and contributes to motor neuron vulnerability in ALS

(2015) Céline Ruegsegger et al.   ACTA NEUROPATHOLOGICA

CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase

(2015) Amir Kumar Singh et al.   AGING CELL

LRPPRCmutations cause early-onset multisystem mitochondrial disease outside of the French-Canadian population

(2015) Monika Oláhová et al.   BRAIN

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

NF-κB pathway controls mitochondrial dynamics

(2015) M Laforge et al.   CELL DEATH AND DIFFERENTIATION

Inverse Size Scaling of the Nucleolus by a Concentration-Dependent Phase Transition

(2015) Stephanie C. Weber et al.   CURRENT BIOLOGY

Structural basis of Cu, Zn-superoxide dismutase amyloid fibril formation involves interaction of multiple peptide core regions

(2015) Masataka Ida et al.   JOURNAL OF BIOCHEMISTRY

Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Spanin Vivo

(2015) Robert O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum

(2015) Stefan Schorr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dopamine Transporter Activity Is Modulated by α-Synuclein

(2015) Brittany Butler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement

(2015) Sarah N. Fontaine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier

(2015) Steffen E. Storck et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

(2015) Xuechao Gao et al.   MOLECULAR CELL

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain

(2015) Guohao Wang et al.   Molecular Neurodegeneration

Panorama of ancient metazoan macromolecular complexes

(2015) Cuihong Wan et al.   NATURE

Huntingtin functions as a scaffold for selective macroautophagy

(2015) Yan-Ning Rui et al.   NATURE CELL BIOLOGY

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

(2015) Andi Mainz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3

(2015) Li Zeng et al.   NEUROBIOLOGY OF DISEASE

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

(2015) Tetsuro Murakami et al.   NEURON

Detailed Analysis of the Human Mitochondrial Contact Site Complex Indicate a Hierarchy of Subunits

(2015) Christine Ott et al.   PLoS One

Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis

(2015) Elizabeth A. Proctor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

(2015) Andi Mainz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

(2015) Fabian Hosp et al.   Cell Reports

Experimental transmissibility of mutant SOD1 motor neuron disease

(2014) Jacob I. Ayers et al.   ACTA NEUROPATHOLOGICA

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways

(2014) Mikko Taipale et al.   CELL

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease

(2014) Stefanie L. Butland et al.   HUMAN MOLECULAR GENETICS

Interaction of the Molecular Chaperone DNAJB6 with Growing Amyloid-beta 42 (Aβ42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation

(2014) Cecilia Månsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Large Scale Huntingtin Protein Interaction Network Implicates Rho GTPase Signaling Pathways in Huntington Disease

(2014) Cendrine Tourette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

The role of the LRRK2 gene in Parkinsonism

(2014) Jie-Qiong Li et al.   Molecular Neurodegeneration

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis

(2014) Janel O Johnson et al.   NATURE NEUROSCIENCE

Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein

(2014) Sudhakar Raja Subramaniam et al.   NEUROBIOLOGY OF DISEASE

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition

(2014) A. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A

(2014) K. P. Bhat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoinhibitory Structure of the WW Domain of HYPB/SETD2 Regulates Its Interaction with the Proline-Rich Region of Huntingtin

(2014) Yong-Guang Gao et al.   STRUCTURE

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

(2013) Karen Castillo et al.   Autophagy

Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: Characterization of inhibition by nucleic acids and 4-aminoquinolines

(2013) Joel A. Cassel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling

(2013) Frank Wippich et al.   CELL

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

25 years of neuroimaging in amyotrophic lateral sclerosis

(2013) Bradley R. Foerster et al.   Nature Reviews Neurology

Hepatic mitochondrial dysfunction in manifest and premanifest Huntington disease

(2013) S. H. Stuwe et al.   NEUROLOGY

Neuronal Ca2+dyshomeostasis in Huntington disease

(2013) Marta Giacomello et al.   Prion

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

(2013) K. Sathasivam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates  -Synuclein Toxicity in Neurons

(2013) D. F. Tardiff et al.   SCIENCE

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

A Census of Human Soluble Protein Complexes

(2012) Pierre C. Havugimana et al.   CELL

Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes

(2012) The HD iPSC Consortium   Cell Stem Cell

Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains

(2012) Douglas G. Walker et al.   EXPERIMENTAL NEUROLOGY

Proteomic Analysis of Wild-type and Mutant Huntingtin-associated Proteins in Mouse Brains Identifies Unique Interactions and Involvement in Protein Synthesis

(2012) Brady P. Culver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Ubiquitinates Tar-DNA Binding Protein-43 (TDP-43) and Promotes Its Cytosolic Accumulation via Interaction with Histone Deacetylase 6 (HDAC6)

(2012) Michaeline L. Hebron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

FBL2 Regulates Amyloid Precursor Protein (APP) Metabolism by Promoting Ubiquitination-Dependent APP Degradation and Inhibition of APP Endocytosis

(2012) T. Watanabe et al.   JOURNAL OF NEUROSCIENCE

Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy

(2012) Jeffrey D Martell et al.   NATURE BIOTECHNOLOGY

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

(2012) Dyna I. Shirasaki et al.   NEURON

Development and application of a DNA microarray-based yeast two-hybrid system

(2012) Bernhard Suter et al.   NUCLEIC ACIDS RESEARCH

Evolution and function of CAG/polyglutamine repeats in protein–protein interaction networks

(2012) Martin H. Schaefer et al.   NUCLEIC ACIDS RESEARCH

The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation

(2012) Lin Qi et al.   PLoS One

Neuronal Properties, In Vivo Effects, and Pathology of a Huntington's Disease Patient-Derived Induced Pluripotent Stem Cells

(2012) Iksoo Jeon et al.   STEM CELLS

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Characterization of Staufen1 Ribonucleoproteins by Mass Spectrometry and Biochemical Analyses Reveal the Presence of Diverse Host Proteins Associated with Human Immunodeficiency Virus Type 1

(2012) Miroslav P. Milev et al.   Frontiers in Microbiology

SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2011) Faisal Fecto   ARCHIVES OF NEUROLOGY

LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE – carrying lipoproteins

(2011) J. Haas et al.   ATHEROSCLEROSIS

Heat Shock Protein 70 Prevents both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport

(2011) Kristina R. Patterson et al.   BIOCHEMISTRY

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Hsc70 Protein Interaction with Soluble and Fibrillar α-Synuclein

(2011) Samantha Pemberton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions of Pathological Hallmark Proteins

(2011) Judit Oláh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Array Based Interactome Analysis of Amyloid-β Indicates an Inhibition of Protein Translation

(2011) Dezso P. Virok et al.   JOURNAL OF PROTEOME RESEARCH

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

(2011) Han-Xiang Deng et al.   NATURE

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

(2011) Magdalini Polymenidou et al.   NATURE NEUROSCIENCE

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Ubiquitinylation of α-Synuclein by Carboxyl Terminus Hsp70-Interacting Protein (CHIP) Is Regulated by Bcl-2-Associated Athanogene 5 (BAG5)

(2011) Lorraine V. Kalia et al.   PLoS One

Ubiquitin ligase Nedd4 promotes  -synuclein degradation by the endosomal-lysosomal pathway

(2011) G. K. Tofaris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Synuclein fate is determined by USP9X-regulated monoubiquitination

(2011) R. Rott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

(2011) Christian Münch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRPPRC is a mitochondrial matrix protein that is conserved in metazoans

(2010) Fredrik H. Sterky et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse

(2010) Lindsey R. Fischer et al.   BRAIN

A Novel ER J-protein DNAJB12 Accelerates ER-associated Degradation of Membrane Proteins Including CFTR

(2010) Yo-hei Yamamoto et al.   CELL STRUCTURE AND FUNCTION

Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing

(2010) Hirokazu Okada et al.   FASEB JOURNAL

Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein

(2010) Pavel F. Pavlov et al.   FASEB JOURNAL

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

Mutation-dependent Polymorphism of Cu,Zn-Superoxide Dismutase Aggregates in the Familial Form of Amyotrophic Lateral Sclerosis

(2010) Yoshiaki Furukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 and Hsp40 Functionally Interact with Soluble Mutant Huntingtin Oligomers in a Classic ATP-dependent Reaction Cycle

(2010) Gregor P. Lotz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyotrophic Lateral Sclerosis-associated Proteins TDP-43 and FUS/TLS Function in a Common Biochemical Complex to Co-regulate HDAC6 mRNA

(2010) Sang Hwa Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Disulfide-Reduced ALS Variants of Cu, Zn Superoxide Dismutase Exhibit Increased Populations of Unfolded Species

(2010) Can Kayatekin et al.   JOURNAL OF MOLECULAR BIOLOGY

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

A DNAJB Chaperone Subfamily with HDAC-Dependent Activities Suppresses Toxic Protein Aggregation

(2010) Jurre Hageman et al.   MOLECULAR CELL

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

SAINT: probabilistic scoring of affinity purification–mass spectrometry data

(2010) Hyungwon Choi et al.   NATURE METHODS

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import

(2010) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation and intrinsic  -secretase activity of presenilin 1

(2010) K. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3ζ protein

(2009) Golam Sadik et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases

(2009) Latha Devi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

(2009) Weihua Zhao et al.   GLIA

Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation

(2009) Zheng Ying et al.   HUMAN MOLECULAR GENETICS

The Molecular Chaperone Hsp90 Modulates Intermediate Steps of Amyloid Assembly of the Parkinson-related Protein α-Synuclein

(2009) S. Fabio Falsone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Role of RanBP9 in BACE1 Processing of Amyloid Precursor Protein and Amyloid β Peptide Generation

(2009) Madepalli K. Lakshmana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

(2009) Leslie Michels Thompson et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial accumulation of APP and Aβ: significance for Alzheimer disease pathogenesis

(2009) Pavel F. Pavlov et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism

(2009) Jozsef Gal et al.   JOURNAL OF NEUROCHEMISTRY

Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery

(2009) Brian D. Freibaum et al.   JOURNAL OF PROTEOME RESEARCH

Beyond the brain: widespread pathology in Huntington's disease

(2009) Jorien MM van der Burg et al.   LANCET NEUROLOGY

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

(2009) Stephen Tam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS

(2009) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Huntingtin as an essential integrator of intracellular vesicular trafficking

(2009) Juliane P. Caviston et al.   TRENDS IN CELL BIOLOGY

Ubiquitin ligase E6-AP and its role in human disease

(2008) Konstantin Matentzoglu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

(2008) Emilie Colin et al.   EMBO JOURNAL

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease

(2008) Chuan-En Wang et al.   HUMAN MOLECULAR GENETICS

A Limited Role for Disulfide Cross-linking in the Aggregation of Mutant SOD1 Linked to Familial Amyotrophic Lateral Sclerosis

(2008) Celeste M. Karch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E6-AP Promotes Misfolded Polyglutamine Proteins for Proteasomal Degradation and Suppresses Polyglutamine Protein Aggregation and Toxicity

(2008) Amit Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHIP Targets Toxic α-Synuclein Oligomers for Degradation

(2008) Julie E. Tetzlaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Optical Reporters for the Conformation of  -Synuclein Reveal a Specific Interaction with Mitochondria

(2008) K. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Proteomics Analysis Identifies Phosphorylation-dependent α-Synuclein Protein Interactions

(2008) Melinda A. McFarland et al.   MOLECULAR & CELLULAR PROTEOMICS

Protein array analysis of oligomerization-induced changes in alpha-synuclein protein–protein interactions points to an interference with Cdc42 effector proteins

(2008) C. Schnack et al.   NEUROSCIENCE

Adherent Monomer-Misfolded SOD1

(2008) Yasuhiro Watanabe et al.   PLoS One

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE

Mutant huntingtin and mitochondrial dysfunction

(2008) Ella Bossy-Wetzel et al.   TRENDS IN NEUROSCIENCES