The cryo-electron microscopy structure of huntingtin

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats

(2017) Tamara Ratovitski et al.   JOURNAL OF PROTEOME RESEARCH

Correcting for cell-type heterogeneity in epigenome-wide association studies: revisiting previous analyses

(2017) Shijie C Zheng et al.   NATURE METHODS

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

(2016) Ravi Vijayvargia et al.   eLife

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation

(2015) M.-T. El-Daher et al.   EMBO JOURNAL

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

(2015) Ashwin Chari et al.   NATURE METHODS

Scalable Production in Human Cells and Biochemical Characterization of Full-Length Normal and Mutant Huntingtin

(2015) Bin Huang et al.   PLoS One

Scalable web services for the PSIPRED Protein Analysis Workbench

(2013) Daniel W. A. Buchan et al.   NUCLEIC ACIDS RESEARCH

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

(2012) Dyna I. Shirasaki et al.   NEURON

Huntington's Disease

(2011) S. Finkbeiner   Cold Spring Harbor Perspectives in Biology

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Huntingtin facilitates polycomb repressive complex 2

(2009) Ihn Sik Seong et al.   HUMAN MOLECULAR GENETICS

Mutant Huntingtin N-terminal Fragments of Specific Size Mediate Aggregation and Toxicity in Neuronal Cells

(2009) Tamara Ratovitski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of Alpha-Rod Protein Repeats Using a Neural Network and Application to Huntingtin

(2009) Gareth A. Palidwor et al.   PLoS Computational Biology

Phylogenetic Comparison of Huntingtin Homologues Reveals the Appearance of a Primitive polyQ in Sea Urchin

(2007) M. Tartari et al.   MOLECULAR BIOLOGY AND EVOLUTION