The Dual Roles of Clusterin in Extracellular and Intracellular Proteostasis

Heparan sulfate is a clearance receptor for aberrant extracellular proteins

(2020) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

Extracellular proteostasis prevents aggregation during pathogenic attack

(2020) Ivan Gallotta et al.   NATURE

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies

(2019) Evangeline M. Foster et al.   Frontiers in Neuroscience

Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice

(2019) Sofía Fernández de Retana et al.   Alzheimers Research & Therapy

Clusterin as a potential marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy

(2019) Joanna Iłżecka et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Secreted Clusterin protein inhibits osteoblast differentiation of bone marrow mesenchymal stem cells by suppressing ERK1/2 signaling pathway

(2018) Basem M. Abdallah et al.   BONE

Expression and Implication of Clusterin in Left Ventricular Remodeling After Myocardial Infarction

(2018) Annie Turkieh et al.   Circulation-Heart Failure

The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation

(2018) Sang Mi Shim et al.   Science Signaling

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers

(2018) Daniel R. Whiten et al.   Cell Reports

The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation

(2018) Sang Mi Shim et al.   Science Signaling

Clusterin from human clinical tear samples: Positive correlation between tear concentration and Schirmer strip test results

(2018) Valerie Yu et al.   Ocular Surface

Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones

(2017) Patrick Constantinescu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correlation of rs9331888 polymorphism with Alzheimer’s disease among Caucasian and Chinese populations: a meta-analysis and systematic review

(2017) Bin Zhu et al.   METABOLIC BRAIN DISEASE

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

(2017) Aleksandra M. Wojtas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Semen amyloids participate in spermatozoa selection and clearance

(2017) Nadia R Roan et al.   eLife

Clusterin protects neurons against intracellular proteotoxicity

(2017) Jenna M. Gregory et al.   Acta Neuropathologica Communications

Clusterin as a therapeutic target

(2016) Mark R. Wilson et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer’s disease risk genes

(2016) Silvia S. Kang et al.   HUMAN MOLECULAR GENETICS

Walking the tightrope: proteostasis and neurodegenerative disease

(2016) Justin J. Yerbury et al.   JOURNAL OF NEUROCHEMISTRY

Fucosylated clusterin in semen promotes the uptake of stress-damaged proteins by dendritic cells via DC-SIGN

(2015) A. Merlotti et al.   HUMAN REPRODUCTION

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations

(2015) Karolien Bettens et al.   Molecular Neurodegeneration

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding

(2015) Hyunjoo Cha-Molstad et al.   NATURE CELL BIOLOGY

Clusterin/Apolipoprotein J immunoreactivity is associated with white matter damage in cerebral small vessel diseases

(2015) Lucinda Craggs et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye

(2015) Aditi Bauskar et al.   PLoS One

Clusterin Is a Ligand for Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR) and Signals via the Reelin-signaling Pathway

(2014) Christian Leeb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connecting the Dots: Potential of Data Integration to Identify Regulatory SNPs in Late-Onset Alzheimer's Disease GWAS Findings

(2014) Samantha L. Rosenthal et al.   PLoS One

Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival

(2014) Fan Zhang et al.   Nature Communications

Complement activation in multiple sclerosis plaques: an immunohistochemical analysis

(2014) Gillian Ingram et al.   Acta Neuropathologica Communications

Extracellular Chaperones and Proteostasis

(2013) Amy R. Wyatt et al.   Annual Review of Biochemistry

Clusterin Associates Specifically with Aβ40 in Alzheimer's Disease Brain Tissue

(2013) David R. Howlett et al.   BRAIN PATHOLOGY

The CLU Gene rs11136000 Variant is Significantly Associated with Alzheimer’s Disease in Caucasian and Asian Populations

(2013) Guiyou Liu et al.   NEUROMOLECULAR MEDICINE

Cerebrospinal fluid and plasma clusterin levels in Parkinson's disease

(2013) Karin D. van Dijk et al.   PARKINSONISM & RELATED DISORDERS

Exon-Skipping Strategy by Ratio Modulation between Cytoprotective versus Pro-Apoptotic Clusterin Forms Increased Sensitivity of LNCaP to Cell Death

(2013) Abdellatif Essabbani et al.   PLoS One

Correction: Non-Secreted Clusterin Isoforms Are Translated in Rare Amounts from Distinct Human mRNA Variants and Do Not Affect Bax-Mediated Apoptosis or the NF-κB Signaling Pathway

(2013) Hans Prochnow et al.   PLoS One

Association Study of Clusterin Polymorphism rs11136000 With Late Onset Alzheimer’s Disease in Chinese Han Population

(2012) Jian-Fang Ma et al.   American Journal of Alzheimers Disease and Other Dementias

Alzheimer Risk Variant CLU and Brain Function During Aging

(2012) Madhav Thambisetty et al.   BIOLOGICAL PSYCHIATRY

Clearance of extracellular misfolded proteins in systemic amyloidosis: Experience with transthyretin

(2012) Maria Rosário Almeida et al.   FEBS LETTERS

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

(2012) Najla Kfoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

(2012) Karolien Bettens et al.   Molecular Neurodegeneration

GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer

(2012) N Li et al.   ONCOGENE

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

(2011) Amy R. Wyatt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Clusterin and COMMD1 Independently Regulate Degradation of the Mammalian Copper ATPases ATP7A and ATP7B

(2011) Stephanie Materia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mda-7/IL-24 differentially regulates soluble and nuclear clusterin in prostate cancer

(2011) Sujit K. Bhutia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Intracellular clusterin negatively regulates ovarian chemoresistance: compromised expression sensitizes ovarian cancer cells to paclitaxel

(2011) Mohamed Kamel Hassan et al.   TUMOR BIOLOGY

Association of Plasma Clusterin Concentration With Severity, Pathology, and Progression in Alzheimer Disease

(2010) Madhav Thambisetty et al.   ARCHIVES OF GENERAL PSYCHIATRY

Region-Specific Protein Abundance Changes in the Brain of MPTP-Induced Parkinson’s Disease Mouse Model

(2010) Xu Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Protein Quality Control in Heart Disease

(2010) Francisco Villarreal et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clusterin Facilitates COMMD1 and I- B Degradation to Enhance NF- B Activity in Prostate Cancer Cells

(2010) A. Zoubeidi et al.   MOLECULAR CANCER RESEARCH

Identification and characterization of glycosylation sites in human serum clusterin

(2009) James T. Kapron et al.   PROTEIN SCIENCE

N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT)

(2008) Ersin Selcuk Unal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES