Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease

Recurrent gain-of-function USP8 mutations in Cushing's disease

(2015) Zeng-Yi Ma et al.   CELL RESEARCH

The endosomal pathway in Parkinson's disease

(2015) Rebecca M. Perrett et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Autophagic Clearance of PolyQ Proteins Mediated by Ubiquitin-Atg8 Adaptors of the Conserved CUET Protein Family

(2014) Kefeng Lu et al.   CELL

Isolation and functional analysis of yeast ubiquitin ligase Rsp5 variants that alleviate the toxicity of human α-synuclein

(2014) Indah Wijayanti et al.   JOURNAL OF BIOCHEMISTRY

Lys-63-linked Ubiquitination by E3 Ubiquitin Ligase Nedd4-1 Facilitates Endosomal Sequestration of Internalized α-Synuclein

(2014) Naoto Sugeno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic Strength Is Bidirectionally Controlled by Opposing Activity-Dependent Regulation of Nedd4-1 and USP8

(2014) S. L. Scudder et al.   JOURNAL OF NEUROSCIENCE

Mutations in the deubiquitinase gene USP8 cause Cushing's disease

(2014) Martin Reincke et al.   NATURE GENETICS

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease

(2014) Sian E. Davies et al.   NEUROBIOLOGY OF DISEASE

Physiological Characterisation of Human iPS-Derived Dopaminergic Neurons

(2014) Elizabeth M. Hartfield et al.   PLoS One

Cross-regulation of Connexin43 and β-catenin influences differentiation of human neural progenitor cells

(2014) F Rinaldi et al.   Cell Death & Disease

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

(2014) Maria Stella Ritorto et al.   Nature Communications

Regulation of proteasome activity in health and disease

(2013) Marion Schmidt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Deubiquitinating Enzyme Specificity for Ubiquitin Chain Topology Profiled by Di-Ubiquitin Activity Probes

(2013) Joanna F. McGouran et al.   CHEMISTRY & BIOLOGY

Recruitment of UBPY and ESCRT Exchange Drive HD-PTP-Dependent Sorting of EGFR to the MVB

(2013) Nazim Ali et al.   CURRENT BIOLOGY

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

(2013) James A Nathan et al.   EMBO JOURNAL

Mapping the Subcellular Distribution of  -Synuclein in Neurons using Genetically Encoded Probes for Correlated Light and Electron Microscopy: Implications for Parkinson's Disease Pathogenesis

(2013) D. Boassa et al.   JOURNAL OF NEUROSCIENCE

Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies

(2012) J. A. Schneider et al.   BRAIN

Synaptic Protein Ubiquitination in Rat Brain Revealed by Antibody-based Ubiquitome Analysis

(2012) Chan Hyun Na et al.   JOURNAL OF PROTEOME RESEARCH

Lysosome-dependent pathways as a unifying theme in Parkinson's disease

(2012) George K. Tofaris   MOVEMENT DISORDERS

A practical guide to evaluating colocalization in biological microscopy

(2011) Kenneth W. Dunn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein

(2011) Takafumi Hasegawa et al.   PLoS One

Ubiquitin ligase Nedd4 promotes  -synuclein degradation by the endosomal-lysosomal pathway

(2011) G. K. Tofaris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

(2010) Akiko Mukai et al.   EMBO JOURNAL

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

(2010) Thomas Wollert et al.   NATURE

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Genomic investigation of α-synuclein multiplication and parkinsonism

(2008) Owen A. Ross et al.   ANNALS OF NEUROLOGY

Expression of the deubiquitinating enzyme mUBPy in the mouse brain

(2008) Federica Bruzzone et al.   BRAIN RESEARCH