Oxidative Stress Induced by Reactive Oxygen Species (ROS) and NADPH Oxidase 4 (NOX4) in the Pathogenesis of the Fibrotic Process in Systemic Sclerosis: A Promising Therapeutic Target
出版年份 2021 全文链接
标题
Oxidative Stress Induced by Reactive Oxygen Species (ROS) and NADPH Oxidase 4 (NOX4) in the Pathogenesis of the Fibrotic Process in Systemic Sclerosis: A Promising Therapeutic Target
作者
关键词
-
出版物
Journal of Clinical Medicine
Volume 10, Issue 20, Pages 4791
出版商
MDPI AG
发表日期
2021-10-20
DOI
10.3390/jcm10204791
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Oxidative stress-induced senescence mediates inflammatory and fibrotic phenotypes in fibroblasts from systemic sclerosis patients
- (2021) Ozge Kizilay Mancini et al. RHEUMATOLOGY
- Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
- (2020) Helmut Sies et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The role of NOX4 in pulmonary diseases
- (2020) Zi‐Ming Li et al. JOURNAL OF CELLULAR PHYSIOLOGY
- State-of-the-art technologies provide new insights linking skin and blood vessel abnormalities in SSc-related disorders
- (2020) Graham Dinsdale et al. MICROVASCULAR RESEARCH
- NADPH oxidases: Pathophysiology and therapeutic potential in age-associated pulmonary fibrosis
- (2020) Kosuke Kato et al. Redox Biology
- The Pathogenesis of Systemic Sclerosis: An Understanding Based on a Common Pathologic Cascade across Multiple Organs and Additional Organ-Specific Pathologies
- (2020) Yoshihide Asano Journal of Clinical Medicine
- Reactive Oxygen Species: Drivers of Physiological and Pathological Processes
- (2020) Javier Checa et al. Journal of Inflammation Research
- Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis
- (2019) Ludivine Doridot et al. Redox Biology
- NADPH Oxidase-Mediated Induction of Reactive Oxygen Species and Extracellular Matrix Deposition by Insulin-like Growth Factor Binding Protein-5
- (2019) Hidekata Yasuoka et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Endothelial-to-Mesenchymal Transition
- (2019) Joyce Bischoff CIRCULATION RESEARCH
- Pathophysiology of systemic sclerosis: current understanding and new insights
- (2019) Maurizio Cutolo et al. Expert Review of Clinical Immunology
- Endothelial to Mesenchymal Transition: Role in Physiology and in the Pathogenesis of Human Diseases
- (2019) Sonsoles Piera-Velazquez et al. PHYSIOLOGICAL REVIEWS
- Oxidant/Antioxidant Disequilibrium in Idiopathic Pulmonary Fibrosis Pathogenesis
- (2019) Paolo Cameli et al. INFLAMMATION
- NADPH oxidase in the vasculature: Expression, regulation and signalling pathways; role in normal cardiovascular physiology and its dysregulation in hypertension
- (2019) Greg A. Knock FREE RADICAL BIOLOGY AND MEDICINE
- Oxidative stress in autoimmune rheumatic diseases
- (2018) Miranda J. Smallwood et al. FREE RADICAL BIOLOGY AND MEDICINE
- NADPH oxidase, oxidative stress and fibrosis in systemic sclerosis
- (2018) Silvia Svegliati et al. FREE RADICAL BIOLOGY AND MEDICINE
- Oxidative stress in the pathogenesis of systemic scleroderma: An overview
- (2018) Rosa Vona et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Oxidative/nitrative stress in the pathogenesis of systemic sclerosis: are antioxidants beneficial?
- (2018) Paul Ames et al. FREE RADICAL RESEARCH
- The Role of Oxidative Stress in the Development of Systemic Sclerosis Related Vasculopathy
- (2018) Amaal E. Abdulle et al. Frontiers in Physiology
- A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis
- (2018) Duong Thi Bich Thuan et al. Frontiers in Immunology
- Transforming growth factor β1-induced collagen production in myofibroblasts is mediated by reactive oxygen species derived from NADPH oxidase 4
- (2018) Yuma Hotta et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The molecular basis of endothelial cell plasticity
- (2017) Elisabetta Dejana et al. Nature Communications
- Long-Term N-Acetylcysteine Therapy in Systemic Sclerosis Interstitial Lung Disease: A Retrospective Study
- (2017) E. Rosato et al. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
- Reactive oxygen species and fibrosis: further evidence of a significant liaison
- (2016) Kati Richter et al. CELL AND TISSUE RESEARCH
- Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis
- (2016) Heba Dosoki et al. EXPERIMENTAL DERMATOLOGY
- Oxidative stress markers in blood in systemic sclerosis: A meta-analysis
- (2016) Jing-Ying Luo et al. Modern Rheumatology
- High reactive oxygen species in fibrotic and nonfibrotic skin of patients with diffuse cutaneous systemic sclerosis
- (2015) Khalil Bourji et al. FREE RADICAL BIOLOGY AND MEDICINE
- Intracellular free radical production by peripheral blood T lymphocytes from patients with systemic sclerosis: role of NADPH oxidase and ERK1/2
- (2015) Donatella Amico et al. ARTHRITIS RESEARCH & THERAPY
- Increased Expression of NAPDH Oxidase 4 in Systemic Sclerosis Dermal Fibroblasts: Regulation by Transforming Growth Factor β
- (2015) Sonsoles Piera-Velazquez et al. Arthritis & Rheumatology
- Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis-Associated Interstitial Lung Disease
- (2015) Fabian A. Mendoza et al. Arthritis & Rheumatology
- A Reactive Oxygen Species-Mediated Loop Maintains Increased Expression of NADPH Oxidases 2 and 4 in Skin Fibroblasts From Patients With Systemic Sclerosis
- (2015) Tatiana Spadoni et al. Arthritis & Rheumatology
- Is Nox4 a key regulator of the activated state of fibroblasts in systemic sclerosis?
- (2014) Markus Böhm et al. EXPERIMENTAL DERMATOLOGY
- A far-upstream AP-1/Smad binding box regulates human NOX4 promoter activation by transforming growth factor-β
- (2014) Guangxing Bai et al. GENE
- Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-β1 and TGF-β2-dependent pathway
- (2014) Ignacio Montorfano et al. LABORATORY INVESTIGATION
- Oxidative Damage and Antioxidative Therapy in Systemic Sclerosis
- (2014) Bogna Grygiel-Górniak et al. MEDIATORS OF INFLAMMATION
- Cellular mechanisms and physiological consequences of redox-dependent signalling
- (2014) Kira M. Holmström et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Transforming growth factor β—at the centre of systemic sclerosis
- (2014) Robert Lafyatis Nature Reviews Rheumatology
- Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension
- (2014) Francesco Boin et al. Orphanet Journal of Rare Diseases
- Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis
- (2014) S. Svegliati et al. Science Signaling
- Role of Cellular Senescence and NOX4-Mediated Oxidative Stress in Systemic Sclerosis Pathogenesis
- (2014) Sonsoles Piera-Velazquez et al. Current Rheumatology Reports
- NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses
- (2014) Fan Jiang et al. Redox Biology
- Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword Revisited
- (2013) J. David Lambeth et al. Annual Review of Pathology-Mechanisms of Disease
- Role of NADPH Oxidases in Liver Fibrosis
- (2013) Yong-Han Paik et al. ANTIOXIDANTS & REDOX SIGNALING
- Myofibroblast Differentiation: Main Features, Biomedical Relevance, and the Role of Reactive Oxygen Species
- (2013) Alessandro Siani et al. ANTIOXIDANTS & REDOX SIGNALING
- NADPH Oxidases in Vascular Pathology
- (2013) Anna Konior et al. ANTIOXIDANTS & REDOX SIGNALING
- NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents
- (2013) Olubukola Babalola et al. ARCHIVES OF DERMATOLOGICAL RESEARCH
- Fibroblast-to-myofibroblast switch is mediated by NAD(P)H oxidase generated reactive oxygen species
- (2013) Lirija Alili et al. BIOSCIENCE REPORTS
- TGF-β signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves
- (2013) Michael A. Hagler et al. CARDIOVASCULAR RESEARCH
- 8-Isoprostane levels in serum and bronchoalveolar lavage in idiopathic pulmonary fibrosis and sarcoidosis
- (2013) Foteini Malli et al. FOOD AND CHEMICAL TOXICOLOGY
- The Nox4 Inhibitor GKT137831 Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation
- (2012) David E. Green et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Targeting NOX enzymes in pulmonary fibrosis
- (2012) Louise Hecker et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The NOX toolbox: validating the role of NADPH oxidases in physiology and disease
- (2012) Sebastian Altenhöfer et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo
- (2012) Joy X. Jiang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent
- (2012) Tomonori Aoyama et al. HEPATOLOGY
- NADPH Oxidase NOX4 Mediates Stellate Cell Activation and Hepatocyte Cell Death during Liver Fibrosis Development
- (2012) Patricia Sancho et al. PLoS One
- Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts
- (2012) X. Shi-wen et al. RHEUMATOLOGY
- Neutrophil-derived reactive oxygen species in SSc
- (2012) T. C. Barnes et al. RHEUMATOLOGY
- Effect of oxidative stress on protein tyrosine phosphatase 1B in scleroderma dermal fibroblasts
- (2011) Pei-Suen Tsou et al. ARTHRITIS AND RHEUMATISM
- Increasing levels of serum antioxidant status, total antioxidant power, in systemic sclerosis
- (2011) Fumihide Ogawa et al. CLINICAL RHEUMATOLOGY
- Signalling pathways from NADPH oxidase-4 to idiopathic pulmonary fibrosis
- (2011) Bruno Crestani et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases
- (2011) Jeffrey L. Barnes et al. KIDNEY INTERNATIONAL
- Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities
- (2011) Swati Bhattacharyya et al. Nature Reviews Rheumatology
- First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
- (2010) Benoı̂t Laleu et al. JOURNAL OF MEDICINAL CHEMISTRY
- High DNA Oxidative Damage in Systemic Sclerosis
- (2010) J. AVOUAC et al. JOURNAL OF RHEUMATOLOGY
- Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate
- (2010) A. Dooley et al. RHEUMATOLOGY
- Increased cysteinyl-leukotrienes and 8-isoprostane in exhaled breath condensate from systemic sclerosis patients
- (2010) E. Tufvesson et al. RHEUMATOLOGY
- Effects of micronutrient antioxidants (alpha-tocopherol and ascorbic acid) on skin thickening and lung function in patients with early diffuse systemic sclerosis
- (2010) Predrag Ostojic et al. RHEUMATOLOGY INTERNATIONAL
- NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF 1-induced fibroblast differentiation into myofibroblasts
- (2010) N. Amara et al. THORAX
- Targeting and Regulation of Reactive Oxygen Species Generation by Nox Family NADPH Oxidases
- (2009) Thomas L. Leto et al. ANTIOXIDANTS & REDOX SIGNALING
- Role of free radicals in liver diseases
- (2009) Pablo Muriel Hepatology International
- Selective Oxidation of DNA Topoisomerase 1 Induces Systemic Sclerosis in the Mouse
- (2009) A. Servettaz et al. JOURNAL OF IMMUNOLOGY
- Increased Serum Pentraxin 3 in Patients with Systemic Sclerosis
- (2009) Y. IWATA et al. JOURNAL OF RHEUMATOLOGY
- NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury
- (2009) Louise Hecker et al. NATURE MEDICINE
- Scleroderma
- (2009) Armando Gabrielli et al. NEW ENGLAND JOURNAL OF MEDICINE
- NADPH Oxidase-Dependent Signaling in Endothelial Cells: Role in Physiology and Pathophysiology
- (2008) Randall S. Frey et al. ANTIOXIDANTS & REDOX SIGNALING
- Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species
- (2008) Hideki Sumimoto FEBS Journal
- Increased Serum Levels of Ne-(hexanoyl)lysine, A New Marker of Oxidative Stress, in Systemic Sclerosis
- (2008) Kazuhiro Shimizu et al. JOURNAL OF RHEUMATOLOGY
- Oxidative stress and the pathogenesis of scleroderma: the Murrell’s hypothesis revisited
- (2008) Armando Gabrielli et al. Seminars in Immunopathology
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started