期刊
RHEUMATOLOGY
卷 49, 期 12, 页码 2322-2326出版社
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/keq271
关键词
Exhaled breath condensate; Fibrosis; High-resolution computer tomography; Leukotriene; Oxidative stress; Systemic sclerosis; Traction bronchiectasis; 8-Isoprostane
类别
资金
- Apotekare Hedbergs Fund
- Crafoord Foundation
- Evy and Gunnar Sandberg Foundation
- Greta and Johan Kock Foundation
- Alfred Osterlund Foundation
- 80-Year Fund of King Gustav V
- Department of Rheumatology Lund University Hospital
- Swedish Heart and Lung Foundation
- Medical Faculty of Lund University
- Swedish Rheumatism Association
- Swedish Society of Medicine
Methods. Twenty-two SSc patients with median disease duration of 2.1 years were investigated. Fifteen patients had lcSSc, four patients had dcSSc and three patients only fulfilled criteria for limited SSc. Sixteen healthy controls were enrolled. Cysteinyl-LTs (CysLTs), LTB4 and 8-isoprostane were measured in EBC with EIA and related to the radiologic extent of pulmonary fibrosis. Results. Compared with controls, SSc patients displayed higher median (interquartile range) CysLT [6.1 (5.3-6.8) vs 4.9 (3.7-6.3) pg/ml; P = 0.040], 8-isoprostane [0.23 (0.20-0.46) vs 0.19 (0.12-0.20) pg/ml; P = 0.0020], but similar levels of LTB4 [0.70 (0.50-0.83) vs 0.60 (0.42-0.70) pg/ml]. CysLT correlated to LTB4, while 8-isoprostane did not correlate to any of the LTs. None of the biomarkers measured in EBC correlated to radiologic findings. Conclusion. Increased levels of CysLT and 8-isoprostane in EBC from patients with SSc reflect the inflammatory pattern involving LTs as well as oxidative stress. These findings may indicate a possible non-invasive assessment of pulmonary involvement in SSc with a potential value for assessment of disease progress and therapy evaluation.
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