期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 236, 期 3, 页码 1628-1637出版社
WILEY
DOI: 10.1002/jcp.30005
关键词
acute respiratory distress syndrome; chronic obstructive pulmonary disease; NOX4; pulmonary fibrosis; signaling pathway
资金
- National Natural Science Foundation of China [81670014, 91949110]
- Natural Science Foundation of Hunan Province [2019JJ50975]
NOX4 is a unique enzyme mainly expressed in the respiratory system, with both protective and damaging roles in different respiratory diseases. Negative and positive feedback play significant roles in regulating NOX4 expression.
Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is a subtype of the NOX family, which is mainly expressed in the pulmonary vasculature and pulmonary endothelial cells in the respiratory system. NOX4 has unique characteristics, and is a constitutively active enzyme that primarily produces hydrogen peroxide. The signaling pathways associated with NOX4 are complicated. Negative and positive feedback play significant roles in regulating NOX4 expression. The role of NOX4 is controversial because NOX4 plays a protective or damaging role in different respiratory diseases. This review summarizes the structure, enzymatic properties, regulation, and signaling pathways of NOX4. This review then introduces the roles of NOX4 in different diseases in the respiratory system, such as acute respiratory distress syndrome, chronic obstructive pulmonary disease, and pulmonary fibrosis.
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