Review
Biochemistry & Molecular Biology
Yoon-Seok Seo, Jung-Min Park, Jae-Hyeong Kim, Moo-Yeol Lee
Summary: Smoking is a significant risk factor for various diseases due to the production of excessive reactive oxygen species (ROS). This review focuses on how cigarette smoke promotes the formation of ROS and provides key mechanisms involved.
Article
Biochemistry & Molecular Biology
Flavia Rezende, Pedro Felipe Malacarne, Niklas Mueller, Birgit Rathkolb, Martin Hrabe de Angelis, Katrin Schroeder, Ralf P. Brandes
Summary: The study found that Nox4 knockout mice exhibited similar weight loss and sodium sparing function under a low sodium diet, but showed reduced systolic blood pressure, heart-rate ratio, and heart to body weight ratio compared to wild-type mice, indicating that Nox4 plays a role in blood pressure regulation induced by low sodium diets.
Review
Medicine, Research & Experimental
Yawei Bi, Xiao Lei, Ningli Chai, Enqiang Linghu
Summary: NOX4 is upregulated in pancreatic cancer and primarily produces hydrogen peroxide, exhibiting different properties from other NOX family subtypes. Recent studies suggest that NOX4 promotes pancreatic cancer occurrence and development, making it a potential therapeutic target in pancreatic cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
David W. Hammers
Summary: This study found that targeting NOX4 is an effective strategy to reduce fibrosis and promote muscle regeneration in disease-burdened muscle, specifically in a model of Duchenne muscular dystrophy (DMD).
Article
Biochemistry & Molecular Biology
Francesca Beretti, Francesca Farnetani, Luca Reggiani Bonetti, Luca Fabbiani, Manuela Zavatti, Antonino Maiorana, Giovanni Pellacani, Tullia Maraldi
Summary: This study reveals a correlation between high positivity for Nox4 and c-met in BRAF mutated patients with melanoma, and metastasis occurring at least one year later than diagnosis. In vitro experiments demonstrate that the HGF/c-met/Nox4/ROS axis triggers epithelial-mesenchymal transition. The findings suggest that Nox4 inhibitors could be a potential addition to current therapies for treating melanoma patients with BRAF mutations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Environmental Sciences
Amlan Das
Summary: Plastic pollution is a significant environmental threat that can cause detrimental effects on terrestrial and marine ecosystems as well as human health. The degradation of macroplastics into microplastics or nanoparticles can lead to organ damage and activation of intracellular signaling, resulting in cell death. Accumulating evidence supports the serious toxicity of microplastics/nanoparticles at various biological levels, and their involvement in oxidative stress and reactive oxygen species production. These particles can accumulate in mitochondria, disrupt the electron transport chain, and generate reactive free radicals that induce DNA damage, protein oxidation, lipid peroxidation, and compromise antioxidant defense. Moreover, microplastic-induced oxidative stress triggers multiple signaling cascades, leading to organ damage such as pulmonary toxicity, neurotoxicity, and hepatotoxicity. Despite ongoing research, there is a lack of proper models, interdisciplinary approaches, and mitigation strategies to fully understand and address the detrimental effects of microplastics/nanoparticles on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Peripheral Vascular Disease
Xuesong Liu, Yansong Guo, Yuxue Yang, Chunlei Qi, Ting Xiong, Yue Chen, Gengze Wu, Chunyu Zeng, Daxin Wang
Summary: Oxidative stress plays a crucial role in the development of abdominal aortic aneurysm (AAA), with DRD4 having a potential protective effect through its antioxidative properties. Experimental evidence shows that activating DRD4 can reduce ROS production and alleviate pathological features of AAA. DRD4 may serve as a novel therapeutic target for AAA treatment by regulating the P38 MAPK/NOX4 axis to decrease ROS production.
Article
Biochemistry & Molecular Biology
Ildiko Szanto
Summary: Cancer cells can adapt to hypoxic environments through metabolic rewiring and synthesis of antioxidant molecules. NOX4, a member of the NOX family enzymes, plays a key role in the oncogenic metabolic adaptation of cancer cells by regulating diverse metabolic processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hongxiang Jiang, Fei Li, Linzhi Cai, Qianxue Chen
Summary: NOX4 plays a role in angiogenesis in glioblastoma through ROS production, and TSPO is an upstream target of NOX4-derived mitochondrial ROS. The TSPO-NOX4 signaling pathway could serve as a potential molecular target for therapeutic strategies in glioblastoma.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hironori Mizutani, Yoshifumi Sato, Masaya Yamazaki, Tatsuya Yoshizawa, Yukio Ando, Mitsuharu Ueda, Kazuya Yamagata
Summary: This study found that the expression of SIRT7 is increased in the brain of Alzheimer's disease patients. Treatment with A beta(42) increased the expression of NOX4, leading to the production of reactive oxygen species (ROS) and apoptosis. Knockdown of SIRT7 inhibited A beta(42)-induced ROS production and apoptosis by suppressing the upregulation of NOX4. These findings suggest that inhibiting SIRT7 may be beneficial in the pathogenesis of AD by regulating ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rayan Bou-Fakhredin, Batoul Dia, Hilda E. Ghadieh, Stefano Rivella, Maria Domenica Cappellini, Assaad A. Eid, Ali T. Taher
Summary: Oxidative damage by reactive oxygen species (ROS) is a major contributor to cell injury and tissue damage in thalassemia patients. Recent studies indicate that ROS generation in non-transfusion-dependent (NTDT) patients is a result of iron overload, but the sources of ROS in these patients are still poorly understood. This study found that CYP450 4A and 4F-induced 20-HETE production through an NADPH-dependent pathway mediates reactive oxygen species overgeneration in Hbb(th3/+) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jin Han, Donghwi Park, Ji Young Park, Seungwoo Han
Summary: Increased oxidative stress in OA cartilage leads to extracellular matrix degradation and chondrocyte apoptosis. This study found that inhibiting NOX can decrease ROS production, suppress oxidative stress marker genes and catabolic proteases, and protect against OA by modulating oxidative stress and gene expression.
Article
Biochemistry & Molecular Biology
Yutong Jin, Brian Dixon, Lyndon Jones, Maud Gorbet
Summary: Tear polymorphonuclear neutrophils (PMNs) invade the ocular surface during sleep, contributing to homeostasis and possessing an arsenal of inflammatory mediators. This study found that tear PMNs exhibit high constitutive ROS production and differential responses to stimuli like PMA, LPS, and fMLP, suggesting their potential role in ocular inflammatory complications involving oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lukas Gola, Laura Bierhansl, Julia Csatari, Christina B. Schroeter, Lisanne Korn, Venu Narayanan, Manuela Cerina, Sara Abdolahi, Anna Speicher, Alexander M. Hermann, Simone Koenig, Albena T. Dinkova-Kostova, Tawfeeq Shekh-Ahmad, Sven G. Meuth, Heinz Wiendl, Ali Gorji, Matthias Pawlowski, Stjepana Kovac
Summary: Hyperexcitability is associated with neuronal dysfunction, cellular death, and neurodegeneration. NOX4, an NADPH oxidase, is found to regulate reactive oxygen species (ROS) levels and calcium homeostasis, thereby preventing hyperexcitability and neuronal death. These findings suggest that NOX4 might have a crucial role in neurodegenerative diseases by acting as a potential redox regulator.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Oncology
Muhammed Burak Demircan, Tina M. Schnoeder, Peter C. Mgbecheta, Katrin Schroeder, Frank-D Boehmer, Florian H. Heidel
Summary: Oxidative stress has been found to be associated with cancer initiation and progression. Recent studies have shown the potential therapeutic role of ROS modulation in various cancers, including acute myeloid leukemia (AML). A detailed understanding of the complex machinery regulating ROS in cancer is essential for defining potential therapeutic applications.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)