期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 125, 期 -, 页码 90-97出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2018.04.554
关键词
Systemic sclerosis; Scleroderma; Free radicals; Oxidative stress; NOX
Systemic sclerosis (SSc) is an autoimmune disease characterized by damage of small vessels, immune abnormalities and exaggerated production of extracellular matrix. The etiology of the disease is unknown and the pathogenesis ill defined. However, there is consistent evidence that oxidative stress contributes to the establishment and progression of the disease. This review examines the most relevant research regarding the involvement of free radicals and of nicotinamide adenine dinucleotide phosphate oxidases (NADPH oxidases; NOX) in the pathogenesis of systemic sclerosis.
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