Article
Biochemistry & Molecular Biology
Neza Brezovec, Katja Perdan-Pirkmajer, Blaz Burja, Ziga Rotar, Josko Osredkar, Snezna Sodin-Semrl, Katja Lakota, Sasa Cucnik
Summary: The balance between reactive oxygen species and antioxidant defense is disrupted in oxidative stress. This study examined the oxidative balance in systemic sclerosis (SSc) patients and healthy controls, and found high levels of reactive oxidative metabolites (ROMs) in both groups. However, SSc patients had significantly higher total antioxidant capacity (TAC) and oxidative stress index, indicating an increased antioxidant capacity. Although there was no difference in lipid peroxidation or oxidative DNA damage, SSc patients had more leukocyte DNA breaks, especially those treated with immunosuppressives.
Article
Environmental Sciences
Xiaole Wang, Jingwen Zhang, Chengbo Lu, Yu Liu, Xiao Yang, Kaixuan Hou, Zhongkun Du, Bing Li, Albert Juhasz, Lusheng Zhu
Summary: This study evaluated the toxicity of environmentally relevant concentrations of pyroxsulam to zebrafish embryos and adults, providing valuable data for assessing its effects on aquatic ecosystems.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Ryan S. Babadi, Anne M. Riederer, Paul D. Sampson, Sheela Sathyanarayana, Terrance J. Kavanagh, Jennifer E. Krenz, Syam S. Andra, Seunghee Kim-Schulze, Karen L. Jansen, Elizabeth Torres, Adriana Perez, Lisa R. Younglove, Maria I. Tchong-French, Catherine J. Karr
Summary: Studies show a positive relationship between phthalate exposure and oxidative stress in children with asthma, indicating a potential adverse impact on asthma morbidity. Further research is needed to confirm these findings and better understand the role of phthalates in childhood asthma.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Agricultural Engineering
Muhammad Ahmad, Ejaz Ahmad Waraich, Usman Zulfiqar, Aman Ullah, Muhammad Farooq
Summary: This study demonstrated that the application of thiourea can improve heat tolerance in camelina, increase seed yield, and protect plants from oxidative damage. Additionally, thiourea application was more effective at the reproductive stage, and genotype 618 showed higher tolerance to heat stress compared to genotype 611.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Nutrition & Dietetics
Daniela Martini, Raul Dominguez-Perles, Alice Rosi, Michele Tassotti, Donato Angelino, Sonia Medina, Cristian Ricci, Alexandre Guy, Camille Oger, Letizia Gigliotti, Thierry Durand, Mirko Marino, Hans Gottfried-Genieser, Marisa Porrini, Monica Antonini, Alessandra Dei Cas, Riccardo C. Bonadonna, Federico Ferreres, Francesca Scazzina, Furio Brighenti, Patrizia Riso, Cristian Del Bo, Pedro Mena, Angel Gil-Izquierdo, Daniele Del Rio
Summary: The study investigated the effect of consuming different doses of coffee or cocoa-based products containing coffee on markers of DNA damage and lipid peroxidation in young healthy volunteers for one month. Overall, the results showed that consumption of these products did not significantly affect oxidative stress markers, except for a time effect on DNA strand breaks and some markers of lipid peroxidation. Further studies are needed to better explain the findings and understand the impact of different dosages on specific target groups.
Article
Biochemistry & Molecular Biology
Luyang Xiong, Michael McCoy, Hitoshi Komuro, Xiaoxia Z. West, Valentin Yakubenko, Detao Gao, Tejasvi Dudiki, Amanda Milo, Jacqueline Chen, Eugene A. Podrez, Bruce Trapp, Tatiana Byzova
Summary: ALS is a progressive neurodegenerative disease with no cure, where inflammation and oxidative stress may play a significant role, particularly in patients with the SOD1 mutation. The accumulation of CEP, a DHA peroxidation product, in ALS brains may be linked to activated inflammatory cells and reduced antioxidant activity due to the mutation, highlighting its potential as a hallmark of oxidative damage in neurodegenerative diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Vesna Sredoja Tisma, Stela Bulimbasic, Danica Galesic Ljubanovic, Kresimir Galesic, Jadranka Morovic-Vergles, Josko Mitrovic, Koji Uchida, Franz Tatzber, Neven Zarkovic, Morana Jaganjac
Summary: This study investigated the implication of oxidative stress in small-vessel vasculitis, focusing on acrolein immunohistochemistry in affected skin vessels and systemic stress response. It was found that systemic redox homeostasis and iron metabolism are altered in SVV patients, with possible biomarkers identified for evaluating oxidative status, disease activity, and prevalence. Furthermore, a strong correlation between the accumulation of acrolein-protein adducts in the skin and disease progression was revealed.
Article
Environmental Sciences
Luciana Eiro-Quirino, Weslley Ferreira de Lima, Walessa Alana Braganca Aragao, Leonardo Oliveira Bittencourt, Paulo Fernando Santos Mendes, Rafael Monteiro Fernandes, Caroline Azulay Rodrigues, Aline Dionizio, Marilia Afonso Rabelo Buzalaf, Marta Chagas Monteiro, Ana Cirovic, Aleksandar Cirovic, Bruna Puty, Rafael Rodrigues Lima
Summary: This study aimed to investigate the potential adverse effects of prolonged exposure to a low dose of aluminum on the spinal cord and systemic biochemical balance. Results showed that exposure to aluminum triggered oxidative stress and proteomic changes, which may affect spinal cord homeostasis.
Article
Cell Biology
Giulia Leanza, Caterina Conte, Francesca Cannata, Camilla Isgro, Alessandra Piccoli, Rocky Strollo, Carlo Cosimo Quattrocchi, Rocco Papalia, Vincenzo Denaro, Mauro Maccarrone, Nicola Napoli, Anna Maria Sardanelli
Summary: In this study, the oxidative stress states were compared between postmenopausal women with and without obesity. The results showed that women with obesity had doubled levels of oxidative stress markers compared to women of normal weight. The severity of oxidative stress was correlated with body mass index, visceral fat mass, and trunk fat percentage, but not with fasting glucose levels. These findings suggest that obesity and visceral fat increase oxidative stress in postmenopausal women, potentially increasing the risks of cardiometabolic and cancer diseases.
Article
Biochemistry & Molecular Biology
Zitong Meng, Yuxiao Liao, Zhao Peng, Xiaolei Zhou, Huanhuan Zhou, Andreas K. Nuessler, Liegang Liu, Wei Yang
Summary: This study investigated the effects of rat BMSC-secreted exos on DON-induced liver damage. It was found that BMSC-exos can alleviate liver pathological changes, reduce liver function indicators and inflammatory factors, and alter oxylipin metabolism.
Article
Chemistry, Multidisciplinary
Yipei Zhang, Anila Bello, David K. Ryan, Philip Demokritou, Dhimiter Bello
Summary: This study investigated oxidative stress induced by exposures to copier-emitted nanoparticles using a panel of urinary oxidative stress biomarkers. The results showed that these nanoparticles can cause damage to DNA, RNA, and lipids, and can be monitored through urinary biomarkers such as 8-OHdG, 8-OHG, HNE, and 8-isoprostane.
Article
Critical Care Medicine
Wei Liu, Linling Yu, Min Zhou, Zi Ye, Ruyi Liang, Qiyou Tan, Jiahao Song, Jixuan Ma, Dongming Wang, Bin Wang, Weihong Chen
Summary: This study found an association between propylene oxide (PO) exposure and lung function decline among community residents. The potential mediating mechanism involves oxidative DNA damage and protein carbonylation. Urinary 2HPMA was used as a biomarker for internal exposure to PO.
Article
Environmental Sciences
Corina Konstantinou, Stephanie Gaengler, Stavros Oikonomou, Thibaut Delplancke, Pantelis Charisiadis, Konstantinos C. Makris
Summary: This study examined the impact of an organic food intervention on urine metabolome in children and its association with pesticide biomarkers. The results showed differential expression of metabolites and pathways related to oxidative damage, suggesting potential health benefits of organic food treatment for children. Further mechanistic studies are needed to better understand the biological mechanisms involved.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Biology
Valeria Marasco, Manrico Sebastiano, David Costantini, Gianni Pola, Leonida Fusani
Summary: The emergence of the migratory phenotype in birds is associated with changes in oxidative status, including higher levels of TBARS in the liver, lower levels of SOD in red blood cells and liver, and higher levels of GPx in the pectoral muscle. Despite higher food intake in migratory birds, there is no link between food intake and markers of oxidative status. The increase in body mass is positively correlated with muscle GPx activity during pre-migratory fattening, suggesting strategic displacement of oxidative costs to safeguard muscles for successful migration.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Shweta Katiyar, Dhananjay Yadav
Summary: This article discusses one of the multiple etiological factors for melasma: oxidative stress. It explores the role of reactive oxygen species in skin health, as well as the development and pathophysiology of reactive oxygen species associated with melasma disorder. The advantages of integrating antioxidants in clinical and experimental environments are also discussed.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Letter
Rheumatology
Jerome Avouac, Paolo Airo, Nicolas Carlier, Marco Matucci-Cerinic, Yannick Allanore
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Jerome Avouac, Muriel Elhai, Marine Forien, Jeremie Sellam, Florent Eymard, Anna Molto, Frederic Banal, Joel Damiano, Philippe Dieude, Etienne Larger, Yannick Allanore
Summary: Patients with RA or OA have severe T2D with insulin resistance associated with inflammation. Insulin resistance is higher in RA compared to OA patients and HbA1c levels are independently associated with bone erosions. Treatment with TNF-alpha inhibitors is associated with increased insulin sensitivity.
Article
Rheumatology
Jerome Avouac, Sonia Pezet, Eloise Vandebeuque, Cindy Orvain, Virginie Gonzalez, Gregory Marin, Gael Mouterde, Claire Daien, Yannick Allanore
Summary: Semaphorins were found to be potential biomarkers and therapeutic candidates in the pathogenesis of rheumatoid arthritis, with confirmed overexpression in ECs, synovial vessels, and serum, and correlation with validated markers of inflammation and angiogenesis. Their presence, especially SEMA4A, could identify patients with residual disease activity even in low disease activity or RA remission.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Goncalo Boleto, Jerome Avouac, Yannick Allanore
JOURNAL OF RHEUMATOLOGY
(2021)
Review
Rheumatology
Cindy Orvain, Morgane Boulch, Philippe Bousso, Yannick Allanore, Jerome Avouac
Summary: CAR-T cell therapy targets tumor antigens with high specificity, demonstrating efficacy in managing B cell malignancies. The technology has potential applications in autoimmune rheumatic diseases, with ongoing research exploring its use and impact in this area.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Jerome Avouac, Corinne Miceli-Richard, Alice Combier, Alexia Steelandt, Olivier Fogel, Alice Andree Mariaggi, Jean-Francois Meritet, Flore Rozenberg, Anna Molto, Yannick Allanore
Summary: This study aimed to identify factors influencing the humoral response to COVID-19 vaccination in RTX-treated patients. The results showed that B cell depletion was the main contributing factor to the antibody response in these patients, and monitoring CD19 levels may help determine the optimal timing for vaccination.
Review
Rheumatology
Michael Hughes, Elisabetta Zanatta, Robert D. Sandler, Jerome Avouac, Yannick Allanore
Summary: This study found that despite the heterogeneity and scarcity of vascular disease in SSc, there have been significant improvements in various vascular complications over time, leading to improved survival rates for patients.
Article
Rheumatology
Amber Vanhaecke, Maurizio Cutolo, Oliver Distler, Valeria Riccieri, Yannick Allanore, Christopher P. Denton, Eric Hachulla, Francesca Ingegnoli, Ellen Deschepper, Jerome Avouac, Suzana Jordan, David Launay, Karin Melsens, Carmen Pizzorni, Alberto Sulli, Massimiliano Vasile, Ariane L. Herrick, Vanessa Smith
Summary: Nailfold videocapillaroscopy (NVC) may be a promising biomarker in SSc, as it is associated with novel severe organ involvement/progression.
Letter
Rheumatology
Jerome Avouac, Roba Ghossan, Omar Al Tabaa, Alice Combier, Alexia Steelandt, Marion Thomas, Olivier Fogel, Alice Andree Mariaggi, Jean-Francois Meritet, Flore Rozenberg, Anna Molto, Corinne Miceli-Richard, Yannick Allanore
Article
Rheumatology
Jerome Avouac, Anna Molto, Camelia Frantz, Sarah Wanono, Elise Descamps, Olivier Fogel, Alice Combier, Lucile Poiroux, Corinne Miceli-Richard, Yannick Allanore
Summary: This study identified patient-reported RA flares and increased CRP values as important indicators in teleconsultation, which are associated with therapeutic modification and the need for a face-to-face consultation.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Amandine Gouverneur, Jerome Avouac, Clement Prati, Jean-Luc Cracowski, Thierry Schaeverbeke, Antoine Pariente, Marie-Elise Truchetet
Summary: The use of baricitinib and tofacitinib is associated with an increased risk of venous thromboembolic events (VTE) and arterial thromboembolic events (ATE).
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Editorial Material
Rheumatology
Marion Thomas, Jerome Avouac
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Rheumatology
Vincent Di Martino, Delphine Weil Verhoeven, Frank Verhoeven, Francois Aubin, Jerome Avouac, Lucine Vuitton, Frederic Liote, Thierry Thevenot, Daniel Wendling
Summary: Methotrexate is an important treatment for inflammatory rheumatic diseases, especially rheumatoid arthritis. Liver toxicity is a concern for long-term methotrexate therapy, particularly in patients with non-alcoholic fatty liver disease (NAFLD). Understanding the mechanisms of hepatotoxicity and liver fibrosis is crucial for pretreatment screening and long-term monitoring in patients with chronic liver disease.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Rheumatology
Jerome Avouac, Anne Cauvet, Cindy Orvain, Morgane Boulch, Francoise Tilotta, Ly Tu, Raphael Thuillet, Mina Ottaviani, Christophe Guignabert, Philippe Bousso, Yannick Allanore
Summary: This study aimed to investigate the efficacy of two B cell depletion strategies, including CD19-targeted CAR T cells, in a preclinical model of severe lung damages observed in systemic sclerosis. The study evaluated B cell depletion strategies in Fra-2 Tg mice. The results showed that CD19-targeted CAR-T cells in combination with anti-CD20 monoclonal antibody achieved deeper B cell depletion compared to anti-CD20 monoclonal antibody alone in both peripheral blood and lesional lungs of Fra-2 Tg mice. However, CAR-T cell infusion worsened the clinical score and increased mortality in Fra-2 Tg mice. CAR-T cell infusion also resulted in increased lung collagen content, histological fibrosis score, and right ventricular systolic pressure. CAR-T cells accumulated in lesional lungs and promoted T activation and inflammatory cytokine production. On the other hand, treatment with anti-CD20 monoclonal antibody alone had no impact on lung inflammation-driven fibrosis and pulmonary hypertension.
ARTHRITIS & RHEUMATOLOGY
(2023)
Letter
Rheumatology
Paola Vidal-Montal, Marion Thomas, Alice Combier, Alexia Steelandt, Corinne Miceli-Richard, Anna Molto, Javier Narvaez, Joan Miquel Nolla, Yannick Allanore, Jerome Avouac