Biocatalysis making waves in organic chemistry

Enzymatic Late‐Stage Modifications: Better Late than Never

(2021) Elvira Romero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal–Organic Framework-Based Enzyme Biocomposites

(2021) Weibin Liang et al.   CHEMICAL REVIEWS

Novel Arylindigoids by Late‐Stage Derivatization of Biocatalytically Synthesized Dibromoindigo

(2021) Christian Schnepel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds

(2021) Micol Santi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Power of Biocatalysis for Organic Synthesis

(2021) Christoph K. Winkler et al.   ACS Central Science

Intramolecular Stereoselective Stetter Reaction Catalyzed by Benzaldehyde Lyase

(2021) Xiaoyang Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flavoprotein monooxygenases: Versatile biocatalysts

(2021) Caroline E. Paul et al.   BIOTECHNOLOGY ADVANCES

Thermodynamics Determine the Diastereochemical Outcome of Catalytic Reactions

(2021) Stefan R. Marsden et al.   ChemCatChem

Biocatalytic Aromaticity-Breaking Epoxidation of Naphthalene and Nucleophilic Ring-Opening Reactions

(2021) Wuyuan Zhang et al.   ACS Catalysis

One-Pot Enzymatic–Chemical Cascade Route for Synthesizing Aromatic α-Hydroxy Ketones

(2021) Lei Wang et al.   ACS Catalysis

Comprehensive Insights into the Production of Long Chain Aliphatic Aldehydes Using a Copper-Radical Alcohol Oxidase as Biocatalyst

(2021) David Ribeaucourt et al.   ACS Sustainable Chemistry & Engineering

Computer-aided enzymatic retrosynthesis

(2021) Dörte Rother et al.   Nature Catalysis

Chemoenzymatic Production of Enantiocomplementary 2‐Substituted 3‐Hydroxycarboxylic Acids from l ‐α‐Amino Acids

(2021) Mathias Pickl et al.   ADVANCED SYNTHESIS & CATALYSIS

Peculiarities of promiscuous l-threonine transaldolases for enantioselective synthesis of β-hydroxy-α-amino acids

(2021) Shan Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Identification and rational engineering of a high substrate‐tolerant leucine dehydrogenase effective for synthesis of L‐tert‐leucine

(2021) Xiangqi Meng et al.   ChemCatChem

Combining organocatalyzed aldolization and reductive amination: an efficient reaction sequence for the synthesis of iminosugars

(2021) Zorana Bozidar Ferjancic et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Engineering a Highly Efficient Carboligase for Synthetic One-Carbon Metabolism

(2021) Maren Nattermann et al.   ACS Catalysis

Thermostability Engineering of a Class II Pyruvate Aldolase from Escherichia coli by in Vivo Folding Interference

(2021) Sandra Bosch et al.   ACS Sustainable Chemistry & Engineering

Biocatalytic Transformations of Silicon—the Other Group 14 Element

(2021) Nicholas S. Sarai et al.   ACS Central Science

Progress in Stereoselective Construction of C–C Bonds Enabled by Aldolases and Hydroxynitrile Lyases

(2021) Mi Liu et al.   Frontiers in Bioengineering and Biotechnology

Identification and characterization of a novel carboxylesterase EstQ7 from a soil metagenomic library

(2021) Zhenzhen Yan et al.   ARCHIVES OF MICROBIOLOGY

Biocatalytic oxidation of fatty alcohols into aldehydes for the flavors and fragrances industry

(2021) David Ribeaucourt et al.   BIOTECHNOLOGY ADVANCES

Multi-reaction kinetic modeling for the peroxidase–aldolase cascade synthesis of a D-fagomine precursor

(2021) Gerard Masdeu et al.   CHEMICAL ENGINEERING SCIENCE

Emerging opportunities of silica-based materials within the food industry

(2021) Diogo Videira-Quintela et al.   MICROCHEMICAL JOURNAL

Repurposing an Aldolase for the Chemoenzymatic Synthesis of Substituted Quinolines

(2021) Douglas J. Fansher et al.   ACS Catalysis

One-Pot Asymmetric Synthesis of an Aminodiol Intermediate of Florfenicol Using Engineered Transketolase and Transaminase

(2021) Qi Liu et al.   ACS Catalysis

Enantioselective Bioamination of Aromatic Alkanes Using Ammonia: A Multienzymatic Cascade Approach

(2020) Hui Wang et al.   ChemCatChem

Interactions between trans-resveratrol and CpLIP2 lipase/acyltransferase: evidenced by fluorescence and in silico

(2020) Thi-Nga Nguyen et al.   FOOD CHEMISTRY

One-Pot Multienzyme Synthesis of Rare Ketoses from Glycerol

(2020) Zijie Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pyruvate Aldolases Catalyze Cross-Aldol Reactions between Ketones: Highly Selective Access to Multi-Functionalized Tertiary Alcohols

(2020) Victor Laurent et al.   ACS Catalysis

Aromas flow: eco-friendly, continuous, and scalable preparation of flavour esters

(2020) Martina Letizia Contente et al.   Journal of Flow Chemistry

Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

(2020) Georg T. Höfler et al.   ACS Sustainable Chemistry & Engineering

DERA in Flow: Synthesis of a Statin Side Chain Precursor in Continuous Flow Employing Deoxyribose-5-Phosphate Aldolase Immobilized in Alginate-Luffa Matrix

(2020) Bianca Grabner et al.   Catalysts

Selective Enzymatic Oxidation of Silanes to Silanols

(2020) Susanne Bähr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CYP505E3 – a novel self‐sufficient ω‐7 in‐chain hydroxylase

(2020) Martha Sophia Smit et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymatic reductions ‐ A Chemist's perspective

(2020) Frank Hollmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sequence‐Based Prediction of Promiscuous Acyltransferase Activity in Hydrolases

(2020) Henrik Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesizing Chiral Drug Intermediates by Biocatalysis

(2020) Wei Jiang et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Emerging strategies for expanding the toolbox of enzymes in biocatalysis

(2020) Braddock A. Sandoval et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Pictet–Spenglerases in alkaloid biosynthesis: Future applications in biocatalysis

(2020) Rebecca Roddan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthesis of Nonulosonic Acids

(2020) Kabita Pradhan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cyanide-Free Enantioselective Catalytic Strategies for the Synthesis of Chiral Nitriles

(2020) Harald Gröger et al.   JOURNAL OF ORGANIC CHEMISTRY

Engineering Cytochrome P450s for Enantioselective Cyclopropenation of Internal Alkynes

(2020) Kai Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzymatic Primary Amination of Benzylic and Allylic C(sp3)–H Bonds

(2020) Zhi-Jun Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An engineered PET depolymerase to break down and recycle plastic bottles

(2020) V. Tournier et al.   NATURE

Enzymatic Lactone-Carbene C–H Insertion to Build Contiguous Chiral Centers

(2020) Andrew Z. Zhou et al.   ACS Catalysis

Bacillus subtilis Lipase A—Lipase or Esterase?

(2020) Paula Bracco et al.   Catalysts

Characterization of imine reductases in reductive amination for the exploration of structure-activity relationships

(2020) Sarah L. Montgomery et al.   Science Advances

Catalytically-active inclusion bodies for biotechnology—general concepts, optimization, and application

(2020) Vera D. Jäger et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

PET Polymer Recycling

(2020) Mary O’Reilly et al.   BIOCHEMISTRY

Enzymatic Synthesis of Aliphatic Acyloins Catalyzed by Thermostable Transketolase

(2020) Laurence Hecquet et al.   ChemCatChem

Suzuki‐Miyaura Cross‐Coupling of Bromotryptophan Derivatives at Ambient Temperature

(2020) Steffen Dachwitz et al.   CHEMISTRY-A EUROPEAN JOURNAL

R ‐hydroxynitrile lyase from the cyanogenic millipede, Chamberlinius hualienensis ‐ A new entry to the carrier protein family Lipocalines

(2020) Fumihiro Motojima et al.   FEBS Journal

Photoenzymatic enantioselective intermolecular radical hydroalkylation

(2020) Xiaoqiang Huang et al.   NATURE

Larger active site in an ancestral hydroxynitrile lyase increases catalytically promiscuous esterase activity

(2020) Bryan J. Jones et al.   PLoS One

Protein Engineering for Enhanced Acyltransferase Activity, Substrate Scope, and Selectivity of the Mycobacterium smegmatis Acyltransferase MsAcT

(2020) Simon P. Godehard et al.   ACS Catalysis

Diversity-Oriented Enzymatic Synthesis of Cyclopropane Building Blocks

(2020) Bruce J. Wittmann et al.   ACS Catalysis

Biocatalytic Monoacylation of Symmetrical Diamines and its Application to the Synthesis of Pharmaceutically Relevant Amides

(2020) Max Lubberink et al.   ACS Catalysis

Discovery and Engineering of an Aldehyde Tolerant 2-deoxy-D-ribose 5-phosphate Aldolase (DERA) from Pectobacterium atrosepticum

(2020) Meera Haridas et al.   Catalysts

Broadening the scope of biocatalytic C–C bond formation

(2020) Lara E. Zetzsche et al.   Nature Reviews Chemistry

NAD(P)H‐Dependent Enzymes for Reductive Amination: Active Site Description and Carbonyl‐Containing Compound Spectrum

(2020) Laurine Ducrot et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate

(2020) Savvas Louka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Current progress towards understanding the biodegradation of synthetic condensation polymers with active hydrolases

(2020) Amber N Johnson et al.   POLYMER INTERNATIONAL

Variants of the Acyltransferase from Mycobacterium smegmatis Enable Enantioselective Acyl Transfer in Water

(2020) Etta Jost et al.   ACS Catalysis

Efficient Chemo-Enzymatic Flow Synthesis of High Value Amides and Esters

(2020) Francesca Annunziata et al.   Catalysts

Discovery and Structural Analysis to Improve the Enantioselectivity of Hydroxynitrile Lyase from Parafontaria laminata Millipedes for (R)-2-Chloromandelonitrile Synthesis

(2020) Aem Nuylert et al.   ACS Omega

Carboxylic Acid Reductase Can Catalyze Ester Synthesis in Aqueous Environments

(2020) Pornkanok Pongpamorn et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery and Design of Family VIII Carboxylesterases as Highly Efficient Acyltransferases

(2020) Henrik Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A multi-enzyme strategy for the production of a highly valuable lactonized statin side-chain precursor

(2020) Anera Švarc et al.   CHEMICAL ENGINEERING RESEARCH & DESIGN

Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water

(2020) Alessa Hinzmann et al.   CHEMISTRY-A EUROPEAN JOURNAL

Expanding the applicability of cytochrome P450s and other haemoproteins

(2020) Shinya Ariyasu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Assessing the Thiamine Diphosphate Dependent Pyruvate Dehydrogenase E1 Subunit for Carboligation Reactions with Aliphatic Ketoacids

(2020) Stefan R. Marsden et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Norcoclaurine Synthase-Mediated Stereoselective Synthesis of 1,1’-Disubstituted, Spiro- and Bis-Tetrahydroisoquinoline Alkaloids

(2020) Jianxiong Zhao et al.   ACS Catalysis

A strategic Ser/Cys exchange in the catalytic triad unlocks an acyltransferase-mediated synthesis of thioesters and tertiary amides

(2020) Martina L. Contente et al.   Nature Catalysis

Recent advances in artificial enzyme cascades for the production of value-added chemicals

(2020) Zilong Wang et al.   BIORESOURCE TECHNOLOGY

An innovative route for the production of atorvastatin side-chain precursor by DERA-catalysed double aldol addition

(2020) Anera Švarc et al.   CHEMICAL ENGINEERING SCIENCE

Thioesters as Acyl Donors in Biocatalytic Friedel-Crafts-type Acylation Catalyzed by Acyltransferase from Pseudomonas Protegens

(2019) Anna Żądło-Dobrowolska et al.   ChemCatChem

Straightforward Regeneration of Reduced Flavin Adenine Dinucleotide Required for Enzymatic Tryptophan Halogenation

(2019) Mohamed Ismail et al.   ACS Catalysis

Biocatalyzed Synthesis of Statins: A Sustainable Strategy for the Preparation of Valuable Drugs

(2019) Pilar Hoyos et al.   Catalysts

Engineering of Cyclohexanone Monooxygenase for the Enantioselective Synthesis of (S)-Omeprazole

(2019) Yan Zhang et al.   ACS Sustainable Chemistry & Engineering

Cytochrome P450 Monooxygenases in Biotechnology and Synthetic Biology

(2019) Vlada B. Urlacher et al.   TRENDS IN BIOTECHNOLOGY

Structural insights into alcohol dehydrogenases catalyzing asymmetric reductions

(2019) Jianhong An et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Enzyme‐Catalyzed Synthesis of Esters in Water

(2019) Luuk Mestrom et al.   ChemCatChem

Regio- and Enantio-selective Chemo-enzymatic C−H-Lactonization of Decanoic Acid to (S )-δ-Decalactone

(2019) Jack Manning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aldolase-Catalyzed Asymmetric Synthesis of N-Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes

(2019) Raquel Roldán et al.   ADVANCED SYNTHESIS & CATALYSIS

Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N‐ Acetylneuraminate Lyase in a Continuous Flow Reactor

(2019) Victor R. L. J. Bloemendal et al.   ADVANCED SYNTHESIS & CATALYSIS

CH‐π Interactions Promote the Conversion of Hydroxypyruvate in a Class II Pyruvate Aldolase

(2019) Stefan R. Marsden et al.   ADVANCED SYNTHESIS & CATALYSIS

Efficient Enzymatic Preparation of Flavor Esters in Water

(2019) Igor Chiarelli Perdomo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Directed Evolution of a Cytochrome P450 Carbene Transferase for Selective Functionalization of Cyclic Compounds

(2019) Oliver F. Brandenberg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Machine learning-assisted directed protein evolution with combinatorial libraries

(2019) Zachary Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemoenzymatic Platform for Synthesis of Chiral Organofluorines Based on Type II Aldolases

(2019) Jason Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Purification and enzymatic characterization of trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from Rhodococcus opacus and enzymatic formation of α, β-unsaturated ketones

(2019) Toshihiro Suzuki et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Enantiodivergent α-Amino C–H Fluoroalkylation Catalyzed by Engineered Cytochrome P450s

(2019) Juner Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Methoxamine Synthesis in a Biocatalytic 1-Pot 2-Step Cascade Approach

(2019) Vanessa Erdmann et al.   ACS Catalysis

Amine dehydrogenases occur in nature

(2019) Andreas S. Bommarius   Nature Catalysis

A Biocatalytically Active Membrane Obtained from Immobilization of 2-Deoxy-d-ribose-5-phosphate Aldolase on a Porous Support

(2019) Shuhao Zhang et al.   ACS Applied Materials & Interfaces

Accessing Enantiopure Epoxides and Sulfoxides: Related Flavin‐Dependent Monooxygenases Provide Reversed Enantioselectivity

(2019) Thomas Heine et al.   ChemCatChem

Low-barrier hydrogen bonds in enzyme cooperativity

(2019) Shaobo Dai et al.   NATURE

Achiral Hydroxypyruvaldehyde Phosphate as a Platform for Multi-Aldolases Cascade Synthesis of Diuloses and for a Quadruple Acetaldehyde Addition Catalyzed by 2-Deoxyribose-5-Phosphate Aldolases

(2019) Victor Laurent et al.   ACS Catalysis

Acceptance and Kinetic Resolution of α-Methyl-Substituted Aldehydes by Norcoclaurine Synthases

(2019) Rebecca Roddan et al.   ACS Catalysis

Formaldehyde as a Promising C1 Source: The Instrumental Role of Biocatalysis for Stereocontrolled Reactions

(2019) Sarah Desmons et al.   ACS Catalysis

S -Adenosyl Methionine Cofactor Modifications Enhance the Biocatalytic Repertoire of Small Molecule C -Alkylation

(2019) Iain J. W. McKean et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture)

(2019) Frances H. Arnold   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoenzymatic Halocyclization of γ,δ‐Unsaturated Carboxylic Acids and Alcohols

(2019) Sabry H. H. Younes et al.   ChemSusChem

Carboxylic acid reductases (CARs): An industrial perspective

(2019) Sasha R. Derrington et al.   JOURNAL OF BIOTECHNOLOGY

Engineering imine reductases for industrial applications

(2019) Matthias Höhne   Nature Catalysis

Thermodynamically and Kinetically Controlled Reactions in Biocatalysis – from Concepts to Perspectives

(2019) Stefan R. Marsden et al.   ChemCatChem

Towards Preparative Chemoenzymatic Oxidative Decarboxylation of Glutamic Acid

(2019) Xiaomin Xu et al.   ChemCatChem

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

(2019) Mark A. Huffman et al.   SCIENCE

Mechanism of Biocatalytic Friedel–Crafts Acylation by Acyltransferase from Pseudomonas protegens

(2019) Xiang Sheng et al.   ACS Catalysis

Rational Engineered C-Acyltransferase Transforms Sterically Demanding Acyl Donors

(2019) Anna Żądło-Dobrowolska et al.   ACS Catalysis

Recent Advances in Flavin-Dependent Halogenase Biocatalysis: Sourcing, Engineering, and Application

(2019) Johannes Büchler et al.   Catalysts

Whole-Cell Biotransformation of Benzene to Phenol Catalysed by Intracellular Cytochrome P450BM3 Activated by External Additives

(2018) Masayuki Karasawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nucleophile Promiscuity of Engineered Class II Pyruvate Aldolase YfaU from E. Coli

(2018) Karel Hernández et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biocatalytic Oxidation Reactions: A Chemist's Perspective

(2018) JiaJia Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization and reshaping of a large and hydrophobic nucleophile pocket in lipases/acyltransferases

(2018) Anne-Helene Jan Deniau et al.   CHEMBIOCHEM

Selective Oxidations of Cyperenoic Acid by Slightly Reshaping the Binding Pocket of Cytochrome P450 BM3

(2018) Yuxin Li et al.   ChemCatChem

Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination

(2018) Scott P. France et al.   ChemCatChem

Photochemically Driven Biocatalysis of Halogenases for the Green Production of Chlorinated Compounds

(2018) Lea Schroeder et al.   ChemCatChem

Biocatalytic reduction of activated C C-bonds and beyond: emerging trends

(2018) Christoph K Winkler et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Halogenases: powerful tools for biocatalysis (mechanisms applications and scope)

(2018) Danai S Gkotsi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Carboxylic acid reductase enzymes (CARs)

(2018) Margit Winkler   CURRENT OPINION IN CHEMICAL BIOLOGY

Chloroperoxidase-Catalyzed Achmatowicz Rearrangements

(2018) Daniel Thiel et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Discovery, Characterization, Engineering, and Applications of Ene-Reductases for Industrial Biocatalysis

(2018) Helen S. Toogood et al.   ACS Catalysis

Selective Synthesis of the Human Drug Metabolite 5′-Hydroxypropranolol by an Evolved Self-Sufficient Peroxygenase

(2018) Patricia Gomez de Santos et al.   ACS Catalysis

Biocatalyzed C−C Bond Formation for the Production of Alkaloids

(2018) Mahesh D. Patil et al.   ChemCatChem

Biocatalytic synthesis of lactones and lactams

(2018) Frank Hollmann et al.   Chemistry-An Asian Journal

Overriding Traditional Electronic Effects in Biocatalytic Baeyer–Villiger Reactions by Directed Evolution

(2018) Guangyue Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocatalytic N -Acylation of Amines in Water Using an Acyltransferase from Mycobacterium smegmatis

(2018) Martina Letizia Contente et al.   ADVANCED SYNTHESIS & CATALYSIS

Chemo- and Regioselective Dihydroxylation of Benzene to Hydroquinone Enabled by Engineered Cytochrome P450 Monooxygenase

(2018) Hangyu Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2-Deoxy-d-ribose-5-phosphate aldolase (DERA): applications and modifications

(2018) Meera Haridas et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enzymatic synthesis of sitagliptin intermediate using a novel ω-transaminase

(2018) Geon-Hee Kim et al.   ENZYME AND MICROBIAL TECHNOLOGY

Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions

(2018) Kai Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Enzyme Syntheses of Napyradiomycins A1 and B1

(2018) Shaun M. K. McKinnie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals

(2018) Matthew P. Thompson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Monoamine Oxidase: Tunable Activity for Amine Resolution and Functionalization

(2018) Vasco F. Batista et al.   ACS Catalysis

A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases

(2018) Mahima Sharma et al.   ACS Catalysis

Selective hydroxylation of 1,8- and 1,4-cineole using bacterial P450 variants

(2018) Joel H.Z. Lee et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Acyl Donors and Additives for the Biocatalytic Friedel-Crafts Acylation

(2017) Nina G. Schmidt et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Expanding the reaction space of aldolases using hydroxypyruvate as a nucleophilic substrate

(2017) Véronique de Berardinis et al.   GREEN CHEMISTRY

Unusual differences in the reactivity of glutamic and aspartic acid in oxidative decarboxylation reactions

(2017) Andrada But et al.   GREEN CHEMISTRY

Enzymatic halocyclization of allenic alcohols and carboxylates: a biocatalytic entry to functionalized O-heterocycles

(2017) J. Naapuri et al.   GREEN CHEMISTRY

Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds

(2017) Tanja Knaus et al.   GREEN CHEMISTRY

Production of dodecanedioic acid via biotransformation of low cost plant-oil derivatives using Candida tropicalis

(2017) Irina Funk et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Genetically programmed chiral organoborane synthesis

(2017) S. B. Jennifer Kan et al.   NATURE

Biocatalytic site- and enantioselective oxidative dearomatization of phenols

(2017) Summer A. Baker Dockrey et al.   Nature Chemistry

Enantioselective, intermolecular benzylic C–H amination catalysed by an engineered iron-haem enzyme

(2017) Christopher K. Prier et al.   Nature Chemistry

A reductive aminase from Aspergillus oryzae

(2017) Godwin A. Aleku et al.   Nature Chemistry

Hydrogen peroxide as a new defensive compound in “benzoyl cyanide” producing polydesmid millipedes

(2017) Yasumasa Kuwahara et al.   NATURWISSENSCHAFTEN

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

(2017) Michele Tavanti et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

What makes a lipase a valuable acyltransferase in water abundant medium?

(2017) M. Subileau et al.   Catalysis Science & Technology

A new d-threonine aldolase as a promising biocatalyst for highly stereoselective preparation of chiral aromatic β-hydroxy-α-amino acids

(2017) Qijia Chen et al.   Catalysis Science & Technology

Are Directed Evolution Approaches Efficient in Exploring Nature’s Potential to Stabilize a Lipase in Organic Cosolvents?

(2017) Ulrich Markel et al.   Catalysts

Old Yellow Enzyme-Catalysed Asymmetric Hydrogenation: Linking Family Roots with Improved Catalysis

(2017) Anika Scholtissek et al.   Catalysts

Hydrogen peroxide as a new defensive compound in “benzoyl cyanide” producing polydesmid millipedes

(2017) Yasumasa Kuwahara et al.   Science of Nature

Specific Enzymatic Halogenation-From the Discovery of Halogenated Enzymes to Their Applications In Vitro and In Vivo

(2016) Veit Weichold et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A High-Throughput Fluorescence Assay to Determine the Activity of Tryptophan Halogenases

(2016) Christian Schnepel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Threonine aldolases: perspectives in engineering and screening the enzymes with enhanced substrate and stereo specificities

(2016) Kateryna Fesko   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Beyond the outer limits of nature by directed evolution

(2016) Patricia Molina-Espeja et al.   BIOTECHNOLOGY ADVANCES

A robust chemo-enzymatic lactone synthesis using acyltransferase from Mycobacterium smegmatis

(2016) A. Drożdż et al.   CATALYSIS COMMUNICATIONS

Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes

(2016) Tanja Knaus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models

(2016) Sheel C. Dodani et al.   Nature Chemistry

Enantioselective synthesis of cyanohydrins catalysed by hydroxynitrile lyases – a review

(2016) Paula Bracco et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life

(2016) S. B. Jennifer Kan et al.   SCIENCE

A bacterium that degrades and assimilates poly(ethylene terephthalate)

(2016) Shosuke Yoshida et al.   SCIENCE

Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies

(2016) Markus Dick et al.   Chemical Science

EPR Study of Substrate Binding to Mn(II) in Hydroxynitrile Lyase from Granulicella tundricola

(2016) Femke Vertregt et al.   ACS Catalysis

Minimalist Protein Engineering of an Aldolase Provokes Unprecedented Substrate Promiscuity

(2016) Deniz Güclü et al.   ACS Catalysis

A Biocatalytic Aza-Achmatowicz Reaction

(2016) Elena Fernández-Fueyo et al.   ACS Catalysis

MsAcT in siliceous monolithic microreactors enables quantitative ester synthesis in water

(2016) Katarzyna Szymańska et al.   Catalysis Science & Technology

One-pot biocatalytic amine transaminase/acyl transferase cascade for aqueous formation of amides from aldehydes or ketones

(2016) Henrik Land et al.   Catalysis Science & Technology

Asymmetric reductive amination by a wild-type amine dehydrogenase from the thermophilic bacteria Petrotoga mobilis

(2016) Ombeline Mayol et al.   Catalysis Science & Technology

Redesigning Aldolase Stereoselectivity by Homologous Grafting

(2016) Carolin Bisterfeld et al.   PLoS One

Recent Developments in Enzymatic Synthesis of Modified Sialic Acid Derivatives

(2015) Ching-Ching Yu et al.   ADVANCED SYNTHESIS & CATALYSIS

An Enzyme Cascade Synthesis of ε-Caprolactone and its Oligomers

(2015) Sandy Schmidt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facile Enzymatic Synthesis of Ketoses

(2015) Liuqing Wen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthesis of l-Sorbose and l-Psicose Based on C—C Bond Formation Catalyzed by Aldolases in an Engineered Corynebacterium glutamicum Strain

(2015) Jiangang Yang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Organic-Synthetic Potential of Recombinant Ene Reductases: Substrate-Scope Evaluation and Process Optimization

(2015) Tina Reß et al.   ChemCatChem

Chemoenzymatic Halogenation of Phenols by using the Haloperoxidase fromCurvularia inaequalis

(2015) Elena Fernández-Fueyo et al.   ChemCatChem

Production of Long-Chain α,ω-Dicarboxylic Acids by Engineered Escherichia coli from Renewable Fatty Acids and Plant Oils

(2015) Chandran Sathesh-Prabu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Discovery and molecular and biocatalytic properties of hydroxynitrile lyase from an invasive millipede,Chamberlinius hualienensis

(2015) Mohammad Dadashipour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes

(2015) Sarah A. Shepherd et al.   Chemical Science

Chemo-, Regio-, and Stereoselective Oxidation of the Monocyclic Diterpenoid β-Cembrenediol by P450 BM3

(2015) Priska Le-Huu et al.   ACS Catalysis

Efficient synthesis of a statin precursor in high space-time yield by a new aldehyde-tolerant aldolase identified from Lactobacillus brevis

(2015) Xue-Cheng Jiao et al.   Catalysis Science & Technology

Sequential Biocatalytic Aldol Reactions in Multistep Asymmetric Synthesis: Pipecolic Acid, Piperidine and Pyrrolidine (Homo)Iminocyclitol Derivatives from Achiral Building Blocks

(2014) Anna Soler et al.   ADVANCED SYNTHESIS & CATALYSIS

Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran

(2014) Z. Jane Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Tailor-Made Chimeric Thiamine Diphosphate Dependent Enzyme for the Direct Asymmetric Synthesis of (S)-Benzoins

(2014) Robert Westphal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-pot Conversion of Cycloalkanes to Lactones

(2014) Alizé Pennec et al.   ChemCatChem

Improving the Properties of BacterialR-Selective Hydroxynitrile Lyases for Industrial Applications

(2014) Romana Wiedner et al.   ChemCatChem

Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer

(2014) Christopher C. Farwell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzymatic aerobic ring rearrangement of optically active furylcarbinols

(2014) Daniel Thiel et al.   Nature Communications

A New Type of Stereoselectivity in Baeyer-Villiger Reactions: Access toE- andZ-Olefins

(2013) Zhi-Gang Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly Selective Hydroxylation of Benzene to Phenol by Wild-type Cytochrome P450BM3 Assisted by Decoy Molecules

(2013) Osami Shoji et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective Arene Halogenation using the FAD-Dependent Halogenase RebH

(2013) James T. Payne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent trends and novel concepts in cofactor-dependent biotransformations

(2013) Selin Kara et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Alternative Hydride Sources for Ene-Reductases: Current Trends

(2013) Helen S. Toogood et al.   ChemCatChem

Escherichia coli/ADH-A: An All-Inclusive Catalyst for the Selective Biooxidation and Deracemisation of Secondary Alcohols

(2013) Caroline E. Paul et al.   ChemCatChem

Biocatalytic Methods for CC Bond Formation

(2013) Kateryna Fesko et al.   ChemCatChem

Enzyme immobilisation in biocatalysis: why, what and how

(2013) Roger A. Sheldon et al.   CHEMICAL SOCIETY REVIEWS

Immobilisation of hydroxynitrile lyases

(2013) Ulf Hanefeld   CHEMICAL SOCIETY REVIEWS

Biochemical and structural characterization of a novel bacterial manganese-dependent hydroxynitrile lyase

(2013) Ivan Hajnal et al.   FEBS Journal

Engineering stereoselectivity of ThDP-dependent enzymes

(2013) Helen C. Hailes et al.   FEBS Journal

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

(2013) Pedro S Coelho et al.   Nature Chemical Biology

Observation of a stable carbene at the active site of a thiamin enzyme

(2013) Danilo Meyer et al.   Nature Chemical Biology

Chemo-enzymatic synthesis and glycosidase inhibitory properties of DAB and LAB derivatives

(2013) Alda Lisa Concia et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of an Amine Dehydrogenase for Synthesis of Chiral Amines

(2012) Michael J. Abrahamson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Carbohydrates in a Continuous Flow Reactor by Immobilized Phosphatase and Aldolase

(2012) Lara Babich et al.   ChemSusChem

Selective Oxidative Decarboxylation of Amino Acids to Produce Industrially Relevant Nitriles by Vanadium Chloroperoxidase

(2012) Andrada But  et al.   ChemSusChem

Controlled Oxidation of Remote sp3 C–H Bonds in Artemisinin via P450 Catalysts with Fine-Tuned Regio- and Stereoselectivity

(2012) Kaidong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis

(2012) Sarah M Barry et al.   Nature Chemical Biology

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

(2012) P. S. Coelho et al.   SCIENCE

Redesign of the Phosphate Binding Site of L-Rhamnulose- 1-Phosphate Aldolase towards a Dihydroxyacetone Dependent Aldolase

(2011) Xavier Garrabou et al.   ADVANCED SYNTHESIS & CATALYSIS

Resting cells of recombinant E. coli show high epoxidation yields on energy source and high sensitivity to product inhibition

(2011) Mattijs K. Julsing et al.   BIOTECHNOLOGY AND BIOENGINEERING

Characterization of a tryptophan 6-halogenase from Streptomyces toxytricini

(2011) Jia Zeng et al.   BIOTECHNOLOGY LETTERS

Structure-guided redesign of d-fructose-6-phosphate aldolase from E. coli: remarkable activity and selectivity towards acceptor substrates by two-point mutation

(2011) Mariana Gutierrez et al.   CHEMICAL COMMUNICATIONS

C−C Bond-Forming Lyases in Organic Synthesis

(2011) Margarita Brovetto et al.   CHEMICAL REVIEWS

Perhydrolase-nanotube-paint sporicidal composites stabilized by intramolecular crosslinking

(2011) Cerasela Zoica Dinu et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Highly efficient aldol additions of DHA and DHAP to N-Cbz-amino aldehydes catalyzed by l-rhamnulose-1-phosphate and l-fuculose-1-phosphate aldolases in aqueous borate buffer

(2011) Xavier Garrabou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Parameters for bromination of pyrroles in bromoperoxidase-catalyzed oxidations

(2011) Diana Wischang et al.   TETRAHEDRON

Exploiting the Regioselectivity of Baeyer-Villiger Monooxygenases for the Formation of β-Amino Acids and β-Amino Alcohols

(2010) Jessica Rehdorf et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox Biocatalysis and Metabolism: Molecular Mechanisms and Metabolic Network Analysis

(2010) Lars M. Blank et al.   ANTIOXIDANTS & REDOX SIGNALING

Recent Developments in the Application of Baeyer-Villiger Monooxygenases as Biocatalysts

(2010) Gonzalo de Gonzalo et al.   CHEMBIOCHEM

α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes

(2010) James L. Galman et al.   CHEMICAL COMMUNICATIONS

Switching from an Esterase to a Hydroxynitrile Lyase Mechanism Requires Only Two Amino Acid Substitutions

(2010) Santosh Kumar Padhi et al.   CHEMISTRY & BIOLOGY

Intensification and economic and ecological assessment of a biocatalytic oxyfunctionalization process

(2010) Daniel Kuhn et al.   GREEN CHEMISTRY

Vanadate(v)-dependent bromoperoxidase immobilized on magnetic beads as reusable catalyst for oxidative bromination

(2010) Diana Wischang et al.   GREEN CHEMISTRY

Use of a Robust Dehydrogenase from an Archael Hyperthermophile in Asymmetric Catalysis−Dynamic Reductive Kinetic Resolution Entry into (S)-Profens

(2010) Jacob A. Friest et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nitroaromatic Compounds, from Synthesis to Biodegradation

(2010) K.-S. Ju et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Non-α-hydroxylated aldehydes with evolved transketolase enzymes

(2010) Armando Cázares et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Biocatalytic Friedel-Crafts Alkylation Using Non-natural Cofactors

(2009) Harald Stecher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conformational changes and catalysis by alcohol dehydrogenase

(2009) Bryce V. Plapp   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Conversion of polycyclic aromatic hydrocarbons, methyl naphthalenes and dibenzofuran by two fungal peroxygenases

(2009) Elisabet Aranda et al.   BIODEGRADATION

Applications of biotransformations and biocatalysis to complexity generation in organic synthesis

(2009) Tomas Hudlicky et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Enzyme-Catalysed Synthesis of Cyanohydrins

(2009) Jarle Holt et al.   CURRENT ORGANIC SYNTHESIS

A green-by-design biocatalytic process for atorvastatin intermediate

(2009) Steven K. Ma et al.   GREEN CHEMISTRY

X-ray Crystal Structure of Michaelis Complex of Aldoxime Dehydratase

(2009) Hitomi Sawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of a Practical Biocatalytic Process for (R)-2-Methylpentanol

(2009) Owen W. Gooding et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Highly Enantioselective Reduction of a Small Heterocyclic Ketone: Biocatalytic Reduction of Tetrahydrothiophene-3-one to the Corresponding (R)-Alcohol

(2009) Jack Liang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Crystal Structure and Functional Assignment of YfaU, a Metal Ion Dependent Class II Aldolase fromEscherichia coliK12†‡

(2008) Dean Rea et al.   BIOCHEMISTRY

Thiamin Diphosphate Catalysis: Enzymic and Nonenzymic Covalent Intermediates

(2008) Ronald Kluger et al.   CHEMICAL REVIEWS

Understanding enzyme immobilisation

(2008) Ulf Hanefeld et al.   CHEMICAL SOCIETY REVIEWS

Serine Hydroxymethyl Transferase fromStreptococcus thermophilus andL-Threonine Aldolase fromEscherichia coli as Stereocomplementary Biocatalysts for the Synthesis of β-Hydroxy-α,ω-diamino Acid Derivatives

(2008) Mariana L. Gutierrez et al.   CHEMISTRY-A EUROPEAN JOURNAL

Heme-iron oxygenases: powerful industrial biocatalysts?

(2008) Mattijs K Julsing et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Chemoenzymatic approaches to the montanine alkaloids: a total synthesis of (+)-nangustine

(2008) Okanya J. Kokas et al.   TETRAHEDRON

Regioselective preparation of (R)-2-(4-hydroxyphenoxy)propionic acid with a fungal peroxygenase

(2008) Matthias Kinne et al.   TETRAHEDRON LETTERS

Four types of threonine aldolases: Similarities and differences in kinetics/thermodynamics

(2007) Kateryna Fesko et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC