One-Pot Asymmetric Synthesis of an Aminodiol Intermediate of Florfenicol Using Engineered Transketolase and Transaminase
出版年份 2021 全文链接
标题
One-Pot Asymmetric Synthesis of an Aminodiol Intermediate of Florfenicol Using Engineered Transketolase and Transaminase
作者
关键词
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出版物
ACS Catalysis
Volume 11, Issue 12, Pages 7477-7488
出版商
American Chemical Society (ACS)
发表日期
2021-06-09
DOI
10.1021/acscatal.1c01229
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Directed Evolution of l-Threonine Aldolase for the Diastereoselective Synthesis of β-Hydroxy-α-amino Acids
- (2021) Wenlong Zheng et al. ACS Catalysis
- Biocatalysis in drug discovery and development
- (2020) Anna Fryszkowska et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Biocatalysis: Enzymatic Synthesis for Industrial Applications
- (2020) Shuke Wu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Multi-enzyme cascade for improving β-hydroxy-α-amino acids production by engineering L-threonine transaldolase and combining acetaldehyde elimination system
- (2020) Lian Xu et al. BIORESOURCE TECHNOLOGY
- Enzymatic Synthesis of Aliphatic Acyloins Catalyzed by Thermostable Transketolase
- (2020) Laurence Hecquet et al. ChemCatChem
- Engineering of l-threonine aldolase for the preparation of 4-(methylsulfonyl)phenylserine, an important intermediate for the synthesis of florfenicol and thiamphenicol
- (2020) Zhicheng Liu et al. ENZYME AND MICROBIAL TECHNOLOGY
- Construction of a Highly Diastereoselective Aldol Reaction System with l-Threonine Aldolase by Computer-Assisted Rational Molecular Modification and Medium Engineering
- (2020) Wenlong Zheng et al. ORGANIC LETTERS
- A Single‐Transaminase‐Catalyzed Biocatalytic Cascade for Efficient Asymmetric Synthesis of l ‐Phosphinothricin
- (2020) Feng Cheng et al. CHEMBIOCHEM
- Methoxamine Synthesis in a Biocatalytic 1-Pot 2-Step Cascade Approach
- (2019) Vanessa Erdmann et al. ACS Catalysis
- One-Pot Biocatalytic Transformation of Adipic Acid to 6-Aminocaproic Acid and 1,6-Hexamethylenediamine Using Carboxylic Acid Reductases and Transaminases
- (2019) Tatiana P. Fedorchuk et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- One-pot, two-step transaminase and transketolase synthesis of l - gluco -heptulose from l -arabinose
- (2018) Maria Bawn et al. ENZYME AND MICROBIAL TECHNOLOGY
- Asymmetric Synthesis of Florfenicol via Dynamic Reductive Kinetic Resolution with Ketoreductases
- (2018) Jie Zou et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Biocatalytic approaches towards the stereoselective synthesis of vicinal amino alcohols
- (2018) Pankaj Gupta et al. NEW JOURNAL OF CHEMISTRY
- Recent Advances in ω-Transaminase-Mediated Biocatalysis for the Enantioselective Synthesis of Chiral Amines
- (2018) Mahesh D. Patil et al. Catalysts
- In Silico Based Engineering Approach to Improve Transaminases for the Conversion of Bulky Substrates
- (2018) Moritz Voss et al. ACS Catalysis
- Engineering a thermostable transketolase for arylated substrates
- (2017) Thangavelu Saravanan et al. GREEN CHEMISTRY
- Transaminase biocatalysis: optimization and application
- (2017) Fei Guo et al. GREEN CHEMISTRY
- Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
- (2017) David K. Romney et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Active Site Engineering of ω-Transaminase Guided by Docking Orientation Analysis and Virtual Activity Screening
- (2017) Sang-Woo Han et al. ACS Catalysis
- Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts
- (2017) Iustina Slabu et al. ACS Catalysis
- Transaminase Triggered Aza-Michael Approach for the Enantioselective Synthesis of Piperidine Scaffolds
- (2016) James Ryan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Catalytic asymmetric transfer hydrogenation/dynamic kinetic resolution: an efficient synthesis of florfenicol
- (2016) Xinlong Wang et al. TETRAHEDRON
- Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes
- (2016) Pierre E. Affaticati et al. Scientific Reports
- Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications
- (2015) Fabian Steffen-Munsberg et al. BIOTECHNOLOGY ADVANCES
- Second generation engineering of transketolase for polar aromatic aldehyde substrates
- (2015) Panwajee Payongsri et al. ENZYME AND MICROBIAL TECHNOLOGY
- ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
- (2015) James A. Maier et al. Journal of Chemical Theory and Computation
- Multi-step synthesis strategies towards 1,2-amino alcohols with special emphasis on phenylpropanolamines
- (2015) Torsten Sehl et al. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
- A Regio- and Stereoselective ω-Transaminase/Monoamine Oxidase Cascade for the Synthesis of Chiral 2,5-Disubstituted Pyrrolidines
- (2014) Elaine O'Reilly et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Structure and functioning mechanism of transketolase
- (2014) German A. Kochetov et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials
- (2013) Torsten Sehl et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Engineering stereoselectivity of ThDP-dependent enzymes
- (2013) Helen C. Hailes et al. FEBS Journal
- PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data
- (2013) Daniel R. Roe et al. Journal of Chemical Theory and Computation
- Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald
- (2013) Romelia Salomon-Ferrer et al. Journal of Chemical Theory and Computation
- An efficient single-enzymatic cascade for asymmetric synthesis of chiral amines catalyzed by ω-transaminase
- (2012) Bo Wang et al. CHEMICAL COMMUNICATIONS
- Stereoselective Synthesis of (−)-Chloramphenicol, (+)-Thiamphenicol and (+)-Sphinganine via Chiral Tricyclic Iminolactone
- (2012) Qiong Li et al. CHINESE JOURNAL OF CHEMISTRY
- An Efficient Enantioselective Synthesis of Florfenicol Based on Sharpless Asymmetric Dihydroxylation
- (2012) Fen-Er Chen et al. SYNTHESIS-STUTTGART
- Kinetic resolution of aromatic β-amino acids by ω-transaminase
- (2011) Han-Seop Bea et al. CHEMICAL COMMUNICATIONS
- A Facile and Efficient Asymmetric Synthesis of Florfenicol
- (2011) Fen-Er Chen et al. SYNLETT
- An efficient enantioselective synthesis of florfenicol via asymmetric aziridination
- (2011) Zhonghua Wang et al. TETRAHEDRON
- An efficient enantioselective synthesis of florfenicol via a vanadium-catalyzed asymmetric epoxidation
- (2011) Feng Li et al. TETRAHEDRON-ASYMMETRY
- Immobilization of Candida rugosa lipase on glass beads for enantioselective hydrolysis of racemic Naproxen methyl ester
- (2010) Elif Yilmaz et al. BIORESOURCE TECHNOLOGY
- α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes
- (2010) James L. Galman et al. CHEMICAL COMMUNICATIONS
- The Crystal Structure of Human Transketolase and New Insights into Its Mode of Action
- (2010) Lars Mitschke et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rational assignment of key motifs for function guides in silico enzyme identification
- (2010) Matthias Höhne et al. Nature Chemical Biology
- ω-Transaminases as efficient biocatalysts to obtain novel chiral selenium-amine ligands for Pd-catalysis
- (2010) Leandro H. Andrade et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture
- (2010) C. K. Savile et al. SCIENCE
- Asymmetric Synthesis of Optically Pure Pharmacologically Relevant Amines Employing ω-Transaminases
- (2008) Dominik Koszelewski et al. ADVANCED SYNTHESIS & CATALYSIS
- New stereoselective synthesis of thiamphenicol and florfenicol from enantiomerically pure cyanohydrin: a chemo-enzymatic approach
- (2008) Wenya Lu et al. TETRAHEDRON
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