标题
Synthesizing Chiral Drug Intermediates by Biocatalysis
作者
关键词
-
出版物
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-04-22
DOI
10.1007/s12010-020-03272-3
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A Biocatalytic Platform for Synthesis of Chiral α-Trifluoromethylated Organoborons
- (2019) Xiongyi Huang et al. ACS Central Science
- Biocatalysis for synthesis of pharmaceuticals
- (2018) Ramesh N. Patel BIOORGANIC & MEDICINAL CHEMISTRY
- Engineering bi-functional enzyme complex of formate dehydrogenase and leucine dehydrogenase by peptide linker mediated fusion for accelerating cofactor regeneration
- (2017) Yonghui Zhang et al. ENGINEERING IN LIFE SCIENCES
- Identification and Characterization ofD-Succinylase, and a Proposed Enzymatic Method forD-Amino Acid Synthesis
- (2016) Yosuke Sumida et al. ADVANCED SYNTHESIS & CATALYSIS
- Efficient Enantioselective Biocatalytic Production of a Chiral Intermediate of Sitagliptin by a Newly Filamentous Fungus Isolate
- (2016) Jia Sun et al. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
- Highly efficient synthesis of ethyl (S)-4-chloro-3-hydroxybutanoate by a novel carbonyl reductase from Yarrowia lipolytica and using mannitol or sorbitol as cosubstrate
- (2016) Qin Xu et al. BIOCHEMICAL ENGINEERING JOURNAL
- Highly enantioselective production of a chiral intermediate of sitagliptin by a novel isolate of Pseudomonas pseudoalcaligenes
- (2016) Yanchan Wei et al. BIOTECHNOLOGY LETTERS
- Enhancement of isomerization activity and lactulose production of cellobiose 2-epimerase from Caldicellulosiruptor saccharolyticus
- (2016) Qiuyun Shen et al. FOOD CHEMISTRY
- Activity improvement of a Kluyveromyces lactis aldo-keto reductase KlAKR via rational design
- (2016) Xi Luo et al. JOURNAL OF BIOTECHNOLOGY
- Construction and evaluation of a novel bifunctional phenylalanine–formate dehydrogenase fusion protein for bienzyme system with cofactor regeneration
- (2016) Wei Jiang et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Asymmetric synthesis of lipitor chiral intermediate using a robust carbonyl reductase at high substrate to catalyst ratio
- (2016) Guo-Chao Xu et al. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
- Three-steps in one-pot: whole-cell biocatalytic synthesis of enantiopure (+)- and (−)-pinoresinol via kinetic resolution
- (2016) Esther Ricklefs et al. Microbial Cell Factories
- Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines
- (2016) Ioannis V. Pavlidis et al. Nature Chemistry
- Engineering of phenylalanine ammonia lyase from Rhodotorula graminis for the enhanced synthesis of unnatural l-amino acids
- (2016) Ian Rowles et al. TETRAHEDRON
- Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis
- (2016) Shuke Wu et al. Nature Communications
- Rational Design of a (S)-Selective-Transaminase for Asymmetric Synthesis of (1S)-1-(1,1′-biphenyl-2-yl)ethanamine
- (2016) Daniel F. A. R. Dourado et al. ACS Catalysis
- Construction of a tunable multi-enzyme-coordinate expression system for biosynthesis of chiral drug intermediates
- (2016) Wei Jiang et al. Scientific Reports
- Tandem Reactions Combining Biocatalysts and Chemical Catalysts for Asymmetric Synthesis
- (2016) Yajie Wang et al. Catalysts
- A Separation-Integrated Cascade Reaction to Overcome Thermodynamic Limitations in Rare-Sugar Synthesis
- (2015) Nina Wagner et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction
- (2015) Corien de Graaff et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Chemoenzymatic synthesis of rasagiline mesylate using lipases
- (2015) Thiago de Sousa Fonseca et al. APPLIED CATALYSIS A-GENERAL
- Efficient synthesis of the intermediate of abacavir and carbovir using a novel (+)-γ-lactamase as a catalyst
- (2015) Shuaihua Gao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Highly efficient production of rare sugarsD-psicose andL-tagatose by two engineeredD-tagatose epimerases
- (2015) Andreas Bosshart et al. BIOTECHNOLOGY AND BIOENGINEERING
- Two-Step One-Pot Synthesis of Pinoresinol from Eugenol in an Enzymatic Cascade
- (2015) Esther Ricklefs et al. ChemCatChem
- Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis
- (2015) Susanne Herter et al. ChemCatChem
- Cloning and characterization of a NADH-dependent aldo-keto reductase from a newly isolated Kluyveromyces lactis XP1461
- (2015) Xi Luo et al. ENZYME AND MICROBIAL TECHNOLOGY
- Lactulose production from lactose by recombinant cellobiose 2-epimerase in permeabilisedEscherichia colicells
- (2015) Mingming Wang et al. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
- The Bacterial Ammonia Lyase EncP: A Tunable Biocatalyst for the Synthesis of Unnatural Amino Acids
- (2015) Nicholas J. Weise et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Biocatalytic One-Pot Synthesis of l-Tyrosine Derivatives from Monosubstituted Benzenes, Pyruvate, and Ammonia
- (2015) Alexander Dennig et al. ACS Catalysis
- A Regio- and Stereoselective ω-Transaminase/Monoamine Oxidase Cascade for the Synthesis of Chiral 2,5-Disubstituted Pyrrolidines
- (2014) Elaine O'Reilly et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Enzymatic dynamic kinetic resolution of racemic N-formyl- and N-carbamoyl-amino acids using immobilized l-N-carbamoylase and N-succinyl-amino acid racemase
- (2014) Pablo Soriano-Maldonado et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Efficient synthesis of l-tert-leucine through reductive amination using leucine dehydrogenase and formate dehydrogenase coexpressed in recombinant E. coli
- (2014) Weiming Liu et al. BIOCHEMICAL ENGINEERING JOURNAL
- Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase
- (2014) Nina Richter et al. CHEMICAL COMMUNICATIONS
- A Highly Efficient Asymmetric Synthesis of Vernakalant
- (2014) John Limanto et al. ORGANIC LETTERS
- Development of a Concise, Asymmetric Synthesis of a Smoothened Receptor (SMO) Inhibitor: Enzymatic Transamination of a 4-Piperidinone with Dynamic Kinetic Resolution
- (2014) Zhihui Peng et al. ORGANIC LETTERS
- On the development of new biocatalytic processes for practical pharmaceutical synthesis
- (2013) Gjalt W Huisman et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Engineering an Enantioselective Amine Oxidase for the Synthesis of Pharmaceutical Building Blocks and Alkaloid Natural Products
- (2013) Diego Ghislieri et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Biocatalytic retrosynthesis
- (2013) Nicholas J Turner et al. Nature Chemical Biology
- Transaminases Applied to the Synthesis of High Added-Value Enantiopure Amines
- (2013) Caroline E. Paul et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Amine(imine)diphosphine Iron Catalysts for Asymmetric Transfer Hydrogenation of Ketones and Imines
- (2013) W. Zuo et al. SCIENCE
- The combi-CLEA approach: enzymatic cascade synthesis of enantiomerically pure (S)-mandelic acid
- (2013) Andrzej Chmura et al. TETRAHEDRON-ASYMMETRY
- Multistep One-Pot Reactions Combining Biocatalysts and Chemical Catalysts for Asymmetric Synthesis
- (2013) Carl A. Denard et al. ACS Catalysis
- Discovery of a Novel (+)-γ-Lactamase from Bradyrhizobium japonicum USDA 6 by Rational Genome Mining
- (2012) Shaozhou Zhu et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Enzymes for the biocatalytic production of rare sugars
- (2012) Koen Beerens et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Efficient, Chemoenzymatic Process for Manufacture of the Boceprevir Bicyclic [3.1.0]Proline Intermediate Based on Amine Oxidase-Catalyzed Desymmetrization
- (2012) Tao Li et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Use of Enzymes in the Manufacture of Active Pharmaceutical Ingredients—A Science and Safety-Based Approach To Ensure Patient Safety and Drug Quality
- (2012) Andrew S. Wells et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Current Trends in Asymmetric Synthesis with Aldolases
- (2011) Pere Clapés et al. ADVANCED SYNTHESIS & CATALYSIS
- Industrial biotransformations in the synthesis of building blocks leading to enantiopure drugs
- (2011) D. Muñoz Solano et al. BIORESOURCE TECHNOLOGY
- Enzymatic reductions for the chemist
- (2011) Frank Hollmann et al. GREEN CHEMISTRY
- Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened
- (2011) Michael J. Munchhof et al. ACS Medicinal Chemistry Letters
- Biocatalysis: Synthesis of Key Intermediates for Development of Pharmaceuticals
- (2011) Ramesh N. Patel ACS Catalysis
- Enantioselective Biocatalytic Oxidative Desymmetrization of Substituted Pyrrolidines
- (2010) Valentin Köhler et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Rare sugar d-psicose improves insulin sensitivity and glucose tolerance in type 2 diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats
- (2010) Mohammad A Hossain et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one
- (2010) Upender Velaparthi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Simultaneous production of 1,3-dihydroxyacetone and xylitol from glycerol and xylose using a nanoparticle-supported multi-enzyme system with in situ cofactor regeneration
- (2010) Ying Zhang et al. BIORESOURCE TECHNOLOGY
- Enzymatic and whole cell catalysis: Finding new strategies for old processes
- (2010) Carla C.C.R. de Carvalho BIOTECHNOLOGY ADVANCES
- Biofuel production by in vitro synthetic enzymatic pathway biotransformation
- (2010) Y-H Percival Zhang et al. CURRENT OPINION IN BIOTECHNOLOGY
- Practical chiral alcohol manufacture using ketoreductases
- (2010) Gjalt W Huisman et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Recent progress in industrial biocatalysis
- (2010) Bettina M Nestl et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Optimizing non-natural protein function with directed evolution
- (2010) Eric M Brustad et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- New Trends in the Recycling of NAD(P)H for the Design of Sustainable Asymmetric Reductions Catalyzed by Dehydrogenases
- (2010) Angel Berenguer-Murcia et al. CURRENT ORGANIC CHEMISTRY
- The genusThermotoga: recent developments
- (2010) Andrew D. Frock et al. ENVIRONMENTAL TECHNOLOGY
- Enzyme-mediated oxidations for the chemist
- (2010) Frank Hollmann et al. GREEN CHEMISTRY
- Ultrahigh-throughput screening in drop-based microfluidics for directed evolution
- (2010) J. J. Agresti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture
- (2010) C. K. Savile et al. SCIENCE
- Microbial cells as catalysts for stereoselective red–ox reactions
- (2009) J.D. Carballeira et al. BIOTECHNOLOGY ADVANCES
- Biocatalysis in development of green pharmaceutical processes
- (2009) Junhua Tao et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Deracemisation of α-Chiral Primary Amines by a One-Pot, Two-Step Cascade Reaction Catalysed by ω-Transaminases
- (2009) Dominik Koszelewski et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- A green-by-design biocatalytic process for atorvastatin intermediate
- (2009) Steven K. Ma et al. GREEN CHEMISTRY
- Pyrococcus CH1, an obligate piezophilic hyperthermophile: extending the upper pressure-temperature limits for life
- (2009) Xiang Zeng et al. ISME Journal
- DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-l-methionine production in Pichia pastoris
- (2009) Hui Hu et al. JOURNAL OF BIOTECHNOLOGY
- Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists
- (2009) Paul J. Gilligan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Highly Efficient Asymmetric Synthesis of Sitagliptin
- (2009) Karl B. Hansen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Automated design of synthetic ribosome binding sites to control protein expression
- (2009) Howard M Salis et al. NATURE BIOTECHNOLOGY
- Enzymatic Desymmetrization of Dimethyl Cylcohex-4-ene-cis-1,2-dicarboxylate to (1S,2R)-2-(Methoxycarbonyl)cyclohex-4-ene-1-carboxylic Acid
- (2009) Animesh Goswami et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Preparation of Saxagliptin, a Novel DPP-IV Inhibitor
- (2009) Scott A. Savage et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Highly Enantioselective Reduction of a Small Heterocyclic Ketone: Biocatalytic Reduction of Tetrahydrothiophene-3-one to the Corresponding (R)-Alcohol
- (2009) Jack Liang et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Preparation of (R)-Amines from Racemic Amines with an (S)-Amine Transaminase fromBacillus megaterium
- (2008) Ronald L. Hanson et al. ADVANCED SYNTHESIS & CATALYSIS
- E factors, green chemistry and catalysis: an odyssey
- (2008) Roger A. Sheldon CHEMICAL COMMUNICATIONS
- Understanding enzyme immobilisation
- (2008) Ulf Hanefeld et al. CHEMICAL SOCIETY REVIEWS
- Synthesis of ethyl-(3R,5S)-dihydroxy-6-benzyloxyhexanoates via diastereo- and enantioselective microbial reduction: Cloning and expression of ketoreductase III from Acinetobacter sp. SC 13874
- (2008) Steven Goldberg et al. ENZYME AND MICROBIAL TECHNOLOGY
- The gastrointestinal microbiota as a site for the biotransformation of drugs
- (2008) Tiago Sousa et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Molecules derived from the extremes of life
- (2008) Zoe E. Wilson et al. NATURAL PRODUCT REPORTS
- Preparative Asymmetric Synthesis of 4,4-Dimethoxytetrahydro-2H-pyran-3-ol with a Ketone Reductase and in Situ Cofactor Recycling using Glucose Dehydrogenase
- (2008) Birgit Kosjek et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Enzymatic Preparation of ad-Amino Acid from a Racemic Amino Acid or Keto Acid
- (2008) Ronald L. Hanson et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Metabolic engineering of a thermophilic bacterium to produce ethanol at high yield
- (2008) A. J. Shaw et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthesis of chiral pharmaceutical intermediates by biocatalysis
- (2007) Ramesh N. Patel COORDINATION CHEMISTRY REVIEWS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started