Chemo-enzymatic synthesis and glycosidase inhibitory properties of DAB and LAB derivatives

The route to diabetes: Loss of complexity in the glycemic profile from health through the metabolic syndrome to type 2 diabetes

(2016) Manuel Varela   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Chemoenzymatic synthesis, structural study and biological activity of novel indolizidine and quinolizidine iminocyclitols

(2012) Livia Gómez et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

d-Fagomine lowers postprandial blood glucose and modulates bacterial adhesion

(2011) Livia Gómez et al.   BRITISH JOURNAL OF NUTRITION

Structure-guided redesign of d-fructose-6-phosphate aldolase from E. coli: remarkable activity and selectivity towards acceptor substrates by two-point mutation

(2011) Mariana Gutierrez et al.   CHEMICAL COMMUNICATIONS

A Versatile Approach toN-Alkylated 1,4-Dideoxy-1,4-imino-d-arabinitols and 1,4-Dideoxy-1,4-imino-l-xylitols

(2011) Guan-Nan Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly efficient aldol additions of DHA and DHAP to N-Cbz-amino aldehydes catalyzed by l-rhamnulose-1-phosphate and l-fuculose-1-phosphate aldolases in aqueous borate buffer

(2011) Xavier Garrabou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

One-pot tandem approach for the synthesis of benzimidazoles and benzothiazoles from alcohols

(2011) Goravanahalli M. Raghavendra et al.   TETRAHEDRON LETTERS

Correlation between pre-operative metabolic syndrome and persistent blood glucose elevation during cardiac surgery in non-diabetic patients

(2010) F. DONATELLI et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Synthesis of 1,4-dideoxy-1,4-iminoheptitol and 1,5-dideoxy-1,5-iminooctitols from d-xylose

(2010) Amit Kumar et al.   CARBOHYDRATE RESEARCH

Structure-Guided Minimalist Redesign of the L-Fuculose-1-Phosphate Aldolase Active Site: Expedient Synthesis of Novel Polyhydroxylated Pyrrolizidines and their Inhibitory Properties Against Glycosidases and Intestinal Disaccharidases

(2010) Xavier Garrabou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Discovery of new β-D-galactosidase inhibitors via pharmacophore modeling and QSAR analysis followed by in silico screening

(2010) Ahmed Mutanabbi Abdula et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Inhibitory effects of fucan sulfates on enzymatic hydrolysis of starch

(2010) MyoungLae Cho et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Parallel synthesis of natural product-like polyhydroxylated pyrrolidine and piperidine alkaloids

(2010) Yi-Fan Chang et al.   MOLECULAR DIVERSITY

Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars

(2010) Daniel Best et al.   TETRAHEDRON LETTERS

Mastering chiral substituted 2-oxopiperazines

(2010) Carmela De Risi et al.   TETRAHEDRON-ASYMMETRY

Asymmetric Self- and Cross-Aldol Reactions of Glycolaldehyde Catalyzed by D-Fructose-6-phosphate Aldolase

(2009) Xavier Garrabou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dihydroxyacetone Phosphate Aldolase Catalyzed Synthesis of Structurally Diverse Polyhydroxylated Pyrrolidine Derivatives and Evaluation of their Glycosidase Inhibitory Properties

(2009) Jordi Calveras et al.   CHEMISTRY-A EUROPEAN JOURNAL

D-Fructose-6-phosphate Aldolase in Organic Synthesis: Cascade Chemical-Enzymatic Preparation of Sugar-Related Polyhydroxylated Compounds

(2009) Alda Lisa Concia et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design, Synthesis, and Biological Evaluation of Enantiomeric β-N-Acetylhexosaminidase Inhibitors LABNAc and DABNAc as Potential Agents against Tay-Sachs and Sandhoff Disease

(2009) J. S. Shane Rountree et al.   ChemMedChem

Synthesis of novel pyrrolidine 3,4-diol derivatives as inhibitors of α-L-fucosidases

(2009) Elena Moreno-Clavijo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Starch digestibility in food matrix: a review

(2009) Jaspreet Singh et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Metabolic Syndrome and Insulin Resistance Significantly Correlate with Body Mass Index

(2008) Alireza Esteghamati et al.   ARCHIVES OF MEDICAL RESEARCH

Structural Analysis of Golgi α-Mannosidase II Inhibitors Identified from a Focused Glycosidase Inhibitor Screen†‡

(2008) Douglas A. Kuntz et al.   BIOCHEMISTRY

Synthesis and biological evaluation of a 2-aryl polyhydroxylated pyrrolidine alkaloid-based library

(2008) En-Lun Tsou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases

(2008) Yasuhiro Minami et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Functionalized pyrrolidine inhibitors of human type II α-mannosidases as anti-cancer agents: Optimizing the fit to the active site

(2008) Hélène Fiaux et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Glycomimetic Inhibitors of Mycobacterial Glycosyltransferases: Targeting the TB Cell Wall

(2008) Ricardo Lucas et al.   CHEMBIOCHEM

The Molecular Basis of Inhibition of Golgi α-Mannosidase II by Mannostatin A

(2008) Douglas A. Kuntz  et al.   CHEMBIOCHEM

Cardiovascular effects of acute hyperglycaemia: pathophysiological underpinnings

(2008) Antonio Ceriello   Diabetes & Vascular Disease Research

New alkaloid from the aerial parts of Codonopsis clematidea

(2008) Shunsuke Ishida et al.   Journal of Natural Medicines

Probing the Substrate Specificity of Golgi α-Mannosidase II by Use of Synthetic Oligosaccharides and a Catalytic Nucleophile Mutant

(2008) Wei Zhong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibitors of proteases and amide hydrolases that employ an α-ketoheterocycle as a key enabling functionality

(2007) Bruce E. Maryanoff et al.   BIOORGANIC & MEDICINAL CHEMISTRY