Specific Enzymatic Halogenation-From the Discovery of Halogenated Enzymes to Their Applications In Vitro and In Vivo

Crystal structure of halogenase PltA from the pyoluteorin biosynthetic pathway

(2015) Allan H. Pang et al.   JOURNAL OF STRUCTURAL BIOLOGY

Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes

(2015) Sarah A. Shepherd et al.   Chemical Science

Enzymatic Halogenation of Tryptophan on a Gram Scale

(2014) Marcel Frese et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Multitasking Vanadium-Dependent Chloroperoxidase as an Inspiration for the Chemical Synthesis of the Merochlorins

(2014) Stefan Diethelm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Localized Tolerance in the Substrate Specificity of the Fluorinase Enzyme enables “Last-Step”18F Fluorination of a RGD Peptide under Ambient Aqueous Conditions

(2014) Stephen Thompson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improving the Stability and Catalyst Lifetime of the Halogenase RebH By Directed Evolution

(2014) Catherine B. Poor et al.   CHEMBIOCHEM

Identification and Characterization of a Welwitindolinone Alkaloid Biosynthetic Gene Cluster in the Stigonematalean CyanobacteriumHapalosiphon welwitschii

(2014) Matthew L. Hillwig et al.   CHEMBIOCHEM

A Tryptophan 6-Halogenase and an Amidotransferase Are Involved in Thienodolin Biosynthesis

(2014) Daniela Milbredt et al.   CHEMBIOCHEM

A High-Throughput Assay for Arylamine Halogenation Based on a Peroxidase-Mediated Quinone-Amine Coupling with Applications in the Screening of Enzymatic Halogenations

(2014) Joseph Hosford et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biosynthesis of polybrominated aromatic organic compounds by marine bacteria

(2014) Vinayak Agarwal et al.   Nature Chemical Biology

A new family of iron-dependent halogenases acts on freestanding substrates

(2014) Matthew L Hillwig et al.   Nature Chemical Biology

Bis-chlorination of a hexapeptide–PCP conjugate by the halogenase involved in vancomycin biosynthesis

(2014) Patrick C. Schmartz et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Defects in the synthetic pathway prevent DIF-1 mediated stalk lineage specification cascade in the non-differentiating social amoeba, Acytostelium subglobosum

(2014) K. Mohri et al.   Biology Open

Regioselective Arene Halogenation using the FAD-Dependent Halogenase RebH

(2013) James T. Payne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens

(2013) Tao Zhu et al.   METABOLIC ENGINEERING

Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[18F]fluoro-5-deoxyribose as a novel tracer

(2013) Sergio Dall'Angelo et al.   NUCLEAR MEDICINE AND BIOLOGY

Diversification of Monoterpene Indole Alkaloid Analogs through Cross-Coupling

(2013) Weerawat Runguphan et al.   ORGANIC LETTERS

Specific chlorination of isoquinolines by a fungal flavin-dependent halogenase

(2012) Jia Zeng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Merochlorins A–D, Cyclic Meroterpenoid Antibiotics Biosynthesized in Divergent Pathways with Vanadium-Dependent Chloroperoxidases

(2012) Leonard Kaysser et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Changing the Regioselectivity of the Tryptophan 7-Halogenase PrnA by Site-Directed Mutagenesis

(2011) Alexander Lang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthetic Chlorination of the Piperazate Residue in Kutzneride Biosynthesis by KthP

(2011) Wei Jiang et al.   BIOCHEMISTRY

A Stereoselective Vanadium-Dependent Chloroperoxidase in Bacterial Antibiotic Biosynthesis

(2011) Peter Bernhardt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reengineering a Tryptophan Halogenase To Preferentially Chlorinate a Direct Alkaloid Precursor

(2011) Weslee S. Glenn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Novel Fungal Flavin-Dependent Halogenase for Natural Product Biosynthesis

(2010) Jia Zeng et al.   CHEMBIOCHEM

The Thioesterase Bhp is Involved in the Formation of β-Hydroxytyrosine during Balhimycin Biosynthesis in Amycolatopsis balhimycina

(2010) Sri Mulyani et al.   CHEMBIOCHEM

Chloramphenicol Biosynthesis: The Structure of CmlS, a Flavin-Dependent Halogenase Showing a Covalent Flavin–Aspartate Bond

(2010) Kateryna Podzelinska et al.   JOURNAL OF MOLECULAR BIOLOGY

Engineering Fluorometabolite Production: Fluorinase Expression inSalinispora tropicaYields Fluorosalinosporamide†

(2010) Alessandra S. Eustáquio et al.   JOURNAL OF NATURAL PRODUCTS

Gene Expression Enabling Synthetic Diversification of Natural Products: Chemogenetic Generation of Pacidamycin Analogs

(2010) Abhijeet Deb Roy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Integrating carbon–halogen bond formation into medicinal plant metabolism

(2010) Weerawat Runguphan et al.   NATURE

A flavin-dependent halogenase catalyzes the chlorination step in the biosynthesis of Dictyostelium differentiation-inducing factor 1

(2010) C. S. Neumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unusual Chemistry in the Biosynthesis of the Antibiotic Chondrochlorens

(2009) Shwan Rachid et al.   CHEMISTRY & BIOLOGY

Structural Insights into Regioselectivity in the Enzymatic Chlorination of Tryptophan

(2009) Xiaofeng Zhu et al.   JOURNAL OF MOLECULAR BIOLOGY

New Insights into the Mechanism of Enzymatic Chlorination of Tryptophan

(2008) Silvana Flecks et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genes for the Biosynthesis of the Fungal Polyketides Hypothemycin from Hypomyces subiculosus and Radicicol from Pochonia chlamydosporia

(2008) C. D. Reeves et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structure and Action of the Myxobacterial Chondrochloren Halogenase CndH: A New Variant of FAD-dependent Halogenases

(2008) Stefan Buedenbender et al.   JOURNAL OF MOLECULAR BIOLOGY

Tandem Action of the O2- and FADH2-Dependent Halogenases KtzQ and KtzR Produce 6,7-Dichlorotryptophan for Kutzneride Assembly

(2008) John R. Heemstra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY