Design of an in vitro biocatalytic cascade for the manufacture of islatravir

The importance of synthetic chemistry in the pharmaceutical industry

(2019) Kevin R. Campos et al.   SCIENCE

Extended Duration MK-8591-Eluting Implant as a Candidate for HIV Treatment and Prevention

(2018) Stephanie E. Barrett et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A generic platform for the immobilisation of engineered biocatalysts

(2018) Matthew P. Thompson et al.   TETRAHEDRON

Extending the application of biocatalysis to meet the challenges of drug development

(2018) Paul N. Devine et al.   Nature Reviews Chemistry

Enantioselective Synthesis of 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) via Enzymatic Desymmetrization

(2017) Mark McLaughlin et al.   ORGANIC LETTERS

Biocatalysis in the Pharmaceutical Industry: The Need for Speed

(2017) Matthew D. Truppo   ACS Medicinal Chemistry Letters

Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies

(2016) Markus Dick et al.   Chemical Science

Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

(2016) Scott P. France et al.   ACS Catalysis

Trading off stability against activity in extremophilic aldolases

(2016) Markus Dick et al.   Scientific Reports

Synthesis of EFdA via a Diastereoselective Aldol Reaction of a Protected 3-Keto Furanose

(2015) Kei Fukuyama et al.   ORGANIC LETTERS

Process Requirements of Galactose Oxidase Catalyzed Oxidation of Alcohols

(2015) Asbjørn Toftgaard Pedersen et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The nature of chemical innovation: new enzymes by evolution

(2015) Frances H. Arnold   QUARTERLY REVIEWS OF BIOPHYSICS

Structure–function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family

(2015) DeLu Yin et al.   Nature Communications

Concise Synthesis of the Anti-HIV Nucleoside EFdA

(2015) Masayuki KAGEYAMA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Engineering aldolases as biocatalysts

(2014) Claire L Windle et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms

(2014) Eleftherios Michailidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxoammonium Salt Oxidations of Alcohols in the Presence of Pyridine Bases

(2014) James M. Bobbitt et al.   JOURNAL OF ORGANIC CHEMISTRY

Bioretrosynthetic construction of a didanosine biosynthetic pathway

(2014) William R Birmingham et al.   Nature Chemical Biology

Biocatalytic retrosynthesis

(2013) Nicholas J Turner et al.   Nature Chemical Biology

Increasing Sequence Diversity with Flexible Backbone Protein Design: The Complete Redesign of a Protein Hydrophobic Core

(2012) Grant S. Murphy et al.   STRUCTURE

Use of Catalytic Fluoride under Neutral Conditions for Cleaving Silicon–Oxygen Bonds

(2011) Anthony M. DiLauro et al.   JOURNAL OF ORGANIC CHEMISTRY

Glycoprotein Labeling Using Engineered Variants of Galactose Oxidase Obtained by Directed Evolution

(2011) Julie B. Rannes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Total Synthesis of the Potent Anti-HIV Nucleoside EFdA

(2011) Masayuki Kageyama et al.   ORGANIC LETTERS

Development of a Scalable Synthesis of (S)-3-Fluoromethyl-γ-butyrolactone, Building Block for Carmegliptin’s Lactam Moiety

(2011) Jean-Michel Adam et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Bacillus cereusPhosphopentomutase Is an Alkaline Phosphatase Family Member That Exhibits an Altered Entry Point into the Catalytic Cycle

(2010) Timothy D. Panosian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Directed Evolution of Galactose Oxidase: Generation of Enantioselective Secondary Alcohol Oxidases

(2008) Franck Escalettes et al.   CHEMBIOCHEM