Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia

Bnip3 in mitophagy: novel insights and potential therapeutic target for diseases of secondary mitochondrial dysfunction

(2020) Anbo Gao et al.   CLINICA CHIMICA ACTA

Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains

(2020) Davide De Biase et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases

(2020) Qian Cai et al.   Cells

Impact of HMGB1, RAGE, and TLR4 in Alzheimer’s Disease (AD): From Risk Factors to Therapeutic Targeting

(2020) Yam Nath Paudel et al.   Cells

Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer’s disease patients

(2020) Carlos Pomilio et al.   GeroScience

Culprit or Bystander: Defective Mitophagy in Alzheimer’s Disease

(2020) Chenglong Xie et al.   Frontiers in Cell and Developmental Biology

Investigating Programmed Cell Death and Tumor Invasion in a Three-Dimensional (3D) Microfluidic Model of Glioblastoma

(2020) Ehsan Samiei et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alteration of the Dopamine Receptors’ Expression in the Cerebellum of the Lysosomal Acid Phosphatase 2 Mutant (Naked–Ataxia (NAX)) Mouse

(2020) Mehdi Mehdizadeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

(2020) Ethan R. Roy et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of neural stem cell‐derived extracellular vesicles on mitochondrial dysfunction, sirtuin 1 level and synaptic deficits in Alzheimer’s disease

(2020) Bo Li et al.   JOURNAL OF NEUROCHEMISTRY

The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer’s Disease

(2020) Courtney M. Kloske et al.   Frontiers in Immunology

ATM loss disrupts the autophagy-lysosomal pathway

(2020) Aifang Cheng et al.   Autophagy

Outside in: Roles of complement in autophagy

(2020) Ben C. King et al.   BRITISH JOURNAL OF PHARMACOLOGY

Alzheimer’s disease: new concepts on the role of autoimmunity and of NLRP3 inflammasome in the pathogenesis of the disease

(2020) Cinzia Severini et al.   Current Neuropharmacology

The role of innate immunity in Alzheimer's disease

(2020) Hannah E. Ennerfelt et al.   IMMUNOLOGICAL REVIEWS

Microglia: Agents of the CNS Pro-Inflammatory Response

(2020) José A. Rodríguez-Gómez et al.   Cells

Mitochondria-Associated ER Membranes – The Origin Site of Autophagy

(2020) Ming Yang et al.   Frontiers in Cell and Developmental Biology

BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation

(2020) Simone C. da Silva Rosa et al.   Autophagy

Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer’s Disease

(2020) Sharmeelavathi Krishnan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emendation of autophagic dysfuction in neurological disorders: a potential therapeutic target

(2020) Shivani R. Sainani et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer’s Disease

(2020) Yidan Zhang et al.   NEUROCHEMICAL RESEARCH

Indirect regulation of HMGB1 release by gasdermin D

(2020) Allen Volchuk et al.   Nature Communications

Mitochondrial Dysfunction and Alzheimer’s Disease: Role of Microglia

(2020) Ishan Agrawal et al.   Frontiers in Aging Neuroscience

Role of Toll Like Receptor 4 in Alzheimer’s Disease

(2020) Maria Calvo-Rodriguez et al.   Frontiers in Immunology

Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells

(2020) Sanaz Dastghaib et al.   Cells

Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice

(2020) Long Yang et al.   Communications Biology

Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases

(2020) An-Guo Wu et al.   AGEING RESEARCH REVIEWS

Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels

(2020) Cristina Sanfilippo et al.   BRAIN RESEARCH

BCL2L13: physiological and pathological meanings

(2020) Fei Meng et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The nuclear factor kappa B (NF-κB) signaling pathway is involved in ammonia-induced mitochondrial dysfunction

(2020) Aida Adlimoghaddam et al.   MITOCHONDRION

Beclin1‐driven autophagy modulates the inflammatory response of microglia via NLRP3

(2019) Judith Houtman et al.   EMBO JOURNAL

The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease

(2019) A. Raquel Esteves et al.   MOLECULAR NEUROBIOLOGY

Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy

(2019) Erin E. Congdon et al.   EBioMedicine

Ataxia‐telangiectasia: A review of clinical features and molecular pathology

(2019) Parisa Amirifar et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons

(2019) Pierre Theurey et al.   AGING CELL

Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics

(2019) Annadurai Thangaraj et al.   Autophagy

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities

(2019) Judit M. Perez Ortiz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanisms and roles of mitophagy in neurodegenerative diseases

(2019) Yan Wang et al.   CNS Neuroscience & Therapeutics

Autophagy in Alzheimer's disease and promising modulatory effects of herbal medicine

(2019) Qiang Zeng et al.   EXPERIMENTAL GERONTOLOGY

Two distinct mechanisms target the autophagy-related E3 complex to the pre-autophagosomal structure

(2019) Kumi Harada et al.   eLife

S100 Proteins in Alzheimer’s Disease

(2019) Joana S. Cristóvão et al.   Frontiers in Neuroscience

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

(2019) P. Hemachandra Reddy et al.   Cells

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

Global Metabolic Shifts in Age and Alzheimer’s Disease Mouse Brains Pivot at NAD +/NADH Redox Sites

(2019) Yue Dong et al.   JOURNAL OF ALZHEIMERS DISEASE

The mitophagy receptor Bcl-2–like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice

(2019) Makoto Fujiwara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regional hypometabolism in the 3xTg mouse model of Alzheimer's disease

(2019) Aida Adlimoghaddam et al.   NEUROBIOLOGY OF DISEASE

Mitophagy and Neuroprotection

(2019) Guofeng Lou et al.   TRENDS IN MOLECULAR MEDICINE

Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APPswe/PS1ΔE9 Transgenic Mice

(2019) Christa Løth Myhre et al.   Frontiers in Cellular Neuroscience

Mechanisms and disease implications of sirtuin-mediated autophagic regulation

(2019) In Hye Lee   EXPERIMENTAL AND MOLECULAR MEDICINE

Simvastatin Increases Temozolomide‐induced Cell Death by Targeting the Fusion of Autophagosomes and Lysosomes

(2019) Shahla Shojaei et al.   FEBS Journal

PINK1 import regulation at a crossroad of mitochondrial fate: the molecular mechanisms of PINK1 import

(2019) Shiori Sekine   JOURNAL OF BIOCHEMISTRY

Activation of BNIP3-mediated mitophagy protects against renal ischemia–reperfusion injury

(2019) Chengyuan Tang et al.   Cell Death & Disease

Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects

(2019) Pascale Barbier et al.   Frontiers in Aging Neuroscience

Mitochondria as Potential Targets in Alzheimer Disease Therapy: An Update

(2019) Giovanna Cenini et al.   Frontiers in Pharmacology

Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition

(2019) Arya Emami et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

(2019) Yang Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease

(2019) Sofie Lautrup et al.   NEUROCHEMISTRY INTERNATIONAL

SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases

(2019) Hao Meng et al.   Frontiers in Aging Neuroscience

Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis

(2019) Anushka Chakravorty et al.   Frontiers in Aging Neuroscience

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

(2019) Henna Konttinen et al.   Stem Cell Reports

What Do Microglia Really Do in Healthy Adult Brain?

(2019) Marcus Augusto-Oliveira et al.   Cells

Pharmacologic Inhibition of Vacuolar H+ATPase Attenuates Features of Severe Asthma in Mice

(2019) Kielan D. McAlinden et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Autophagy and synaptic plasticity: epigenetic regulation

(2019) Jee-Yeon Hwang et al.   CURRENT OPINION IN NEUROBIOLOGY

CXCL12 promotes proliferation of radial glia like cells after traumatic brain injury in rats

(2019) Weifeng Mao et al.   CYTOKINE

URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

(2019) Shao-Hua Su et al.   Journal of Neuroinflammation

Alzheimer’s Disease and Parkinson’s Disease: A Nutritional Toxicology Perspective of the Impact of Oxidative Stress, Mitochondrial Dysfunction, Nutrigenomics and Environmental Chemicals

(2019) Aayushi Agnihotri et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

New perspectives in cancer biology from a study of canonical and non-canonical functions of base excision repair proteins with a focus on early steps

(2019) Matilde Clarissa Malfatti et al.   MUTAGENESIS

Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment

(2019) Massimiliano Castellazzi et al.   Scientific Reports

The role of autophagy in the regulation of yeast life span

(2018) Jessica K. Tyler et al.   Annals of the New York Academy of Sciences

NAD+ Deficiency Is a Common Central Pathological Factor of a Number of Diseases and Aging: Mechanisms and Therapeutic Implications

(2018) Mingchao Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

CXCR4-mediated signaling regulates autophagy and influences acute myeloid leukemia cell survival and drug resistance

(2018) Xiaojia Hu et al.   CANCER LETTERS

Mitochonic acid 5 activates the MAPK–ERK–yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy

(2018) Qingyun Lei et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer’s disease

(2018) P Hemachandra Reddy et al.   HUMAN MOLECULAR GENETICS

Mitochondrial Function, Dynamics, and Permeability Transition: A Complex Love Triangle as A Possible Target for the Treatment of Brain Aging and Alzheimer’s Disease

(2018) Carola Stockburger et al.   JOURNAL OF ALZHEIMERS DISEASE

Future Trends and the Economic Burden of Dementia in Manitoba: Comparison with the Rest of Canada and the World

(2018) Aida Adlimoghaddam et al.   NEUROEPIDEMIOLOGY

NAD+supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

(2018) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH

(2018) Hari Prasad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease

(2018) Estela Area-Gomez et al.   Cell Death & Disease

TREM2-Dependent Effects on Microglia in Alzheimer’s Disease

(2018) Yingyue Zhou et al.   Frontiers in Aging Neuroscience

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

(2018) Md. Sahab Uddin et al.   Frontiers in Aging Neuroscience

Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration

(2018) María J. Pérez et al.   Frontiers in Neuroscience

The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease

(2018) Ying Cheng et al.   Frontiers in Neuroscience

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Mitochondria: An Organelle of Bacterial Origin Controlling Inflammation

(2018) Alain Meyer et al.   Frontiers in Immunology

A review of clinical treatment considerations of donepezil in severe Alzheimer's disease

(2018) Aida Adlimoghaddam et al.   CNS Neuroscience & Therapeutics

Increased expression of toll-like receptor 3, an anti-viral signaling molecule, and related genes in Alzheimer's disease brains

(2018) Douglas G. Walker et al.   EXPERIMENTAL NEUROLOGY

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling

(2018) Cheong-Meng Chong et al.   Cell Death & Disease

S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury as a Precursor State for Alzheimer’s Disease

(2018) Chao Wang et al.   Scientific Reports

IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis

(2018) Ada Ng et al.   Scientific Reports

HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction

(2018) Yam Nath Paudel et al.   Frontiers in Neuroscience

Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice

(2018) Francesca Vitale et al.   Acta Neuropathologica Communications

The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis

(2018) Shashank Rai et al.   Autophagy

TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia

(2018) Ji-Won Lee et al.   Autophagy

Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria

(2018) Nadia Cummins et al.   EMBO JOURNAL

Autophagic dysfunction in Alzheimer’s disease: Cellular and molecular mechanistic approaches to halt Alzheimer’s pathogenesis

(2018) Md. Sahab Uddin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

New insights into the role of TREM2 in Alzheimer’s disease

(2018) Maud Gratuze et al.   Molecular Neurodegeneration

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

The progression of HMGB1-induced autophagy in cancer biology

(2018) Tianwei Xu et al.   OncoTargets and Therapy

TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism

(2018) Honghua Zheng et al.   Frontiers in Aging Neuroscience

A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration

(2018) Meng-meng Jin et al.   Frontiers in Aging Neuroscience

HMGB1 gene silencing inhibits neuroinflammation via down-regulation of NF-κB signaling in primary hippocampal neurons induced by Aβ25–35

(2018) Ke Nan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells

(2017) Li Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging

(2017) Ainhoa Plaza-Zabala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer’s Disease

(2017) Lan Guo et al.   JOURNAL OF ALZHEIMERS DISEASE

Proteomics Analysis of Blood Serums from Alzheimer’s Disease Patients Using iTRAQ Labeling Technology

(2017) Liming Shen et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Microglia in Alzheimer’s disease

(2017) Heela Sarlus et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of autophagy in pro-inflammatory responses of microglia activation via mitochondrial reactive oxygen species in vitro

(2017) Junli Ye et al.   JOURNAL OF NEUROCHEMISTRY

Genome instability in Alzheimer disease

(2017) Yujun Hou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Inflammasome and Autophagy Regulation: A Two-way Street

(2017) Qian Sun et al.   MOLECULAR MEDICINE

Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury

(2017) Anthony R. Anzell et al.   MOLECULAR NEUROBIOLOGY

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

(2017) Shane M. Bemiller et al.   Molecular Neurodegeneration

Caspase-3-dependent cleavage of Akt modulates tau phosphorylation via GSK3β kinase: implications for Alzheimer’s disease

(2017) J Chu et al.   MOLECULAR PSYCHIATRY

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Autophagy, mitophagy and apoptotic gene changes in the hippocampal CA1 area in a rat ischemic model of Alzheimer’s disease

(2017) Marzena Ułamek-Kozioł et al.   Pharmacological Reports

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

(2017) Cheryl E. G. Leyns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil-derived mitochondrial DNA promotes receptor activator of nuclear factor κB and its ligand signalling in rheumatoid arthritis

(2017) Anne Contis et al.   RHEUMATOLOGY

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

ApoE Influences the Blood-Brain Barrier Through the NF-κB/MMP-9 Pathway After Traumatic Brain Injury

(2017) Zhipeng Teng et al.   Scientific Reports

The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer

(2017) Jie Yin et al.   Journal of Immunology Research

A NH2 Tau Fragment Targets Neuronal Mitochondria at AD Synapses: Possible Implications for Neurodegeneration

(2017) Giuseppina Amadoro et al.   JOURNAL OF ALZHEIMERS DISEASE

Autophagy down regulates pro-inflammatory mediators in BV2 microglial cells and rescues both LPS and alpha-synuclein induced neuronal cell death

(2017) Claudio Bussi et al.   Scientific Reports

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation

(2016) Ana S. Falcão et al.   ACS Chemical Neuroscience

Lysosomal cathepsins and their regulation in aging and neurodegeneration

(2016) Veronika Stoka et al.   AGEING RESEARCH REVIEWS

Mitochondrial DNA mutations increase in early stage Alzheimer disease and are inconsistent with oxidative damage

(2016) Jake G. Hoekstra et al.   ANNALS OF NEUROLOGY

Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis

(2016) Dah Ihm Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Effects of CX3CR1 and Fractalkine Chemokines in Amyloid Beta Clearance and p-Tau Accumulation in Alzheimer,s Disease (AD) Rodent Models: Is Fractalkine a Systemic Biomarker for AD?

(2016) José Joaquín Merino et al.   Current Alzheimer Research

The role of Resveratrol-induced mitophagy/autophagy in peritoneal mesothelial cells inflammatory injury via NLRP3 inflammasome activation triggered by mitochondrial ROS

(2016) Jun Wu et al.   EXPERIMENTAL CELL RESEARCH

Apoptosis, autophagy and unfolded protein response pathways in Arbovirus replication and pathogenesis

(2016) Mahmoud Iranpour et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Interactions between Autophagy and Inhibitory Cytokines

(2016) Tian-tian Wu et al.   International Journal of Biological Sciences

Impaired Autophagy in APOE4 Astrocytes

(2016) Shira Simonovitch et al.   JOURNAL OF ALZHEIMERS DISEASE

Stimulation of TLR4 Attenuates Alzheimer’s Disease–Related Symptoms and Pathology in Tau-Transgenic Mice

(2016) Yiren Qin et al.   JOURNAL OF IMMUNOLOGY

Regulation of autophagy by Beclin 1 in the heart

(2016) Yasuhiro Maejima et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regulation of Autophagy By Signaling Through the Atg1/ULK1 Complex

(2016) Daniel Papinski et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanisms of Selective Autophagy

(2016) Gabriele Zaffagnini et al.   JOURNAL OF MOLECULAR BIOLOGY

Defective Phagocytic Corpse Processing Results in Neurodegeneration and Can Be Rescued by TORC1 Activation

(2016) J. I. Etchegaray et al.   JOURNAL OF NEUROSCIENCE

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

(2016) Taylor R. Jay et al.   JOURNAL OF NEUROSCIENCE

Aggregation of the Inflammatory S100A8 Precedes Aβ Plaque Formation in Transgenic APP Mice: Positive Feedback for S100A8 and Aβ Productions

(2016) Maria Lodeiro et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice

(2016) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

Caspase-3-Dependent Proteolytic Cleavage of Tau Causes Neurofibrillary Tangles and Results in Cognitive Impairment During Normal Aging

(2016) John C. Means et al.   NEUROCHEMICAL RESEARCH

CXCL12/CXCR4 Axis Improves Migration of Neuroblasts Along Corpus Callosum by Stimulating MMP-2 Secretion After Traumatic Brain Injury in Rats

(2016) Weifeng Mao et al.   NEUROCHEMICAL RESEARCH

The role of autophagy in modulation of neuroinflammation in microglia

(2016) P. Su et al.   NEUROSCIENCE

Alterations in Mitochondrial Quality Control in Alzheimer’s Disease

(2016) Qian Cai et al.   Frontiers in Cellular Neuroscience

Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis

(2016) Xiaoting Wu et al.   Nature Communications

Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins

(2016) Xia-Chun Li et al.   Scientific Reports

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

(2016) Seung-Hye Lee et al.   Cell Reports

CX3CL1/CX3CR1 in Alzheimer’s Disease: A Target for Neuroprotection

(2016) Peiqing Chen et al.   Biomed Research International

Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1

(2016) Sabine Sellner et al.   Acta Neuropathologica Communications

HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease

(2016) Kyota Fujita et al.   Scientific Reports

Calcium and mitochondria in the regulation of cell death

(2015) Sten Orrenius et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Endosymbiosis and Eukaryotic Cell Evolution

(2015) John M. Archibald   CURRENT BIOLOGY

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells

(2015) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury

(2015) Heidi Y. Febinger et al.   Journal of Neuroinflammation

Mechanisms of Mitochondrial Dysfunction in Alzheimer’s Disease

(2015) Chris Cadonic et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Genomic integrity and the ageing brain

(2015) Hei-man Chow et al.   NATURE REVIEWS NEUROSCIENCE

Abnormal Glucose Metabolism in Alzheimer’s Disease: Relation to Autophagy/Mitophagy and Therapeutic Approaches

(2015) Kalpita Banerjee et al.   NEUROCHEMICAL RESEARCH

Modulation of Innate Immune Signalling by Lipid-Mediated MAVS Transmembrane Domain Oligomerization

(2015) Luis Nobre et al.   PLoS One

Receptor for advanced glycation end-products in neurodegenerative diseases

(2015) Judyta Juranek et al.   REVIEWS IN THE NEUROSCIENCES

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium

(2015) Sung Wook Park et al.   Oncotarget

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

(2015) Audrey Gustin et al.   PLoS One

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

Brain PET in the Diagnosis of Alzheimer’s Disease

(2014) Charles Marcus et al.   CLINICAL NUCLEAR MEDICINE

Autophagy and Heart Disease: Implications for Cardiac Ischemia- Reperfusion Damage

(2014) S. Ghavami et al.   CURRENT MOLECULAR MEDICINE

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

(2014) V. A. Polito et al.   EMBO Molecular Medicine

Fibrillar Amyloid-  Peptides Activate Microglia via TLR2: Implications for Alzheimer's Disease

(2014) M. Jana et al.   JOURNAL OF IMMUNOLOGY

Endothelial PINK1 Mediates the Protective Effects of NLRP3 Deficiency during Lethal Oxidant Injury

(2014) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice

(2014) Arne Ittner et al.   JOURNAL OF NEUROCHEMISTRY

Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice

(2014) Arnaud François et al.   Journal of Neuroinflammation

Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

(2014) Deborah Doens et al.   Journal of Neuroinflammation

Phagocytosis of Microglia in the Central Nervous System Diseases

(2014) Ruying Fu et al.   MOLECULAR NEUROBIOLOGY

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

(2014) Jason D Ulrich et al.   Molecular Neurodegeneration

Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy

(2014) Pasquale Picone et al.   Oxidative Medicine and Cellular Longevity

The Receptor for Advanced Glycation End-Products (RAGE) Is Only Present in Mammals, and Belongs to a Family of Cell Adhesion Molecules (CAMs)

(2014) Luca Sessa et al.   PLoS One

The worldwide economic impact of dementia 2010

(2013) Anders Wimo et al.   Alzheimers & Dementia

Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

(2013) Valasani Koteswara Rao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

Changes in tau phosphorylation in hibernating rodents

(2013) Gonzalo León-Espinosa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Metabolic features of the cell danger response

(2013) Robert K. Naviaux   MITOCHONDRION

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Blockage of CR1 prevents activation of rodent microglia

(2013) Helen Crehan et al.   NEUROBIOLOGY OF DISEASE

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

(2013) Kurt M. Lucin et al.   NEURON

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

(2013) Amanda L. Wright et al.   PLoS One

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

Cerebrovascular Effects of Apolipoprotein E

(2013) Berislav V. Zlokovic   JAMA Neurology

Eat-Me: Autophagy, Phagocytosis, and Reactive Oxygen Species Signaling

(2012) Philip J. Vernon et al.   ANTIOXIDANTS & REDOX SIGNALING

The Role of PGC-1α in the Pathogenesis of Neurodegenerative Disorders

(2012) Krisztina Rona-Voros et al.   CURRENT DRUG TARGETS

Toll-like receptor 2 ligands promote microglial cell death by inducing autophagy

(2012) Daniela S. Arroyo et al.   FASEB JOURNAL

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Mrp14 Deficiency Ameliorates Amyloid   Burden by Increasing Microglial Phagocytosis and Modulation of Amyloid Precursor Protein Processing

(2012) M. P. Kummer et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy

(2012) Chinatsu Otomo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Role of S100a9 in the Pathogenesis of Alzheimer’s Disease: The Therapeutic Effects of S100a9 Knockdown or Knockout

(2012) Keun-A Chang et al.   Neurodegenerative Diseases

Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo

(2012) Brian DuBoff et al.   NEURON

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nuclear and Mitochondrial DNA Repair in Selected Eukaryotic Aging Model Systems

(2012) Ricardo Gredilla et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial dynamics in neurodegeneration

(2012) Kie Itoh et al.   TRENDS IN CELL BIOLOGY

Influence of Alzheimer Disease Family History and Genetic Risk on Cognitive Performance in Healthy Middle-Aged and Older People

(2011) Markus Donix et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

(2011) Katherine J. Kopeikina et al.   AMERICAN JOURNAL OF PATHOLOGY

SnapShot: Mitochondrial Quality Control

(2011) Douglas R. Green et al.   CELL

S100B Protein Stimulates Microglia Migration via RAGE-dependent Up-regulation of Chemokine Expression and Release

(2011) Roberta Bianchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

(2011) Seo-Hyun Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

(2011) Min Song et al.   Journal of Neuroinflammation

The Role of Microglia in the Healthy Brain

(2011) M.-E. Tremblay et al.   JOURNAL OF NEUROSCIENCE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

(2011) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of BCL2 family members in the regulation of human oocyte and early embryo survival and death: gene expression and beyond

(2011) Imene Boumela et al.   REPRODUCTION

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

(2011) C J Garwood et al.   Cell Death & Disease

HMGB1 release by inflammasomes

(2011) Lieselotte Vande Walle et al.   Virulence

Impairing the Mitochondrial Fission and Fusion Balance: A New Mechanism of Neurodegeneration

(2010) Andrew B. Knott et al.   Annals of the New York Academy of Sciences

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Serum levels of S100B and NSE proteins in Alzheimer's disease patients

(2010) Márcia L Chaves et al.   Journal of Neuroinflammation

Microglial Receptor for Advanced Glycation End Product-Dependent Signal Pathway Drives  -Amyloid-Induced Synaptic Depression and Long-Term Depression Impairment in Entorhinal Cortex

(2010) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

(2010) Dimitrios Kapogiannis et al.   LANCET NEUROLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Current Views of Toll-Like Receptor Signaling Pathways

(2010) Masahiro Yamamoto et al.   Gastroenterology Research and Practice

Mitochondrial Peptides Are Potent Immune Activators That Activate Human Neutrophils Via FPR-1

(2010) Mustafa Raoof et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

(2009) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival

(2009) R Kang et al.   CELL DEATH AND DIFFERENTIATION

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3

(2009) Saeid Ghavami et al.   CELL RESEARCH

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

(2009) Céline Castanier et al.   EMBO REPORTS

RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

(2009) Fang Fang et al.   FASEB JOURNAL

The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA

(2009) Bo Zhong et al.   IMMUNITY

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Involvement of Fc Receptors in Disorders of the Central Nervous System

(2009) Eitan Okun et al.   NEUROMOLECULAR MEDICINE

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy: A lysosomal degradation pathway with a central role in health and disease

(2008) Eeva-Liisa Eskelinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Frequency and Case Identification of Dementia with Lewy Bodies Using the Revised Consensus Criteria

(2008) Dag Aarsland et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Toll-like receptors control autophagy

(2008) Mónica A Delgado et al.   EMBO JOURNAL

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

(2008) Stefanie Frank et al.   GLIA

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

S100B/RAGE-dependent activation of microglia via NF-κB and AP-1

(2008) Roberta Bianchi et al.   NEUROBIOLOGY OF AGING

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia

(2008) L. M. Ittner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA