The role of autophagy in the regulation of yeast life span

Pleiotropic responses to methionine restriction

(2017) Gene P. Ables et al.   EXPERIMENTAL GERONTOLOGY

Caloric restriction alleviates alpha-synuclein toxicity in aged yeast cells by controlling the opposite roles of Tor1 and Sir2 on autophagy

(2017) Ana Guedes et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability

(2017) Tobias Wilms et al.   PLoS Genetics

Pexophagy in yeasts

(2016) Masahide Oku et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion

(2016) Ying Cai et al.   Oncotarget

Selective sorting and destruction of mitochondrial membrane proteins in aged yeast

(2016) Adam L Hughes et al.   eLife

Feedback regulation between autophagy and PKA

(2015) Francisco Torres-Quiroz et al.   Autophagy

Phosphatidylethanolamine positively regulates autophagy and longevity

(2015) P Rockenfeller et al.   CELL DEATH AND DIFFERENTIATION

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

(2015) Mark A. McCormick et al.   Cell Metabolism

Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells

(2015) Vitor Teixeira et al.   CELLULAR SIGNALLING

A yeast model of the Parkinson׳s disease-associated protein Parkin

(2015) Clara Pereira et al.   EXPERIMENTAL CELL RESEARCH

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Systematic identification of signal integration by protein kinase A

(2015) Marie Filteau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput analysis of yeast replicative aging using a microfluidic system

(2015) Myeong Chan Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome Scale Screen for Mutants with Delayed Exit from Mitosis: Ire1-Independent Induction of Autophagy Integrates ER Homeostasis into Mitotic Lifespan

(2015) Ata Ghavidel et al.   PLoS Genetics

Interplay among Gcn5, Sch9 and Mitochondria during Chronological Aging of Wine Yeast Is Dependent on Growth Conditions

(2015) Cecilia Picazo et al.   PLoS One

Methionine restriction slows down senescence in human diploid fibroblasts

(2014) Rafał Kozieł et al.   AGING CELL

A lifespan-extending form of autophagy employs the vacuole-vacuole fusion machinery

(2014) Fusheng Tang et al.   Autophagy

Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan

(2014) Tobias Eisenberg et al.   Cell Metabolism

Methionine Restriction Activates the Retrograde Response and Confers Both Stress Tolerance and Lifespan Extension to Yeast, Mouse and Human Cells

(2014) Jay E. Johnson et al.   PLoS One

Calorie restriction does not elicit a robust extension of replicative lifespan in Saccharomyces cerevisiae

(2014) D. H. E. W. Huberts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

(2014) Byung Cheon Lee et al.   Nature Communications

High-Resolution Profiling of Stationary-Phase Survival Reveals Yeast Longevity Factors and Their Genetic Interactions

(2014) Erika Garay et al.   PLoS Genetics

Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification

(2014) Christoph Ruckenstuhl et al.   PLoS Genetics

Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast

(2013) John P. Aris et al.   EXPERIMENTAL GERONTOLOGY

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Independent and Additive Effects of Glutamic Acid and Methionine on Yeast Longevity

(2013) Ziyun Wu et al.   PLoS One

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy

(2012) Belém Sampaio-Marques et al.   Autophagy

pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast

(2012) Christopher Murakami et al.   CELL CYCLE

Nutritional Control of Growth and Development in Yeast

(2012) J. R. Broach   GENETICS

Wine yeast sirtuins and Gcn5p control aging and metabolism in a natural growth medium

(2012) Helena Orozco et al.   MECHANISMS OF AGEING AND DEVELOPMENT

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

(2012) Adam L. Hughes et al.   NATURE

Function and Molecular Mechanism of Acetylation in Autophagy Regulation

(2012) C. Yi et al.   SCIENCE

An Overview of Autophagy and Yeast Pseudohyphal Growth: Integration of Signaling Pathways during Nitrogen Stress

(2012) Qingxuan Song et al.   Cells

Acetylation of Yeast AMPK Controls Intrinsic Aging Independently of Caloric Restriction

(2011) Jin-Ying Lu et al.   CELL

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy

(2011) Vinay Choubey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

(2011) Eugenia Morselli et al.   JOURNAL OF CELL BIOLOGY

Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness

(2011) Anabela C. Ferretti et al.   MOLECULAR GENETICS AND METABOLISM

Resveratrol and rapamycin: are they anti-aging drugs?

(2010) Matt Kaeberlein   BIOESSAYS

A molecular mechanism of chronological aging in yeast

(2010) Christopher R. Burtner et al.   CELL CYCLE

Impaired quality control of mitochondria: Aging from a new perspective

(2010) Tobias A. Weber et al.   EXPERIMENTAL GERONTOLOGY

Lessons on longevity from budding yeast

(2010) Matt Kaeberlein   NATURE

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation

(2010) Paola Fabrizio et al.   PLoS Genetics

A Microarray-Based Genetic Screen for Yeast Chronological Aging Factors

(2010) Mirela Matecic et al.   PLoS Genetics

Autophagy and amino acid homeostasis are required for chronological longevity inSaccharomyces cerevisiae

(2009) Ashley L. Alvers et al.   AGING CELL

Regulation of autophagy in yeast Saccharomyces cerevisiae

(2009) Eduardo Cebollero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

(2009) Koji Okamoto et al.   DEVELOPMENTAL CELL

Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy

(2009) Y. Kamada et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy

(2009) J. S. Stephan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A network biology approach to aging in yeast

(2009) D. R. Lorenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension

(2009) Min Wei et al.   PLoS Genetics

Multiple pathways of mitochondrial-nuclear communication in yeast: Intergenomic signaling involves ABF1 and affects a different set of genes than retrograde regulation

(2008) Dong Kyun Woo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Genome-wide expression analysis reveals TORC1-dependent and -independent functions of Sch9

(2008) Bart Smets et al.   FEMS YEAST RESEARCH