Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

Hypoxia enhances lipid uptake in macrophages: Role of the scavenger receptors Lox1, SRA, and CD36

(2013) Margot Crucet et al.   ATHEROSCLEROSIS

FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease

(2013) Tae-In Kam et al.   JOURNAL OF CLINICAL INVESTIGATION

Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology

(2013) Maria I Fonseca et al.   Journal of Neuroinflammation

Immunotherapy for Alzheimer’s disease: hoops and hurdles

(2013) Cynthia A Lemere   Molecular Neurodegeneration

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology

(2013) J.-P. Michaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunoglobulin G Fc receptor deficiency prevents Alzheimer-like pathology and cognitive impairment in mice

(2012) P. Fernandez-Vizarra et al.   BRAIN

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

(2012) Hongjun Fu et al.   GLIA

TLR4 polymorphisms and disease susceptibility

(2012) Mamoona Noreen et al.   INFLAMMATION RESEARCH

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer’s disease

(2012) Jonny Daborg et al.   JOURNAL OF NEURAL TRANSMISSION

Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells

(2012) Alexander Slowik et al.   Molecular Neurodegeneration

Aβ Potentiates Inflammatory Activation of Glial Cells Induced by Scavenger Receptor Ligands and Inflammatory Mediators in Culture

(2012) P. Murgas et al.   NEUROTOXICITY RESEARCH

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

RAGE Expression in Human T Cells: A Link between Environmental Factors and Adaptive Immune Responses

(2012) Eitan M. Akirav et al.   PLoS One

Emerging role of Toll-like receptors in the control of pain and itch

(2012) Tong Liu et al.   Neuroscience Bulletin

The Interaction of Amyloid β and the Receptor for Advanced Glycation Endproducts Induces Matrix Metalloproteinase-2 Expression in Brain Endothelial Cells

(2011) Huan Du et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

(2011) Etsushi Kuroda et al.   IMMUNITY

Complement receptor 1 (CR1) and Alzheimer's disease

(2011) Helen Crehan et al.   IMMUNOBIOLOGY

Deregulated inflammasome signaling in disease

(2011) Mohamed Lamkanfi et al.   IMMUNOLOGICAL REVIEWS

Scavenger receptors: Implications in atherothrombotic disorders

(2011) Mohammad Z. Ashraf et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A High Content Drug Screen Identifies Ursolic Acid as an Inhibitor of Amyloid β Protein Interactions with Its Receptor CD36

(2011) Kim Wilkinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis

(2011) Benedikt J Braun et al.   Journal of Neuroinflammation

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

(2011) Min Song et al.   Journal of Neuroinflammation

Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity

(2011) Dan Zhang et al.   Journal of Neuroinflammation

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

(2011) N Brouwers et al.   MOLECULAR PSYCHIATRY

Mechanism mediating oligomeric Aβ clearance by naïve primary microglia

(2011) Cheng-Ning Yang et al.   NEUROBIOLOGY OF DISEASE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

PF-04494700, an Oral Inhibitor of Receptor for Advanced Glycation End Products (RAGE), in Alzheimer Disease

(2010) Marwan N. Sabbagh et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Genetic Variation and Neuroimaging Measures in Alzheimer Disease

(2010) Alessandro Biffi   ARCHIVES OF NEUROLOGY

RAGE: A Multi-Ligand Receptor Unveiling Novel Insights in Health and Disease

(2010) P. Alexiou et al.   CURRENT MEDICINAL CHEMISTRY

Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides

(2010) Nada Choucair-Jaafar et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

(2010) Jason J. Corneveaux et al.   HUMAN MOLECULAR GENETICS

Immunotherapy for Alzheimer’s disease

(2010) D. Morgan   JOURNAL OF INTERNAL MEDICINE

Endogenous ligands of TLR2 and TLR4: agonists or assistants?

(2010) Clett Erridge   JOURNAL OF LEUKOCYTE BIOLOGY

Microglial C5aR (CD88) expression correlates with amyloid-β deposition in murine models of Alzheimer’s disease

(2010) Rahasson R. Ager et al.   JOURNAL OF NEUROCHEMISTRY

Microglial Receptor for Advanced Glycation End Product-Dependent Signal Pathway Drives  -Amyloid-Induced Synaptic Depression and Long-Term Depression Impairment in Entorhinal Cortex

(2010) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

Microglia Activated with the Toll-Like Receptor 9 Ligand CpG Attenuate Oligomeric Amyloid β Neurotoxicity in in Vitro and in Vivo Models of Alzheimer’s Disease

(2009) Yukiko Doi et al.   AMERICAN JOURNAL OF PATHOLOGY

RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

(2009) Fang Fang et al.   FASEB JOURNAL

Structural Basis for the Recognition of Oxidized Phospholipids in Oxidized Low Density Lipoproteins by Class B Scavenger Receptors CD36 and SR-BI

(2009) Detao Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer's Disease

(2009) M. I. Fonseca et al.   JOURNAL OF IMMUNOLOGY

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

The Role of the Complement System and the Activation Fragment C5a in the Central Nervous System

(2009) Trent M. Woodruff et al.   NEUROMOLECULAR MEDICINE

Involvement of Fc Receptors in Disorders of the Central Nervous System

(2009) Eitan Okun et al.   NEUROMOLECULAR MEDICINE

Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice

(2009) Stefanie Frank et al.   NEUROSCIENCE LETTERS

Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

(2008) Lars Bertram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Binding of S100 proteins to RAGE: An update

(2008) Estelle Leclerc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

(2008) Stefanie Frank et al.   GLIA

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

(2008) Jing-Ji Jin et al.   Journal of Neuroinflammation

Receptor for Advanced Glycation End Product-Dependent Activation of p38 Mitogen-Activated Protein Kinase Contributes to Amyloid- -Mediated Cortical Synaptic Dysfunction

(2008) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

Complement C3 Deficiency Leads to Accelerated Amyloid   Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

(2008) M. Maier et al.   JOURNAL OF NEUROSCIENCE

Toll-Like Receptor 2 Acts as a Natural Innate Immune Receptor to Clear Amyloid  1-42 and Delay the Cognitive Decline in a Mouse Model of Alzheimer's Disease

(2008) K. L. Richard et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses

(2008) Reisuke H. Takahashi et al.   NEUROBIOLOGY OF AGING

Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization and signal transduction of amyloid beta 1-42 in glial cells

(2008) L.-O. Brandenburg et al.   NEUROSCIENCE