PINK1 import regulation at a crossroad of mitochondrial fate: the molecular mechanisms of PINK1 import

Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1

(2019) Shiori Sekine et al.   MOLECULAR CELL

PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis

(2019) Chaojun Yan et al.   Autophagy

Mechanisms of PINK1, ubiquitin and Parkin interactions in mitochondrial quality control and beyond

(2019) Andrew N. Bayne et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria

(2018) Shotaro Saita et al.   EMBO JOURNAL

Membrane protein insertion through a mitochondrial β-barrel gate

(2018) Alexandra I. C. Höhr et al.   SCIENCE

Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology

(2018) Fenglei Jian et al.   Cell Reports

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

(2017) Jonathon L. Burman et al.   JOURNAL OF CELL BIOLOGY

Structure of PINK1 in complex with its substrate ubiquitin

(2017) Alexander F. Schubert et al.   NATURE

PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis

(2017) Shotaro Saita et al.   NATURE CELL BIOLOGY

Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import

(2017) Ireos Filipuzzi et al.   Nature Chemical Biology

Mitochondrial contact site and cristae organizing system

(2016) Martin van der Laan et al.   CURRENT OPINION IN CELL BIOLOGY

The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation

(2016) Koji Yamano et al.   EMBO REPORTS

The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i ‐AAA protease YME1L

(2016) Timothy Wai et al.   EMBO REPORTS

PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60

(2016) Shiori Akabane et al.   MOLECULAR CELL

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

(2016) Thanh N. Nguyen et al.   TRENDS IN CELL BIOLOGY

Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment

(2015) K. Okatsu et al.   JOURNAL OF CELL SCIENCE

The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles

(2014) Matthew Freeman   Annual Review of Cell and Developmental Biology

Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics

(2014) M. J. Baker et al.   EMBO JOURNAL

Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage

(2014) K. Zhang et al.   EMBO REPORTS

PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix

(2014) Ruth E. Thomas et al.   PLoS Genetics

PINK1 is degraded through the N-end rule pathway

(2013) Koji Yamano et al.   Autophagy

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

(2013) Seok Min Jin et al.   Autophagy

A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment

(2013) Kei Okatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

(2013) Samuel A. Hasson et al.   NATURE

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

(2012) Michael Lazarou et al.   DEVELOPMENTAL CELL

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

Rhomboid Protease PARL Mediates the Mitochondrial Membrane Potential Loss-induced Cleavage of PGAM5

(2012) Shiori Sekine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

Lateral release of proteins from the TOM complex into the outer membrane of mitochondria

(2011) Max Harner et al.   EMBO JOURNAL

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

(2011) Cathrin Meissner et al.   JOURNAL OF NEUROCHEMISTRY

PINK1 cleavage at position A103 by the mitochondrial protease PARL

(2010) Emma Deas et al.   HUMAN MOLECULAR GENETICS

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Regulation of OPA1 processing and mitochondrial fusion bym-AAA protease isoenzymes and OMA1

(2009) Sarah Ehses et al.   JOURNAL OF CELL BIOLOGY

Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells

(2009) Brian Head et al.   JOURNAL OF CELL BIOLOGY

Dissecting Membrane Insertion of Mitochondrial β-Barrel Proteins

(2008) Stephan Kutik et al.   CELL

Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria

(2008) C. Merkwirth et al.   GENES & DEVELOPMENT

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY