Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration

Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease

(2018) Paige E. Cramer et al.   NEUROBIOLOGY OF AGING

GSK3 and Tau: Two Convergence Points in Alzheimer's Disease

(2018) Felix Hernandez et al.   JOURNAL OF ALZHEIMERS DISEASE

Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer’s Disease

(2017) María José Pérez et al.   MOLECULAR NEUROBIOLOGY

Ultrastructural evidence for impaired mitochondrial fission in the aged rhesus monkey dorsolateral prefrontal cortex

(2017) Yury M. Morozov et al.   NEUROBIOLOGY OF AGING

Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration

(2017) Noemí Esteras et al.   Redox Biology

Truncation of Tau Protein and its Pathological Significance in Alzheimer's Disease

(2017) Francisco García-Sierra et al.   JOURNAL OF ALZHEIMERS DISEASE

A Mitocentric View of Alzheimer's Disease Suggests Multi-Faceted Treatments

(2017) Gary E. Gibson et al.   JOURNAL OF ALZHEIMERS DISEASE

A NH2 Tau Fragment Targets Neuronal Mitochondria at AD Synapses: Possible Implications for Neurodegeneration

(2017) Giuseppina Amadoro et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Deletion Prevents Stress-Induced Dendritic Atrophy in Prefrontal Cortex: Role of Synaptic Mitochondria

(2016) Sofia Lopes et al.   CEREBRAL CORTEX

Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease

(2016) Chang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau physiology and pathomechanisms in frontotemporal lobar degeneration

(2016) Liviu-Gabriel Bodea et al.   JOURNAL OF NEUROCHEMISTRY

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons

(2016) Teresa Rodríguez-Martín et al.   NEUROBIOLOGY OF DISEASE

Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin

(2016) Yu Hu et al.   Oncotarget

Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins

(2016) Xia-Chun Li et al.   Scientific Reports

Tau Structures

(2016) Jesus Avila et al.   Frontiers in Aging Neuroscience

Analyzing dendritic spine pathology in Alzheimer’s disease: problems and opportunities

(2015) Mario M. Dorostkar et al.   ACTA NEUROPATHOLOGICA

From ATP to PTP and Back: A Dual Function for the Mitochondrial ATP Synthase

(2015) P. Bernardi et al.   CIRCULATION RESEARCH

NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease

(2015) V. Corsetti et al.   HUMAN MOLECULAR GENETICS

The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection

(2015) Paolo Bernardi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Role of Cdk5 in Alzheimer’s Disease

(2015) Shu-Lei Liu et al.   MOLECULAR NEUROBIOLOGY

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

(2015) Yingjun Zhao et al.   NEURON

Tau facilitates Aβ-induced loss of mitochondrial membrane potential independent of cytosolic calcium fluxes in mouse cortical neurons

(2015) Susanne P. Pallo et al.   NEUROSCIENCE LETTERS

Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer’s Disease

(2015) Fabian A. Cabezas-Opazo et al.   Oxidative Medicine and Cellular Longevity

Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F1FO ATP synthase

(2015) Elizabeth A. Jonas et al.   PHARMACOLOGICAL RESEARCH

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

(2015) Harindranath Kadavath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau immunotherapy for Alzheimer's disease

(2015) Jan Torleif Pedersen et al.   TRENDS IN MOLECULAR MEDICINE

Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

(2015) Maxime Derisbourg et al.   Scientific Reports

Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity

(2014) Satish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons

(2014) Rodrigo A. Quintanilla et al.   NEUROBIOLOGY OF DISEASE

The Mixture of “Ecstasy” and Its Metabolites Impairs Mitochondrial Fusion/Fission Equilibrium and Trafficking in Hippocampal Neurons, at In Vivo Relevant Concentrations

(2014) Daniel José Barbosa et al.   TOXICOLOGICAL SCIENCES

The role of extracellular Tau in the spreading of neurofibrillary pathology

(2014) Miguel Medina et al.   Frontiers in Cellular Neuroscience

Protein phosphorylation in neurodegeneration: friend or foe?

(2014) Sandra Tenreiro et al.   Frontiers in Molecular Neuroscience

Dissecting the molecular mechanism by which NH2htau and Aβ1-42 peptides impair mitochondrial ANT-1 in Alzheimer disease

(2013) A. Bobba et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

(2013) Valasani Koteswara Rao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Tau phosphorylation affects its axonal transport and degradation

(2013) Teresa Rodríguez-Martín et al.   NEUROBIOLOGY OF AGING

AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons

(2013) G. Amadoro et al.   NEUROBIOLOGY OF DISEASE

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice

(2012) Pedro M Quirós et al.   EMBO JOURNAL

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Regulation of Mitochondrial Transport and Inter-Microtubule Spacing by Tau Phosphorylation at the Sites Hyperphosphorylated in Alzheimer's Disease

(2012) K. Shahpasand et al.   JOURNAL OF NEUROSCIENCE

A New Link to Mitochondrial Impairment in Tauopathies

(2012) Kathrin L. Schulz et al.   MOLECULAR NEUROBIOLOGY

Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease

(2012) Theodore J. Wilson et al.   NEUROBIOLOGY OF DISEASE

Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo

(2012) Brian DuBoff et al.   NEURON

Mitochondrial dynamics in neurodegeneration

(2012) Kie Itoh et al.   TRENDS IN CELL BIOLOGY

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

(2011) Katherine J. Kopeikina et al.   AMERICAN JOURNAL OF PATHOLOGY

SnapShot: Mitochondrial Dynamics

(2011) Yasushi Tamura et al.   CELL

Mitochondrial division: molecular machinery and physiological functions

(2011) Yusuke Kageyama et al.   CURRENT OPINION IN CELL BIOLOGY

Increased hippocampal tau phosphorylation and axonal mitochondrial transport in a mouse model of chronic stress

(2011) Li-Feng Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

(2011) Susanne M. Pritchard et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tau splicing and the intricacies of dementia

(2011) Athena Andreadis   JOURNAL OF CELLULAR PHYSIOLOGY

Truncation of tau at E391 Promotes Early Pathologic Changes in Transgenic Mice

(2011) Pamela J. McMillan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Interaction between NH2-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration

(2011) Giuseppina Amadoro et al.   NEUROBIOLOGY OF AGING

Truncated tau and Aβ cooperatively impair mitochondria in primary neurons

(2011) Rodrigo A. Quintanilla et al.   NEUROBIOLOGY OF AGING

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

GSK3β Is Involved in the Relief of Mitochondria Pausing in a Tau-Dependent Manner

(2011) María Llorens-Martín et al.   PLoS One

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1

(2010) Chuang-Rung Chang et al.   Annals of the New York Academy of Sciences

How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?

(2010) Elena Ziviani et al.   Autophagy

Tau cleavage and tau aggregation in neurodegenerative disease: Figure 1

(2010) Diane P. Hanger et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Proteolytic processing of tau

(2010) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Mitochondrial dynamics in cell death and neurodegeneration

(2010) Dong-Hyung Cho et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Parkin-mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network

(2010) Atsushi Tanaka   FEBS LETTERS

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

Convergence of Amyloid-β and Tau Pathologies on Mitochondria In Vivo

(2010) Anne Eckert et al.   MOLECULAR NEUROBIOLOGY

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

(2009) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mediators of tau phosphorylation in the pathogenesis of Alzheimer’s disease

(2009) Diane P Hanger et al.   Expert Review of Neurotherapeutics

Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons

(2009) Rodrigo A. Quintanilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Association Between Rough Endoplasmic Reticulum Membranes and Mitochondria in Transgenic Mice That Express P301L Tau

(2009) Sébastien Perreault et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion

(2009) Zhiyin Song et al.   MOLECULAR BIOLOGY OF THE CELL

The role of tau in neurodegeneration

(2009) Tania F Gendron et al.   Molecular Neurodegeneration

Amyloid-  and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

(2009) V. Rhein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A peptide containing residues 26–44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator

(2008) A. Atlante et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin

(2008) Inmaculada Cuchillo-Ibanez et al.   FASEB JOURNAL

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON

Tau inhibits anterograde axonal transport and perturbs stability in growing axonal neurites in part by displacing kinesin cargo: Neurofilaments attenuate tau-mediated neurite instability

(2007) Maya Dubey et al.   CELL MOTILITY AND THE CYTOSKELETON