Transporters at the Interface between Cytosolic and Mitochondrial Amino Acid Metabolism

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

(2021) Arafath K. Najumudeen et al.   NATURE GENETICS

Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

(2020) Sharanya Sivanand et al.   CANCER CELL

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

(2020) Jin-Tao Li et al.   NATURE CELL BIOLOGY

Novel Chemical Scaffolds to Inhibit the Neutral Amino Acid Transporter B0AT1 (SLC6A19), a Potential Target to Treat Metabolic Diseases

(2020) Aditya Yadav et al.   Frontiers in Pharmacology

Serine Catabolism Feeds NADH when Respiration Is Impaired

(2020) Lifeng Yang et al.   Cell Metabolism

20,000 picometers under the OMM : diving into the vastness of mitochondrial metabolite transport

(2020) Corey N Cunningham et al.   EMBO REPORTS

First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors

(2020) Naohiro Okano et al.   INVESTIGATIONAL NEW DRUGS

Quantitative analysis of amino acid metabolism in liver cancer links glutamate excretion to nucleotide synthesis

(2020) Avlant Nilsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer

(2020) Manabu Kodama et al.   Nature Communications

Selective alanine transporter utilization creates a targetable metabolic niche in pancreatic cancer

(2020) Seth J Parker et al.   Cancer Discovery

D-serine Ameliorates Motor and Cognitive Impairments in β-amyloid 1-42 Injected Mice by Inhibiting JNK Signaling Pathway

(2020) Hongqing Liu et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Leucine regulates autophagy via acetylation of the mTORC1 component raptor

(2020) Sung Min Son et al.   Nature Communications

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

(2020) Bryan Ngo et al.   Cancer Discovery

Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

(2020) Allison N Lau et al.   eLife

Cancer Cachexia: Definition, Staging, and Emerging Treatments

(2020) Jun Ni et al.   Cancer Management and Research

A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells

(2020) G. Jordan Ray et al.   iScience

A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity

(2020) Katharina Koch et al.   Cell Death Discovery

Amino Acid Transporters as Targets for Cancer Therapy: Why, Where, When, and How

(2020) Stefan Bröer   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SLC25A51 is a mammalian mitochondrial NAD+ transporter

(2020) Timothy S. Luongo et al.   NATURE

Age-induced accumulation of methylmalonic acid promotes tumour progression

(2020) Ana P. Gomes et al.   NATURE

Multifaceted role of branched-chain amino acid metabolism in cancer

(2020) Hui Peng et al.   ONCOGENE

The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology

(2020) Edmund R. S. Kunji et al.   PHYSIOLOGY

Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer

(2020) Kate E.R. Hollinshead et al.   Cell Reports

Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain

(2020) Lynne Chantranupong et al.   eLife

MCART1/SLC25A51 is required for mitochondrial NAD transport

(2020) Nora Kory et al.   Science Advances

Amino Acid Transporter SLC6A14 (ATB0,+) – A Target in Combined Anti-cancer Therapy

(2020) Katarzyna A. Nałęcz   Frontiers in Cell and Developmental Biology

MFSD12 mediates the import of cysteine into melanosomes and lysosomes

(2020) Charles H. Adelmann et al.   NATURE

Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import

(2020) Enrico Girardi et al.   Nature Communications

Epigenetic silencing affects L-asparaginase sensitivity and predicts outcome in T-ALL

(2019) Aurore Touzart et al.   CLINICAL CANCER RESEARCH

Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells

(2019) Angelika Bröer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo assessment of increased oxidation of branched-chain amino acids in glioblastoma

(2019) Eul Hyun Suh et al.   Scientific Reports

HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis

(2019) Florinda Meléndez-Rodríguez et al.   Cell Reports

Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells

(2019) Won Dong Lee et al.   Nature Communications

The Expanding and Unexpected Functions of Mitochondria Contact Sites

(2019) Laura L. Lackner   TRENDS IN CELL BIOLOGY

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

(2019) Ilaria Elia et al.   NATURE

Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation

(2019) Ruoxi Hong et al.   Molecular Oncology

Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

(2019) Mark R. Sullivan et al.   Cell Metabolism

Tissue-Specific Characterization of Mitochondrial Branched-Chain Keto Acid Oxidation Using a Multiplexed Assay Platform

(2019) Emma J Goldberg et al.   BIOCHEMICAL JOURNAL

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

(2019) Mark R Sullivan et al.   eLife

Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis

(2019) Harald Weinstabl et al.   JOURNAL OF MEDICINAL CHEMISTRY

Competition for nutrients and its role in controlling immune responses

(2019) Nidhi Kedia-Mehta et al.   Nature Communications

Reconstitution in Proteoliposomes of the Recombinant Human Riboflavin Transporter 2 (SLC52A2) Overexpressed in E. coli

(2019) Lara Console et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans

(2019) Kitt Falk Petersen et al.   JOURNAL OF CLINICAL INVESTIGATION

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

(2019) Takeshi Yoneshiro et al.   NATURE

T Cell Activation Depends on Extracellular Alanine

(2019) Noga Ron-Harel et al.   Cell Reports

The complexity of the serine glycine one-carbon pathway in cancer

(2019) Miguel Reina-Campos et al.   JOURNAL OF CELL BIOLOGY

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

New aspects of amino acid metabolism in cancer

(2019) Lisa Vettore et al.   BRITISH JOURNAL OF CANCER

A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

(2019) Hee Chan Yoo et al.   Cell Metabolism

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

(2019) Alba Luengo et al.   Nature Communications

Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways

(2018) Michelle van Geldermalsen et al.   BMC CANCER

The role of ASCT2 in cancer: A review

(2018) Yang Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeted Suppression and Knockout of ASCT2 or LAT1 in Epithelial and Mesenchymal Human Liver Cancer Cells Fail to Inhibit Growth

(2018) Paige Bothwell et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis

(2018) Jiaqiu Li et al.   MOLECULAR THERAPY

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

(2018) Javier Garcia-Bermudez et al.   NATURE CELL BIOLOGY

Aspartate is an endogenous metabolic limitation for tumour growth

(2018) Lucas B. Sullivan et al.   NATURE CELL BIOLOGY

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

(2018) Michael L Schulte et al.   NATURE MEDICINE

Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements

(2018) Milan Holeček   Nutrition & Metabolism

Elevated mitochondrial SLC25A29 in cancer modulates metabolic status by increasing mitochondria-derived nitric oxide

(2018) Huiyuan Zhang et al.   ONCOGENE

Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition

(2018) Seungyeon Yang et al.   Cell Death & Disease

Increased formate overflow is a hallmark of oxidative cancer

(2018) Johannes Meiser et al.   Nature Communications

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis

(2018) Kate E.R. Hollinshead et al.   Cell Reports

PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21

(2018) Xiaoye Liu et al.   Cell Reports

Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets

(2018) Angelika Bröer et al.   Frontiers in Pharmacology

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

(2018) Sung Min Son et al.   Cell Metabolism

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting

(2018) H. Furkan Alkan et al.   Cell Metabolism

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3

(2018) Mylène Tajan et al.   Cell Metabolism

Avian reovirus σA-modulated suppression of lactate dehydrogenase and upregulation of glutaminolysis and the mTOC1/eIF4E/HIF-1α pathway to enhance glycolysis and the TCA cycle for virus replication

(2018) Pei-I Chi et al.   CELLULAR MICROBIOLOGY

Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS

(2018) Sebastián Beltrán-Castillo et al.   MEDIATORS OF INFLAMMATION

We're Not “DON” Yet: Optimal Dosing and Prodrug Delivery of6-Diazo-5-oxo-L-norleucine

(2018) Kathryn M. Lemberg et al.   MOLECULAR CANCER THERAPEUTICS

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues

(2018) Martina Wallace et al.   Nature Chemical Biology

MitoMiner v4.0: an updated database of mitochondrial localization evidence, phenotypes and diseases

(2018) Anthony C Smith et al.   NUCLEIC ACIDS RESEARCH

MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo

(2018) Erol C. Bayraktar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

(2018) Nora Kory et al.   SCIENCE

Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation

(2018) Vinicius Cruzat et al.   Nutrients

Digitonin does not flip across cholesterol-poor membranes

(2017) Helen Y. Fan et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders

(2017) Michael T. Nedelcovych et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of mitochondrial metabolism in situ : Combining stable isotope labeling with selective permeabilization

(2017) Yannic Nonnenmacher et al.   METABOLIC ENGINEERING

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

(2017) Prasenjit Dey et al.   NATURE

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

(2017) Simon Raffel et al.   NATURE

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

(2017) Oliver D. K. Maddocks et al.   NATURE

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma

(2017) Gregory S. Ducker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis

(2017) María Moreno-Morcillo et al.   STRUCTURE

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

(2017) Orianne Olivares et al.   Nature Communications

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

(2017) Douglas E. Biancur et al.   Nature Communications

Discoveries, metabolic roles and diseases of mitochondrial carriers: A review

(2016) Ferdinando Palmieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

(2016) V Coothankandaswamy et al.   BRITISH JOURNAL OF PHARMACOLOGY

PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis

(2016) D. Samanta et al.   CANCER RESEARCH

Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth

(2016) Y. Cormerais et al.   CANCER RESEARCH

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

(2016) Walter W. Chen et al.   CELL

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

(2016) Dan Y. Gui et al.   Cell Metabolism

Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth

(2016) Lifeng Yang et al.   Cell Metabolism

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway

(2016) Gregory S. Ducker et al.   Cell Metabolism

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial

(2016) M. Ruiz-Canela et al.   CLINICAL CHEMISTRY

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer

(2016) Pan Xu et al.   GENES & DEVELOPMENT

Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells

(2016) Angelika Bröer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The importance of serine metabolism in cancer

(2016) Katherine R. Mattaini et al.   JOURNAL OF CELL BIOLOGY

Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma

(2016) Rana Rais et al.   JOURNAL OF MEDICINAL CHEMISTRY

Post-translational modification by acetylation regulates the mitochondrial carnitine/acylcarnitine transport protein

(2016) Nicola Giangregorio et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

(2016) Michael E Pacold et al.   Nature Chemical Biology

Lactate metabolism is associated with mammalian mitochondria

(2016) Ying-Jr Chen et al.   Nature Chemical Biology

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

(2016) Edouard Mullarky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

(2016) Michael J. Lukey et al.   Nature Communications

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

(2016) Yujun Hao et al.   Nature Communications

Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia

(2016) J. Pedro Fernández-Murray et al.   PLoS Genetics

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Serine one-carbon catabolism with formate overflow

(2016) J. Meiser et al.   Science Advances

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

(2015) N. Jacque et al.   BLOOD

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

A Call for Systematic Research on Solute Carriers

(2015) Adrián César-Razquin et al.   CELL

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

(2015) Linchong Sun et al.   CELL RESEARCH

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

(2015) Yan Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

(2015) Dohoon Kim et al.   NATURE

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

(2015) Simone Cardaci et al.   NATURE CELL BIOLOGY

Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis

(2015) Courtney R Green et al.   Nature Chemical Biology

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Famine versus feast: understanding the metabolism of tumors in vivo

(2015) Jared R. Mayers et al.   TRENDS IN BIOCHEMICAL SCIENCES

MYC-induced reprogramming of glutamine catabolism supports optimal virus replication

(2015) Minh Thai et al.   Nature Communications

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

(2015) Charlotte Lussey-Lepoutre et al.   Nature Communications

Catabolism of Branched Chain Amino Acids Contributes Significantly to Synthesis of Odd-Chain and Even-Chain Fatty Acids in 3T3-L1 Adipocytes

(2015) Scott B. Crown et al.   PLoS One

Serine Deprivation Enhances Antineoplastic Activity of Biguanides

(2014) S.-P. Gravel et al.   CANCER RESEARCH

The Human GeneSLC25A29, of Solute Carrier Family 25, Encodes a Mitochondrial Transporter of Basic Amino Acids

(2014) Vito Porcelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia

(2014) C Rosilio et al.   LEUKEMIA

Carnitine/acylcarnitine translocase and carnitine palmitoyltransferase 2 form a complex in the inner mitochondrial membrane

(2014) Lara Console et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

(2014) Caroline A. Lewis et al.   MOLECULAR CELL

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

(2014) Jared R Mayers et al.   NATURE MEDICINE

Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis

(2014) Joshua K Salabei et al.   Nature Protocols

UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation

(2014) A. Vozza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells

(2014) Christiaan F. Labuschagne et al.   Cell Reports

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

(2014) Andrew R. Mullen et al.   Cell Reports

Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology

(2014) Revati Wani et al.   Frontiers in Pharmacology

Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health

(2014) Lorena Pochini et al.   Frontiers in Chemistry

Thiol-Dependent Recovery of Catalytic Activity from Oxidized Protein Tyrosine Phosphatases

(2013) Zachary D. Parsons et al.   BIOCHEMISTRY

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Effect of Glutamine Synthetase Inhibition on Brain and Interorgan Ammonia Metabolism in Bile Duct Ligated Rats

(2013) Andreas W Fries et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

A quantitative liposome microarray to systematically characterize protein-lipid interactions

(2013) Antoine-Emmanuel Saliba et al.   NATURE METHODS

Metabolic Reprogramming for Producing Energy and Reducing Power in Fumarate Hydratase Null Cells from Hereditary Leiomyomatosis Renal Cell Carcinoma

(2013) Youfeng Yang et al.   PLoS One

Selective cancer targeting with prodrugs activated by histone deacetylases and a tumour-associated protease

(2013) Nobuhide Ueki et al.   Nature Communications

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

(2013) Sarah-Maria Fendt et al.   Nature Communications

Proteoliposomes as Tool for Assaying Membrane Transporter Functions and Interactions with Xenobiotics

(2013) Mariafrancesca Scalise et al.   Pharmaceutics

The NF-κB member p65 controls glutamine metabolism through miR-23a

(2012) Moeez G. Rathore et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Detailed Mitochondrial Phenotyping by High Resolution Metabolomics

(2012) James R. Roede et al.   PLoS One

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial Evolution

(2012) M. W. Gray   Cold Spring Harbor Perspectives in Biology

Control of Oxidative Posttranslational Cysteine Modifications: From Intricate Chemistry to Widespread Biological and Medical Applications

(2011) Claus Jacob et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays

(2011) Petra Krumpochova et al.   FASEB JOURNAL

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Comparative Metabolic Flux Profiling of Melanoma Cell Lines

(2011) David A. Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Predicting selective drug targets in cancer through metabolic networks

(2011) O. Folger et al.   Molecular Systems Biology

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

(2010) E. L. Carr et al.   JOURNAL OF IMMUNOLOGY

Arginine Is Synthesized From Proline, Not Glutamate, in Enterally Fed Human Preterm Neonates

(2010) Chris Tomlinson et al.   PEDIATRIC RESEARCH

Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines

(2010) Rajaa Hussien et al.   PHYSIOLOGICAL GENOMICS

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The origin and early evolution of eukaryotes in the light of phylogenomics

(2010) Eugene V Koonin   GENOME BIOLOGY

Mitochondrial Glutathione, a Key Survival Antioxidant

(2009) Montserrat Marí et al.   ANTIOXIDANTS & REDOX SIGNALING

l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth

(2009) Koji Oda et al.   CANCER SCIENCE

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer

(2009) Linda J. Nicholson et al.   INTERNATIONAL JOURNAL OF CANCER

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia

(2009) Duane L Guernsey et al.   NATURE GENETICS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

(2008) David J. Pagliarini et al.   CELL