Effect of Glutamine Synthetase Inhibition on Brain and Interorgan Ammonia Metabolism in Bile Duct Ligated Rats

Brain Alanine Formation as an Ammonia-Scavenging Pathway during Hyperammonemia: Effects of Glutamine Synthetase Inhibition in Rats and Astrocyte—Neuron Co-Cultures

(2013) Sherry Dadsetan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake

(2012) Gitte Dam et al.   HEPATOLOGY

Possible treatment of end-stage hyperammonemic encephalopathy by inhibition of glutamine synthetase

(2012) Arthur J. L. Cooper   METABOLIC BRAIN DISEASE

Glutamine in the pathogenesis of acute hepatic encephalopathy

(2012) Kakulavarapu V. Rama Rao et al.   NEUROCHEMISTRY INTERNATIONAL

Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects

(2011) Gitte Dam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons

(2011) Sherry Dadsetan et al.   NEUROCHEMISTRY INTERNATIONAL

Human 13N-ammonia PET studies: the importance of measuring 13N-ammonia metabolites in blood

(2010) Susanne Keiding et al.   METABOLIC BRAIN DISEASE

Astrocyte glutamine synthetase: Importance in hyperammonemic syndromes and potential target for therapy

(2010) Saul W. Brusilow et al.   Neurotherapeutics

Detoxification of Ammonia in Mouse Cortical GABAergic Cell Cultures Increases Neuronal Oxidative Metabolism and Reveals an Emerging Role for Release of Glucose-Derived Alanine

(2010) Renata Leke et al.   NEUROTOXICITY RESEARCH

Experimental models of hepatic encephalopathy: ISHEN guidelines

(2009) Roger F. Butterworth et al.   LIVER INTERNATIONAL

Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia

(2008) Lasse K. Bak et al.   METABOLIC BRAIN DISEASE

Cerebral Glutamine Concentration and Lactate–Pyruvate Ratio in Patients with Acute Liver Failure

(2008) Peter Nissen Bjerring et al.   Neurocritical Care

Quantitative cerebral water content mapping in hepatic encephalopathy

(2008) N.J. Shah et al.   NEUROIMAGE