The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

Elevated expression of glutaminase confers glucose utilization via glutaminolysis in prostate cancer

(2015) Tiejun Pan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation

(2015) Alex J. Bott et al.   Cell Metabolism

COP1 and GSK3β Cooperate to Promote c-Jun Degradation and Inhibit Breast Cancer Cell Tumorigenesis

(2015) Jing Shao et al.   NEOPLASIA

Genome-wide Profiling of AP-1-Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer

(2014) C. Zhao et al.   CANCER RESEARCH

The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation

(2014) Alfredo Csibi et al.   CURRENT BIOLOGY

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells

(2014) Clint A. Stalnecker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types

(2014) Zheng Xia et al.   Nature Communications

Altered Glutamine Metabolism and Therapeutic Opportunities for Lung Cancer

(2013) Amr Mohamed et al.   Clinical Lung Cancer

Therapeutic strategies impacting cancer cell glutamine metabolism

(2013) Michael J Lukey et al.   Future Medicinal Chemistry

ErbB2 Activation Upregulates Glutaminase 1 Expression Which Promotes Breast Cancer Cell Proliferation

(2013) Shuo Qie et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Control of glutamine metabolism by the tumor suppressor Rb

(2013) M R Reynolds et al.   ONCOGENE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Silencing of GLS and overexpression of GLS2 genes cooperate in decreasing the proliferation and viability of glioblastoma cells

(2013) Monika Szeliga et al.   TUMOR BIOLOGY

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition

(2012) Dai Horiuchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

(2012) Wanjuan Yang et al.   NUCLEIC ACIDS RESEARCH

MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression

(2012) M Kappelmann et al.   ONCOGENE

Interferon-α Regulates Glutaminase 1 Promoter through STAT1 Phosphorylation: Relevance to HIV-1 Associated Neurocognitive Disorders

(2012) Lixia Zhao et al.   PLoS One

Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism

(2012) A. Cassago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis

(2012) Dania Daye et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Isoform-specific palmitoylation of JNK regulates axonal development

(2011) G Yang et al.   CELL DEATH AND DIFFERENTIATION

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular determinants of de novo nucleotide biosynthesis in cancer cells

(2009) Xuemei Tong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Elevated expression of phosphorylated c-Jun NH2-terminal kinase in basal-like and “triple-negative” breast cancers

(2009) Xiao Wang et al.   HUMAN PATHOLOGY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

A novel glutaminase isoform in mammalian tissues

(2009) Vanessa de la Rosa et al.   NEUROCHEMISTRY INTERNATIONAL

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance

(2008) Rajat Singh et al.   HEPATOLOGY

Positional distribution of human transcription factor binding sites

(2008) Mark Koudritsky et al.   NUCLEIC ACIDS RESEARCH

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA