Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis

(2016) Nisebita Sahu et al.   Cell Metabolism

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism

(2016) Annelies Quaegebeur et al.   Cell Metabolism

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

(2016) Mohammad A. Mandegar et al.   Cell Stem Cell

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

(2016) Stefan Christen et al.   Cell Reports

In vivo cancer metabolism is defined by the nutrient microenvironment

(2016) Ilaria Elia et al.   Translational Cancer Research

Metabolic control of signalling pathways and metabolic auto-regulation

(2015) Doriane Lorendeau et al.   BIOLOGY OF THE CELL

14-3-3ζ Turns TGF-β’s Function from Tumor Suppressor to Metastasis Promoter in Breast Cancer by Contextual Changes of Smad Partners from p53 to Gli2

(2015) Jia Xu et al.   CANCER CELL

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

A roadmap for interpreting 13 C metabolite labeling patterns from cells

(2015) Joerg M Buescher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

(2015) Devon A. Lawson et al.   NATURE

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides

(2015) Wei Liu et al.   Scientific Reports

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Proline Biosynthesis Is Required for Endoplasmic Reticulum Stress Tolerance inSaccharomyces cerevisiae

(2014) Xinwen Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer

(2014) L. Yang et al.   Molecular Systems Biology

Autophagy-Dependent Production of Secreted Factors Facilitates Oncogenic RAS-Driven Invasion

(2014) R. Lock et al.   Cancer Discovery

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

Proline Oxidase Promotes Tumor Cell Survival in Hypoxic Tumor Microenvironments

(2012) W. Liu et al.   CANCER RESEARCH

Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death

(2012) Sathish Kumar Natarajan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

DNA methylation profiling reveals a predominant immune component in breast cancers

(2011) Sarah Dedeurwaerder et al.   EMBO Molecular Medicine

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation

(2011) A. R. Grassian et al.   GENES & DEVELOPMENT

Metabolite extraction from suspension-cultured mammalian cells for global metabolite profiling

(2011) Christopher A Sellick et al.   Nature Protocols

miR-23b* targets proline oxidase, a novel tumor suppressor protein in renal cancer

(2010) W Liu et al.   ONCOGENE

Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture

(2009) Karen M Imbalzano et al.   Cancer Cell International

Proline Oxidase Functions as a Mitochondrial Tumor Suppressor in Human Cancers

(2009) Y. Liu et al.   CANCER RESEARCH

Regulation and function of proline oxidase under nutrient stress

(2009) Jui Pandhare et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Metabolic profiling of the fission yeast S. pombe: quantification of compounds under different temperatures and genetic perturbation

(2009) Tomáš Pluskal et al.   Molecular BioSystems

BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases

(2009) M J Hoenerhoff et al.   ONCOGENE

Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress

(2007) Navasona Krishnan et al.   FREE RADICAL BIOLOGY AND MEDICINE