First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors
出版年份 2020 全文链接
标题
First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors
作者
关键词
-
出版物
INVESTIGATIONAL NEW DRUGS
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-03-21
DOI
10.1007/s10637-020-00924-3
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- The L-Type Amino Acid Transporter LAT1—An Emerging Target in Cancer
- (2019) Pascal Häfliger et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- ABC-06 | A randomised phase III, multi-centre, open-label study of active symptom control (ASC) alone or ASC with oxaliplatin / 5-FU chemotherapy (ASC+mFOLFOX) for patients (pts) with locally advanced / metastatic biliary tract cancers (ABC) previously-treated with cisplatin/gemcitabine (CisGem) chemotherapy.
- (2019) Angela Lamarca et al. JOURNAL OF CLINICAL ONCOLOGY
- Nivolumab alone or in combination with cisplatin plus gemcitabine in Japanese patients with unresectable or recurrent biliary tract cancer: a non-randomised, multicentre, open-label, phase 1 study
- (2019) Makoto Ueno et al. Lancet Gastroenterology & Hepatology
- Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1
- (2018) Natesh Singh et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Regulation and Function of the L-Type Amino Acid Transporter 1 (LAT1) in Cancer
- (2018) Travis Salisbury et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Increase in L-type amino acid transporter 1 expression during cholangiocarcinogenesis caused by liver fluke infection and its prognostic significance
- (2017) Supak Yothaisong et al. PARASITOLOGY INTERNATIONAL
- Inhibition of l-type amino acid transporter 1 activity as a new therapeutic target for cholangiocarcinoma treatment
- (2017) Supak Yothaisong et al. TUMOR BIOLOGY
- Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth
- (2016) Y. Cormerais et al. CANCER RESEARCH
- Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
- (2016) Aaron M. Hosios et al. DEVELOPMENTAL CELL
- Prognostic significance of amino-acid transporter expression (LAT1, ASCT2 and xCT) in surgically resected tongue cancer
- (2014) M Toyoda et al. BRITISH JOURNAL OF CANCER
- Downregulation of LAT1 expression suppresses cholangiocarcinoma cell invasion and migration
- (2014) Keatdamrong Janpipatkul et al. CELLULAR SIGNALLING
- L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia
- (2014) C Rosilio et al. LEUKEMIA
- High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas
- (2014) Nobuyuki Yanagisawa et al. Cancer Medicine
- Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer
- (2013) Kyoichi Kaira et al. BMC CANCER
- Investigation of the role of transporters on the hepatic elimination of an LAT1 selective inhibitor JPH203
- (2013) Junko Toyoshima et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer
- (2012) K Kaira et al. BRITISH JOURNAL OF CANCER
- Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis
- (2011) Mio Furuya et al. CANCER SCIENCE
- Metabolism and Pharmacokinetic Studies of JPH203, an L-Amino Acid Transporter 1 (LAT1) Selective Compound
- (2011) Michael F. Wempe et al. Drug Metabolism and Pharmacokinetics
- High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: Comparison with non-cancerous lesions
- (2011) Masaaki Ichinoe et al. PATHOLOGY INTERNATIONAL
- Accuracy of various humanNAT2SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes
- (2011) David W Hein et al. PHARMACOGENOMICS
- Arylamine N-Acetyltransferase 2 (NAT2) Genetic Diversity and Traditional Subsistence: A Worldwide Population Survey
- (2011) Audrey Sabbagh et al. PLoS One
- Inhibition of L-Type Amino Acid Transporter Modulates the Expression of Cell Cycle Regulatory Factors in KB Oral Cancer Cells
- (2010) Chun Sung Kim et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth
- (2009) Koji Oda et al. CANCER SCIENCE
- Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I–III nonsmall cell lung cancer
- (2008) K Kaira et al. BRITISH JOURNAL OF CANCER
- Evaluation of thoracic tumors with18F-FMT and18F-FDG PET-CT: A clinicopathological study
- (2008) Kyoichi Kaira et al. INTERNATIONAL JOURNAL OF CANCER
- L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer
- (2008) Takeshi Sakata et al. PATHOLOGY INTERNATIONAL
- Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond
- (2008) Vadivel Ganapathy et al. PHARMACOLOGY & THERAPEUTICS
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started