Novel Chemical Scaffolds to Inhibit the Neutral Amino Acid Transporter B0AT1 (SLC6A19), a Potential Target to Treat Metabolic Diseases

Mice Lacking the Intestinal and Renal Neutral Amino Acid Transporter SLC6A19 Demonstrate the Relationship between Dietary Protein Intake and Amino Acid Malabsorption

(2019) Kiran Javed et al.   Nutrients

Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance

(2018) Adriano Maida et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Characterization of a murine nonalcoholic steatohepatitis model induced by high fat high calorie diet plus fructose and glucose in drinking water

(2018) Xue-Jing Liu et al.   LABORATORY INVESTIGATION

Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets

(2018) Angelika Bröer et al.   Frontiers in Pharmacology

Amino Acid Transporters as Disease Modifiers and Drug Targets

(2018) Stefan Bröer   SLAS Discovery

Development of Biomarkers for Inhibition of SLC6A19 (B0AT1)—A Potential Target to Treat Metabolic Disorders

(2018) Kiran Javed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification and Characterization of Inhibitors of a Neutral Amino Acid Transporter, SLC6A19, Using Two Functional Cell-Based Assays

(2018) Sanjay J. Danthi et al.   SLAS Discovery

α,α-Diarylethylene Glycols as Valuable Precursor for Synthesis of 1,1-Diarylethenes and α,α-Diaryl Acetaldehydes

(2017) Praveen Kumar Tiwari et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Structure–Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1)

(2017) Lars Jørgensen et al.   JOURNAL OF MEDICINAL CHEMISTRY

A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution

(2016) Adriano Maida et al.   JOURNAL OF CLINICAL INVESTIGATION

X-ray structures and mechanism of the human serotonin transporter

(2016) Jonathan A. Coleman et al.   NATURE

Molecular Basis for the Interaction of the Mammalian Amino Acid Transporters B0AT1 and B0AT3 with Their Ancillary Protein Collectrin

(2015) Stephen J. Fairweather et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control

(2015) Yang Jiang et al.   Molecular Metabolism

Nimesulide binding site in the B0AT1 (SLC6A19) amino acid transporter. Mechanism of inhibition revealed by proteoliposome transport assay and molecular modelling

(2014) Lorena Pochini et al.   BIOCHEMICAL PHARMACOLOGY

A Perspective on 10-Years HTS Experience at the Walter and Eliza Hall Institute of Medical Research – Eighteen Million Assays and Counting

(2014) Kurt Lackovic et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Fibroblast Growth Factor 21 Limits Lipotoxicity by Promoting Hepatic Fatty Acid Activation in Mice on Methionine and Choline-Deficient Diets

(2014) Ffolliott M. Fisher et al.   GASTROENTEROLOGY

How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters

(2013) Aravind Penmatsa et al.   JOURNAL OF PHYSIOLOGY-LONDON

X-ray structure of dopamine transporter elucidates antidepressant mechanism

(2013) Aravind Penmatsa et al.   NATURE

Defective intestinal amino acid absorption in Ace2 null mice

(2012) Dustin Singer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation

(2012) Ana Luísa De Sousa-Coelho et al.   BIOCHEMICAL JOURNAL

Impaired Nutrient Signaling and Body Weight Control in a Na+Neutral Amino Acid Cotransporter (Slc6a19)-deficient Mouse

(2011) Angelika Bröer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of the neutral amino acid transporter B0AT1 (SLC6A19) in Hartnup disorder and protein nutrition

(2009) Stefan Bröer   IUBMB LIFE

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

A protein complex in the brush-border membrane explains a Hartnup disorder allele

(2008) Sonja Kowalczuk et al.   FASEB JOURNAL

The Mechanism of a Neurotransmitter:Sodium Symporter—Inward Release of Na+ and Substrate Is Triggered by Substrate in a Second Binding Site

(2008) Lei Shi et al.   MOLECULAR CELL

Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia

(2008) Stefan Bröer   PHYSIOLOGICAL REVIEWS

A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation

(2008) S. K. Singh et al.   SCIENCE