Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation

BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism

(2018) Karina Vázquez-Arreguín et al.   MOLECULAR CANCER RESEARCH

Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition

(2018) Seungyeon Yang et al.   Cell Death & Disease

Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression

(2018) Maren Feist et al.   Nature Communications

Histidine catabolism is a major determinant of methotrexate sensitivity

(2018) Naama Kanarek et al.   NATURE

Erratum: Cancer metabolism: a therapeutic perspective

(2017) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

CellMiner Companion: an interactive web application to explore CellMiner NCI-60 data

(2016) Sufang Wang et al.   BIOINFORMATICS

Tumour microenvironment factors shaping the cancer metabolism landscape

(2016) Dimitrios Anastasiou   BRITISH JOURNAL OF CANCER

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells

(2016) Jonathan L. Coloff et al.   Cell Metabolism

Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

(2015) Lingtao Jin et al.   CANCER CELL

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth

(2015) H. Yang et al.   EMBO JOURNAL

Nestin regulates proliferation and invasion of gastrointestinal stromal tumor cells by altering mitochondrial dynamics

(2015) J Wang et al.   ONCOGENE

Dysregulated metabolism contributes to oncogenesis

(2015) Matthew D. Hirschey et al.   SEMINARS IN CANCER BIOLOGY

Famine versus feast: understanding the metabolism of tumors in vivo

(2015) Jared R. Mayers et al.   TRENDS IN BIOCHEMICAL SCIENCES

The aspartate metabolism pathway is differentiable in human hepatocellular carcinoma: transcriptomics and13C-isotope based metabolomics

(2014) Moses M. Darpolor et al.   NMR IN BIOMEDICINE

BRCA1 Induces Major Energetic Metabolism Reprogramming in Breast Cancer Cells

(2014) Maud Privat et al.   PLoS One

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomics

(2012) D. Tabas-Madrid et al.   NUCLEIC ACIDS RESEARCH

Cancer metabolism: current perspectives and future directions

(2012) C Muñoz-Pinedo et al.   Cell Death & Disease

Mechanisms of BRCA1 Tumor Suppression: Figure 1.

(2012) Daniel P. Silver et al.   Cancer Discovery

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Transcriptional regulation of BRCA1 expression by a metabolic switch

(2010) Li-Jun Di et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

ZBRK1 Acts as a Metastatic Suppressor by Directly Regulating MMP9 in Cervical Cancer

(2009) L.-F. Lin et al.   CANCER RESEARCH

Derepression of HMGA2 via Removal of ZBRK1/BRCA1/CtIP Complex Enhances Mammary Tumorigenesis

(2009) Kazi Mokim Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative Regulation of AKT Activation by BRCA1

(2008) T. Xiang et al.   CANCER RESEARCH