Quantitative flux analysis reveals folate-dependent NADPH production

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

(2014) Roland Nilsson et al.   Nature Communications

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells

(2013) P M Tedeschi et al.   Cell Death & Disease

IsoCor: correcting MS data in isotope labeling experiments

(2012) P. Millard et al.   BIOINFORMATICS

Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

(2012) Wen Cai Zhang et al.   CELL

Quantitative Importance of the Pentose Phosphate Pathway Determined by Incorporation of 13C from [2-13C]- and [3-13C]Glucose into TCA Cycle Intermediates and Neurotransmitter Amino Acids in Functionally Intact Neurons

(2012) Eva M F Brekke et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation

(2012) J. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Predicting selective drug targets in cancer through metabolic networks

(2011) O. Folger et al.   Molecular Systems Biology

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Metabolomic Analysis and Visualization Engine for LC−MS Data

(2010) Eugene Melamud et al.   ANALYTICAL CHEMISTRY

Metabolomic Analysis via Reversed-Phase Ion-Pairing Liquid Chromatography Coupled to a Stand Alone Orbitrap Mass Spectrometer

(2010) Wenyun Lu et al.   ANALYTICAL CHEMISTRY

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

(2010) Anne S. Tibbetts et al.   Annual Review of Nutrition

Disruption of Pyridine Nucleotide Redox Status During Oxidative Challenge at Normal and Low-Glucose States: Implications for Cellular Adenosine Triphosphate, Mitochondrial Respiratory Activity, and Reducing Capacity in Colon Epithelial Cells

(2010) Magdalena L. Circu et al.   ANTIOXIDANTS & REDOX SIGNALING

Quiescent Fibroblasts Exhibit High Metabolic Activity

(2010) Johanna M. S. Lemons et al.   PLOS BIOLOGY

Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells

(2009) Christian M. Metallo et al.   JOURNAL OF BIOTECHNOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes

(2008) Teresa WM Fan et al.   Molecular Cancer

Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

(2008) Joshua Munger et al.   NATURE BIOTECHNOLOGY

Kinetic flux profiling for quantitation of cellular metabolic fluxes

(2008) Jie Yuan et al.   Nature Protocols