A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity
出版年份 2020 全文链接
标题
A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity
作者
关键词
-
出版物
Cell Death Discovery
Volume 6, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-04-16
DOI
10.1038/s41420-020-0258-3
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mitochondrial pyruvate carrier 1 expression controls cancer EMT and radioresistance
- (2019) Yuji Takaoka et al. CANCER SCIENCE
- Inhibition of GLS suppresses proliferation and promotes apoptosis in prostate cancer
- (2019) Junfeng Zhang et al. BIOSCIENCE REPORTS
- GLS1 promotes proliferation in hepatocellular carcinoma cells via AKT/GSK3β/CyclinD1 pathway
- (2019) Jianbo Xi et al. EXPERIMENTAL CELL RESEARCH
- Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials
- (2019) Ann Lin et al. Science Translational Medicine
- An omics perspective on drug target discovery platforms
- (2019) Jussi Paananen et al. BRIEFINGS IN BIOINFORMATICS
- Influence of synthesis methods on the internalization of fluorescent gold nanoparticles into glioblastoma stem-like cells
- (2019) Beatriz Giesen et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State
- (2018) Anneleen Daemen et al. Cell Metabolism
- Targeting glutaminase-mediated glutamine dependence in papillary thyroid cancer
- (2018) Yang Yu et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis
- (2018) Jiaqiu Li et al. MOLECULAR THERAPY
- PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT
- (2018) Carmen Mecca et al. Frontiers in Cellular Neuroscience
- Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism
- (2018) Jae Hyun Kim et al. Scientific Reports
- Glutamate-Weighted Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Detects Glutaminase Inhibition in a Mouse Model of Triple-Negative Breast Cancer
- (2018) Rong Zhou et al. CANCER RESEARCH
- Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
- (2018) Samuel K. McBrayer et al. CELL
- Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice
- (2018) Gunnar Boysen et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway
- (2018) Binghua Li et al. EBioMedicine
- Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling
- (2017) Jianwei Liao et al. Molecular Cancer
- Metabolic Differences in Glutamine Utilization Lead to Metabolic Vulnerabilities in Prostate Cancer
- (2017) Niki Marie Zacharias et al. Scientific Reports
- Metabolic reprogramming during neuronal differentiation
- (2016) M Agostini et al. CELL DEATH AND DIFFERENTIATION
- Targeting cancer stem-like cells in glioblastoma and colorectal cancer through metabolic pathways
- (2016) U.D. Kahlert et al. INTERNATIONAL JOURNAL OF CANCER
- Clinical aggressiveness of malignant gliomas is linked to augmented metabolism of amino acids
- (2016) Eduard H. Panosyan et al. JOURNAL OF NEURO-ONCOLOGY
- Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling
- (2016) Lili Guo et al. TUMOR BIOLOGY
- Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells
- (2016) Katharina Koch et al. Oncotarget
- Fundamentals of cancer metabolism
- (2016) R. J. DeBerardinis et al. Science Advances
- The Glutaminase-1 Inhibitor 968 Enhances Dihydroartemisinin-Mediated Antitumor Efficacy in Hepatocellular Carcinoma Cells
- (2016) Diancheng Wang et al. PLoS One
- ZEB1 Promotes Invasion in Human Fetal Neural Stem Cells and Hypoxic Glioma Neurospheres
- (2015) Ulf D. Kahlert et al. BRAIN PATHOLOGY
- NVP-BEZ235, a novel dual PI3K–mTOR inhibitor displays anti-glioma activity and reduces chemoresistance to temozolomide in human glioma cells
- (2015) Zhiyun Yu et al. CANCER LETTERS
- Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells
- (2015) Ulf D. Kahlert et al. INTERNATIONAL JOURNAL OF CANCER
- Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
- (2015) Kazuhiro Tanaka et al. JOURNAL OF CLINICAL INVESTIGATION
- Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
- (2015) Saverio Tardito et al. NATURE CELL BIOLOGY
- LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program
- (2015) Xing-gang Mao et al. Oncotarget
- Differences among brain tumor stem cell types and fetal neural stem cells in focal regions of histone modifications and DNA methylation, broad regions of modifications, and bivalent promoters
- (2014) Sally Yoo et al. BMC GENOMICS
- Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer
- (2014) M. I. Gross et al. MOLECULAR CANCER THERAPEUTICS
- Comparative Expression Study of the Endo–G Protein Coupled Receptor (GPCR) Repertoire in Human Glioblastoma Cancer Stem-like Cells, U87-MG Cells and Non Malignant Cells of Neural Origin Unveils New Potential Therapeutic Targets
- (2014) Marie Fève et al. PLoS One
- Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells
- (2014) A. Janzer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glutaminase 1 Is Essential for the Differentiation, Proliferation, and Survival of Human Neural Progenitor Cells
- (2014) Yi Wang et al. STEM CELLS AND DEVELOPMENT
- The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance
- (2013) Florian A. Siebzehnrubl et al. EMBO Molecular Medicine
- Original article CD133/CD15 defines distinct cell subpopulations with differential in vitro clonogenic activity and stem cell-related gene expression profile in in vitro propagated glioblastoma multiforme-derived cell line with a PNET-like component
- (2013) Ulf D. Kahlert et al. FOLIA NEUROPATHOLOGICA
- Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells
- (2013) Mercedes Martín-Rufián et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Metabolic targets for cancer therapy
- (2013) Lorenzo Galluzzi et al. NATURE REVIEWS DRUG DISCOVERY
- Amino Acids and mTOR Mediate Distinct Metabolic Checkpoints in Mammalian G1 Cell Cycle
- (2013) Mahesh Saqcena et al. PLoS One
- The Metabolomic Signature of Malignant Glioma Reflects Accelerated Anabolic Metabolism
- (2012) P. Chinnaiyan et al. CANCER RESEARCH
- Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo
- (2012) Isaac Marin-Valencia et al. Cell Metabolism
- Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression
- (2012) Dallas R. Donohoe et al. JOURNAL OF CELLULAR PHYSIOLOGY
- NIH Image to ImageJ: 25 years of image analysis
- (2012) Caroline A Schneider et al. NATURE METHODS
- Interactions between epigenetics and metabolism in cancers
- (2012) Jihye Yun et al. Frontiers in Oncology
- Elevated invasive potential of glioblastoma stem cells
- (2011) Lin Cheng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
- (2011) T. Cheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation
- (2010) Jian-Bin Wang et al. CANCER CELL
- Glutamine addiction: a new therapeutic target in cancer
- (2010) David R. Wise et al. TRENDS IN BIOCHEMICAL SCIENCES
- c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
- (2009) Ping Gao et al. NATURE
- Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
- (2009) R J DeBerardinis et al. ONCOGENE
- Restricted Spontaneous In Vitro Differentiation and Region-Specific Migration of Long-Term Expanded Fetal Human Neural Precursor Cells After Transplantation Into the Adult Rat Brain
- (2009) Jaroslaw Maciaczyk et al. STEM CELLS AND DEVELOPMENT
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
- (2008) Ralph J. DeBerardinis et al. Cell Metabolism
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
- (2008) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started