Landscape of extracellular vesicles in the tumour microenvironment: Interactions with stromal cells and with non-cell components, and impacts on metabolic reprogramming, horizontal transfer of neoplastic traits, and the emergence of therapeutic resistance

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Extracellular vesicle‐derived circ_SLC19A1 promotes prostate cancer cell growth and invasion through the miR‐497/septin 2 pathway

(2020) Yu Zheng et al.   CELL BIOLOGY INTERNATIONAL

Extracellular vesicles originating from glioblastoma cells increase metalloproteinase release by astrocytes: the role of CD147 (EMMPRIN) and ionizing radiation

(2020) Nicholas W. Colangelo et al.   Cell Communication and Signaling

Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells

(2020) Emily Clement et al.   EMBO JOURNAL

Loss of p53 protein strikes a nerve to aid tumour growth

(2020) Marco Napoli et al.   NATURE

Loss of p53 drives neuron reprogramming in head and neck cancer

(2020) Moran Amit et al.   NATURE

Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation

(2020) Qing Ji et al.   Nature Communications

Exosome miR-155 Derived from Gastric Carcinoma Promotes Angiogenesis by Targeting the c-MYB/VEGF Axis of Endothelial Cells

(2020) Ting Deng et al.   Molecular Therapy-Nucleic Acids

Exosomes derived from HeLa cells break down vascular integrity by triggering endoplasmic reticulum stress in endothelial cells

(2020) Yinuo Lin et al.   Journal of Extracellular Vesicles

Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells

(2020) Emanuela Mensà et al.   Journal of Extracellular Vesicles

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

(2020) Bhagyashree S. Joshi et al.   ACS Nano

An emerging focus on lipids in extracellular vesicles

(2020) Tore Skotland et al.   ADVANCED DRUG DELIVERY REVIEWS

Basic knowledge on BCR-ABL1-positive extracellular vesicles

(2020) Ancuta Jurj et al.   Biomarkers in Medicine

The Matrix Revolution: Matricellular Proteins and Restructuring of the Cancer Microenvironment

(2020) Casimiro Gerarduzzi et al.   CANCER RESEARCH

Hypoxic cancer-secreted exosomal miR-182-5p promotes glioblastoma angiogenesis by targeting Kruppel-like factor 2 and 4

(2020) Nanxiang Xiong et al.   MOLECULAR CANCER RESEARCH

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

(2020) Richard S. Finn et al.   NEW ENGLAND JOURNAL OF MEDICINE

A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells

(2020) Bong Hwan Sung et al.   Nature Communications

Extracellular vesicles from genetically unstable, oncogene-driven cancer cells trigger micronuclei formation in endothelial cells

(2020) Shilpa Chennakrishnaiah et al.   Scientific Reports

Natural-Killer-Derived Extracellular Vesicles: Immune Sensors and Interactors

(2020) Cristina Federici et al.   Frontiers in Immunology

Extracellular vesicle tetraspanin-8 level predicts distant metastasis in non–small cell lung cancer after concurrent chemoradiation

(2020) Yang Liu et al.   Science Advances

Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

(2020) Peng-Fei Zhang et al.   Molecular Cancer

Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

(2020) Chunxiao Li et al.   Molecular Cancer

Bioactive DNA from extracellular vesicles and particles

(2020) Ethan Z. Malkin et al.   Cell Death & Disease

Radiotherapy targeting cancer stem cells “awakens” them to induce tumour relapse and metastasis in oral cancer

(2020) Yangfan Liu et al.   International Journal of Oral Science

Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles

(2020) Allaura S. Cone et al.   BMC Molecular and Cell Biology

Antitumor immunity by small extracellular vesicles collected from activated dendritic cells through effective induction of cellular and humoral immune responses

(2020) Akihiro Matsumoto et al.   BIOMATERIALS

Transforming growth factor beta orchestrates PD-L1 enrichment in tumor-derived exosomes and mediates CD8 T-cell dysfunction regulating early phosphorylation of TCR signalome in breast cancer

(2020) Soumya Chatterjee et al.   CARCINOGENESIS

microRNA exchange via extracellular vesicles in cancer

(2020) Luyen Tien Vu et al.   CELL PROLIFERATION

Evidence for Enhanced Exosome Production in Aromatase Inhibitor-Resistant Breast Cancer Cells

(2020) Giuseppina Augimeri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles as natural therapeutic agents and innate drug delivery systems for cancer treatment: Recent advances, current obstacles, and challenges for clinical translation

(2020) Marco Pirisinu et al.   SEMINARS IN CANCER BIOLOGY

The Convergence of Extracellular Vesicle and GPCR Biology

(2020) Maarten P. Bebelman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Therapeutic plasma exchange clears circulating soluble PD-L1 and PD-L1-positive extracellular vesicles

(2020) Jacob J Orme et al.   Journal for ImmunoTherapy of Cancer

Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery

(2020) Xuan T. T. Dang et al.   Cells

PI3K-AKT-mTOR pathway alterations in advanced NSCLC patients after progression on EGFR-TKI and clinical response to EGFR-TKI plus everolimus combination therapy

(2020) Wenfeng Fang et al.   Translational Lung Cancer Research

Expression profiles and potential functions of circular RNAs in extracellular vesicles isolated from radioresistant glioma cells

(2019) Mengjie Zhao et al.   ONCOLOGY REPORTS

Transfer of Extracellular Vesicle-Associated-RNAs Induces Drug Resistance in ALK-Translocated Lung Adenocarcinoma

(2019) Hoi-Hin Kwok et al.   Cancers

CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells

(2019) Kai Härkönen et al.   Cells

Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors

(2019) Sahil Seth et al.   Cell Reports

Regulation of Endothelial Cell Permeability by Platelet-Derived Extracellular Vesicles

(2019) Byron Miyazawa et al.   Journal of Trauma and Acute Care Surgery

Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer

(2019) Wei-Lun Hwang et al.   Journal of Hematology & Oncology

Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non–small cell lung cancer

(2019) Bo Gong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Matrix metalloproteinases participation in the metastatic process and their diagnostic and therapeutic applications in cancer

(2019) Georgina Gonzalez-Avila et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions

(2019) Sachiko Matsuhashi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells

(2019) Fei Chen et al.   NATURE CELL BIOLOGY

Advances in therapeutic applications of extracellular vesicles

(2019) Oscar P. B. Wiklander et al.   Science Translational Medicine

Citraconylated exosomes for improved internalization into macrophages

(2019) Youngjun Kim et al.   Applied Biological Chemistry

A miR-567-PIK3AP1-PI3K/AKT-c-Myc feedback loop regulates tumour growth and chemoresistance in gastric cancer

(2019) Feifei Zhang et al.   EBioMedicine

Macrophage Polarization in the Development and Progression of Ovarian Cancers: An Overview

(2019) Huiyan Cheng et al.   Frontiers in Oncology

Future of Radiotherapy in Nasopharyngeal Carcinoma

(2019) Xue-Song Sun et al.   BRITISH JOURNAL OF RADIOLOGY

LncRNA H19 regulates PI3K–Akt signal pathway by functioning as a ceRNA and predicts poor prognosis in colorectal cancer: integrative analysis of dysregulated ncRNA-associated ceRNA network

(2019) Min-Er Zhong et al.   Cancer Cell International

RhoA inhibitor suppresses the production of microvesicles and rescues high ventilation induced lung injury

(2019) Huijun Dai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Metabolome of Exosomes: Focus on Vesicles Released by Cancer Cells and Present in Human Body Fluids

(2019) Aneta Zebrowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Advances in cancer immunotherapy 2019 – latest trends

(2019) Stephan Kruger et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

(2019) Yuxin Lin et al.   Journal of Hematology & Oncology

The pleiotropic role of proteoglycans in extracellular vesicle mediated communication in the tumor microenvironment

(2019) M. Cerezo-Magaña et al.   SEMINARS IN CANCER BIOLOGY

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles

(2019) Chiara Cianciaruso et al.   Cell Reports

Role of Neutrophil Extracellular Traps and Vesicles in Regulating Vascular Endothelial Permeability

(2019) Yonggang Ma et al.   Frontiers in Immunology

Tumor-Derived Extracellular Vesicles Inhibit Natural Killer Cell Function in Pancreatic Cancer

(2019) Jiangang Zhao et al.   Cancers

Frizzled-10 Extracellular Vesicles Plasma Concentration Is Associated with Tumoral Progression in Patients with Colorectal and Gastric Cancer

(2019) Scavo Maria Principia et al.   Journal of Oncology

Anti-angiogenesis triggers exosomes release from endothelial cells to promote tumor vasculogenesis

(2019) Ye Zeng et al.   Journal of Extracellular Vesicles

Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment

(2019) Tianyi Liu et al.   Frontiers in Cell and Developmental Biology

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

(2019) Golnaz Morad et al.   ACS Nano

The multi-factorial nature of clinical multidrug resistance in cancer

(2019) Yehuda G. Assaraf et al.   DRUG RESISTANCE UPDATES

Electrical and synaptic integration of glioma into neural circuits

(2019) Humsa S. Venkatesh et al.   NATURE

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

Synaptic proximity enables NMDAR signalling to promote brain metastasis

(2019) Qiqun Zeng et al.   NATURE

LMP1‐positive extracellular vesicles promote radioresistance in nasopharyngeal carcinoma cells through P38 MAPK signaling

(2019) Zhibao Zhang et al.   Cancer Medicine

Degradation of tumour stromal hyaluronan by small extracellular vesicle-PH20 stimulates CD103+ dendritic cells and in combination with PD-L1 blockade boosts anti-tumour immunity

(2019) Yeonsun Hong et al.   Journal of Extracellular Vesicles

The tumour microenvironment as an integrated framework to understand cancer biology

(2019) Rebeca Burgos-Panadero et al.   CANCER LETTERS

Cancer‐associated fibroblasts–derived exosomes‐mediated transfer of LINC00355 regulates bladder cancer cell proliferation and invasion

(2019) Lei Yan et al.   CELL BIOCHEMISTRY AND FUNCTION

Hyaluronan-CD44 axis orchestrates cancer stem cell functions

(2019) Spyros S. Skandalis et al.   CELLULAR SIGNALLING

Immune checkpoint inhibitors: a promising anticancer therapy

(2019) Sima Singh et al.   DRUG DISCOVERY TODAY

Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo

(2019) Nikki Heath et al.   Nanomedicine

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

c-Myc shuttled by tumour-derived extracellular vesicles promotes lung bronchial cell proliferation through miR-19b and miR-92a

(2019) Cristina Borzi et al.   Cell Death & Disease

Tunneling nanotube-mediated intercellular vesicle and protein transfer in the stroma-provided imatinib resistance in chronic myeloid leukemia cells

(2019) Marta D. Kolba et al.   Cell Death & Disease

Targeting CDC7 sensitizes resistance melanoma cells to BRAFV600E-specific inhibitor by blocking the CDC7/MCM2-7 pathway

(2019) Shaimaa A. Gad et al.   Scientific Reports

Targeting extracellular nutrient dependencies of cancer cells

(2019) Javier Garcia-Bermudez et al.   Molecular Metabolism

Functional extracellular vesicles engineered with lipid-grafted hyaluronic acid effectively reverse cancer drug resistance

(2019) Jia Liu et al.   BIOMATERIALS

Effects of gefitinib treatment on cellular uptake of extracellular vesicles in EGFR-mutant non-small cell lung cancer cells

(2019) Tomoya Takenaka et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Chemotherapeutic drugs stimulate the release and recycling of extracellular vesicles to assist cancer cells in developing an urgent chemoresistance

(2019) Xiaokun Wang et al.   Molecular Cancer

Real-time imaging of multivesicular body–plasma membrane fusion to quantify exosome release from single cells

(2019) Maarten P. Bebelman et al.   Nature Protocols

Inhibiting extracellular vesicles formation and release: a review of EV inhibitors

(2019) Mariadelva Catalano et al.   Journal of Extracellular Vesicles

Immune evasion via PD-1/PD-L1 on NK cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL

(2018) Frank Vari et al.   BLOOD

Active DNA end processing in micronuclei of ovarian cancer cells

(2018) Zizhi Tang et al.   BMC CANCER

Mechanism of recipient cell-dependent differences in exosome uptake

(2018) Sayo Horibe et al.   BMC CANCER

PD-L1 mRNA expression in plasma-derived exosomes is associated with response to anti-PD-1 antibodies in melanoma and NSCLC

(2018) Marzia Del Re et al.   BRITISH JOURNAL OF CANCER

Exosome-packaged miR-1246 contributes to bystander DNA damage by targeting LIG4

(2018) Li-Jun Mo et al.   BRITISH JOURNAL OF CANCER

Delivery of MGMT mRNA to glioma cells by reactive astrocyte-derived exosomes confers a temozolomide resistance phenotype

(2018) Tianfu Yu et al.   CANCER LETTERS

Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages

(2018) Ineta Popēna et al.   Cell Communication and Signaling

Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth

(2018) Yi Yang et al.   CELL RESEARCH

Functions of NKG2D in CD8+ T cells: an opportunity for immunotherapy

(2018) Kushal Prajapati et al.   Cellular & Molecular Immunology

Exosome-Based Detection ofEGFRT790M in Plasma from Non–Small Cell Lung Cancer Patients

(2018) Elena Castellanos-Rizaldos et al.   CLINICAL CANCER RESEARCH

Exosomes and Ectosomes in Intercellular Communication

(2018) Jacopo Meldolesi   CURRENT BIOLOGY

Molecular targeted therapy: treating cancer with specificity

(2018) Yeuan Ting Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Exosomes derived from imatinib-resistant chronic myeloid leukemia cells mediate a horizontal transfer of drug-resistant trait by delivering miR-365

(2018) Qing-Hua Min et al.   EXPERIMENTAL CELL RESEARCH

Hepatoma cell-secreted exosomal microRNA-103 increases vascular permeability and promotes metastasis by targeting junction proteins

(2018) Jian-Hong Fang et al.   HEPATOLOGY

Resistance to Anti-Angiogenic Therapy in Cancer—Alterations to Anti-VEGF Pathway

(2018) Yoshiro Itatani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles

(2018) Claudia Verderio et al.   JOURNAL OF LIPID RESEARCH

Cholesterol and the journey of extracellular vesicles

(2018) Frank W. Pfrieger et al.   JOURNAL OF LIPID RESEARCH

Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior

(2018) Shyam K. Bandari et al.   MATRIX BIOLOGY

Advances in studies of tyrosine kinase inhibitors and their acquired resistance

(2018) Qinlian Jiao et al.   Molecular Cancer

Extracellular vesicles as drivers of epithelial-mesenchymal transition and carcinogenic characteristics in normal prostate cells

(2018) Aline G. Souza et al.   MOLECULAR CARCINOGENESIS

Hypoxic Lung-Cancer-Derived Extracellular Vesicle MicroRNA-103a Increases the Oncogenic Effects of Macrophages by Targeting PTEN

(2018) Ya-Ling Hsu et al.   MOLECULAR THERAPY

Exosome-Mediated Transfer of Cancer Cell Resistance to Antiestrogen Drugs

(2018) Svetlana Semina et al.   MOLECULES

The role of p38 MAPK pathway in p53 compromised state and telomere mediated DNA damage response

(2018) Shomereeta Roy et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Technical challenges of working with extracellular vesicles

(2018) Marcel I. Ramirez et al.   Nanoscale

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

(2018) Wei Yan et al.   NATURE CELL BIOLOGY

Tumor-derived exosomes antagonize innate antiviral immunity

(2018) Liang Gao et al.   NATURE IMMUNOLOGY

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular vesicle budding is inhibited by redundant regulators of TAT-5 flippase localization and phospholipid asymmetry

(2018) Katharina B. Beer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab GTPase Function in Endosome and Lysosome Biogenesis

(2018) Lars Langemeyer et al.   TRENDS IN CELL BIOLOGY

SIRPα–CD47 Immune Checkpoint Blockade in Anticancer Therapy

(2018) André Veillette et al.   TRENDS IN IMMUNOLOGY

Hypoxia-Induced Matrix Metalloproteinase-13 Expression in Exosomes from Nasopharyngeal Carcinoma Enhances Metastases

(2018) Ying Shan et al.   Cell Death & Disease

Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells

(2018) Naohiro Seo et al.   Nature Communications

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

(2018) Tomer Cooks et al.   Nature Communications

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

(2018) Eduard Willms et al.   Frontiers in Immunology

Mechanisms of Resistance to Immune Checkpoint Blockade

(2018) David Liu et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Extracellular vesicles from triple-negative breast cancer cells promote proliferation and drug resistance in non-tumorigenic breast cells

(2018) Patricia Midori Murobushi Ozawa et al.   BREAST CANCER RESEARCH AND TREATMENT

Exosomes derived from hypoxic epithelial ovarian cancer cells deliver microRNAs to macrophages and elicit a tumor-promoted phenotype

(2018) Xin Chen et al.   CANCER LETTERS

Shedding of bevacizumab in tumour cells-derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma

(2018) Thomas Simon et al.   Molecular Cancer

Exosome-Derived miR-130a Activates Angiogenesis in Gastric Cancer by Targeting C-MYB in Vascular Endothelial Cells

(2018) Haiou Yang et al.   MOLECULAR THERAPY

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Extracellular vesicles and their nucleic acids for biomarker discovery

(2018) Fatemeh Momen-Heravi et al.   PHARMACOLOGY & THERAPEUTICS

NKG2D Ligands–Critical Targets for Cancer Immune Escape and Therapy

(2018) Dominik Schmiedel et al.   Frontiers in Immunology

Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p

(2018) Yao-yin Li et al.   EBioMedicine

The Tumor Vascular Endothelium as Decision Maker in Cancer Therapy

(2018) Diana Klein   Frontiers in Oncology

Fibronectin on the Surface of Extracellular Vesicles Mediates Fibroblast Invasion

(2018) Diptiman Chanda et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

31PPD-L1 expression on circulating monocytes in patients with breast cancer

(2018) M Nagano et al.   ANNALS OF ONCOLOGY

Effects of Cold Atmospheric Plasma on the Expression of Chemokines, Growth Factors, TNF Superfamily Members, Interleukins, and Cytokines in Human Osteosarcoma Cells

(2018) LYUBOMIR HARALAMBIEV et al.   ANTICANCER RESEARCH

Apoptosis and apoptotic body: disease message and therapeutic target potentials

(2018) Xuebo Xu et al.   BIOSCIENCE REPORTS

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

Role of Extracellular Matrix in Development and Cancer Progression

(2018) Cameron Walker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AHIF promotes glioblastoma progression and radioresistance via exosomes

(2018) Xuejun Dai et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Role of platelets and platelet receptors in cancer metastasis

(2018) Martin Schlesinger   Journal of Hematology & Oncology

Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration

(2018) Xu Zhang et al.   Molecular Cancer

A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells

(2018) Giulia Cesi et al.   Molecular Cancer

Internalization of Exosomes through Receptor-mediated Endocytosis

(2018) Amber Gonda et al.   MOLECULAR CANCER RESEARCH

Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways

(2018) S. Hallal et al.   MOLECULAR NEUROBIOLOGY

Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer cell lines

(2018) America Campos et al.   Nanomedicine

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment

(2018) Michinobu Umakoshi et al.   ONCOGENE

Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer

(2018) Yi Lei et al.   ONCOLOGY REPORTS

Phospholipid flippases enable precursor B cells to flee engulfment by macrophages

(2018) Katsumori Segawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

(2018) Zhicheng Zeng et al.   Nature Communications

Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer

(2018) Jieru Zhou et al.   Cancer Immunology Research

EGFR detection in extracellular vesicles of breast cancer patients through immunosensor based on silica-chitosan nanoplatform

(2018) Francisco G. Ortega et al.   TALANTA

Nuclear transportation of exogenous epidermal growth factor receptor and androgen receptor via extracellular vesicles

(2017) Jolene Read et al.   EUROPEAN JOURNAL OF CANCER

The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients

(2017) Marzia Del Re et al.   EUROPEAN UROLOGY

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

(2017) Vikram R. Juneja et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of Lymphocyte Subsets in the Immune Response to Primary B Cell–Derived Exosomes

(2017) Sarah C. Saunderson et al.   JOURNAL OF IMMUNOLOGY

Regulated Polarization of Tumor-Associated Macrophages by miR-145 via Colorectal Cancer–Derived Extracellular Vesicles

(2017) Haruka Shinohara et al.   JOURNAL OF IMMUNOLOGY

UCH-L1-containing exosomes mediate chemotherapeutic resistance transfer in breast cancer

(2017) Kuan Ning et al.   JOURNAL OF SURGICAL ONCOLOGY

The future of personalised radiotherapy for head and neck cancer

(2017) Jimmy J Caudell et al.   LANCET ONCOLOGY

Molecular testing for BRAF mutations to inform melanoma treatment decisions: a move toward precision medicine

(2017) Liang Cheng et al.   MODERN PATHOLOGY

Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Pro-inflammatory Microenvironment in the Lymph Node

(2017) Lifang Cheng et al.   MOLECULAR THERAPY

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery

(2017) Michael L. Merchant et al.   Nature Reviews Nephrology

Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1

(2017) Y-L Hsu et al.   ONCOGENE

Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype

(2017) Soliman Oushy et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct features of multivesicular body-lysosome fusion revealed by a new cell-free content-mixing assay

(2017) Mahmoud Abdul Karim et al.   TRAFFIC

Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity

(2017) Purnima Bhat et al.   Cell Death & Disease

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

(2017) Masaki Takasugi et al.   Nature Communications

Exosome secretion promotes chemotaxis of cancer cells

(2017) Bong Hwan Sung et al.   Cell Adhesion & Migration

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

A function-blocking CD47 antibody modulates extracellular vesicle-mediated intercellular signaling between breast carcinoma cells and endothelial cells

(2017) Sukhbir Kaur et al.   Journal of Cell Communication and Signaling

Intercellular Resistance to BRAF Inhibition Can Be Mediated by Extracellular Vesicle–Associated PDGFRβ

(2017) Laura J. Vella et al.   NEOPLASIA

Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms

(2017) Laurent Muller et al.   OncoImmunology

The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)

(2017) Theresa L. Whiteside   Translational Cancer Research

Tumor-derived exosomes induce CD8+ T cell suppressors

(2017) Brian T. Maybruck et al.   Journal for ImmunoTherapy of Cancer

Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival

(2017) Sistiana Aiello et al.   Scientific Reports

Tumor-Derived Exosomes Induce the Formation of Neutrophil Extracellular Traps: Implications For The Establishment of Cancer-Associated Thrombosis

(2017) Ana C. Leal et al.   Scientific Reports

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

(2016) Yanfang Liu et al.   CANCER CELL

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport

(2016) Marlieke L.M. Jongsma et al.   CELL

Testosterone Therapy in Men With Prostate Cancer

(2016) Alan L. Kaplan et al.   EUROPEAN UROLOGY

Neutrophils in the tumor microenvironment: trying to heal the wound that cannot heal

(2016) Kelly L. Singel et al.   IMMUNOLOGICAL REVIEWS

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4+T-cell responses

(2016) Yingping Xu et al.   IMMUNOLOGY

Donor dendritic cell–derived exosomes promote allograft-targeting immune response

(2016) Quan Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

(2016) Christoph S N Klose et al.   NATURE IMMUNOLOGY

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

(2016) J. Park et al.   Science Translational Medicine

Spatial Heterogeneity in the Tumor Microenvironment

(2016) Yinyin Yuan   Cold Spring Harbor Perspectives in Medicine

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

The Enrichment of Survivin in Exosomes from Breast Cancer Cells Treated with Paclitaxel Promotes Cell Survival and Chemoresistance

(2016) Bridget Kreger et al.   Cancers

Cancer associated fibroblasts transfer lipids and proteins to cancer cells through cargo vesicles supporting tumor growth

(2015) Alice Santi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

How Do Cytotoxic Lymphocytes Kill Cancer Cells?

(2015) L. Martinez-Lostao et al.   CLINICAL CANCER RESEARCH

Carvedilol use is associated with reduced cancer risk: A nationwide population-based cohort study

(2015) Chin-Sheng Lin et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

(2015) Miranda Y. Fong et al.   NATURE CELL BIOLOGY

Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma

(2015) L Treps et al.   ONCOGENE

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

(2015) Mark A. Feitelson et al.   SEMINARS IN CANCER BIOLOGY

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

(2015) W.G. Jiang et al.   SEMINARS IN CANCER BIOLOGY

Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis

(2015) Mélanie Tichet et al.   Nature Communications

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

(2015) Naoomi Tominaga et al.   Nature Communications

Directional cell movement through tissues is controlled by exosome secretion

(2015) Bong Hwan Sung et al.   Nature Communications

Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Cathepsin B Mediates the pH-Dependent Proinvasive Activity of Tumor-Shed Microvesicles

(2015) Ilaria Giusti et al.   NEOPLASIA

Programmed cell death 4 and microRNA 21 inverse expression is maintained in cells and exosomes from ovarian serous carcinoma effusions

(2014) Rocco Cappellesso et al.   CANCER CYTOPATHOLOGY

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

Microvesicles mediate transfer of P-glycoprotein to paclitaxel-sensitive A2780 human ovarian cancer cells, conferring paclitaxel-resistance

(2014) Fang-fang Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

miR-200–containing extracellular vesicles promote breast cancer cell metastasis

(2014) Minh T.N. Le et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells

(2014) Dhafer Mrizak et al.   JNCI-Journal of the National Cancer Institute

CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells

(2014) Sukhbir Kaur et al.   MATRIX BIOLOGY

Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells

(2014) Chiara Cossetti et al.   MOLECULAR CELL

RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation

(2014) Woosook Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment

(2014) Do-Young Choi et al.   PROTEOMICS

Role of Flippases, Scramblases and Transfer Proteins in Phosphatidylserine Subcellular Distribution

(2014) Hannah M. Hankins et al.   TRAFFIC

Tetraspanins in Extracellular Vesicle Formation and Function

(2014) Zoraida Andreu et al.   Frontiers in Immunology

Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8

(2013) A Q Sukkurwala et al.   CELL DEATH AND DIFFERENTIATION

Macrophage polarization in response to wear particles in vitro

(2013) Joseph K Antonios et al.   Cellular & Molecular Immunology

8q24 amplification is associated with Myc expression and prostate cancer progression and is an independent predictor of recurrence after radical prostatectomy

(2013) Gaelle Fromont et al.   HUMAN PATHOLOGY

Chemotherapy

(2013) Deborah Tolmach Sugerman   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dendritic Cell-Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity

(2013) T. I. Naslund et al.   JOURNAL OF IMMUNOLOGY

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology

(2013) Neal I. Lindeman et al.   Journal of Thoracic Oncology

Fludarabine treatment favors the retention of miR-485-3p by prostate cancer cells: implications for survival

(2013) Serena Lucotti et al.   Molecular Cancer

Bladder cancer cell-derived exosomes inhibit tumor cell apoptosis and induce cell proliferation in vitro

(2013) LIN YANG et al.   Molecular Medicine Reports

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autonomic Nerve Development Contributes to Prostate Cancer Progression

(2013) C. Magnon et al.   SCIENCE

Evading apoptosis in cancer

(2013) Kaleigh Fernald et al.   TRENDS IN CELL BIOLOGY

Dasatinib: From Treatment of Imatinib-Resistant or -Intolerant Patients With Chronic Myeloid Leukemia to Treatment of Patients With Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia

(2012) Brian L. Abbott   CLINICAL THERAPEUTICS

Obesity and risk of malignant melanoma: A meta-analysis of cohort and case–control studies

(2012) Theodoros N. Sergentanis et al.   EUROPEAN JOURNAL OF CANCER

Various modes of cell death induced by DNA damage

(2012) O Surova et al.   ONCOGENE

RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

(2012) B Li et al.   ONCOGENE

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

(2012) J. F. Nabhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Ectosomes

(2011) Emanuele Cocucci et al.   CURRENT BIOLOGY

Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts

(2011) Jung Ah Cho et al.   GYNECOLOGIC ONCOLOGY

Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells

(2011) Kyo Lee   INTERNATIONAL JOURNAL OF ONCOLOGY

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

(2011) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells

(2011) Yuan Xue et al.   NATURE MEDICINE

Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2–mediated heparin-binding EGF signaling in endothelial cells

(2011) Katrin J. Svensson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cells

(2011) Xing-Xiang Peng et al.   Chinese Journal of Cancer

Dendritic Cell-Derived Exosomes for Cancer Immunotherapy: What's Next?

(2010) S. Viaud et al.   CANCER RESEARCH

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

(2010) I. Nazarenko et al.   CANCER RESEARCH

Activation-induced internalization differs for the tetraspanins CD9 and Tspan8: Impact on tumor cell motility

(2010) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Microvesicles: mediators of extracellular communication during cancer progression

(2010) V. Muralidharan-Chari et al.   JOURNAL OF CELL SCIENCE

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

(2010) Fanny Chalmin et al.   JOURNAL OF CLINICAL INVESTIGATION

Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide/MHC Class I and Fas Ligand-Mediated Cytotoxicity

(2010) Y. Xie et al.   JOURNAL OF IMMUNOLOGY

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

(2010) Gideon Bollag et al.   NATURE

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis

(2010) M Tessema et al.   ONCOGENE

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

The Role of Fibroblast Growth Factors in Tumor Growth

(2009) M. Korc et al.   CURRENT CANCER DRUG TARGETS

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

(2009) E. U. Wieckowski et al.   JOURNAL OF IMMUNOLOGY

Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells

(2009) M Bebawy et al.   LEUKEMIA

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR

(2009) K. Al-Nedawi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Targeting EGFR in Colorectal Cancer

(2008) Wells A. Messersmith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer Immunology

(2008) Olivera J. Finn   NEW ENGLAND JOURNAL OF MEDICINE