Inhibiting extracellular vesicles formation and release: a review of EV inhibitors

Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A

(2019) Eun-Ju Im et al.   Nature Communications

Extracellular vesicles and anti-Cancer drug resistance

(2018) Niamh Mc Namee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The biology of extracellular microvesicles

(2018) Alanna E. Sedgwick et al.   TRAFFIC

Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells

(2018) Gati K. Panigrahi et al.   Scientific Reports

Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy

(2017) Uchini Kosgodage et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery

(2017) Liliane Christ et al.   TRENDS IN BIOCHEMICAL SCIENCES

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling

(2017) Qiyu Wang et al.   Nature Communications

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

(2016) K E Richards et al.   ONCOGENE

Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles

(2015) Dan Stratton et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction

(2015) Kobina Essandoh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Syntenin and syndecan in the biogenesis of exosomes

(2015) Véronique Friand et al.   BIOLOGY OF THE CELL

Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

(2015) Nicolas Chiaruttini et al.   CELL

Prion protein fragment (106–126) induces prothrombotic state by raising platelet intracellular calcium and microparticle release

(2015) Ram L. Mallick et al.   CELL CALCIUM

Heparanase activates the syndecan-syntenin-ALIX exosome pathway

(2015) Bart Roucourt et al.   CELL RESEARCH

Efficient inhibition of infectious prions multiplication and release by targeting the exosomal pathway

(2015) Didier Vilette et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nuclear Trapping through Inhibition of Exosomal Export by Indomethacin Increases Cytostatic Efficacy of Doxorubicin and Pixantrone

(2015) R. Koch et al.   CLINICAL CANCER RESEARCH

The Role of Exosomes in Breast Cancer

(2015) M. C. Lowry et al.   CLINICAL CHEMISTRY

Targeting Microparticle Biogenesis: A Novel Approach to the Circumvention of Cancer Multidrug Resistance

(2015) Ariane Roseblade et al.   CURRENT CANCER DRUG TARGETS

A critical role of cardiac fibroblast-derived exosomes in activating renin angiotensin system in cardiomyocytes

(2015) Linmao Lyu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Negative membrane curvature catalyzes nucleation of endosomal sorting complex required for transport (ESCRT)-III assembly

(2015) Il-Hyung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and membrane remodeling activity of ESCRT-III helical polymers

(2015) J. McCullough et al.   SCIENCE

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

(2015) Valentina R. Minciacchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo

(2015) Samireh Jorfi et al.   Scientific Reports

Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion

(2015) Alanna E. Sedgwick et al.   Scientific Reports

Pantethine Prevents Murine Systemic Sclerosis Through the Inhibition of Microparticle Shedding

(2015) Niloufar Kavian et al.   Arthritis & Rheumatology

Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors

(2015) Marton Siklos et al.   Acta Pharmaceutica Sinica B

Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer

(2015) Yibing Hu et al.   PLoS One

Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD

(2014) A. O. Awojoodu et al.   BLOOD

The Neutral Sphingomyelinase Pathway Regulates Packaging of the Prion Protein into Exosomes

(2014) Belinda B. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microvesicle Shedding and Lysosomal Repair Fulfill Divergent Cellular Needs during the Repair of Streptolysin O-Induced Plasmalemmal Damage

(2014) Alexander P. Atanassoff et al.   PLoS One

The Volatile Anesthetic Isoflurane Increases Endothelial Adenosine Generation via Microparticle Ecto-5′-Nucleotidase (CD73) Release

(2014) Mihwa Kim et al.   PLoS One

Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver

(2014) Alyssa Charrier et al.   SURGERY

Emerging concepts on the role of exosomes in lipid metabolic diseases

(2013) Michel Record et al.   BIOCHIMIE

ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion

(2013) Sabrina Schlienger et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular Mechanisms of the Membrane Sculpting ESCRT Pathway

(2013) W. M. Henne et al.   Cold Spring Harbor Perspectives in Biology

Extracellular vesicles in physiological and pathological conditions

(2012) Yuana Yuana et al.   BLOOD REVIEWS

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

(2012) B Li et al.   ONCOGENE

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

(2012) J. F. Nabhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a src-dependent fashion

(2011) Marco Mineo et al.   ANGIOGENESIS

Clopidogrel Effectively Suppresses Endothelial Microparticle Generation Induced by Indoxyl Sulfate via Inhibition of the p38 Mitogen-Activated Protein Kinase Pathway

(2011) Jung-Hwa Ryu et al.   BLOOD PURIFICATION

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Calpains as potential anti-cancer targets

(2011) Ludovic Leloup et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Flippin' lipids

(2011) Marcus R Clark   NATURE IMMUNOLOGY

Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3

(2011) T. Aung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anticoagulant effects of an antidiabetic drug on monocytes in vitro

(2011) C.E. Henriksson et al.   THROMBOSIS RESEARCH

Survivin is released from cancer cells via exosomes

(2010) Salma Khan et al.   APOPTOSIS

Tobacco Smoke Induces the Generation of Procoagulant Microvesicles From Human Monocytes/Macrophages

(2010) Mingzhen Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Small Molecule Inhibitors of Acid Sphingomyelinase

(2010) Christoph Arenz   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Microvesicles: mediators of extracellular communication during cancer progression

(2010) V. Muralidharan-Chari et al.   JOURNAL OF CELL SCIENCE

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

Acid sphingomyelinase activity triggers microparticle release from glial cells

(2009) Fabio Bianco et al.   EMBO JOURNAL

The enterocyte microvillus is a vesicle-generating organelle

(2009) Russell E. McConnell et al.   JOURNAL OF CELL BIOLOGY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Activation of PAK1/2 during the shedding of platelet microvesicles

(2008) Malvina Crespin et al.   BLOOD COAGULATION & FIBRINOLYSIS

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Protection against cerebral malaria by the low-molecular-weight thiol pantethine

(2008) M.-F. Penet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE