Apoptosis and apoptotic body: disease message and therapeutic target potentials

HIV/AIDS Vaccine Candidates Based on Replication-Competent Recombinant Poxvirus NYVAC-C-KC Expressing Trimeric gp140 and Gag-Derived Virus-Like Particles or Lacking the Viral Molecule B19 That Inhibits Type I Interferon Activate Relevant HIV-1-Specific B and T Cell Immune Functions in Nonhuman Primates

(2017) Juan García-Arriaza et al.   JOURNAL OF VIROLOGY

Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death

(2017) Decha Pinkaew et al.   Nature Communications

Anti-tumor effects of a recombinant anti-prostate specific membrane antigen immunotoxin against prostate cancer cells

(2017) Ping Meng et al.   BMC Urology

Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells

(2017) Kirti S. Prabhu et al.   PLoS One

Role of inflammation and apoptosis in multiple sclerosis: Comparative analysis between the periphery and the central nervous system

(2015) Beatrice Macchi et al.   JOURNAL OF NEUROIMMUNOLOGY

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax and show no preference for Bak versus Bax

(2015) C Hockings et al.   Cell Death & Disease

A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure

(2015) Georgia K. Atkin-Smith et al.   Nature Communications

DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer

(2014) Rui Yu et al.   CANCER BIOLOGY & THERAPY

Shotgun proteomics: Identification of unique protein profiles of apoptotic bodies from biliary epithelial cells

(2014) Ana Lleo et al.   HEPATOLOGY

Cross-talk between Endoplasmic Reticulum (ER) Stress and the MEK/ERK Pathway Potentiates Apoptosis in Human Triple Negative Breast Carcinoma Cells

(2014) Swatilekha Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-inflammatory response following uptake of apoptotic bodies by meningothelial cells

(2014) Jia Li et al.   Journal of Neuroinflammation

Unexpected link between an antibiotic, pannexin channels and apoptosis

(2014) Ivan K. H. Poon et al.   NATURE

Emerging role of extracellular vesicles in inflammatory diseases

(2014) Edit I. Buzas et al.   Nature Reviews Rheumatology

Small-molecule SMAC mimetics as new cancer therapeutics

(2014) Longchuan Bai et al.   PHARMACOLOGY & THERAPEUTICS

Annexin V-TRAIL fusion protein is a more sensitive and potent apoptotic inducer for cancer therapy

(2013) Fan Qiu et al.   Scientific Reports

How apoptotic cells aid in the removal of their own cold dead bodies

(2012) G Wickman et al.   CELL DEATH AND DIFFERENTIATION

Targeting the Bcl-2 family for cancer therapy

(2012) Shibu Thomas et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Induction of non-small cell lung carcinoma apoptosis using soluble RGD-TRAIL by targeting the integrin receptor of tumor cells

(2012) RUYONG YAO et al.   Molecular Medicine Reports

A novel recombinant immunocasp-6 fusion gene specifically and efficiently suppresses HER2-overexpressing osteosarcoma

(2012) BEN-GEN ZHOU et al.   ONCOLOGY REPORTS

Tubular cell HIV-entry through apoptosed CD4 T cells: A novel pathway

(2012) Priyanka Singh et al.   VIROLOGY

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

(2011) Kodi S. Ravichandran   IMMUNITY

Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice

(2011) Lilla Turiák et al.   Journal of Proteomics

Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1 

(2011) Y. Berda-Haddad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4+ T Cell Depletion in Human Immunodeficiency Virus (HIV) Infection: Role of Apoptosis

(2011) Michèle Février et al.   Viruses-Basel

XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38− cells in a phase 1/2 study of patients with relapsed/refractory AML

(2010) Bing Z. Carter et al.   APOPTOSIS

Cellular Mechanisms Underlying the Formation of Circulating Microparticles

(2010) Olivier Morel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Phase 1b/2 trial of mapatumumab in patients with relapsed/refractory non-Hodgkin's lymphoma

(2010) A Younes et al.   BRITISH JOURNAL OF CANCER

Apoptotic volume decrease as a geometric determinant for cell dismantling into apoptotic bodies

(2010) R Núñez et al.   CELL DEATH AND DIFFERENTIATION

Dendritic cells pulsed with antigen-specific apoptotic bodies prevent experimental type 1 diabetes

(2010) S. Marin-Gallen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Phase 1b Study of Dulanermin (recombinant human Apo2L/TRAIL) in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Patients With Advanced Non-Squamous Non–Small-Cell Lung Cancer

(2010) Jean-Charles Soria et al.   JOURNAL OF CLINICAL ONCOLOGY

Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain–dependent manner

(2010) Jan Kranich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HIV and Mature Dendritic Cells: Trojan Exosomes Riding the Trojan Horse?

(2010) Nuria Izquierdo-Useros et al.   PLoS Pathogens

Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors

(2009) H. A. Wakelee et al.   ANNALS OF ONCOLOGY

The Urokinase Plasminogen Activator Receptor Promotes Efferocytosis of Apoptotic Cells

(2009) Veera D'mello et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways

(2009) Joy X. Jiang et al.   JOURNAL OF HEPATOLOGY

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

(2009) A. Zernecke et al.   Science Signaling

Imaging and dosimetry of 99mTc EC annexin V: Preliminary clinical study targeting apoptosis in breast tumors

(2008) Hiroaki Kurihara et al.   APPLIED RADIATION AND ISOTOPES

Cationic Gradient Reversal and Cytoskeleton-independent Volume Regulatory Pathways Define an Early Stage of Apoptosis

(2008) Carl D. Bortner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptotic Bodies Convey Activity Capable of Initiating Osteoclastogenesis and Localized Bone Destruction

(2008) Giolanta Kogianni et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins

(2008) Cheol-Min Park et al.   JOURNAL OF MEDICINAL CHEMISTRY

A pathway for phagosome maturation during engulfment of apoptotic cells

(2008) Jason M. Kinchen et al.   NATURE CELL BIOLOGY