Peptides to combat viral infectious diseases

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

(2020) Aiping Wu et al.   Cell Host & Microbe

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

Antimicrobial host defence peptides: functions and clinical potential

(2020) Neeloffer Mookherjee et al.   NATURE REVIEWS DRUG DISCOVERY

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

(2020) Shuai Xia et al.   CELL RESEARCH

SARS-CoV-2 Vaccines: Status Report

(2020) Fatima Amanat et al.   IMMUNITY

Interpreting Diagnostic Tests for SARS-CoV-2

(2020) Nandini Sethuraman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

The search for an HIV vaccine, the journey continues

(2020) Carl W Dieffenbach et al.   Journal of the International AIDS Society

Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases

(2020) Cynthia Liu et al.   ACS Central Science

Efficacy of FLU-v, a broad-spectrum influenza vaccine, in a randomized phase IIb human influenza challenge study

(2020) Olga Pleguezuelos et al.   npj Vaccines

Design of a peptide-based subunit vaccine against novel coronavirus SARS-CoV-2

(2020) Parismita Kalita et al.   MICROBIAL PATHOGENESIS

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

In Silico Prediction of Human Leukocytes Antigen (HLA) Class II Binding Hepatitis B Virus (HBV) Peptides in Botswana

(2020) Wonderful Tatenda Choga et al.   Viruses-Basel

Re-boost immunizations with the peptide-based therapeutic HIV vaccine, Vacc-4x, restores geometric mean viral load set-point during treatment interruption

(2019) Jürgen K. Rockstroh et al.   PLoS One

A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice

(2019) Tian-Ying Zhang et al.   GUT

The PSIPRED Protein Analysis Workbench: 20 years on

(2019) Daniel W A Buchan et al.   NUCLEIC ACIDS RESEARCH

Enhanced inhibition of influenza virus infection by peptide–noble-metal nanoparticle conjugates

(2019) Zaid K Alghrair et al.   Beilstein Journal of Nanotechnology

A peptide-based inhibitor of gp96 suppresses HBsAg expression and HBV replication by upregulation of p53

(2019) Liyuan Qian et al.   JOURNAL OF GENERAL VIROLOGY

Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41

(2019) Pu et al.   Viruses-Basel

Peptide Antiviral Strategies as an Alternative to Treat Lower Respiratory Viral Infections

(2019) Origène Nyanguile   Frontiers in Immunology

Detection of influenza virus by agglutination using nanoparticles conjugated with a sialic acid-mimic peptide

(2019) Teruhiko Matsubara et al.   POLYMER JOURNAL

Development of multi-epitope driven subunit vaccine against Fasciola gigantica using immunoinformatics approach

(2019) Parismita Kalita et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Peptide-Based Vaccines: Current Progress and Future Challenges

(2019) Ryan J. Malonis et al.   CHEMICAL REVIEWS

Genetic characterization of the HIV-1 reservoir after Vacc-4x and romidepsin therapy in HIV-1 infected individuals

(2018) Anni Winckelmann et al.   AIDS

Optimization of the EC26-2A4 Epitope in the gp41 Membrane Proximal External Region Targeted by Neutralizing Antibodies from an Elite Controller

(2018) Oliver Ringel et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Innovation and trends in the development and approval of antiviral medicines: 1987–2017 and beyond

(2018) Shuvam Chaudhuri et al.   ANTIVIRAL RESEARCH

Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19)

(2018) Dan H Barouch et al.   LANCET

Pharmacokinetic and Chemical Synthesis Optimization of a Potent d-Peptide HIV Entry Inhibitor Suitable for Extended-Release Delivery

(2018) Joseph S. Redman et al.   MOLECULAR PHARMACEUTICS

Evaluation of the fusion inhibitor P3 peptide as a potential microbicide to prevent HIV transmission in women

(2018) Inês Bártolo et al.   PLoS One

A novel peptide-based vaccine candidate with protective efficacy against influenza A in a mouse model

(2018) José Herrera-Rodriguez et al.   VIROLOGY

Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials

(2018) Preetha Balasubramanian et al.   Scientific Reports

A Novel Natural Influenza A H1N1 Virus Neuraminidase Inhibitory Peptide Derived from Cod Skin Hydrolysates and Its Antiviral Mechanism

(2018) Jianpeng Li et al.   Marine Drugs

Origin and evolution of pathogenic coronaviruses

(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

Sequential Vacc-4x and romidepsin during combination antiretroviral therapy (cART): Immune responses to Vacc-4x regions on p24 and changes in HIV reservoirs

(2017) G. Tapia et al.   JOURNAL OF INFECTION

HBV-Derived Synthetic Long Peptide Can Boost CD4+ and CD8+ T-Cell Responses in Chronic HBV Patients Ex Vivo

(2017) Yingying Dou et al.   JOURNAL OF INFECTIOUS DISEASES

A Lipopeptide HIV-1/2 Fusion Inhibitor with Highly Potent In Vitro , Ex Vivo , and In Vivo Antiviral Activity

(2017) Huihui Chong et al.   JOURNAL OF VIROLOGY

Design of HIV Coreceptor Derived Peptides That Inhibit Viral Entry at Submicromolar Concentrations

(2017) Kostyantyn D. Bobyk et al.   MOLECULAR PHARMACEUTICS

Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase

(2017) Yousuke FURUTA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Potent peptidic fusion inhibitors of influenza virus

(2017) Rameshwar U. Kadam et al.   SCIENCE

Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP

(2017) Joanne M. Donkers et al.   Scientific Reports

Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus

(2017) Ben Hu et al.   PLoS Pathogens

The improved efficacy of Sifuvirtide compared with enfuvirtide might be related to its selectivity for the rigid biomembrane, as determined through surface plasmon resonance

(2017) Ping Cao et al.   PLoS One

Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors

(2017) Maria Carmina Scala et al.   Scientific Reports

Definition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor

(2016) M.J. Gómara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Simple, rapid detection of influenza A (H1N1) viruses using a highly sensitive peptide-based molecular beacon

(2016) Eun-Kyung Lim et al.   CHEMICAL COMMUNICATIONS

A liposomal formulation for the oral application of the investigational hepatitis B drug Myrcludex B

(2016) P. Uhl et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Early events in hepatitis B virus infection: From the cell surface to the nucleus

(2016) C Nelson Hayes et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Randomized phase II study of GS-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis B

(2016) Anna S. Lok et al.   JOURNAL OF HEPATOLOGY

A Helical Short-Peptide Fusion Inhibitor with Highly Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus

(2016) Shengwen Xiong et al.   JOURNAL OF VIROLOGY

Coronaviruses — drug discovery and therapeutic options

(2016) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

SARS and MERS: recent insights into emerging coronaviruses

(2016) Emmie de Wit et al.   NATURE REVIEWS MICROBIOLOGY

Highly sensitive detection of influenza virus by boron-doped diamond electrode terminated with sialic acid-mimic peptide

(2016) Teruhiko Matsubara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HBV Slow Maturation Process Leads to Infection

(2016) Koichi Watashi   TRENDS IN MICROBIOLOGY

Elucidation of the early infection machinery of hepatitis B virus by using bio-nanocapsule

(2016) Qiushi Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Current Approaches for Diagnosis of Influenza Virus Infections in Humans

(2016) Sai Vemula et al.   Viruses-Basel

A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses

(2016) Hanjun Zhao et al.   Scientific Reports

Tyrosine-sulfated V2 peptides inhibit HIV-1 infection via coreceptor mimicry

(2016) Raffaello Cimbro et al.   EBioMedicine

Immunotherapy With the PreS-based Grass Pollen Allergy Vaccine BM32 Induces Antibody Responses Protecting Against Hepatitis B Infection

(2016) Carolin Cornelius et al.   EBioMedicine

Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide

(2016) Xiaoli Ye et al.   Scientific Reports

Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer

(2015) Bo Wu et al.   CANCER LETTERS

Hepatitis B virus peptide inhibitors: solution structures and interactions with the viral capsid

(2015) Azira Muhamad et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects

(2015) Masaaki Yoshikawa   PEPTIDES

Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses

(2015) Shweta Tripathi et al.   PLoS One

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

(2015) Xiaojie Zhu et al.   Scientific Reports

Screening of FDA-Approved Drugs for Treatment of Emerging Pathogens

(2015) Jeanne M. Sisk et al.   ACS Infectious Diseases

Selection of HBV preS1-binding penta-peptides by phage display

(2014) Yonggang He et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial—ANRS HB02 VAC-ADN

(2014) H Fontaine et al.   GUT

Synthesis and Influenza Virus Inhibitory Activities of Carbosilane Dendrimers Peripherally Functionalized with Hemagglutinin-Binding Peptide

(2014) Ken Hatano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacokinetics of Sifuvirtide in Treatment-Naive and Treatment-Experienced HIV-Infected Patients

(2014) Qingfang Meng et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Therapeutic vaccines in treating chronic hepatitis B: the end of the beginning or the beginning of the end?

(2014) Marie-Louise Michel et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral, immunomodulatory, and anti-diabetic agents

(2014) J. Michael Conlon et al.   PEPTIDES

Current progress in antiviral strategies

(2014) Zhiyong Lou et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Priming by a novel universal influenza vaccine (Multimeric-001)—A gateway for improving immune response in the elderly population

(2014) Jacob Atsmon et al.   VACCINE

An ancestral HIV-2/simian immunodeficiency virus peptide with potent HIV-1 and HIV-2 fusion inhibitor activity

(2013) Pedro Borrego et al.   AIDS

Nonproteinogenic Amino Acid Building Blocks for Nonribosomal Peptide and Hybrid Polyketide Scaffolds

(2013) Christopher T. Walsh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regulation of Antiviral CD8 T-Cell Responses

(2013) Joseph M. Kulinski et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)

(2013) Koichi Watashi et al.   HEPATOLOGY

Multiple antigenic peptide (MAP): a synthetic peptide dendrimer for diagnostic, antiviral and vaccine strategies for emerging and re-emerging viral diseases

(2013) Vinay Ganeshrao Joshi et al.   Indian Journal of Virology

Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: Experiences and findings

(2013) Dao-Zhen Xu et al.   JOURNAL OF HEPATOLOGY

Scalable web services for the PSIPRED Protein Analysis Workbench

(2013) Daniel W. A. Buchan et al.   NUCLEIC ACIDS RESEARCH

Increased Expression of Gp96 by HBx-Induced NF-κB Activation Feedback Enhances Hepatitis B Virus Production

(2013) Hongxia Fan et al.   PLoS One

In Silico Approach for Predicting Toxicity of Peptides and Proteins

(2013) Sudheer Gupta et al.   PLoS One

Inhibition of Influenza A Virus Infection In Vitro by Peptides Designed In Silico

(2013) Rogelio López-Martínez et al.   PLoS One

Approaches for Identification of HIV-1 Entry Inhibitors Targeting gp41 Pocket

(2013) Fei Yu et al.   Viruses-Basel

A Recombinant Multiepitope Protein for Hepatitis B Diagnosis

(2013) Marilen Queiroz de Souza et al.   Biomed Research International

A Rationally Engineered Anti-HIV Peptide Fusion Inhibitor with Greatly Reduced Immunogenicity

(2012) F. Brauer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Peptides from Second Extracellular Loop of C-C Chemokine Receptor Type 5 (CCR5) Inhibit Diverse Strains of HIV-1

(2012) Cajetan Dogo-Isonagie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel family of peptides with potent activity against influenza A viruses

(2012) M. Q. Nicol et al.   JOURNAL OF GENERAL VIROLOGY

The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus

(2012) Tassilo Volz et al.   JOURNAL OF HEPATOLOGY

Hapivirins and Diprovirins: Novel  -Defensin Analogs with Potent Activity against Influenza A Virus

(2012) M. Doss et al.   JOURNAL OF IMMUNOLOGY

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

(2012) Chien-Te Tseng et al.   PLoS One

Synthetic Influenza vaccine (FLU-v) stimulates cell mediated immunity in a double-blind, randomised, placebo-controlled Phase I trial

(2012) Olga Pleguezuelos et al.   VACCINE

Influenza Virus-Mediated Membrane Fusion: Determinants of Hemagglutinin Fusogenic Activity and Experimental Approaches for Assessing Virus Fusion

(2012) Brian S. Hamilton et al.   Viruses-Basel

Bovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus

(2012) Maria Grazia Ammendolia et al.   Pathogens and Global Health

Investigating Endogenous Peptides and Peptidases Using Peptidomics

(2011) Arthur D. Tinoco et al.   BIOCHEMISTRY

Sensing HIV related protein using epitope imprinted hydrophilic polymer coated quartz crystal microbalance

(2011) Chun-Hua Lu et al.   BIOSENSORS & BIOELECTRONICS

Retrocyclins and their activity against HIV-1

(2011) W. Todd Penberthy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HBV life cycle and novel drug targets

(2011) Daniel Grimm et al.   Hepatology International

The performance of the VIKIA® HIV1/2 rapid test—Evaluation of the reliability and sensitivity

(2011) C. Gomes et al.   JOURNAL OF VIROLOGICAL METHODS

Effects of cathelicidin and its fragments on three key enzymes of HIV-1

(2011) Jack Ho Wong et al.   PEPTIDES

Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat

(2010) Kazuki Izumi et al.   ANTIVIRAL RESEARCH

Detection of HIV-1 Specific Monoclonal Antibodies Using Enhancement of Dye-Labeled Antigenic Peptides

(2010) Kim E. Sapsford et al.   BIOCONJUGATE CHEMISTRY

Sialic Acid-Mimic Peptides As Hemagglutinin Inhibitors for Anti-Influenza Therapy

(2010) Teruhiko Matsubara et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Pre-S2 Domain of the Hepatitis B Virus Is Dispensable for Infectivity but Serves a Spacer Function for L-Protein-Connected Virus Assembly

(2010) Y. Ni et al.   JOURNAL OF VIROLOGY

An optimally constrained V3 peptide is a better immunogen than its linear homolog or HIV-1 gp120

(2010) Adi Moseri et al.   VIROLOGY

An Albumin-Conjugated Peptide Exhibits Potent Anti-HIV Activity and Long In Vivo Half-Life

(2009) D. Xie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An electrochemical peptide-based biosensing platform for HIV detection

(2009) Jennifer Y. Gerasimov et al.   CHEMICAL COMMUNICATIONS

Hepatitis B virus infection

(2009) Yun-Fan Liaw et al.   LANCET

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Peptides modulating conformational changes in secreted chaperones: From in silico design to preclinical proof of concept

(2009) Y. Kliger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza Virus

(2009)   TRANSFUSION MEDICINE AND HEMOTHERAPY

SC29EK, a Peptide Fusion Inhibitor with Enhanced  -Helicity, Inhibits Replication of Human Immunodeficiency Virus Type 1 Mutants Resistant to Enfuvirtide

(2008) T. Naito et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovering and improving novel peptide therapeutics

(2008) D MCGREGOR   CURRENT OPINION IN PHARMACOLOGY

Design and Evaluation of Sifuvirtide, a Novel HIV-1 Fusion Inhibitor

(2008) Yuxian He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of Two Rapid Human Immunodeficiency Virus (HIV) Assays, Determine HIV-1/2 and OraQuick Advance Rapid HIV-1/2, for Detection of Recent HIV Seroconversion

(2008) R. Kshatriya et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein

(2008) Joerg Petersen et al.   NATURE BIOTECHNOLOGY

Potent HIV fusion inhibitors against Enfuvirtide-resistant HIV-1 strains

(2008) Y. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA